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The map label for this gene is atpA

Identifier: 221230051

GI number: 221230051

Start: 1333498

End: 1335174

Strand: Direct

Name: atpA

Synonym: MLBr_01143

Alternate gene names: 221230051

Gene position: 1333498-1335174 (Clockwise)

Preceding gene: 221230050

Following gene: 221230052

Centisome position: 40.8

GC content: 59.39

Gene sequence:

>1677_bases
ATGGCCGAGTTGACAATCTCCGCTGACGACATTCAGAACGCGATCGAAGAGTACGTAAGCTCCTTCACCGCCGACACGTT
CCGCGAGGAAGTCGGTACCGTTGTCGACGTCGGGGACAGCATCGCGCACGTCGAGGGTTTGCCCTCCGTGATGACCCAGG
AGCTGCTCGAGTTCCCCGGTGGGATCCTGGGTGTCGCACTCAACCTCGACGAACATAACGTTGGCGCGGTGATACTTGGT
GACTTCGAAAACATCAAAGAAGGCCAAAAGGTCAAGCGTACCGGCGACGTTCTCTCGGTCCCCGTAGGGGAAGCGTTCAT
GGGGCGGGTGGTCAATCCGCTTGGTCAGCCGATCGACGGGCGCGGAGATATCGAGGCCGAGGCTCGGCGTGCGCTGGAAC
TTCAGGCGCCCTCGGTAGTCCAGCGGCAAAGCGTGAAAGAGCCGCTGCAAACTGGGATCAAGGCCATCGACGCGATGACT
CCGATCGGTCGCGGACAGCGTCAGTTGGTCATCGGCGACCGCAAGACTGGCAAGACTGCGGTGTGTGTTGACACCATCCT
CAACCAGCGCCAGAACTGGGAGAGCGGCGATCCCAAGCGGCAGGTGCGTTGTGTGTACGTGGCCATCGGGCAGAAAGGTA
CCACCATCGCTTCTGTCCGCCGCGCTCTGGAGGAGGGCGGAGCGATGGACTATACCACCATCGTTGCGGCGCTGGCATCA
GATTCCGCTGGCTTCAAGTGGCTTGCGCCGTATACTGGTTCGGCGATCGCTCAGCACTGGATGTACGACGGTAAGCATGT
GCTGATCGTCTTCGACGACCTTACCAAGCAGGCCGAGGCATACCGCGCTATCTCCTTGCTGTTGCGTCGCCCGCCGGGTC
GCGAAGCTTATCCTGGTGACGTGTTCTACTTGCACTCGCGGTTGTTGGAGCGGTGCGCAAAGCTTGCTGACCACCTCGGT
GGCGGCTCGCTGACGGGTTTGCCGATCATCGAAACCAAGGCCAATGACATTTCGGCCTACATCCCTACCAATGTCATCTC
AATCACCGACGGGCAGTGCTTCCTAGAGACCGATCTGTTCAACCAGGGGGTCCGGCCGGCCATTAACGTCGGTGTCTCGG
TGTCCCGGGTCGGCGGTGCTGCACAGATCAAGGCCATGAAGGAAGTGGCCGGCTCGCTGCGTCTGGACTTGTCGCAGTAT
CGTGAGCTAGAGGCTTTCGCTGCCTTTGCCTCGGACCTGGATGCCACCTCCAAGGCACAGTTGGAGCGTGGTGCGCGGCT
GGTCGAATTGCTCAAACAACCGCAGTACCAGCCCATGCCCGTCGAGGAGCAAGTGATATCCCTCTTTTTGGGTACTGGCG
GCCACCTGGACTCAGTGCCGGTCGGGGATGTCAGGCGGTTCGAAACCGAGCTGCTGGACCACATCCGGGTTGCACAAGAG
GAAATTTTGACTGAGATTCGGGAGAGCCAGAAGCTCACCGACGAAGCCGCCGATTCACTCACTGAAGTCATCAAGAGCTT
CAAGAAGGGTTTCGCGGCGACTGGTGGTGCATCGGTGGTGCCCAACGAGCACGTCGCAGCCCTCGATGAGGAGAAGTTGG
ACAAGGAATCAGTGAAAGTGCACCAGGCTATTCCAGCAAAGACTTCGGAGAAAAGCAAAAATAGCACACCCAGGTAA

Upstream 100 bases:

>100_bases
TCTTGTCTGGTCGCCGCTGAGGCTGCGTTGCCCGACTGAACACGAACTAGTCACTAAATCCGCGCGAAAGACGAAAATCA
AGTAGGAAGACGAAAAAGCC

Downstream 100 bases:

>100_bases
TAGAGGGTAATGGAGATATGGCTGCCACACTTCGCGAACTACGCGGACGGATCCGTTCAGTGGGCTCGATCAAGAAGATC
ACCAAGGCCCAGGAGCTGAT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MAELTISADDIQNAIEEYVSSFTADTFREEVGTVVDVGDSIAHVEGLPSVMTQELLEFPGGILGVALNLDEHNVGAVILG
DFENIKEGQKVKRTGDVLSVPVGEAFMGRVVNPLGQPIDGRGDIEAEARRALELQAPSVVQRQSVKEPLQTGIKAIDAMT
PIGRGQRQLVIGDRKTGKTAVCVDTILNQRQNWESGDPKRQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAALAS
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLADHLG
GGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQY
RELEAFAAFASDLDATSKAQLERGARLVELLKQPQYQPMPVEEQVISLFLGTGGHLDSVPVGDVRRFETELLDHIRVAQE
EILTEIRESQKLTDEAADSLTEVIKSFKKGFAATGGASVVPNEHVAALDEEKLDKESVKVHQAIPAKTSEKSKNSTPR

Sequences:

>Translated_558_residues
MAELTISADDIQNAIEEYVSSFTADTFREEVGTVVDVGDSIAHVEGLPSVMTQELLEFPGGILGVALNLDEHNVGAVILG
DFENIKEGQKVKRTGDVLSVPVGEAFMGRVVNPLGQPIDGRGDIEAEARRALELQAPSVVQRQSVKEPLQTGIKAIDAMT
PIGRGQRQLVIGDRKTGKTAVCVDTILNQRQNWESGDPKRQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAALAS
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLADHLG
GGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQY
RELEAFAAFASDLDATSKAQLERGARLVELLKQPQYQPMPVEEQVISLFLGTGGHLDSVPVGDVRRFETELLDHIRVAQE
EILTEIRESQKLTDEAADSLTEVIKSFKKGFAATGGASVVPNEHVAALDEEKLDKESVKVHQAIPAKTSEKSKNSTPR
>Mature_557_residues
AELTISADDIQNAIEEYVSSFTADTFREEVGTVVDVGDSIAHVEGLPSVMTQELLEFPGGILGVALNLDEHNVGAVILGD
FENIKEGQKVKRTGDVLSVPVGEAFMGRVVNPLGQPIDGRGDIEAEARRALELQAPSVVQRQSVKEPLQTGIKAIDAMTP
IGRGQRQLVIGDRKTGKTAVCVDTILNQRQNWESGDPKRQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAALASD
SAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLADHLGG
GSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYR
ELEAFAAFASDLDATSKAQLERGARLVELLKQPQYQPMPVEEQVISLFLGTGGHLDSVPVGDVRRFETELLDHIRVAQEE
ILTEIRESQKLTDEAADSLTEVIKSFKKGFAATGGASVVPNEHVAALDEEKLDKESVKVHQAIPAKTSEKSKNSTPR

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=504, Percent_Identity=53.5714285714286, Blast_Score=574, Evalue=1e-164,
Organism=Homo sapiens, GI4757810, Length=504, Percent_Identity=53.5714285714286, Blast_Score=574, Evalue=1e-164,
Organism=Homo sapiens, GI19913428, Length=293, Percent_Identity=30.3754266211604, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI19913426, Length=293, Percent_Identity=29.6928327645051, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI32189394, Length=486, Percent_Identity=25.1028806584362, Blast_Score=109, Evalue=8e-24,
Organism=Escherichia coli, GI1790172, Length=516, Percent_Identity=49.8062015503876, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1790170, Length=366, Percent_Identity=25.1366120218579, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788251, Length=322, Percent_Identity=26.7080745341615, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988063, Length=505, Percent_Identity=55.2475247524753, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI71988080, Length=505, Percent_Identity=55.2475247524753, Blast_Score=589, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71988074, Length=505, Percent_Identity=51.8811881188119, Blast_Score=540, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17570191, Length=294, Percent_Identity=30.6122448979592, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17510931, Length=328, Percent_Identity=30.1829268292683, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25144756, Length=452, Percent_Identity=24.1150442477876, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=503, Percent_Identity=54.6719681908549, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322581, Length=417, Percent_Identity=26.6187050359712, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319603, Length=297, Percent_Identity=28.2828282828283, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24658560, Length=502, Percent_Identity=53.5856573705179, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281361666, Length=302, Percent_Identity=29.8013245033113, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646341, Length=302, Percent_Identity=29.8013245033113, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17136796, Length=302, Percent_Identity=29.8013245033113, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24638766, Length=440, Percent_Identity=26.3636363636364, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574560, Length=410, Percent_Identity=25.3658536585366, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_MYCLB (B8ZR40)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503467.1
- ProteinModelPortal:   B8ZR40
- SMR:   B8ZR40
- EnsemblBacteria:   EBMYCT00000085836
- GeneID:   7327252
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000014996
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 60435; Mature: 60304

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTISADDIQNAIEEYVSSFTADTFREEVGTVVDVGDSIAHVEGLPSVMTQELLEFPG
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHCCCHHHHHHHHHHCCC
GILGVALNLDEHNVGAVILGDFENIKEGQKVKRTGDVLSVPVGEAFMGRVVNPLGQPIDG
CEEEEEEECCCCCCCEEEECCHHHHHCCHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCC
RGDIEAEARRALELQAPSVVQRQSVKEPLQTGIKAIDAMTPIGRGQRQLVIGDRKTGKTA
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHH
VCVDTILNQRQNWESGDPKRQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAALAS
HHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGD
CCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCH
VFYLHSRLLERCAKLADHLGGGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCEEEECCCCEEEEEHHH
NQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDATSKAQ
CCCCCCHHHCCEEHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHH
LERGARLVELLKQPQYQPMPVEEQVISLFLGTGGHLDSVPVGDVRRFETELLDHIRVAQE
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EILTEIRESQKLTDEAADSLTEVIKSFKKGFAATGGASVVPNEHVAALDEEKLDKESVKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHCCHHHHHH
HQAIPAKTSEKSKNSTPR
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AELTISADDIQNAIEEYVSSFTADTFREEVGTVVDVGDSIAHVEGLPSVMTQELLEFPG
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHCCCHHHHHHHHHHCCC
GILGVALNLDEHNVGAVILGDFENIKEGQKVKRTGDVLSVPVGEAFMGRVVNPLGQPIDG
CEEEEEEECCCCCCCEEEECCHHHHHCCHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCC
RGDIEAEARRALELQAPSVVQRQSVKEPLQTGIKAIDAMTPIGRGQRQLVIGDRKTGKTA
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHH
VCVDTILNQRQNWESGDPKRQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAALAS
HHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
DSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGD
CCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCH
VFYLHSRLLERCAKLADHLGGGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCEEEECCCCEEEEEHHH
NQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDATSKAQ
CCCCCCHHHCCEEHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHH
LERGARLVELLKQPQYQPMPVEEQVISLFLGTGGHLDSVPVGDVRRFETELLDHIRVAQE
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EILTEIRESQKLTDEAADSLTEVIKSFKKGFAATGGASVVPNEHVAALDEEKLDKESVKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHCCHHHHHH
HQAIPAKTSEKSKNSTPR
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA