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The map label for this gene is lytS [H]

Identifier: 220931884

GI number: 220931884

Start: 1128653

End: 1130389

Strand: Direct

Name: lytS [H]

Synonym: Hore_10410

Alternate gene names: 220931884

Gene position: 1128653-1130389 (Clockwise)

Preceding gene: 220931883

Following gene: 220931885

Centisome position: 43.78

GC content: 38.46

Gene sequence:

>1737_bases
ATGTCAGCTATAGATTTAGAAACAGGTCTTTTATTTATTTTAGTGAGAAATATGGGTGTTGTTGTCACTTTTGCCTATAT
ATTAAGTATGACCAGGCTCTTTAAAAGATTTTTCTATGCCCCATTATCTCGAAAAGAAAAGATTTTTCTGGTCATTTTTT
TTGGGCTCTTATCGGCATCAGGCACATATCTCAGTATATATATTATGGATGCTTATGCAAATATAAGGGCGATTGGGGCC
GTAGTAGCTGGCTTTCTGGGAGGTCCCCTGATAGGGGTTCTGGTCGGGACTGTTGGTGGAATACACCGTTTTACGCTCGG
GGGGTTTACAGCTCTGGCCTGTGCAATAGGAACCATGACTTCTGGTTTAATCGGTGGTTTATTTCATAAATCTTTTAAAA
ATCAACAAATTAATAGTAAGAATTCTTTTTATATTGGGGCAGTAGCTCTGATTATAGAGATGGTAATTGTAATTATATTT
AGCAGACCAATTGAACTTGCCCTTCAACTGGTGTCGGTTATAAGTTTACCAATGATAATAGCCAATGCTGCAGGGATTTC
ATTATTTGTCAGTATTCTCAATAATGTTGAAAAGGAAAATGAAAATATTAAGGCAAAACAGGCGAGATTGACGCTGGATA
TTGCTAATCAGACCATAAACTATTTCAGGGAGGGTTTAGCCCACGGCAGGGCTGTTAAAAAAGCATCAGAAATTATATTA
CAAAAAACAGGGGCTTCTGCAGTAGCAATTACAGACAGAGAGAAGATTATTGCCTTTGCCGGTAAGGGTTCAGATCATCA
TTTTCCGGGAGAACCATTTTTAACTTCTGTTACCAGACAGACCATAAATGAAGGTAAGGTTTCGGTGGCAAAAACTAAAA
AAGAAGTCGGTTGTCCGGTTGAAAATTGTCCACTAGAGTCAGTCGTGGTAGCTCCACTGAAATGGGATGGGAGAGTAATG
GGGTCCTTAAAACTATACCATACAGAACGTAAATTATCTAAAGTTGATATAAGCCTGGCCGAGGGTATTTCAACCCTCTT
ATCTACCCAGATTCAGCTATCCCGTTTATCGGAACAGGCTAAATTAAAGACAGAAGCTGAATTAAAAGCCTTACAGGCCC
AGGTGAATCCCCACTTTTTATTTAATTCACTGAATACAATTGCCTCTTTTACAAGGACAGATCCAGAAAAAGCCAGGGAA
TTACTCCTGAGGCTATCCGATTTTTTTAGAACAACCCTTTCAAAGGGCCATGACCTGGTGTCATTAGAGACTGAAATTAA
ATCTGTCAGGAATTATTTCTTTTTAGAAAAAGCCAGGTTTGGAGAAAGGCTCGAATTAGTTATAAATATTCCTGATGAAT
ATATGTCGGTTATGATCCCCAGTTTTACCTTGCAGCCCCTTATTGAAAATGCTGTAAAACATGGTATATTTCCAAAAAAT
CGAAAGGGGAAAATAGACCTGTCAGTCCGTAGCAATGAAGATATTATTGAACTAATTGTAAGGGATAATGGGGTTGGTAT
TCCGGAAGAAGAATTAAAAATGGTCTTAAAAGAGGGTTATGGTAAAGGTTCCGGGATTGGTTTAAGTAACGTTATGGCCA
GAATCAAGAATATTTTTGGTCCAGAGTATGGACTTACCATGGAGAGTGAAGAAAATACGGGGACCGAAGTTGTAATAAAA
GTACCGTTACAGACAATTAAAAGAGAGGAGAACACCCCATGGAAATGCAGGCTTTAG

Upstream 100 bases:

>100_bases
CAAAAATAACATAAAATAGTAAAAAATAATAATGATTGTCATTAATGTAAACATATGTTATTATTAAACTGGATTAATAT
TGGAAGGAAGGGGGAAATTA

Downstream 100 bases:

>100_bases
TAGTTGACGATGAAGCACCGGCCAGAAATGAGTTAATATTTATGCTTGAAAATAGTAAGGTTAATTTCCGGGTCAGGGAG
GCAGATAATGGGAAAAAAGC

Product: signal transduction histidine kinase LytS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSAIDLETGLLFILVRNMGVVVTFAYILSMTRLFKRFFYAPLSRKEKIFLVIFFGLLSASGTYLSIYIMDAYANIRAIGA
VVAGFLGGPLIGVLVGTVGGIHRFTLGGFTALACAIGTMTSGLIGGLFHKSFKNQQINSKNSFYIGAVALIIEMVIVIIF
SRPIELALQLVSVISLPMIIANAAGISLFVSILNNVEKENENIKAKQARLTLDIANQTINYFREGLAHGRAVKKASEIIL
QKTGASAVAITDREKIIAFAGKGSDHHFPGEPFLTSVTRQTINEGKVSVAKTKKEVGCPVENCPLESVVVAPLKWDGRVM
GSLKLYHTERKLSKVDISLAEGISTLLSTQIQLSRLSEQAKLKTEAELKALQAQVNPHFLFNSLNTIASFTRTDPEKARE
LLLRLSDFFRTTLSKGHDLVSLETEIKSVRNYFFLEKARFGERLELVINIPDEYMSVMIPSFTLQPLIENAVKHGIFPKN
RKGKIDLSVRSNEDIIELIVRDNGVGIPEEELKMVLKEGYGKGSGIGLSNVMARIKNIFGPEYGLTMESEENTGTEVVIK
VPLQTIKREENTPWKCRL

Sequences:

>Translated_578_residues
MSAIDLETGLLFILVRNMGVVVTFAYILSMTRLFKRFFYAPLSRKEKIFLVIFFGLLSASGTYLSIYIMDAYANIRAIGA
VVAGFLGGPLIGVLVGTVGGIHRFTLGGFTALACAIGTMTSGLIGGLFHKSFKNQQINSKNSFYIGAVALIIEMVIVIIF
SRPIELALQLVSVISLPMIIANAAGISLFVSILNNVEKENENIKAKQARLTLDIANQTINYFREGLAHGRAVKKASEIIL
QKTGASAVAITDREKIIAFAGKGSDHHFPGEPFLTSVTRQTINEGKVSVAKTKKEVGCPVENCPLESVVVAPLKWDGRVM
GSLKLYHTERKLSKVDISLAEGISTLLSTQIQLSRLSEQAKLKTEAELKALQAQVNPHFLFNSLNTIASFTRTDPEKARE
LLLRLSDFFRTTLSKGHDLVSLETEIKSVRNYFFLEKARFGERLELVINIPDEYMSVMIPSFTLQPLIENAVKHGIFPKN
RKGKIDLSVRSNEDIIELIVRDNGVGIPEEELKMVLKEGYGKGSGIGLSNVMARIKNIFGPEYGLTMESEENTGTEVVIK
VPLQTIKREENTPWKCRL
>Mature_577_residues
SAIDLETGLLFILVRNMGVVVTFAYILSMTRLFKRFFYAPLSRKEKIFLVIFFGLLSASGTYLSIYIMDAYANIRAIGAV
VAGFLGGPLIGVLVGTVGGIHRFTLGGFTALACAIGTMTSGLIGGLFHKSFKNQQINSKNSFYIGAVALIIEMVIVIIFS
RPIELALQLVSVISLPMIIANAAGISLFVSILNNVEKENENIKAKQARLTLDIANQTINYFREGLAHGRAVKKASEIILQ
KTGASAVAITDREKIIAFAGKGSDHHFPGEPFLTSVTRQTINEGKVSVAKTKKEVGCPVENCPLESVVVAPLKWDGRVMG
SLKLYHTERKLSKVDISLAEGISTLLSTQIQLSRLSEQAKLKTEAELKALQAQVNPHFLFNSLNTIASFTRTDPEKAREL
LLRLSDFFRTTLSKGHDLVSLETEIKSVRNYFFLEKARFGERLELVINIPDEYMSVMIPSFTLQPLIENAVKHGIFPKNR
KGKIDLSVRSNEDIIELIVRDNGVGIPEEELKMVLKEGYGKGSGIGLSNVMARIKNIFGPEYGLTMESEENTGTEVVIKV
PLQTIKREENTPWKCRL

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=562, Percent_Identity=37.7224199288256, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1788723, Length=544, Percent_Identity=33.0882352941176, Blast_Score=303, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63749; Mature: 63617

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIDLETGLLFILVRNMGVVVTFAYILSMTRLFKRFFYAPLSRKEKIFLVIFFGLLSAS
CCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHCC
GTYLSIYIMDAYANIRAIGAVVAGFLGGPLIGVLVGTVGGIHRFTLGGFTALACAIGTMT
CCEEEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SGLIGGLFHKSFKNQQINSKNSFYIGAVALIIEMVIVIIFSRPIELALQLVSVISLPMII
HHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ANAAGISLFVSILNNVEKENENIKAKQARLTLDIANQTINYFREGLAHGRAVKKASEIIL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKTGASAVAITDREKIIAFAGKGSDHHFPGEPFLTSVTRQTINEGKVSVAKTKKEVGCPV
HCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHCCCC
ENCPLESVVVAPLKWDGRVMGSLKLYHTERKLSKVDISLAEGISTLLSTQIQLSRLSEQA
CCCCCCCEEEECCCCCCEEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLKTEAELKALQAQVNPHFLFNSLNTIASFTRTDPEKARELLLRLSDFFRTTLSKGHDLV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
SLETEIKSVRNYFFLEKARFGERLELVINIPDEYMSVMIPSFTLQPLIENAVKHGIFPKN
EHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
RKGKIDLSVRSNEDIIELIVRDNGVGIPEEELKMVLKEGYGKGSGIGLSNVMARIKNIFG
CCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
PEYGLTMESEENTGTEVVIKVPLQTIKREENTPWKCRL
CCCCCEECCCCCCCCEEEEEECHHHHCCCCCCCCEECC
>Mature Secondary Structure 
SAIDLETGLLFILVRNMGVVVTFAYILSMTRLFKRFFYAPLSRKEKIFLVIFFGLLSAS
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHCC
GTYLSIYIMDAYANIRAIGAVVAGFLGGPLIGVLVGTVGGIHRFTLGGFTALACAIGTMT
CCEEEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SGLIGGLFHKSFKNQQINSKNSFYIGAVALIIEMVIVIIFSRPIELALQLVSVISLPMII
HHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ANAAGISLFVSILNNVEKENENIKAKQARLTLDIANQTINYFREGLAHGRAVKKASEIIL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKTGASAVAITDREKIIAFAGKGSDHHFPGEPFLTSVTRQTINEGKVSVAKTKKEVGCPV
HCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHCCCC
ENCPLESVVVAPLKWDGRVMGSLKLYHTERKLSKVDISLAEGISTLLSTQIQLSRLSEQA
CCCCCCCEEEECCCCCCEEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLKTEAELKALQAQVNPHFLFNSLNTIASFTRTDPEKARELLLRLSDFFRTTLSKGHDLV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
SLETEIKSVRNYFFLEKARFGERLELVINIPDEYMSVMIPSFTLQPLIENAVKHGIFPKN
EHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
RKGKIDLSVRSNEDIIELIVRDNGVGIPEEELKMVLKEGYGKGSGIGLSNVMARIKNIFG
CCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
PEYGLTMESEENTGTEVVIKVPLQTIKREENTPWKCRL
CCCCCEECCCCCCCCEEEEEECHHHHCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]