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The map label for this gene is pntAA [H]

Identifier: 220918302

GI number: 220918302

Start: 3553187

End: 3554284

Strand: Direct

Name: pntAA [H]

Synonym: A2cp1_3205

Alternate gene names: 220918302

Gene position: 3553187-3554284 (Clockwise)

Preceding gene: 220918301

Following gene: 220918303

Centisome position: 70.65

GC content: 75.96

Gene sequence:

>1098_bases
ATGCGCATCGCGGTGCTACGTGAGGGGGCGCCCGGAGAGCTCCGGGTGGCCCTGGTCCCCGAGAACGTCACACGGCTGGT
GAAGCAGGGCCACGAGGTCCGCGTGGAGCGCGGCGCGGGCGAGGCCGCCGGCTTCCCCGACGCGGCCTACACGGCGGCCG
GCGCGCAGGTGGGCGACGCGGCCGCCGCGCTCGACGGCGCGCGCGTGGTCGCGGCGGTGCAGCGGCCCTCCGAGGCGCAG
GTGGAGCGGCTCCCGCCCGGCGCGCTGCTGGTCGGCCTGCTCGCGCCGCACGCCGCCGGGCCGCTCCTCGAGCGGCTCGC
CGCGCGCGGCGTGGACGCGATGGCCATGGAGAAGGTCCCCCGCACCACGCGGGCACAGTCCATGGACGCGCTCTCGTCGC
AGGCCACGCTCGCCGGCTACAAGGCCGTGCTGCTCGGCGCGAGCGCCCTCCCCCGCATCCTCCCCATGATGACCACCGCG
GCCGGCACGCTCGCGCCCGCGAAGGCGTTCGTGGTCGGCGCCGGCGTGGCGGGGCTGCAGGCGATCGCCACGGCGCGCCG
GCTCGGCGCCGTGGTGTCCGCGTTCGACGTGCGGCCGGTCGTGAAGGAGCAGGTGCAGTCGCTCGGCGCCGCGTTCGTGG
AGGTGCCCGCGGTGGCCGCCGAGGGCACGGGCGGCTACGCGAAGGAGCTGGGCCAGTCCGAGCAGGAGCGCGTCCTCGCC
GCCATCGCCGGCCACGTGAAGGACATGGACCTCGTGATCACCACCGCGCAGATTCCGGGCCGGCCGGCGCCGCGCCTGAT
CACCGCGGACATGGTCCGCTCCATGCGGCCCGGCTCGGTGGTGGTGGACCTGGCCGCCGAGACCGGGGGCAACTGCGAGC
TGACGCGCGCCGGCGAGACGGTGGTGGACGCCGGCGTGTCGGTGATCGGCGCGGTCAACCTCCCGTCCACGGTGCCGTTC
CACGCCAGCCAGATGTACGGCCGCAACGTGGTCACGCTGCTCGCCCACCTGTTCAAGGACGGGAAGGCGGACCTCGACGC
GCAGGAGGAGATCGCCGCCGCCATGCTGGTGGTGCACGGCGGGAAGGTGCGGGCCTGA

Upstream 100 bases:

>100_bases
GGCGGGACGACCCGGCTCGCCTTGCGGGTATTCCCCGCGTGGGGCCTTCTTTTGCCCACGTCCGGGGGATACCCCCGATG
GACCGAGGTCTACGACGACG

Downstream 100 bases:

>100_bases
CCACATGCTCGAGCTCATCCAGATCTACGTCTTCGTCCTCGCCGGCTTCGTCGGGTTCTTCGTCATCACCCGGGTCCCGG
CGCTGCTGCACACCCCGCTC

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MRIAVLREGAPGELRVALVPENVTRLVKQGHEVRVERGAGEAAGFPDAAYTAAGAQVGDAAAALDGARVVAAVQRPSEAQ
VERLPPGALLVGLLAPHAAGPLLERLAARGVDAMAMEKVPRTTRAQSMDALSSQATLAGYKAVLLGASALPRILPMMTTA
AGTLAPAKAFVVGAGVAGLQAIATARRLGAVVSAFDVRPVVKEQVQSLGAAFVEVPAVAAEGTGGYAKELGQSEQERVLA
AIAGHVKDMDLVITTAQIPGRPAPRLITADMVRSMRPGSVVVDLAAETGGNCELTRAGETVVDAGVSVIGAVNLPSTVPF
HASQMYGRNVVTLLAHLFKDGKADLDAQEEIAAAMLVVHGGKVRA

Sequences:

>Translated_365_residues
MRIAVLREGAPGELRVALVPENVTRLVKQGHEVRVERGAGEAAGFPDAAYTAAGAQVGDAAAALDGARVVAAVQRPSEAQ
VERLPPGALLVGLLAPHAAGPLLERLAARGVDAMAMEKVPRTTRAQSMDALSSQATLAGYKAVLLGASALPRILPMMTTA
AGTLAPAKAFVVGAGVAGLQAIATARRLGAVVSAFDVRPVVKEQVQSLGAAFVEVPAVAAEGTGGYAKELGQSEQERVLA
AIAGHVKDMDLVITTAQIPGRPAPRLITADMVRSMRPGSVVVDLAAETGGNCELTRAGETVVDAGVSVIGAVNLPSTVPF
HASQMYGRNVVTLLAHLFKDGKADLDAQEEIAAAMLVVHGGKVRA
>Mature_365_residues
MRIAVLREGAPGELRVALVPENVTRLVKQGHEVRVERGAGEAAGFPDAAYTAAGAQVGDAAAALDGARVVAAVQRPSEAQ
VERLPPGALLVGLLAPHAAGPLLERLAARGVDAMAMEKVPRTTRAQSMDALSSQATLAGYKAVLLGASALPRILPMMTTA
AGTLAPAKAFVVGAGVAGLQAIATARRLGAVVSAFDVRPVVKEQVQSLGAAFVEVPAVAAEGTGGYAKELGQSEQERVLA
AIAGHVKDMDLVITTAQIPGRPAPRLITADMVRSMRPGSVVVDLAAETGGNCELTRAGETVVDAGVSVIGAVNLPSTVPF
HASQMYGRNVVTLLAHLFKDGKADLDAQEEIAAAMLVVHGGKVRA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=359, Percent_Identity=42.0612813370474, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI122939153, Length=359, Percent_Identity=42.0612813370474, Blast_Score=248, Evalue=7e-66,
Organism=Escherichia coli, GI1787887, Length=367, Percent_Identity=44.6866485013624, Blast_Score=297, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI17550456, Length=365, Percent_Identity=43.8356164383562, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 37274; Mature: 37274

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVLREGAPGELRVALVPENVTRLVKQGHEVRVERGAGEAAGFPDAAYTAAGAQVGDA
CEEEEEECCCCCCEEEEECCHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCCHH
AAALDGARVVAAVQRPSEAQVERLPPGALLVGLLAPHAAGPLLERLAARGVDAMAMEKVP
HHHHCCHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCC
RTTRAQSMDALSSQATLAGYKAVLLGASALPRILPMMTTAAGTLAPAKAFVVGAGVAGLQ
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHEEECCHHHHH
AIATARRLGAVVSAFDVRPVVKEQVQSLGAAFVEVPAVAAEGTGGYAKELGQSEQERVLA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCHHHHHHH
AIAGHVKDMDLVITTAQIPGRPAPRLITADMVRSMRPGSVVVDLAAETGGNCELTRAGET
HHHHCCCCCEEEEEEECCCCCCCCCEEEHHHHHCCCCCCEEEEEECCCCCCEEEEECCCH
VVDAGVSVIGAVNLPSTVPFHASQMYGRNVVTLLAHLFKDGKADLDAQEEIAAAMLVVHG
HHHCCHHEEEECCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEC
GKVRA
CCCCC
>Mature Secondary Structure
MRIAVLREGAPGELRVALVPENVTRLVKQGHEVRVERGAGEAAGFPDAAYTAAGAQVGDA
CEEEEEECCCCCCEEEEECCHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCCHH
AAALDGARVVAAVQRPSEAQVERLPPGALLVGLLAPHAAGPLLERLAARGVDAMAMEKVP
HHHHCCHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCC
RTTRAQSMDALSSQATLAGYKAVLLGASALPRILPMMTTAAGTLAPAKAFVVGAGVAGLQ
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHEEECCHHHHH
AIATARRLGAVVSAFDVRPVVKEQVQSLGAAFVEVPAVAAEGTGGYAKELGQSEQERVLA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCHHHHHHH
AIAGHVKDMDLVITTAQIPGRPAPRLITADMVRSMRPGSVVVDLAAETGGNCELTRAGET
HHHHCCCCCEEEEEEECCCCCCCCCEEEHHHHHCCCCCCEEEEEECCCCCCEEEEECCCH
VVDAGVSVIGAVNLPSTVPFHASQMYGRNVVTLLAHLFKDGKADLDAQEEIAAAMLVVHG
HHHCCHHEEEECCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEC
GKVRA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]