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The map label for this gene is trxC [H]

Identifier: 220918754

GI number: 220918754

Start: 4083663

End: 4084115

Strand: Direct

Name: trxC [H]

Synonym: A2cp1_3665

Alternate gene names: 220918754

Gene position: 4083663-4084115 (Clockwise)

Preceding gene: 220918753

Following gene: 220918758

Centisome position: 81.2

GC content: 77.04

Gene sequence:

>453_bases
ATGGCCTCGCCCCTCATCTACCGGTGCGCCCGCTGCGGCGCGATGAACCGCCTCGCCCCGCTCACGCCGGGGCGCGAACC
CGTCTGCGGCAAGTGCAAGGCGGACCTCGACACCAGCGGGGCCCCCGGCCACGCCGACCTCGCGGCGCTGGAGCGCGCGG
TCGGGAGCAGCCCGGCGCCCGTGCTGGTGGACTTCTGGGCGCCGTGGTGCGCCCCGTGCCGCGCCTTCGCGCCGGTGCTC
GAGCGGCTCGCGCGCGAGCAGGCCGGGCGGCTGGTGGTGCTGAAGGTGGACACCGAGGCGAGCCCGGCGGCCGGCGCGCG
CTTCGGGATCCAGGCCATCCCCACGCTCGTCGTGTTCCGCGACGGCAAGGAGGTGGACCGGGTCTCGGGCGCGCTGCCGT
ACGAGGAGCTGCGCCGGTTCACCACGGCCGCGACGCTCGGCGTGGCGGGCTGA

Upstream 100 bases:

>100_bases
CGTCGGGGCGGTGAACCGGCCCGGGGCGCGGCCGGCGGCGCGAGCAGGCCGCTGCACCGGGCGCGTTTGACACGGCCGGC
GTCGGACGCATGTTCTGCTC

Downstream 100 bases:

>100_bases
GCCTCAGCGCAGCACCACGCCCGGCCGGCGTCGCTCCACGAAGGCGGCCACCGCCGCGACCTCGCGGTCGGACCCGAGCG
CCACGCAGCCGGCGGTCCAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MASPLIYRCARCGAMNRLAPLTPGREPVCGKCKADLDTSGAPGHADLAALERAVGSSPAPVLVDFWAPWCAPCRAFAPVL
ERLAREQAGRLVVLKVDTEASPAAGARFGIQAIPTLVVFRDGKEVDRVSGALPYEELRRFTTAATLGVAG

Sequences:

>Translated_150_residues
MASPLIYRCARCGAMNRLAPLTPGREPVCGKCKADLDTSGAPGHADLAALERAVGSSPAPVLVDFWAPWCAPCRAFAPVL
ERLAREQAGRLVVLKVDTEASPAAGARFGIQAIPTLVVFRDGKEVDRVSGALPYEELRRFTTAATLGVAG
>Mature_149_residues
ASPLIYRCARCGAMNRLAPLTPGREPVCGKCKADLDTSGAPGHADLAALERAVGSSPAPVLVDFWAPWCAPCRAFAPVLE
RLAREQAGRLVVLKVDTEASPAAGARFGIQAIPTLVVFRDGKEVDRVSGALPYEELRRFTTAATLGVAG

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=91, Percent_Identity=32.967032967033, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1788936, Length=125, Percent_Identity=40.8, Blast_Score=109, Evalue=8e-26,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=36, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI87081747, Length=83, Percent_Identity=37.3493975903614, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=90, Percent_Identity=35.5555555555556, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=82, Percent_Identity=36.5853658536585, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=71, Percent_Identity=40.8450704225352, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=37.3493975903614, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=39.7260273972603, Blast_Score=64, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=38.5416666666667, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=36.4583333333333, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15787; Mature: 15656

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPLIYRCARCGAMNRLAPLTPGREPVCGKCKADLDTSGAPGHADLAALERAVGSSPAP
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
VLVDFWAPWCAPCRAFAPVLERLAREQAGRLVVLKVDTEASPAAGARFGIQAIPTLVVFR
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHCEEEEEE
DGKEVDRVSGALPYEELRRFTTAATLGVAG
CCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASPLIYRCARCGAMNRLAPLTPGREPVCGKCKADLDTSGAPGHADLAALERAVGSSPAP
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
VLVDFWAPWCAPCRAFAPVLERLAREQAGRLVVLKVDTEASPAAGARFGIQAIPTLVVFR
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHCEEEEEE
DGKEVDRVSGALPYEELRRFTTAATLGVAG
CCCHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]