Click here to switch to the map view.

The map label for this gene is tdcB [H]

Identifier: 220918689

GI number: 220918689

Start: 4016723

End: 4017934

Strand: Direct

Name: tdcB [H]

Synonym: A2cp1_3597

Alternate gene names: 220918689

Gene position: 4016723-4017934 (Clockwise)

Preceding gene: 220918688

Following gene: 220918690

Centisome position: 79.87

GC content: 72.28

Gene sequence:

>1212_bases
ATGGTGACGCTCCCCGACGTCCAGGCCGCGCTCGGCCGGATCCGCGACCGGATCTACCTCTCCCCCTGTGCCCGCACCGA
GACCCTCTCCCGCCTGAGCGGCACCAGCGCCTTCCTCAAGCTCGAGAACCTCCAGATGACCGGCTCCTACAAGGAGCGCG
GCGCCCTCAACACGCTGCTGCTGGCGGCCGAGGCCGAGCGCGCCCGGGGGCTGATCGCGGCGAGCGCCGGCAACCACGCG
CAGGGGGTCGCGTACCACGCCGGTCGCCTTGGGGTGAAGGCCACCATCGTGATGCCGGAGTCCACGCCCATCATGAAGGT
GGCGAACACCCGGGCGCACGGCGCGCGCATCGTGCTCCACGGGGCGAACTACGACGAGGCGTACGCCGAGGCGCGCCGGC
TCGAGCAGGCCGAGGGGCTCACCTTCGTGCACCCGTTCGACGACCCGCGCATCATCGCGGGCCAGGGCACGGTCGGGCTC
GAGATCCTGGACCAGGTCCCGGAGGTGGACGCGATCCTGGTGCCCATCGGCGGCGGCGGGCTCGCCTCCGGAGTGGCCGT
GGCCGCGAAGGCGCTGCGCCCCGAGGTTCGGATCGTGGGCGTCGAGACCGAGGTGCTCCCCAGCATGCTGGCGGCGATCG
AGGCGGGCCGGCCGGTCACGCTCGAGCCGGCCAGCACCGTCGCGGACGGCATCGCCGTGAAGCGCGCCGGCGACCTCACC
TTCGAGCACGTCCGCCGCCTGGTGGACGAGATCGTGACCGTCTCCGAGGAGGAGATCGCGAGCGCGATCCTGTACCTGCT
CGAGAAGGAGAAGACGGTCGCGGAGGGGGCGGGCGCGGTCACGGTGGCGGCGCTCATGAACCGCCGCGCGACCGGCCTCG
AGGGCCGGCGCGTGGTCGGCATCGTCTCCGGCGGCAACATCGACGTGAACCTGGTCGCGCGCATCATCGAGCGGGGCCTG
GTGAAGGACGGGCGGCTGGTGCGGGTGAGCGTCGCGCTCACCGACAAGCCGGGACAGCTCGCCAAGGTGTCGGCGATCAT
CGCCCACCACCGCGCCAACGTCATCGAGGTGCACCACACGCGGGCGTTCGCGACGCGGTTCGGCGACACCACCCTCCAGC
TGACGCTGGAGACCCGCGGCCTCGAGCACGTCCAGGAGCTCCTCCAGGCGTTGCGCGAGCGCGGGTACCAGGTCCAGCAG
CTCGGGATGTGA

Upstream 100 bases:

>100_bases
GGCGTCCGGCGCCGCCGCGACGCCCGTTCCTCGTCCGGTCCTCGCGCGCGTGCGGCGCTTGCCGTTCGCCCGCGCGGGGC
GGTAGCGTTCGCGATCCGCC

Downstream 100 bases:

>100_bases
CGTGTCCTTCCGCGCCCGGACCGCGATCGCCGCGCTCCTGCTCGCCGCCGCGATCGGGTTCGCCGCCGGCTGGCTGGTCG
GGCTGCGGTCGGACGACAGC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MVTLPDVQAALGRIRDRIYLSPCARTETLSRLSGTSAFLKLENLQMTGSYKERGALNTLLLAAEAERARGLIAASAGNHA
QGVAYHAGRLGVKATIVMPESTPIMKVANTRAHGARIVLHGANYDEAYAEARRLEQAEGLTFVHPFDDPRIIAGQGTVGL
EILDQVPEVDAILVPIGGGGLASGVAVAAKALRPEVRIVGVETEVLPSMLAAIEAGRPVTLEPASTVADGIAVKRAGDLT
FEHVRRLVDEIVTVSEEEIASAILYLLEKEKTVAEGAGAVTVAALMNRRATGLEGRRVVGIVSGGNIDVNLVARIIERGL
VKDGRLVRVSVALTDKPGQLAKVSAIIAHHRANVIEVHHTRAFATRFGDTTLQLTLETRGLEHVQELLQALRERGYQVQQ
LGM

Sequences:

>Translated_403_residues
MVTLPDVQAALGRIRDRIYLSPCARTETLSRLSGTSAFLKLENLQMTGSYKERGALNTLLLAAEAERARGLIAASAGNHA
QGVAYHAGRLGVKATIVMPESTPIMKVANTRAHGARIVLHGANYDEAYAEARRLEQAEGLTFVHPFDDPRIIAGQGTVGL
EILDQVPEVDAILVPIGGGGLASGVAVAAKALRPEVRIVGVETEVLPSMLAAIEAGRPVTLEPASTVADGIAVKRAGDLT
FEHVRRLVDEIVTVSEEEIASAILYLLEKEKTVAEGAGAVTVAALMNRRATGLEGRRVVGIVSGGNIDVNLVARIIERGL
VKDGRLVRVSVALTDKPGQLAKVSAIIAHHRANVIEVHHTRAFATRFGDTTLQLTLETRGLEHVQELLQALRERGYQVQQ
LGM
>Mature_403_residues
MVTLPDVQAALGRIRDRIYLSPCARTETLSRLSGTSAFLKLENLQMTGSYKERGALNTLLLAAEAERARGLIAASAGNHA
QGVAYHAGRLGVKATIVMPESTPIMKVANTRAHGARIVLHGANYDEAYAEARRLEQAEGLTFVHPFDDPRIIAGQGTVGL
EILDQVPEVDAILVPIGGGGLASGVAVAAKALRPEVRIVGVETEVLPSMLAAIEAGRPVTLEPASTVADGIAVKRAGDLT
FEHVRRLVDEIVTVSEEEIASAILYLLEKEKTVAEGAGAVTVAALMNRRATGLEGRRVVGIVSGGNIDVNLVARIIERGL
VKDGRLVRVSVALTDKPGQLAKVSAIIAHHRANVIEVHHTRAFATRFGDTTLQLTLETRGLEHVQELLQALRERGYQVQQ
LGM

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=316, Percent_Identity=37.0253164556962, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=33.112582781457, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI33469958, Length=303, Percent_Identity=29.7029702970297, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=44.1269841269841, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1790207, Length=387, Percent_Identity=39.2764857881137, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=44.5012787723785, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17537387, Length=389, Percent_Identity=40.3598971722365, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17508781, Length=315, Percent_Identity=31.4285714285714, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320930, Length=364, Percent_Identity=36.8131868131868, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=37.5796178343949, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319788, Length=260, Percent_Identity=27.6923076923077, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322024, Length=145, Percent_Identity=28.9655172413793, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355833, Length=398, Percent_Identity=40.7035175879397, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24645328, Length=302, Percent_Identity=40.3973509933775, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42976; Mature: 42976

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLPDVQAALGRIRDRIYLSPCARTETLSRLSGTSAFLKLENLQMTGSYKERGALNTLL
CCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHCCCEEEEEEEEEEECCCHHHCCCHHHEE
LAAEAERARGLIAASAGNHAQGVAYHAGRLGVKATIVMPESTPIMKVANTRAHGARIVLH
EEECHHHHCCEEEECCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEE
GANYDEAYAEARRLEQAEGLTFVHPFDDPRIIAGQGTVGLEILDQVPEVDAILVPIGGGG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCHHHHHHCCCCCCEEEEEECCCC
LASGVAVAAKALRPEVRIVGVETEVLPSMLAAIEAGRPVTLEPASTVADGIAVKRAGDLT
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCEEECCHHHHHHCEEEECCCCCC
FEHVRRLVDEIVTVSEEEIASAILYLLEKEKTVAEGAGAVTVAALMNRRATGLEGRRVVG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCCCCCCCCEEEE
IVSGGNIDVNLVARIIERGLVKDGRLVRVSVALTDKPGQLAKVSAIIAHHRANVIEVHHT
EEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEHH
RAFATRFGDTTLQLTLETRGLEHVQELLQALRERGYQVQQLGM
HHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MVTLPDVQAALGRIRDRIYLSPCARTETLSRLSGTSAFLKLENLQMTGSYKERGALNTLL
CCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHCCCEEEEEEEEEEECCCHHHCCCHHHEE
LAAEAERARGLIAASAGNHAQGVAYHAGRLGVKATIVMPESTPIMKVANTRAHGARIVLH
EEECHHHHCCEEEECCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEE
GANYDEAYAEARRLEQAEGLTFVHPFDDPRIIAGQGTVGLEILDQVPEVDAILVPIGGGG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCHHHHHHCCCCCCEEEEEECCCC
LASGVAVAAKALRPEVRIVGVETEVLPSMLAAIEAGRPVTLEPASTVADGIAVKRAGDLT
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCEEECCHHHHHHCEEEECCCCCC
FEHVRRLVDEIVTVSEEEIASAILYLLEKEKTVAEGAGAVTVAALMNRRATGLEGRRVVG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCCCCCCCCEEEE
IVSGGNIDVNLVARIIERGLVKDGRLVRVSVALTDKPGQLAKVSAIIAHHRANVIEVHHT
EEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEHH
RAFATRFGDTTLQLTLETRGLEHVQELLQALRERGYQVQQLGM
HHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA