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The map label for this gene is iscS [H]

Identifier: 220933037

GI number: 220933037

Start: 2401261

End: 2402406

Strand: Direct

Name: iscS [H]

Synonym: Hore_22050

Alternate gene names: 220933037

Gene position: 2401261-2402406 (Clockwise)

Preceding gene: 220933036

Following gene: 220933038

Centisome position: 93.14

GC content: 40.84

Gene sequence:

>1146_bases
ATGAAAGAAATATATCTGGATAACAGTGCTACAACCCGTCCCCTCCCTGAAGTAGTGTCTCAAGTTGAGGAAGTATTGAC
AACAAACTACGGAAATCCCTCTTCACTACATAATAAAGGCCTTTCCGCTGAAAAAATTTTAAAAGAAGCCAGGCAGACCA
TTGCCGGAAAATTAAACGTTAAACCAGATGAAATTATTTTTACATCCGGTGGTACTGAAAGTAACAACCTGGCTCTTAAA
GGGACTGCCTATCTATATAAAAACCGGGGGCGACACTTGATTACTACCAAAATAGAACACGCTTCGGTTATTGATACCTT
CAAAGCTCTGGAAGATGAAGGCTTTGAAGTCACCTATCTAAAACCCGATAAAAGGGGCATAATCTCCTTAGAAGAACTTA
AAAGGTCAATAAGAGATGATACCATCCTGATAAGTATTATGCATATTAATAATGAACTGGGAAGTCTACAACCCATTGCT
GAGGCCGGATCCATTATTAAAGATATCAATAAAAAAACCATTTTTCACGTTGATGCCGTCCAGTCATTTGGTAAAGTGCT
AATAAAACCTGCTGACTGGAATATTGACCTTCTAACAATAAGTGCCCATAAAGTTCATGGCCCCAAGGGAGTAGGCGCCC
TCTATAAACGGAAAAACCTTGACATAAAGCCCCTGTTAAACGGGGGAGGTCAGGAAGATGGCCTGAGGTCCGGAACGGAA
AACATCCCCGGGATTGCCGGTTTTATTCCTGCTGTAAAGGCCCTTCCAGACTTTAATGAAAGGAATACCTTTAACCGGAA
ACTGGACAGGCTTAAAAATCATTTAATAGATATGATTAAAGAAAAACTACCTGATGTAAGGCTAAATACCCCGGAACAAT
CGGCCCCCCATATCGTCAATATCTCCATCCCTCGAGTAAAGGGAGAGGTAGTTGTTCACAGCCTTGAAGCAAAAGGTATA
TATGTATCAACCGGTTCAGCCTGTCATTCCCGGGAAAGAGAAAAAAGCCATGTCTTAAGGGCCATTGGACTACCTTCTGA
ACTAATAGATGGTACAATAAGAATCAGTCTGTCTGAATATAACACAGAAACAGACTTAAACACTGCAGTAAAAACCCTGG
CAGAACAGTTGCGGTATTTCTTTTAA

Upstream 100 bases:

>100_bases
AATGCTTTATTTATGTTATAATACAGGTAATGGTTAATTTTAAATAAAGGTAATACGCAGATAAAACTGGAGGCAAAGTA
GCTTAATAGGGGGTTTAATT

Downstream 100 bases:

>100_bases
CACTATAGGGAGGTGAACCATATGTACAAAGTTATTCTGATTCGCTATGGAGAGATAGCCCTTAAGGGTCAAAACAGGCA
TGTTTTTATCAATAAACTGA

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKEIYLDNSATTRPLPEVVSQVEEVLTTNYGNPSSLHNKGLSAEKILKEARQTIAGKLNVKPDEIIFTSGGTESNNLALK
GTAYLYKNRGRHLITTKIEHASVIDTFKALEDEGFEVTYLKPDKRGIISLEELKRSIRDDTILISIMHINNELGSLQPIA
EAGSIIKDINKKTIFHVDAVQSFGKVLIKPADWNIDLLTISAHKVHGPKGVGALYKRKNLDIKPLLNGGGQEDGLRSGTE
NIPGIAGFIPAVKALPDFNERNTFNRKLDRLKNHLIDMIKEKLPDVRLNTPEQSAPHIVNISIPRVKGEVVVHSLEAKGI
YVSTGSACHSREREKSHVLRAIGLPSELIDGTIRISLSEYNTETDLNTAVKTLAEQLRYFF

Sequences:

>Translated_381_residues
MKEIYLDNSATTRPLPEVVSQVEEVLTTNYGNPSSLHNKGLSAEKILKEARQTIAGKLNVKPDEIIFTSGGTESNNLALK
GTAYLYKNRGRHLITTKIEHASVIDTFKALEDEGFEVTYLKPDKRGIISLEELKRSIRDDTILISIMHINNELGSLQPIA
EAGSIIKDINKKTIFHVDAVQSFGKVLIKPADWNIDLLTISAHKVHGPKGVGALYKRKNLDIKPLLNGGGQEDGLRSGTE
NIPGIAGFIPAVKALPDFNERNTFNRKLDRLKNHLIDMIKEKLPDVRLNTPEQSAPHIVNISIPRVKGEVVVHSLEAKGI
YVSTGSACHSREREKSHVLRAIGLPSELIDGTIRISLSEYNTETDLNTAVKTLAEQLRYFF
>Mature_381_residues
MKEIYLDNSATTRPLPEVVSQVEEVLTTNYGNPSSLHNKGLSAEKILKEARQTIAGKLNVKPDEIIFTSGGTESNNLALK
GTAYLYKNRGRHLITTKIEHASVIDTFKALEDEGFEVTYLKPDKRGIISLEELKRSIRDDTILISIMHINNELGSLQPIA
EAGSIIKDINKKTIFHVDAVQSFGKVLIKPADWNIDLLTISAHKVHGPKGVGALYKRKNLDIKPLLNGGGQEDGLRSGTE
NIPGIAGFIPAVKALPDFNERNTFNRKLDRLKNHLIDMIKEKLPDVRLNTPEQSAPHIVNISIPRVKGEVVVHSLEAKGI
YVSTGSACHSREREKSHVLRAIGLPSELIDGTIRISLSEYNTETDLNTAVKTLAEQLRYFF

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=382, Percent_Identity=41.6230366492147, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=31.1594202898551, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI48994898, Length=374, Percent_Identity=44.6524064171123, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1789175, Length=402, Percent_Identity=25.8706467661692, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787970, Length=392, Percent_Identity=24.4897959183673, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=368, Percent_Identity=43.2065217391304, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17533177, Length=339, Percent_Identity=31.858407079646, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319831, Length=382, Percent_Identity=40.5759162303665, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI20129463, Length=384, Percent_Identity=41.40625, Blast_Score=273, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42220; Mature: 42220

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIYLDNSATTRPLPEVVSQVEEVLTTNYGNPSSLHNKGLSAEKILKEARQTIAGKLNV
CCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
KPDEIIFTSGGTESNNLALKGTAYLYKNRGRHLITTKIEHASVIDTFKALEDEGFEVTYL
CCCEEEEECCCCCCCCEEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEE
KPDKRGIISLEELKRSIRDDTILISIMHINNELGSLQPIAEAGSIIKDINKKTIFHVDAV
CCCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEEHHHH
QSFGKVLIKPADWNIDLLTISAHKVHGPKGVGALYKRKNLDIKPLLNGGGQEDGLRSGTE
HHCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
NIPGIAGFIPAVKALPDFNERNTFNRKLDRLKNHLIDMIKEKLPDVRLNTPEQSAPHIVN
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
ISIPRVKGEVVVHSLEAKGIYVSTGSACHSREREKSHVLRAIGLPSELIDGTIRISLSEY
EECCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHCCCEEEEEEECC
NTETDLNTAVKTLAEQLRYFF
CCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEIYLDNSATTRPLPEVVSQVEEVLTTNYGNPSSLHNKGLSAEKILKEARQTIAGKLNV
CCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
KPDEIIFTSGGTESNNLALKGTAYLYKNRGRHLITTKIEHASVIDTFKALEDEGFEVTYL
CCCEEEEECCCCCCCCEEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEE
KPDKRGIISLEELKRSIRDDTILISIMHINNELGSLQPIAEAGSIIKDINKKTIFHVDAV
CCCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEEHHHH
QSFGKVLIKPADWNIDLLTISAHKVHGPKGVGALYKRKNLDIKPLLNGGGQEDGLRSGTE
HHCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
NIPGIAGFIPAVKALPDFNERNTFNRKLDRLKNHLIDMIKEKLPDVRLNTPEQSAPHIVN
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
ISIPRVKGEVVVHSLEAKGIYVSTGSACHSREREKSHVLRAIGLPSELIDGTIRISLSEY
EECCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHCCCEEEEEEECC
NTETDLNTAVKTLAEQLRYFF
CCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA