BacMap

Definition	Mycobacterium leprae Br4923 chromosome, complete genome.
Accession	NC_011896
Length	3,268,071

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The map label for this gene is xclC [H]

Identifier: 221229986

GI number: 221229986

Start: 1217149

End: 1218579

Strand: Direct

Name: xclC [H]

Synonym: MLBr_01051

Alternate gene names: 221229986

Gene position: 1217149-1218579 (Clockwise)

Preceding gene: 221229985

Following gene: 221229988

Centisome position: 37.24

GC content: 61.5

Gene sequence:

>1431_bases
GTGTTGTTGGCATCACTGAATCCGTCCGTCGTTACCGCCACCGATATCGCTGACGCGGTATGTGTTGACGGCGTCGTGCT
GAGCCGCAGCGGCTTGGTTGGTGCCGCAACGTCGGTGGCTGAGCGTGTCGGAGGTGCACGCCTGGTAGCGGTGCTGGCCA
CGCCGACGGCATCGACTGTGCTAGCGATTACTGGTTGCCTGATTGCCGGTGTGCCGGTGGTCCCGGTGCCCGCGGATATC
GGTGTGGTCGAACGCCGGCATATGCTCACCGATTCTGGGGCGCAGGCCTGGCTGGGTCCGGGGCCCAGTGCGGACTCGGC
GCCGGACGGGTTGCCGCATATCCCGGTTCAACTAGATGCTCGCTCCTGGAACCGCTATCCTGAGCCGTCACCTGATGCCA
CCGCGATGGTGATCTACACCTCGGGTACTACTGGGCCCCCTAAGGGGGTACTGTTGAGCCGGCGAGCGATCGCCGTTGAT
TTGGACGCGCTTGCCCAGGCCTGGCAGTGGACGGCCGATGACGTTTTGGTACATGGATTGCCGCTGTTTCACGTGCACGG
CCTTGTACTCGGTTTGCTTGGATCGCTTCGGATTGGAAATCGCTTTGTACACACCGGAAAACCCACTCCGACCGCCTATG
CTCAGGCTTGCTCTGAAGCCGGGGGATCTCTGTATTTCGGCGTTCCCACGGTATGGTCGCGGCTGGTGGCAGACGAGGCA
GTTGCCCGGGCGTTAAGACCCGCGCGGCTACTAGTGTCTGGGAGTGCCTCATTGCCGGTTCCGGTATTTGATCGGCTAGC
GCACCTCACAGGTCATCGGCCCATCGAACGGTATGGCAGCACGGAATCACTGATCACCCTGTCGACGTTGGCGGACGGTG
AGCGCCGTGCGGGCTGGGTGGGATTGCCGCTGGCGGGCGTGCAGACCAGGCTGGTCGATGAGTCCGGAGGTCCAGTGCCC
TACGACGGGGAAACCGTTGGGAGGCTTCAGGTTCGTAGTCCGACGATGTTCGGCGGCTATCTAAATCGACCGGAAGCGAC
AGCCGAGGCGTTCGACGAGGACGGTTGGTACCGTACAGGTGATGTTGCGGTCGTGGACAGTGGCGGGATGCATCGCATCG
TGGGTCGCGAGTCGGTTGACCTAATCAAATTGGGCGGATACCGGATCGGCGCAGGAGAAATCGAGATGGCGCTGCTAGGA
CATCCGGATGTGCGGGAGGTGGCAGTTGTCGGGCTGCCTGACGAGGATTTGGGTCAACGGATCGTTGCATTCGTCGTAGG
CGCAGAGGCATTAGATGCCGATGAGTTGATTAACTATGTTGCCCAACAGCTTTCGATACATAAGCGGCCGCGTGAAGTCC
GCTTCGTGGACGCGCTGCCGCGCAACGCGATGGGAAAGGTCCTCAAAAAGCAGTTGCTCTTCGAGGGCTGA

Upstream 100 bases:

>100_bases
TGGCCGAGGCGAGGAAATTCTGTGCACCTTGATGGCGATTTAGGACCGCTATTAGCGAGCGTGACTCGGTCTTGCAACTA
CCCCGGGTAACCTTGCTCAC

Downstream 100 bases:

>100_bases
CTGGCGCTACGACGAGTAGTGATTATGCGGGCACGCCATCGTTGCGACCGGCACGGGGGCCGGATGTGTTGGTTTGGTCG
CCGCGCCACTGTAGAGCTTC

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAGVPVVPVPADI
GVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVD
LDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEA
VARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAGWVGLPLAGVQTRLVDESGGPVP
YDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLG
HPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG

Sequences:

>Translated_476_residues
MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAGVPVVPVPADI
GVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVD
LDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEA
VARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAGWVGLPLAGVQTRLVDESGGPVP
YDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLG
HPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG
>Mature_476_residues
MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAGVPVVPVPADI
GVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVD
LDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEA
VARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAGWVGLPLAGVQTRLVDESGGPVP
YDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLG
HPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=375, Percent_Identity=40.5333333333333, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI187761343, Length=375, Percent_Identity=40.5333333333333, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI156151445, Length=372, Percent_Identity=28.2258064516129, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI122937307, Length=349, Percent_Identity=29.2263610315186, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI38505220, Length=349, Percent_Identity=28.9398280802292, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI42544132, Length=349, Percent_Identity=27.5071633237822, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI157311624, Length=468, Percent_Identity=25.6410256410256, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI157311622, Length=468, Percent_Identity=25.6410256410256, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI58082049, Length=468, Percent_Identity=25.4273504273504, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI40807491, Length=353, Percent_Identity=29.4617563739377, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI115511026, Length=377, Percent_Identity=28.3819628647215, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI57165412, Length=345, Percent_Identity=27.8260869565217, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI57165410, Length=344, Percent_Identity=27.3255813953488, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI42794756, Length=359, Percent_Identity=27.0194986072423, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI42794760, Length=359, Percent_Identity=27.0194986072423, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI42794758, Length=359, Percent_Identity=27.0194986072423, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI28416953, Length=377, Percent_Identity=26.525198938992, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI13325057, Length=393, Percent_Identity=26.4631043256997, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI13375727, Length=365, Percent_Identity=27.3972602739726, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI13236579, Length=409, Percent_Identity=24.6943765281174, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788107, Length=378, Percent_Identity=31.7460317460317, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI145693145, Length=345, Percent_Identity=32.463768115942, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786810, Length=352, Percent_Identity=31.25, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI221142682, Length=355, Percent_Identity=27.3239436619718, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1789201, Length=360, Percent_Identity=28.0555555555556, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790505, Length=362, Percent_Identity=28.1767955801105, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786801, Length=335, Percent_Identity=29.5522388059701, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786529, Length=382, Percent_Identity=28.5340314136126, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788595, Length=438, Percent_Identity=26.7123287671233, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=492, Percent_Identity=32.3170731707317, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI32563687, Length=470, Percent_Identity=31.2765957446809, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17559526, Length=357, Percent_Identity=31.9327731092437, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=363, Percent_Identity=30.5785123966942, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=353, Percent_Identity=29.7450424929178, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71994694, Length=363, Percent_Identity=30.0275482093664, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994703, Length=363, Percent_Identity=30.0275482093664, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994690, Length=363, Percent_Identity=30.0275482093664, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=363, Percent_Identity=28.099173553719, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=408, Percent_Identity=27.4509803921569, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=361, Percent_Identity=28.5318559556787, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17556552, Length=390, Percent_Identity=27.9487179487179, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25141359, Length=442, Percent_Identity=23.0769230769231, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17510401, Length=364, Percent_Identity=27.7472527472527, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=365, Percent_Identity=25.4794520547945, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=351, Percent_Identity=25.3561253561254, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319699, Length=341, Percent_Identity=30.791788856305, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320852, Length=417, Percent_Identity=26.1390887290168, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=381, Percent_Identity=27.2965879265092, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319264, Length=397, Percent_Identity=25.4408060453401, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859661, Length=354, Percent_Identity=29.6610169491525, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21355181, Length=344, Percent_Identity=30.8139534883721, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24581924, Length=354, Percent_Identity=30.225988700565, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI221329755, Length=403, Percent_Identity=24.8138957816377, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19922652, Length=361, Percent_Identity=30.4709141274238, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24653035, Length=373, Percent_Identity=27.3458445040214, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656500, Length=371, Percent_Identity=31.266846361186, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356947, Length=348, Percent_Identity=27.0114942528736, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648260, Length=506, Percent_Identity=25.296442687747, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161076582, Length=380, Percent_Identity=26.5789473684211, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648257, Length=349, Percent_Identity=26.9340974212034, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281366413, Length=353, Percent_Identity=28.6118980169972, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666501, Length=353, Percent_Identity=28.6118980169972, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666497, Length=353, Percent_Identity=28.6118980169972, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356441, Length=327, Percent_Identity=26.605504587156, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130357, Length=349, Percent_Identity=25.7879656160458, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281365686, Length=321, Percent_Identity=22.7414330218069, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358303, Length=156, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648253, Length=352, Percent_Identity=23.2954545454545, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648255, Length=353, Percent_Identity=23.5127478753541, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 50131; Mature: 50131

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTV
CEEECCCCCEEEHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCHHHH
LAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDA
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCEEEEC
RSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGL
CCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCEEEEEHHHHHHHHCCCCCHHHHCCC
PLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEA
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHH
VARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAGWV
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCCCCCCEE
GLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTG
ECCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCCCCCHHHHHHCCCCCEEEC
DVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQR
CEEEECCCCEEEECCCCCCCEEEECCEEECCCCEEEEEECCCCCHHEEEEECCCHHHHHH
IVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTV
CEEECCCCCEEEHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCHHHH
LAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDA
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCEEEEC
RSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGL
CCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCEEEEEHHHHHHHHCCCCCHHHHCCC
PLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEA
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHH
VARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAGWV
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCCCCCCEE
GLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTG
ECCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCCCCCHHHHHHCCCCCEEEC
DVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQR
CEEEECCCCEEEECCCCCCCEEEECCEEECCCCEEEEEECCCCCHHEEEEECCCHHHHHH
IVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]