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The map label for this gene is gdh [H]

Identifier: 220918316

GI number: 220918316

Start: 3574395

End: 3575744

Strand: Direct

Name: gdh [H]

Synonym: A2cp1_3219

Alternate gene names: 220918316

Gene position: 3574395-3575744 (Clockwise)

Preceding gene: 220918315

Following gene: 220918318

Centisome position: 71.07

GC content: 66.3

Gene sequence:

>1350_bases
ATGACCAACAAGATGGATGAGAGGCTGGAGTCGATGTACCAGGACGTGCTTCGCCGCAACCCGGGCGAGGCCGAGTTCCA
CCAGGCGGTGCGCGAGGTGCTCGAGACGCTCGGGCCGGTCCTCGCGAAGTACCCCGAGTTCCGCGAGCGCAAGATCATCG
AGCGCATCTGCGAGCCGGAGCGGCAGATCATCTTCCGCGTGCCGTGGCAGGACGACCGCGGCGAGGTCCACGTCAACCGC
GGGTTCCGCGTCCAGTACAACAGCTCGCTCGGCCCGTACAAGGGCGGCCTGCGCTTCCACCCGTCCGTCTACCTGGGGAT
CATCAAGTTCCTCGGGTTCGAGCAGATCTTCAAGAACGCGCTCACCGGCCTGCCCATCGGCGGCGGCAAGGGCGGCTCCG
ACTTCGACCCGAAGGGCAAGTCGGACAACGAGATCATGCGGTTCTGCCAGAGCTTCATGACCGAGCTGTGGCGGTACATC
GGCGACACCACCGACGTGCCCGCCGGAGACATCGGCGTGGGCGGCCGCGAGATCGGCTACATGTACGGTCAGTTCAAGCG
CCTCACCTCGCGCTACGAGGCGGGCGTGCTCACCGGCAAGGGCCTCGACTACGGCGGCTCGCTGGTCCGCACCGAGGCGA
CCGGCTACGGCGCCACGTTCTTCGTGGAGGAGATGCTGAAGGTCCGGAAGGACTCCTTCGACGGCAAGCGCTGCGTGGTC
TCCGGCTCCGGCAACGTGGCCATCTACACGATCGAGAAGATCACCCAGCTCGGCGGCCGCGTGGTCGCGTGCTCCGACTC
CAACGGCTACATCCTCGACGAGAAGGGCCTCGACCTCGACCTGGTGAAGCAGCTGAAGGAGGTCGAGCGGCGCCGCATCA
AGGACTACGTCGAGTATCGCAGCCACGCGCGCTACGTCGCCGGCGGGAACATCTGGGAGATCCCGTGCCAGGTGGCGATG
CCGTCCGCCACCCAGAACGAGATCAACGGCCACGACGCCAAGACGCTGGTGAAGAACGGCTGCATCGCGGTCGGCGAGGG
CGCGAACATGCCCACCACGCCCGAGGGCATCAAGGTGTTCCTCGACGCGAAGATCTCCTACGGGCCGGGCAAGGCCGCCA
ACGCCGGCGGCGTCGCCACGAGCGCGCTCGAGATGCAGCAGAACGCGACCCGCGACAGCTGGACGTTCGAGTACACCGAG
AAGCGGCTCGCGAACATCATGAAGAACATCCACCAGAACTGCTACGAGACCGCCGAGGAGTTCGGCGCCCCGGGCAACTA
CGTGGTGGGCGCGAACATCGCCGGGTTCATCAAGGTGGCGAAGGCGATGGTGGCGCACGGGCTCATCTGA

Upstream 100 bases:

>100_bases
TCAGTCGATTTCCCGCCCCGGCCCCTTCTCAGGTGCCTGCGATGCGTGCAGACTGCCCGATCTTCGAACGCGGGATCGCG
CCCGCAACGAAAGGGAGAGC

Downstream 100 bases:

>100_bases
GCTCGGGCGCAGGCACGGTCTGAGAGGGGCCCGGCGGCGACGCCGGGCCCTTTCTGTTTCTTCGGGCAATGAGGGTGCGA
CGGGGGTCGGGGGCGGTGCT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTNKMDERLESMYQDVLRRNPGEAEFHQAVREVLETLGPVLAKYPEFRERKIIERICEPERQIIFRVPWQDDRGEVHVNR
GFRVQYNSSLGPYKGGLRFHPSVYLGIIKFLGFEQIFKNALTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELWRYI
GDTTDVPAGDIGVGGREIGYMYGQFKRLTSRYEAGVLTGKGLDYGGSLVRTEATGYGATFFVEEMLKVRKDSFDGKRCVV
SGSGNVAIYTIEKITQLGGRVVACSDSNGYILDEKGLDLDLVKQLKEVERRRIKDYVEYRSHARYVAGGNIWEIPCQVAM
PSATQNEINGHDAKTLVKNGCIAVGEGANMPTTPEGIKVFLDAKISYGPGKAANAGGVATSALEMQQNATRDSWTFEYTE
KRLANIMKNIHQNCYETAEEFGAPGNYVVGANIAGFIKVAKAMVAHGLI

Sequences:

>Translated_449_residues
MTNKMDERLESMYQDVLRRNPGEAEFHQAVREVLETLGPVLAKYPEFRERKIIERICEPERQIIFRVPWQDDRGEVHVNR
GFRVQYNSSLGPYKGGLRFHPSVYLGIIKFLGFEQIFKNALTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELWRYI
GDTTDVPAGDIGVGGREIGYMYGQFKRLTSRYEAGVLTGKGLDYGGSLVRTEATGYGATFFVEEMLKVRKDSFDGKRCVV
SGSGNVAIYTIEKITQLGGRVVACSDSNGYILDEKGLDLDLVKQLKEVERRRIKDYVEYRSHARYVAGGNIWEIPCQVAM
PSATQNEINGHDAKTLVKNGCIAVGEGANMPTTPEGIKVFLDAKISYGPGKAANAGGVATSALEMQQNATRDSWTFEYTE
KRLANIMKNIHQNCYETAEEFGAPGNYVVGANIAGFIKVAKAMVAHGLI
>Mature_448_residues
TNKMDERLESMYQDVLRRNPGEAEFHQAVREVLETLGPVLAKYPEFRERKIIERICEPERQIIFRVPWQDDRGEVHVNRG
FRVQYNSSLGPYKGGLRFHPSVYLGIIKFLGFEQIFKNALTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELWRYIG
DTTDVPAGDIGVGGREIGYMYGQFKRLTSRYEAGVLTGKGLDYGGSLVRTEATGYGATFFVEEMLKVRKDSFDGKRCVVS
GSGNVAIYTIEKITQLGGRVVACSDSNGYILDEKGLDLDLVKQLKEVERRRIKDYVEYRSHARYVAGGNIWEIPCQVAMP
SATQNEINGHDAKTLVKNGCIAVGEGANMPTTPEGIKVFLDAKISYGPGKAANAGGVATSALEMQQNATRDSWTFEYTEK
RLANIMKNIHQNCYETAEEFGAPGNYVVGANIAGFIKVAKAMVAHGLI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=378, Percent_Identity=29.1005291005291, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4885281, Length=378, Percent_Identity=29.1005291005291, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1788059, Length=449, Percent_Identity=55.456570155902, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17544676, Length=376, Percent_Identity=26.5957446808511, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319256, Length=454, Percent_Identity=48.6784140969163, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324951, Length=452, Percent_Identity=49.3362831858407, Blast_Score=391, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45549226, Length=373, Percent_Identity=28.686327077748, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45553475, Length=373, Percent_Identity=28.4182305630027, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24649283, Length=419, Percent_Identity=26.7303102625298, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24649460, Length=313, Percent_Identity=28.1150159744409, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49790; Mature: 49659

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKMDERLESMYQDVLRRNPGEAEFHQAVREVLETLGPVLAKYPEFRERKIIERICEPE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
RQIIFRVPWQDDRGEVHVNRGFRVQYNSSLGPYKGGLRFHPSVYLGIIKFLGFEQIFKNA
CEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHH
LTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELWRYIGDTTDVPAGDIGVGGREIGY
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
MYGQFKRLTSRYEAGVLTGKGLDYGGSLVRTEATGYGATFFVEEMLKVRKDSFDGKRCVV
HHHHHHHHHHHHHCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGSGNVAIYTIEKITQLGGRVVACSDSNGYILDEKGLDLDLVKQLKEVERRRIKDYVEYR
ECCCCEEEEEHHHHHHHCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
SHARYVAGGNIWEIPCQVAMPSATQNEINGHDAKTLVKNGCIAVGEGANMPTTPEGIKVF
HCCCEEECCCEEECCCCEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCCCCCCEEEE
LDAKISYGPGKAANAGGVATSALEMQQNATRDSWTFEYTEKRLANIMKNIHQNCYETAEE
EEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FGAPGNYVVGANIAGFIKVAKAMVAHGLI
HCCCCCEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNKMDERLESMYQDVLRRNPGEAEFHQAVREVLETLGPVLAKYPEFRERKIIERICEPE
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
RQIIFRVPWQDDRGEVHVNRGFRVQYNSSLGPYKGGLRFHPSVYLGIIKFLGFEQIFKNA
CEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHH
LTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELWRYIGDTTDVPAGDIGVGGREIGY
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
MYGQFKRLTSRYEAGVLTGKGLDYGGSLVRTEATGYGATFFVEEMLKVRKDSFDGKRCVV
HHHHHHHHHHHHHCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGSGNVAIYTIEKITQLGGRVVACSDSNGYILDEKGLDLDLVKQLKEVERRRIKDYVEYR
ECCCCEEEEEHHHHHHHCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
SHARYVAGGNIWEIPCQVAMPSATQNEINGHDAKTLVKNGCIAVGEGANMPTTPEGIKVF
HCCCEEECCCEEECCCCEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCCCCCCEEEE
LDAKISYGPGKAANAGGVATSALEMQQNATRDSWTFEYTEKRLANIMKNIHQNCYETAEE
EEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FGAPGNYVVGANIAGFIKVAKAMVAHGLI
HCCCCCEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]