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The map label for this gene is lpxB [H]

Identifier: 220932589

GI number: 220932589

Start: 1874540

End: 1875679

Strand: Reverse

Name: lpxB [H]

Synonym: Hore_17530

Alternate gene names: 220932589

Gene position: 1875679-1874540 (Counterclockwise)

Preceding gene: 220932590

Following gene: 220932588

Centisome position: 72.75

GC content: 45.26

Gene sequence:

>1140_bases
TTGGGCAAAATAATGGTAGTAGCCGGAGAAGTCTCTGGTGATATGCATGCAGCCAGGGTGGTCCGGGAAATTAAAAAATT
AGCCCCTGAAACCCGGTTTTTTGGTATGGGGTCAAAATGCCTCCGGGAAGCAGGGGTTGAGGTTCTTGTTGATCCGACCG
ATATAAGCACCATCGGTTTTAGTGAGGCTCTGAAGAACTACAGACAGCACCGGGATCATTTGAAAATGATGAAAAAGGCC
CTGGAGCGGGAAAAACCTGATGTAGCTTTACTGGTGGATTATTCAGGTTTTAATATAAAGATGGCCCGGATTACCAAACG
AAAAAAAATCCCCACTGTCAGTTATTTTAGTCCTTCGGCATGGGTCTGGGGGAAACGTCGGGCCCGGAAAATGGCGAGGG
CCCGGGCGGTTATTGCGTCAGTCTTTCCTATGGAAGAAAAAGTATACCGGGAAGCCGGGGCTGAGGTTCATTTTGTTGGA
CATCCCCTGTTAGATATGGTTAATGTCGAGGAGTCTAAAGATGAAATATGTAGAAAACTGGAGCTTGATGGGGAAAAACC
CATTATCGGGTTAATGCCGGGAAGCCGGAAACAGGAAGTGGAATACCTTCTCCCTGAGATGTTGAAGGCAGCAGAACGGT
TAAAGAAGGAAAAGGGTGATTTTCAATTTGTTATTCCCGTAGCTCCAGGGATTGACCGGGATAAAATTGTTGAAATGGCC
TCCCGGTATAAATTGGTACTCAAGGTGGTTGAAGGGGCCAATTATGAGGTAATGAAGGCTTCTGATTTCCTGGTGGTTGC
TTCAGGTACTGCTACCCTTGAAGCGACAATAATCGGAACCCCTATGGTCATCGTTTACCGGACGAGCTGGTCTACCTATC
ACCTAGGAAAATTACTGGTTAACCTTGACTACATAGGCCTCCCCAATATTATTGCTGACCGGGAGATTGTACCGGAATTG
CTCCAGCAGGATGTTACCGCTGACAATATTTATCGGGAAATTACAAATTTCATGAGTAAACCCTATCTTATTAAAAGCAT
AAAAAGGGACCTGGAATATGTCAAAAATAAACTGGGAAGGCCTGGTGCCGTGAGGAGAACTGCAGAACTTGTTTTGAAAA
AGGGCAAATTGTATATTTAG

Upstream 100 bases:

>100_bases
TATTGTCGACAGGGAAGAATTTATTGAAACGGCGGAGGCCAGTGGAATTACCGTTATGGCTTTAGAGTCTGCCTCCCCTG
AATAAGGTGGTGAGTAATCT

Downstream 100 bases:

>100_bases
AATAGTTATAGATAAGTTATGTTTATACCCATATTTTTATATCCATATAAAGATATCCTGATTGATAAATCTAAAAAATT
GTTTATATTCAAAACAGGGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MGKIMVVAGEVSGDMHAARVVREIKKLAPETRFFGMGSKCLREAGVEVLVDPTDISTIGFSEALKNYRQHRDHLKMMKKA
LEREKPDVALLVDYSGFNIKMARITKRKKIPTVSYFSPSAWVWGKRRARKMARARAVIASVFPMEEKVYREAGAEVHFVG
HPLLDMVNVEESKDEICRKLELDGEKPIIGLMPGSRKQEVEYLLPEMLKAAERLKKEKGDFQFVIPVAPGIDRDKIVEMA
SRYKLVLKVVEGANYEVMKASDFLVVASGTATLEATIIGTPMVIVYRTSWSTYHLGKLLVNLDYIGLPNIIADREIVPEL
LQQDVTADNIYREITNFMSKPYLIKSIKRDLEYVKNKLGRPGAVRRTAELVLKKGKLYI

Sequences:

>Translated_379_residues
MGKIMVVAGEVSGDMHAARVVREIKKLAPETRFFGMGSKCLREAGVEVLVDPTDISTIGFSEALKNYRQHRDHLKMMKKA
LEREKPDVALLVDYSGFNIKMARITKRKKIPTVSYFSPSAWVWGKRRARKMARARAVIASVFPMEEKVYREAGAEVHFVG
HPLLDMVNVEESKDEICRKLELDGEKPIIGLMPGSRKQEVEYLLPEMLKAAERLKKEKGDFQFVIPVAPGIDRDKIVEMA
SRYKLVLKVVEGANYEVMKASDFLVVASGTATLEATIIGTPMVIVYRTSWSTYHLGKLLVNLDYIGLPNIIADREIVPEL
LQQDVTADNIYREITNFMSKPYLIKSIKRDLEYVKNKLGRPGAVRRTAELVLKKGKLYI
>Mature_378_residues
GKIMVVAGEVSGDMHAARVVREIKKLAPETRFFGMGSKCLREAGVEVLVDPTDISTIGFSEALKNYRQHRDHLKMMKKAL
EREKPDVALLVDYSGFNIKMARITKRKKIPTVSYFSPSAWVWGKRRARKMARARAVIASVFPMEEKVYREAGAEVHFVGH
PLLDMVNVEESKDEICRKLELDGEKPIIGLMPGSRKQEVEYLLPEMLKAAERLKKEKGDFQFVIPVAPGIDRDKIVEMAS
RYKLVLKVVEGANYEVMKASDFLVVASGTATLEATIIGTPMVIVYRTSWSTYHLGKLLVNLDYIGLPNIIADREIVPELL
QQDVTADNIYREITNFMSKPYLIKSIKRDLEYVKNKLGRPGAVRRTAELVLKKGKLYI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=324, Percent_Identity=32.7160493827161, Blast_Score=188, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42903; Mature: 42772

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIMVVAGEVSGDMHAARVVREIKKLAPETRFFGMGSKCLREAGVEVLVDPTDISTIGF
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHEECCCHHHHHHCCCEEEECCCCCCCCCH
SEALKNYRQHRDHLKMMKKALEREKPDVALLVDYSGFNIKMARITKRKKIPTVSYFSPSA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEHHHHCCCCEEEECCCCC
WVWGKRRARKMARARAVIASVFPMEEKVYREAGAEVHFVGHPLLDMVNVEESKDEICRKL
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCHHHHHCCCCHHHHHHHHH
ELDGEKPIIGLMPGSRKQEVEYLLPEMLKAAERLKKEKGDFQFVIPVAPGIDRDKIVEMA
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
SRYKLVLKVVEGANYEVMKASDFLVVASGTATLEATIIGTPMVIVYRTSWSTYHLGKLLV
HHHHHHHHHHCCCCEEEEECCCEEEEECCCCEEEEEEECCCEEEEEECCCCHHHHHHHHH
NLDYIGLPNIIADREIVPELLQQDVTADNIYREITNFMSKPYLIKSIKRDLEYVKNKLGR
EECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
PGAVRRTAELVLKKGKLYI
CCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GKIMVVAGEVSGDMHAARVVREIKKLAPETRFFGMGSKCLREAGVEVLVDPTDISTIGF
CEEEEEEECCCCCHHHHHHHHHHHHHCCCHHEECCCHHHHHHCCCEEEECCCCCCCCCH
SEALKNYRQHRDHLKMMKKALEREKPDVALLVDYSGFNIKMARITKRKKIPTVSYFSPSA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEHHHHCCCCEEEECCCCC
WVWGKRRARKMARARAVIASVFPMEEKVYREAGAEVHFVGHPLLDMVNVEESKDEICRKL
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCHHHHHCCCCHHHHHHHHH
ELDGEKPIIGLMPGSRKQEVEYLLPEMLKAAERLKKEKGDFQFVIPVAPGIDRDKIVEMA
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
SRYKLVLKVVEGANYEVMKASDFLVVASGTATLEATIIGTPMVIVYRTSWSTYHLGKLLV
HHHHHHHHHHCCCCEEEEECCCEEEEECCCCEEEEEEECCCEEEEEECCCCHHHHHHHHH
NLDYIGLPNIIADREIVPELLQQDVTADNIYREITNFMSKPYLIKSIKRDLEYVKNKLGR
EECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
PGAVRRTAELVLKKGKLYI
CCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA