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The map label for this gene is fkpA [H]

Identifier: 220918637

GI number: 220918637

Start: 3964097

End: 3964807

Strand: Direct

Name: fkpA [H]

Synonym: A2cp1_3545

Alternate gene names: 220918637

Gene position: 3964097-3964807 (Clockwise)

Preceding gene: 220918636

Following gene: 220918638

Centisome position: 78.82

GC content: 70.46

Gene sequence:

>711_bases
ATGAAGCCGATCCGCATCGCCCTCCTCGCCGCCCTGGTGCTGGCCACCGCGGCGCGCGCCGAGGACAAGAAGCCGGCCGC
GCCCGCGGCCAAGCCGGCCCCGGCCGCGAAGGCGCCGGCCGACACCGACCGCGCGCTGTACTCGGTCGGCCTGGCGGTGG
CCAAGAGCCTGGACGTGTTCTCGCTGCAGCCGGGCGAGCTCGAGAAGGTGATCCAGGGCATCCGCGACGGCGCCGCCGGC
AAGCCGAAGTTCCAGCTCGACGAGAAGTCGCAGCAGCAGGTGAACGAGCTGGCGCGCTCGCGCATGTCGGTCACCGCCGA
GCGCGAGAAGACCAAGGGCGCCGGCTACCTCGACAAGATGGCGAAGGAGAAGGGCGCCATCAAGACCGCGTCCGGCGCGG
TCGTGATCCCGGAGAAGCAGGGCACCGGCGCCACCCCCACCGCCACCGACAAGGTGAAGGTGCACTACGAGGGCAAGCTG
GTGGACGGGACGGTGTTCGACTCCTCCCGCAAGCGCAACGAGCCGGCCGAGTTCCCGCTGAACGGCGTCATCAAGTGCTG
GACCGAGGCGCTGCAGAAGATGAAGGTCGGCGGCAAGGCCAAGGTGGTCTGCCCGGCCGCCATCGCCTACGGCGAGCAGG
GCCGCCCGCCGGTCATCCCCGGCAACGCCGTCCTGACGTTCGACGTCGAGCTGCTCGACATCGTGAAGTAG

Upstream 100 bases:

>100_bases
AGGTCGAGCTGGACGAGCGCGCCGCCGTCCCGGTCGTCCAGAGCGTCTCCGCAGCGCCGGGACCGGCCCCGTCAACGCCG
GACCAGAAAGGGAGCCCCAC

Downstream 100 bases:

>100_bases
CGTCCTCGCGGCGCCGCCCGTCCCCTCGCGGGCGGGCGGCGGCCGCGCAGGCGGGCTTGCGACCCGGCCCGGCGGCGCAT
AGACAGCGCGGCATGACCGA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKPIRIALLAALVLATAARAEDKKPAAPAAKPAPAAKAPADTDRALYSVGLAVAKSLDVFSLQPGELEKVIQGIRDGAAG
KPKFQLDEKSQQQVNELARSRMSVTAEREKTKGAGYLDKMAKEKGAIKTASGAVVIPEKQGTGATPTATDKVKVHYEGKL
VDGTVFDSSRKRNEPAEFPLNGVIKCWTEALQKMKVGGKAKVVCPAAIAYGEQGRPPVIPGNAVLTFDVELLDIVK

Sequences:

>Translated_236_residues
MKPIRIALLAALVLATAARAEDKKPAAPAAKPAPAAKAPADTDRALYSVGLAVAKSLDVFSLQPGELEKVIQGIRDGAAG
KPKFQLDEKSQQQVNELARSRMSVTAEREKTKGAGYLDKMAKEKGAIKTASGAVVIPEKQGTGATPTATDKVKVHYEGKL
VDGTVFDSSRKRNEPAEFPLNGVIKCWTEALQKMKVGGKAKVVCPAAIAYGEQGRPPVIPGNAVLTFDVELLDIVK
>Mature_236_residues
MKPIRIALLAALVLATAARAEDKKPAAPAAKPAPAAKAPADTDRALYSVGLAVAKSLDVFSLQPGELEKVIQGIRDGAAG
KPKFQLDEKSQQQVNELARSRMSVTAEREKTKGAGYLDKMAKEKGAIKTASGAVVIPEKQGTGATPTATDKVKVHYEGKL
VDGTVFDSSRKRNEPAEFPLNGVIKCWTEALQKMKVGGKAKVVCPAAIAYGEQGRPPVIPGNAVLTFDVELLDIVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4503729, Length=110, Percent_Identity=43.6363636363636, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI224809329, Length=110, Percent_Identity=45.4545454545455, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI224809327, Length=110, Percent_Identity=45.4545454545455, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4758384, Length=110, Percent_Identity=45.4545454545455, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI224809331, Length=110, Percent_Identity=45.4545454545455, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=51.7241379310345, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=51.7241379310345, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=51.7241379310345, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4758380, Length=83, Percent_Identity=49.3975903614458, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI17149836, Length=83, Percent_Identity=49.3975903614458, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503725, Length=83, Percent_Identity=49.3975903614458, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706131, Length=88, Percent_Identity=37.5, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33469985, Length=87, Percent_Identity=41.3793103448276, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=43.4343434343434, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082390, Length=199, Percent_Identity=42.713567839196, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789745, Length=207, Percent_Identity=37.6811594202899, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=51.7241379310345, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17561782, Length=119, Percent_Identity=41.1764705882353, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561778, Length=104, Percent_Identity=41.3461538461538, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=41.7582417582418, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=53.4090909090909, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=97, Percent_Identity=44.3298969072165, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=118, Percent_Identity=40.6779661016949, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=116, Percent_Identity=37.9310344827586, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=49.0566037735849, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583150, Length=97, Percent_Identity=47.4226804123711, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=46.5909090909091, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=46.5909090909091, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647110, Length=108, Percent_Identity=39.8148148148148, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24926; Mature: 24926

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIRIALLAALVLATAARAEDKKPAAPAAKPAPAAKAPADTDRALYSVGLAVAKSLDVF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
SLQPGELEKVIQGIRDGAAGKPKFQLDEKSQQQVNELARSRMSVTAEREKTKGAGYLDKM
ECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AKEKGAIKTASGAVVIPEKQGTGATPTATDKVKVHYEGKLVDGTVFDSSRKRNEPAEFPL
HHHCCCEEECCCCEEEECCCCCCCCCCCCCEEEEEECCEEECCEEECCCCCCCCCCCCCH
NGVIKCWTEALQKMKVGGKAKVVCPAAIAYGEQGRPPVIPGNAVLTFDVELLDIVK
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHCC
>Mature Secondary Structure
MKPIRIALLAALVLATAARAEDKKPAAPAAKPAPAAKAPADTDRALYSVGLAVAKSLDVF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
SLQPGELEKVIQGIRDGAAGKPKFQLDEKSQQQVNELARSRMSVTAEREKTKGAGYLDKM
ECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AKEKGAIKTASGAVVIPEKQGTGATPTATDKVKVHYEGKLVDGTVFDSSRKRNEPAEFPL
HHHCCCEEECCCCEEEECCCCCCCCCCCCCEEEEEECCEEECCEEECCCCCCCCCCCCCH
NGVIKCWTEALQKMKVGGKAKVVCPAAIAYGEQGRPPVIPGNAVLTFDVELLDIVK
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]