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The map label for this gene is gltT [H]

Identifier: 220918139

GI number: 220918139

Start: 3365012

End: 3366286

Strand: Direct

Name: gltT [H]

Synonym: A2cp1_3042

Alternate gene names: 220918139

Gene position: 3365012-3366286 (Clockwise)

Preceding gene: 220918138

Following gene: 220918140

Centisome position: 66.91

GC content: 74.2

Gene sequence:

>1275_bases
ATGCCCTCGCACCGCAGGATGCTGATCGCCGTGGTGGCCGGCGCCGTCCTCGGCGCGCTCGCGAACGCGCTGGGCGGCGG
CGCGCCCTGGCTCGACGTCGCGGTGCGCGACGTGGCCCAGCCCATCGGCCAGCTCTTCATCCGGCTCCTGTTCATGCTGG
TGGTGCCGCTCCTGTTCTCGGCGCTGGTGCTGGGCGTCGCGGACCTCGAGCTGCGCCACCTGGGCCGCCTGGGCGCGCGG
ATGCTCGGCTACACCGCCGCGGTGTCGTCCATCGCGGTGCTCATCGGCGTGACGCTCGTGAACGTGCTCGGGCCCGGTCG
CGGCCTGCCCGACGCCGTGCGCGAGGCCGCGCGGGGGGCCGCCACCATCAAGCCGGCCCCGCTCCCCGGCGGCGACTCGG
TGGCCGGGTTCGTCCTCGCGCTCGTCCCGGACAACCCGGTGAAGGCGGCAGCCACCGGCGACCTCATGGGCCTCATCGTG
TTCGCGCTGCTGTTCGGCGTGGCGCTCGCCGTGACCGACACGCCCGGCGCGCGCACGCTGAAGGCGGCGCTGCAGGGGCT
CTACGACGTCTCCATGAAGCTCATCGAGGGCGTGCTGCGGCTCGCGCCCCTCGGCGTCGGCGCGCTGCTCTTCGTCATGG
CCGCCCGCCTCGGCGCGGCGGTGGTCCGGCCCATCGCCGCCTACGTGGGCGTGGTGGTGCTCGGGCTCGCGCTGCACCAG
TTCGTGGTCTATTCGCTGTCCGTGAAGCTCTTCGGCGGCATGAGCCCGCGCGCGTTCTTCTCGGGCGTGCGGCTCGCGAT
GGTGACGGCGTTCTCCACCGCCTCCTCGTCCGCCACCCTCCCCACCGCGCTCCGCGTGGCCGAGGAGAACCTGCGCCTGC
CGCGGCACGTGGCGCGGTTCGTCCTCACCGCCGGCTCCGCCATGAACCAGAACGGCTCGGCGTTGTTCGAGGGCGTCACG
GTGCTGTTCCTGGCGCAGGTCTACGGCGTCGAGCTCTCGCTCGGCCAGCAGGCCATCGCGGTGGGGATCGCCGTCCTGGC
CGGCATCGGCACGGCCGGCGTGCCGGCCGCCTCCATGCCGTTCATCGCGATGATCCTCGGCGTCCTCGGGATCCCGGTGG
AGGGCATCGGCCTGGTGCTCGGCGTGGATCGCTTCCTCGACATGTGCCGGACCACGGTGAACGTCACCGGCGACCTCGCC
GCCGCCGTGTTCGTCGCCCGCGGCGAGCCCGCCGAGGCGACCGAGCCGGCCGCCGGGGTGCCGCCCGCGCCGTAG

Upstream 100 bases:

>100_bases
GGCGCTGACCGTTCGATTCACCCAGCGGCGATGGCGGACGCCCCGGGAGGTCCGCCGCCCGCCTTGCCGGCCCACCGCGG
GGCGGGGTACACGGACCGGA

Downstream 100 bases:

>100_bases
CGCCCCTGGCGCGCGGCGCGTCCGGGCCGCTCGCGATGGGGGAGGCCCCCCCTCGCGCGCCGCGAATCGCAACTCGCCCC
TCCCGGCGGCGGGGGCGCCC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MPSHRRMLIAVVAGAVLGALANALGGGAPWLDVAVRDVAQPIGQLFIRLLFMLVVPLLFSALVLGVADLELRHLGRLGAR
MLGYTAAVSSIAVLIGVTLVNVLGPGRGLPDAVREAARGAATIKPAPLPGGDSVAGFVLALVPDNPVKAAATGDLMGLIV
FALLFGVALAVTDTPGARTLKAALQGLYDVSMKLIEGVLRLAPLGVGALLFVMAARLGAAVVRPIAAYVGVVVLGLALHQ
FVVYSLSVKLFGGMSPRAFFSGVRLAMVTAFSTASSSATLPTALRVAEENLRLPRHVARFVLTAGSAMNQNGSALFEGVT
VLFLAQVYGVELSLGQQAIAVGIAVLAGIGTAGVPAASMPFIAMILGVLGIPVEGIGLVLGVDRFLDMCRTTVNVTGDLA
AAVFVARGEPAEATEPAAGVPPAP

Sequences:

>Translated_424_residues
MPSHRRMLIAVVAGAVLGALANALGGGAPWLDVAVRDVAQPIGQLFIRLLFMLVVPLLFSALVLGVADLELRHLGRLGAR
MLGYTAAVSSIAVLIGVTLVNVLGPGRGLPDAVREAARGAATIKPAPLPGGDSVAGFVLALVPDNPVKAAATGDLMGLIV
FALLFGVALAVTDTPGARTLKAALQGLYDVSMKLIEGVLRLAPLGVGALLFVMAARLGAAVVRPIAAYVGVVVLGLALHQ
FVVYSLSVKLFGGMSPRAFFSGVRLAMVTAFSTASSSATLPTALRVAEENLRLPRHVARFVLTAGSAMNQNGSALFEGVT
VLFLAQVYGVELSLGQQAIAVGIAVLAGIGTAGVPAASMPFIAMILGVLGIPVEGIGLVLGVDRFLDMCRTTVNVTGDLA
AAVFVARGEPAEATEPAAGVPPAP
>Mature_423_residues
PSHRRMLIAVVAGAVLGALANALGGGAPWLDVAVRDVAQPIGQLFIRLLFMLVVPLLFSALVLGVADLELRHLGRLGARM
LGYTAAVSSIAVLIGVTLVNVLGPGRGLPDAVREAARGAATIKPAPLPGGDSVAGFVLALVPDNPVKAAATGDLMGLIVF
ALLFGVALAVTDTPGARTLKAALQGLYDVSMKLIEGVLRLAPLGVGALLFVMAARLGAAVVRPIAAYVGVVVLGLALHQF
VVYSLSVKLFGGMSPRAFFSGVRLAMVTAFSTASSSATLPTALRVAEENLRLPRHVARFVLTAGSAMNQNGSALFEGVTV
LFLAQVYGVELSLGQQAIAVGIAVLAGIGTAGVPAASMPFIAMILGVLGIPVEGIGLVLGVDRFLDMCRTTVNVTGDLAA
AVFVARGEPAEATEPAAGVPPAP

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=408, Percent_Identity=31.6176470588235, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI66773030, Length=410, Percent_Identity=30, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI40254478, Length=461, Percent_Identity=30.1518438177874, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21314632, Length=394, Percent_Identity=29.9492385786802, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI194239697, Length=421, Percent_Identity=30.166270783848, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4827012, Length=289, Percent_Identity=34.9480968858132, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI5032093, Length=398, Percent_Identity=31.1557788944724, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI223468564, Length=273, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223468566, Length=282, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI262359914, Length=345, Percent_Identity=29.5652173913043, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI301601644, Length=140, Percent_Identity=37.8571428571429, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI1790514, Length=410, Percent_Identity=32.9268292682927, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1789947, Length=380, Percent_Identity=28.6842105263158, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788024, Length=416, Percent_Identity=27.8846153846154, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789473, Length=286, Percent_Identity=27.972027972028, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71996953, Length=413, Percent_Identity=30.9927360774818, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71983099, Length=445, Percent_Identity=30.7865168539326, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71983106, Length=445, Percent_Identity=30.7865168539326, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193206505, Length=405, Percent_Identity=30.1234567901235, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=395, Percent_Identity=29.620253164557, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=432, Percent_Identity=29.6296296296296, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=27.1186440677966, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24583025, Length=442, Percent_Identity=26.9230769230769, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17137668, Length=442, Percent_Identity=26.9230769230769, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24583023, Length=442, Percent_Identity=26.9230769230769, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281360481, Length=465, Percent_Identity=26.4516129032258, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360483, Length=465, Percent_Identity=26.4516129032258, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137666, Length=465, Percent_Identity=26.4516129032258, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43062; Mature: 42931

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSHRRMLIAVVAGAVLGALANALGGGAPWLDVAVRDVAQPIGQLFIRLLFMLVVPLLFS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVLGVADLELRHLGRLGARMLGYTAAVSSIAVLIGVTLVNVLGPGRGLPDAVREAARGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
ATIKPAPLPGGDSVAGFVLALVPDNPVKAAATGDLMGLIVFALLFGVALAVTDTPGARTL
CCCCCCCCCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAALQGLYDVSMKLIEGVLRLAPLGVGALLFVMAARLGAAVVRPIAAYVGVVVLGLALHQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVVYSLSVKLFGGMSPRAFFSGVRLAMVTAFSTASSSATLPTALRVAEENLRLPRHVARF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHH
VLTAGSAMNQNGSALFEGVTVLFLAQVYGVELSLGQQAIAVGIAVLAGIGTAGVPAASMP
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCCCCCCCCCHH
FIAMILGVLGIPVEGIGLVLGVDRFLDMCRTTVNVTGDLAAAVFVARGEPAEATEPAAGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCC
PPAP
CCCC
>Mature Secondary Structure 
PSHRRMLIAVVAGAVLGALANALGGGAPWLDVAVRDVAQPIGQLFIRLLFMLVVPLLFS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVLGVADLELRHLGRLGARMLGYTAAVSSIAVLIGVTLVNVLGPGRGLPDAVREAARGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
ATIKPAPLPGGDSVAGFVLALVPDNPVKAAATGDLMGLIVFALLFGVALAVTDTPGARTL
CCCCCCCCCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAALQGLYDVSMKLIEGVLRLAPLGVGALLFVMAARLGAAVVRPIAAYVGVVVLGLALHQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVVYSLSVKLFGGMSPRAFFSGVRLAMVTAFSTASSSATLPTALRVAEENLRLPRHVARF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHH
VLTAGSAMNQNGSALFEGVTVLFLAQVYGVELSLGQQAIAVGIAVLAGIGTAGVPAASMP
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCCCCCCCCCHH
FIAMILGVLGIPVEGIGLVLGVDRFLDMCRTTVNVTGDLAAAVFVARGEPAEATEPAAGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCC
PPAP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]