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The map label for this gene is hom

Identifier: 221230037

GI number: 221230037

Start: 1319682

End: 1321007

Strand: Direct

Name: hom

Synonym: MLBr_01129

Alternate gene names: 221230037

Gene position: 1319682-1321007 (Clockwise)

Preceding gene: 221230036

Following gene: 221230038

Centisome position: 40.38

GC content: 59.58

Gene sequence:

>1326_bases
GTGTTCAGTGATGAAAGGACGGTCGGTGTAGCGGTACTCGGGTTGGGCAATGTCGGCAGCGAAGTTGTTCGCATTATCGA
GGGCAGCGCTGACGACCTCGCGGCTCGTATCGGCGCTCCATTGATGCTGCGTGGCATCGGGGTGCGTCGTGTCGCCGTCG
ACCGGGGTGTTCCGGTCGATTTGTTGACCGACAACATTGAAGAACTCGTCTCCCGTGCGGACGTCGACATTGTCGTTGAA
GTGATGGGACCAGTTGAGCTGTCTCGCAAGGCGATCTTGTCAGCGCTCGAACATGGCAAGTCTGTCGTCACGGCGAACAA
GGCGTTGCTTGCCGCCTCCACTGGTGAATTGGCGCAGGCTGCCGAAAGTGCGCATGTCGACTTGTATTTTGAAGCTGCAG
TAGCAGGTGCCATCCCGGTAATCCGCCCATTAACCCAGTCACTGGCCGGTGACACCGTGCTGCGGGTGGCTGGTATTGTG
AACGGTACCACCAACTACATCTTGTCTGCGATGGACAGCACCGGTGCCGACTACGACAGCGCGCTGGCCGGTGCGAGAGC
GCTCGGCTACGCCGAAGCCGATCCCACCGCGGACGTCGAAGGCCATGACGCTGCGGCTAAGGCCGCGATCCTGGCATCGA
TCGCTTTCCACACTCGGGTAACCGCCGATGATGTCTATCGCGAGGGCATCACCAAGATCACTCCGGCCGACTTCGTGTCG
GCGCGGGCGTTAGGTTGCACCATTAAGCTGCTGTTCATTTGCGAGCGCATTACCGCCGCCGATGGCCAGCAACGAGTTTC
GGCCCGCGTTTATCCTGCATTGGTCCCCATGTCACATCCGCTTGCCACGGTCAGCGGAGCGTTCAACGCCGTGGTGGTGG
AGGCTGAGGCCGCCGGGCGGCTGATGTTCTACGGCCAGGGCGCCGGTGGTGCTCCTACCGCGTCGGCGGTGACTGGTGAC
TTGGTAATGGCGGCGCGCAACCGAGTGCTCGGCAGTCGCGGTCCAAAAGAATCCAAGTATGCTCAATTGCCTATGGAAAC
AATAGGTTTCATTTCTACTCGATATTACGTGAGCATGAATGTAGCCGACAAGCCTGGTGTATTATCAGGGGTAGCAGCAG
AATTCGCCAAGCGCGAAGTGAGCATCGCCGAAGTTCGTCAAGAAGGTGTGGTGGATGACGGCGGACGACGGGTGGGAGCC
CGTATTGTAGTGGTCACTCATGGCGCCACCGACGCCGCGCTCTCCGAAACCGTCGATGCGTTGGCTGACTTAGACGTCGT
GCAGGGTGTCACAAGTGTGTTGCGACTGGAAGGAATCAGCCTGTGA

Upstream 100 bases:

>100_bases
CGGCCGCCCCGCTGTGGTTGCGGTGTGCGCGGGGCAAGCTCGTCTGATCCTGCGCCGGGAGACGGTTGACGATCTGCTGA
GTCTGGAAGTGAGGTGACCT

Downstream 100 bases:

>100_bases
GCGGCCAGCAGACGACCACCCACCAGCCTTGGCCGGGTGTGATCGCAGCGTACCGAGACCGACTACCAGTGGGCGACGAT
TGGACCCCGGTTACCTTGCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVE
VMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIV
NGTTNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVS
ARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGD
LVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGA
RIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL

Sequences:

>Translated_441_residues
MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVE
VMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIV
NGTTNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVS
ARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGD
LVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGA
RIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL
>Mature_441_residues
MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVE
VMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIV
NGTTNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVS
ARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGD
LVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGA
RIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Escherichia coli, GI1790376, Length=365, Percent_Identity=26.027397260274, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=29.3172690763052, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHOM_MYCLE (P46806)

Other databases:

- EMBL:   U15186
- EMBL:   AL583920
- PIR:   T09992
- RefSeq:   NP_301823.1
- ProteinModelPortal:   P46806
- EnsemblBacteria:   EBMYCT00000028455
- GeneID:   910223
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1129
- NMPDR:   fig|272631.1.peg.695
- Leproma:   ML1129
- GeneTree:   EBGT00050000016352
- HOGENOM:   HBG527379
- OMA:   GIPIIEP
- ProtClustDB:   PRK06349
- BioCyc:   MLEP272631:ML1129-MONOMER
- BRENDA:   1.1.1.3
- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000098

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3

EC number: =1.1.1.3

Molecular weight: Translated: 45607; Mature: 45607

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: ACT_SITE 207-207 BINDING 107-107 BINDING 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVD
CCCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCHH
LLTDNIEELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHHH
AESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDS
HHCCCEEEEEEHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
ALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVS
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHH
ARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCHHHHCCCCEEEEEEECCCCE
LMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHEEEEEEEEEE
VADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGARIVVVTHGATDAALSETVDA
CCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEECEEEEEEECCCCHHHHHHHHHH
LADLDVVQGVTSVLRLEGISL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVD
CCCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCHH
LLTDNIEELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHHH
AESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDS
HHCCCEEEEEEHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
ALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVS
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHH
ARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCHHHHCCCCEEEEEEECCCCE
LMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHEEEEEEEEEE
VADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGARIVVVTHGATDAALSETVDA
CCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEECEEEEEEECCCCHHHHHHHHHH
LADLDVVQGVTSVLRLEGISL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002