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The map label for this gene is htrA [H]

Identifier: 221230005

GI number: 221230005

Start: 1240812

End: 1242413

Strand: Direct

Name: htrA [H]

Synonym: MLBr_01078

Alternate gene names: 221230005

Gene position: 1240812-1242413 (Clockwise)

Preceding gene: 221230004

Following gene: 221230006

Centisome position: 37.97

GC content: 60.86

Gene sequence:

>1602_bases
GTGAATACTAGGGTGGACACCGACAACGCGGTAATCCGATATCGGCGCCGTAACAGGCCCTGTCTCGAGCGCTCAGAAGA
GGATAATGTGACCTCCGACCAAGGCACCAACAACGACCAAAATCCCGGCCATCACCTGGCGACGCGCCCCGTCGCCAGGC
CTCCTGTCGACGCCGCGTCCCGTGAGGCGTTCGGCCGCCCCTGTGGGTTTTCGGGATCCTTTGTAGCTGAATATGTGCGC
CCACAGAAATATCGAGACCGCAGCGAATTCAGGCCTGATGATCAACCAGCCGACCCCGTCCTTGCCGAGGCATTCAGCCG
GCCATTCGGGAGCGTCGATTCGCTGCAGCGCCATCCTATCGATGCGGGTGCGCTGGCTGCTGAGAAAGATGCCACTCAGC
TGGACGAACCCGATGATCCGTGGCGAGACCCTGCGGCTGCGGCTACTCTGGCGAGTCCTGCAGTGGCTTCACCGGTGCCG
CACACTGAGTTGGGTCAATGCGGCAAACTCGGTGTGCGCGACGTGCTATTTGGCGGCAGAGTGTCCTACCTTGCCCTGGT
CATCTTGGTCTTTATTGCTTTGGCGCTGGGTGCTATCGGCGGTGTGATCGGTCGTAAGACGGCTGAAATCGTCGACGCGT
TCACCACGTCGAAAGTGACGTTGGCAACCACTAACAATACTGAAGAGCCGGCCGGTCGTTTCGCCAAGGTGGCGGCGGCG
GTAGCTGACTCCGTGGTGACGATTGAGTCGAAGAGTGACCAGGAGGAAATGCAGGGCTCCGGTGTCATCATCGATGGCCG
CGGCTACATCGTCACTAACAACCACGTGATTTCCGAAGCGGCCAACAAGCCCAGCCAGTTCAAGACGACCGTGGTGTTCA
ACGACGGCAAGGACGTGCCCGCCAATCTGGTGGGCCGCGACCCCAAGACCGACCTGGCCGTACTCAAGGTCGATAACGTC
GACAACCTGACGGTGGCGCGGCTTGGTGATTCCGGCAAGGTGCGGGTTGGTGATGAGGTTATCGCAGCGGGTGCGCCGCT
TGGGCTGCGCAGCACGGTGACCCACGGCATCGTTAGCGCACTGCACCGCCCTGTCCCGTTATCGGGAGAGGGATCTGACA
CGGACACCGTCATCGATGCCATCCAGACCGACGCATCAATCAACCATGGCAACTCTGGTGGGCCGCTGATCGACATGGAT
TCCCAGGTGATCGGCATCAATACTGCCGGCAAGTCACTGTCGGACAGCGCCAGTGGGCTGAGCTTTGCGATCCCGGTCGA
CGAGATGAAATCGGTTGTGCAAACACTGATCAAGGACGGCAAGATCGTGCACCCGACGTTGGGGGTCAGCACCCGGTCGG
TGAGCAACGCTATCGCGTCCGGCGCCCAGGTGGCCAATGTGAAGGCAGGAAGCCCCGCGCAAAAGGGCGGAATCCTGGAA
AACGACGTCATAGTCAAGGTCGGCAACCGGAAAGTCGCCGACGCCGATGAGTTCATCGTTGCCGTGCGGCAGCTGACCAT
TGGACAGGACGCCTCAGTAGAGGTGGTCCGCGACGGTCGGCACGTCACGCTGACGGTGAAATCCGACCCCGATAGTAGCT
AG

Upstream 100 bases:

>100_bases
TTGCCCGTGAACAGGGTAAACGCTGATAGCTTGACAGCTAAGTTACCGAGTTCAGGTGATAGCTGCTGGCGTGTGACTGC
GTGCCGACCAAGCGGGGACG

Downstream 100 bases:

>100_bases
TGTTCGCCAACATTGGTTGGGGGGAAATGCTCGTCCTTGTGGTCGTCGGGCTGGTGGTGCTTGGCCCGGAACGGTTTCCC
GGAGCCATCCGCTGGACGTT

Product: possinble serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAASREAFGRPCGFSGSFVAEYVR
PQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVP
HTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAA
VADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNV
DNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMD
SQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILE
NDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS

Sequences:

>Translated_533_residues
MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAASREAFGRPCGFSGSFVAEYVR
PQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVP
HTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAA
VADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNV
DNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMD
SQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILE
NDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS
>Mature_533_residues
MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAASREAFGRPCGFSGSFVAEYVR
PQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVP
HTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAA
VADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNV
DNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMD
SQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILE
NDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=265, Percent_Identity=36.9811320754717, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4506141, Length=290, Percent_Identity=34.1379310344828, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI7019477, Length=293, Percent_Identity=32.0819112627986, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI24308541, Length=287, Percent_Identity=32.404181184669, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1786356, Length=278, Percent_Identity=35.6115107913669, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789629, Length=283, Percent_Identity=36.3957597173145, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789630, Length=287, Percent_Identity=36.2369337979094, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646839, Length=347, Percent_Identity=30.835734870317, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 56002; Mature: 56002

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAAS
CCCCCCCCCHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
REAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPI
HHHCCCCCCCCCHHHHHHHCCHHHCCHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCC
DAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVPHTELGQCGKLGVRDVLFGGR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHCCH
VSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
VADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVP
HHCCEEEEECCCCHHHHCCCCEEECCCEEEEECCEEEEHHCCCCCCEEEEEEEECCCCCC
ANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSA
HHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEECCEEEECCCCCCHHHHHHHHHHHH
LHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDSQVIGINTAGKSLSDSASGL
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCC
SFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILE
EEEECHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHCCCCC
NDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS
CCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCC
>Mature Secondary Structure
MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAAS
CCCCCCCCCHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
REAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPI
HHHCCCCCCCCCHHHHHHHCCHHHCCHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCC
DAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVPHTELGQCGKLGVRDVLFGGR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHCCH
VSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
VADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVP
HHCCEEEEECCCCHHHHCCCCEEECCCEEEEECCEEEEHHCCCCCCEEEEEEEECCCCCC
ANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSA
HHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEECCEEEECCCCCCHHHHHHHHHHHH
LHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDSQVIGINTAGKSLSDSASGL
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCC
SFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILE
EEEECHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHCCCCC
NDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS
CCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]