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The map label for this gene is wecG [H]

Identifier: 220918052

GI number: 220918052

Start: 3265183

End: 3266064

Strand: Reverse

Name: wecG [H]

Synonym: A2cp1_2953

Alternate gene names: 220918052

Gene position: 3266064-3265183 (Counterclockwise)

Preceding gene: 220918054

Following gene: 220918049

Centisome position: 64.94

GC content: 78.68

Gene sequence:

>882_bases
ATGGTGCCTGGAGCGGGGAGCGCGGAGGCGAAGGCGCACGGCGGCGCGGGCAGCGGCGTCCGCCGCGTCCGGATCGGGCA
GCTCTGGCTCGACGCGCTGACCGCGGCCGAGGCGCTCGACCGGGTCGAGGCCCTGGTCGCGGCGGGCCTGGGCGGGAGCG
TCTTCACGCCCAACGTGGATCACGTGGTCACGGCGGAGGACGACTGCGCGTTCCGTGCCGCGTACGCGGCGGCCAGCCTC
TCGCTCGCCGACGGCCAGGCGCTGGTGTGGGCGACGCGGCTGCTCGGGACGCCGGTGCCGGAGAAGGTGTCGGGCTCGGA
CCTGGTCTGGCCGCTCATGGAGCGCGCGGCCGGGGCGCGGTGGGGCGTGTACCTGCTCGGTGGCGGGCCGGGGGCGGCCG
AGGTGGCCGCGGCGCGGCTGGAGCGGGAGCTCGGGGTGCGCATCGTCGGCGTGGACGCGCCGCGCATCGCGGTGGACGGC
GACGCGAGCGAGTCCGCCGTGCTGGAGCGCGTCCGTCGCTCCGGCGCACACGTCGTCGTGGTGGGGCTGGGCGCGCCGAA
GCAGGAGCGCTTCATCCACCGCGCGGCGGAGGCGCTGCGGCCCGCGGTCGCGTTCGGGCTCGGGGCGTCGATCGACTTCC
TGGCGGGTCGCGTGCGCCGCGCGCCGGGCTGGATCTCCCGCGCCGGGCTGGAGTGGATGTTCCGGCTGGTGCAGGAGCCG
CGGCGCCTCGCCCACCGGTACCTGGTGAAGGACCCGCGCTTCCTGGGCGTGCTGGCGCGGACCGCGCGATTGCCCGCCGG
CGAGCGGCAGGCGCGGCGGCGCGCGCAGCCGACGCGCGACGCGGTCGCCGCGGCGCCCCGGCGCACCGGCGGGACGCCCT
GA

Upstream 100 bases:

>100_bases
GCCCTCCGGGCGCGAGGAGCTGAGCGTAGCACGGGGACCCGGCCGGCGCCGCGTGGGCGCTGTCCCCAGGGCGGTTGACG
TGAGGGGAGGGGGAGCGCGG

Downstream 100 bases:

>100_bases
CGTCCGGCGACGTCGCCGCGCGGCTCAGGGGCTCAGCGTGGGACCGCCGAGGTCCAGCGAGACGAACGCACCCGACTCGT
CGAACGACGGCACGCTGGGG

Product: WecB/TagA/CpsF family glycosyl transferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MVPGAGSAEAKAHGGAGSGVRRVRIGQLWLDALTAAEALDRVEALVAAGLGGSVFTPNVDHVVTAEDDCAFRAAYAAASL
SLADGQALVWATRLLGTPVPEKVSGSDLVWPLMERAAGARWGVYLLGGGPGAAEVAAARLERELGVRIVGVDAPRIAVDG
DASESAVLERVRRSGAHVVVVGLGAPKQERFIHRAAEALRPAVAFGLGASIDFLAGRVRRAPGWISRAGLEWMFRLVQEP
RRLAHRYLVKDPRFLGVLARTARLPAGERQARRRAQPTRDAVAAAPRRTGGTP

Sequences:

>Translated_293_residues
MVPGAGSAEAKAHGGAGSGVRRVRIGQLWLDALTAAEALDRVEALVAAGLGGSVFTPNVDHVVTAEDDCAFRAAYAAASL
SLADGQALVWATRLLGTPVPEKVSGSDLVWPLMERAAGARWGVYLLGGGPGAAEVAAARLERELGVRIVGVDAPRIAVDG
DASESAVLERVRRSGAHVVVVGLGAPKQERFIHRAAEALRPAVAFGLGASIDFLAGRVRRAPGWISRAGLEWMFRLVQEP
RRLAHRYLVKDPRFLGVLARTARLPAGERQARRRAQPTRDAVAAAPRRTGGTP
>Mature_293_residues
MVPGAGSAEAKAHGGAGSGVRRVRIGQLWLDALTAAEALDRVEALVAAGLGGSVFTPNVDHVVTAEDDCAFRAAYAAASL
SLADGQALVWATRLLGTPVPEKVSGSDLVWPLMERAAGARWGVYLLGGGPGAAEVAAARLERELGVRIVGVDAPRIAVDG
DASESAVLERVRRSGAHVVVVGLGAPKQERFIHRAAEALRPAVAFGLGASIDFLAGRVRRAPGWISRAGLEWMFRLVQEP
RRLAHRYLVKDPRFLGVLARTARLPAGERQARRRAQPTRDAVAAAPRRTGGTP

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis [H]

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family [H]

Homologues:

Organism=Escherichia coli, GI2367289, Length=197, Percent_Identity=33.502538071066, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023085
- InterPro:   IPR004629 [H]

Pfam domain/function: PF03808 Glyco_tran_WecB [H]

EC number: 2.4.1.- [C]

Molecular weight: Translated: 30810; Mature: 30810

Theoretical pI: Translated: 11.44; Mature: 11.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPGAGSAEAKAHGGAGSGVRRVRIGQLWLDALTAAEALDRVEALVAAGLGGSVFTPNVD
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
HVVTAEDDCAFRAAYAAASLSLADGQALVWATRLLGTPVPEKVSGSDLVWPLMERAAGAR
EEEECCCCHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
WGVYLLGGGPGAAEVAAARLERELGVRIVGVDAPRIAVDGDASESAVLERVRRSGAHVVV
CCEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHHCCCEEEE
VGLGAPKQERFIHRAAEALRPAVAFGLGASIDFLAGRVRRAPGWISRAGLEWMFRLVQEP
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RRLAHRYLVKDPRFLGVLARTARLPAGERQARRRAQPTRDAVAAAPRRTGGTP
HHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVPGAGSAEAKAHGGAGSGVRRVRIGQLWLDALTAAEALDRVEALVAAGLGGSVFTPNVD
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
HVVTAEDDCAFRAAYAAASLSLADGQALVWATRLLGTPVPEKVSGSDLVWPLMERAAGAR
EEEECCCCHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
WGVYLLGGGPGAAEVAAARLERELGVRIVGVDAPRIAVDGDASESAVLERVRRSGAHVVV
CCEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHHCCCEEEE
VGLGAPKQERFIHRAAEALRPAVAFGLGASIDFLAGRVRRAPGWISRAGLEWMFRLVQEP
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RRLAHRYLVKDPRFLGVLARTARLPAGERQARRRAQPTRDAVAAAPRRTGGTP
HHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]