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The map label for this gene is atpB

Identifier: 221230047

GI number: 221230047

Start: 1330460

End: 1331215

Strand: Direct

Name: atpB

Synonym: MLBr_01139

Alternate gene names: 221230047

Gene position: 1330460-1331215 (Clockwise)

Preceding gene: 221230046

Following gene: 221230048

Centisome position: 40.71

GC content: 55.95

Gene sequence:

>756_bases
ATGACTGAGACAATCCTATCCGGAGGTCAAATCGAGGTCGGCGAGCACCACACCACCACCTGGTTTGGGATGACCGTCAA
CACCGATACGGTGCTCTCCACTGCGATCGCGGCGGCGATCGTAATCGCGCTGGCTTTCTTCTTGCGTACCAAGGTCAACT
CAACAGGTGTTCCTTGTGGCATGCAGTTGTTCTGGGAGGCGATCACGGTACAGATGCGCACTCAGATCGAGAGCGCTATC
GGCATGCGGATTGCCCCGTTCGTGCTGCCGTTGGCGGTCACGATCTTCGTGTTCATCCTGATCTCCAACTGGCTCTCGGT
GCTGCCGCTGCAATACACCAACGCAGATGGGCACACCACCGAGGTGCTCAGTTCGGCGGCGGCCGACATCAATTACGTGC
TGGCGCTGGCGTTTTTCGTCTTCGTCTGCTATCACTTGGCGGGTATCTGGCGTCGCGGCATTGTCGGGCATCCGGTGGCG
GTGCTCAAAGGTCACGTGGCGTTCTTGGCGCCGATTAACCTGGTTGAAGAAATCACAAAGCCCATTTCGTTGTCGCTTCG
ACTTTTCGGCAATATCTTCGCCGGCGGGATCCTGGTTACCCTGATCGCACTGTTCCCTCCGTACATTATGTGGGCGCCGA
ATGCGATCTGGAAGTCTTTCGACCTGTTCGTGGGCGCCATTCAGGCATTCATTTTCTCAATTCTGACCATCTTGTATTTC
AGCCAAGCCATGGAGGTTGAGGACCATCATGACTAA

Upstream 100 bases:

>100_bases
TATTGGTGTTATCGACCATGCTGCCGGTCTGGAGGAAGTTCCGCTTCGGGGAAGCGGACGGCGGTGTACTCAAAGGATCA
GAAGGTGAGGAGCAGCAGCG

Downstream 100 bases:

>100_bases
AAACGCCACGCATTATCCTGGCCCACAAGCCACTACTTCAAGCCAGGTAGACCGCTACACAGATAGTAGCTATTGAGGTA
TAAGGAGGACAAAGTATGGA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTETILSGGQIEVGEHHTTTWFGMTVNTDTVLSTAIAAAIVIALAFFLRTKVNSTGVPCGMQLFWEAITVQMRTQIESAI
GMRIAPFVLPLAVTIFVFILISNWLSVLPLQYTNADGHTTEVLSSAAADINYVLALAFFVFVCYHLAGIWRRGIVGHPVA
VLKGHVAFLAPINLVEEITKPISLSLRLFGNIFAGGILVTLIALFPPYIMWAPNAIWKSFDLFVGAIQAFIFSILTILYF
SQAMEVEDHHD

Sequences:

>Translated_251_residues
MTETILSGGQIEVGEHHTTTWFGMTVNTDTVLSTAIAAAIVIALAFFLRTKVNSTGVPCGMQLFWEAITVQMRTQIESAI
GMRIAPFVLPLAVTIFVFILISNWLSVLPLQYTNADGHTTEVLSSAAADINYVLALAFFVFVCYHLAGIWRRGIVGHPVA
VLKGHVAFLAPINLVEEITKPISLSLRLFGNIFAGGILVTLIALFPPYIMWAPNAIWKSFDLFVGAIQAFIFSILTILYF
SQAMEVEDHHD
>Mature_250_residues
TETILSGGQIEVGEHHTTTWFGMTVNTDTVLSTAIAAAIVIALAFFLRTKVNSTGVPCGMQLFWEAITVQMRTQIESAIG
MRIAPFVLPLAVTIFVFILISNWLSVLPLQYTNADGHTTEVLSSAAADINYVLALAFFVFVCYHLAGIWRRGIVGHPVAV
LKGHVAFLAPINLVEEITKPISLSLRLFGNIFAGGILVTLIALFPPYIMWAPNAIWKSFDLFVGAIQAFIFSILTILYFS
QAMEVEDHHD

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=207, Percent_Identity=32.8502415458937, Blast_Score=88, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_MYCLE (P45829)

Other databases:

- EMBL:   U15186
- EMBL:   AL583920
- PIR:   T09980
- RefSeq:   NP_301833.1
- ProteinModelPortal:   P45829
- SMR:   P45829
- EnsemblBacteria:   EBMYCT00000028452
- GeneID:   910232
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1139
- NMPDR:   fig|272631.1.peg.705
- Leproma:   ML1139
- GeneTree:   EBGT00050000016888
- HOGENOM:   HBG734175
- OMA:   APINVVE
- ProtClustDB:   PRK05815
- BioCyc:   MLEP272631:ML1139-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27559; Mature: 27428

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x29cf313c)-; HASH(0x29b498f8)-; HASH(0x29b4bf50)-; HASH(0x29b41378)-; HASH(0x29b3eba0)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETILSGGQIEVGEHHTTTWFGMTVNTDTVLSTAIAAAIVIALAFFLRTKVNSTGVPCG
CCCCCCCCCCEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
MQLFWEAITVQMRTQIESAIGMRIAPFVLPLAVTIFVFILISNWLSVLPLQYTNADGHTT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHH
EVLSSAAADINYVLALAFFVFVCYHLAGIWRRGIVGHPVAVLKGHVAFLAPINLVEEITK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
PISLSLRLFGNIFAGGILVTLIALFPPYIMWAPNAIWKSFDLFVGAIQAFIFSILTILYF
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQAMEVEDHHD
HHHHCCCCCCH
>Mature Secondary Structure 
TETILSGGQIEVGEHHTTTWFGMTVNTDTVLSTAIAAAIVIALAFFLRTKVNSTGVPCG
CCCCCCCCCEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
MQLFWEAITVQMRTQIESAIGMRIAPFVLPLAVTIFVFILISNWLSVLPLQYTNADGHTT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHH
EVLSSAAADINYVLALAFFVFVCYHLAGIWRRGIVGHPVAVLKGHVAFLAPINLVEEITK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
PISLSLRLFGNIFAGGILVTLIALFPPYIMWAPNAIWKSFDLFVGAIQAFIFSILTILYF
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQAMEVEDHHD
HHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002