Click here to switch to the map view.

The map label for this gene is glyA

Identifier: 220918027

GI number: 220918027

Start: 3241200

End: 3242453

Strand: Reverse

Name: glyA

Synonym: A2cp1_2928

Alternate gene names: 220918027

Gene position: 3242453-3241200 (Counterclockwise)

Preceding gene: 220918028

Following gene: 220918026

Centisome position: 64.47

GC content: 70.41

Gene sequence:

>1254_bases
ATGATGCCCACGCAGCGCCTCGCCGAGGCCGATCCGCAGATCGCGAAGCTCATCCGCGAGGAGACGCGGCGCCAGGCGGA
GGGGCTCGAGCTCATCGCCAGCGAGAACTTCGTCTCGCCGGCGGTGCTCGAGGCCCTCGGCTCGACCCTCACCAACAAGT
ACGCCGAGGGCTACCCGGGCAAGCGCTACTACGGCGGCTGCGAGGTGGTGGACCAGGTCGAGCAGCTCGCCATCGACCGG
GCCAAGCAGCTGTTCGGCGCCGACCACGCGAACGTGCAGCCGCACGCCGGCTCGCAGGCCAACATGGCCGCGTACTTCGC
GCTCGCGAAGCCGGGCGACACGGTGCTCGCGATGAGCCTGAACTTCGGTGGGCACCTCACCCACGGCTCGCCGGTGAACT
TCTCCGGCAAGCTCTTCAAGATCGTCCCGTACGGCCTCCGCCAGTCCGACGAGACCATCGACATGGACGAGGTGGCGCGC
CTCGCCCGCGAGCACAAGCCGCGCATCCTGATGGTCGGCGCGAGCGCCTACTCGCGGACGCTGCACTTCGATCGCTTCGC
CGAGATCGCGAACGAGGTCGGCGCGGCCATGGTGGTGGACATGGCGCACATCGCCGGCCTGGTCGCGGCCGGGCTGCACC
CGTCGCCGGTGCCGCACTCGGAGATCGTCACCACCACCACGCACAAGACGCTCCGCGGCCCGCGCGGCGGCATGATCCTC
TGCCGCGAGGCGCACGCGAAGACGCTCAACTCGCAGATCTTCCCCGGCATCCAGGGTGGCCCGCTCGAGCACGTGATCGC
CGCGAAGGCGGTGGCGTTCGGCGAGGCGCTCCGCCCCGAGTTCAAGGCGTACCAGCGGCGCATCGTGGAGAACGCGCAGG
TGCTGGCGGAGGGGCTGAAGTCGGCCGGGCTGCGGCTCGTCTCCGGCGGCACCGACAACCACCTGATGCTGGTGGACCTC
CGCCCGAAGAAGCTCACCGGCAAGATCGCCGAGGAGGCGCTCGGCAAGGCCGGCATCACCGTGAACAAGAACATGATCCC
GTGGGACCCGGAGAAGCCGATGACCACCTCCGGGATCCGGGTCGGGACGCCGGCGCTCACCACCCGCGGGATGGGCAGCC
GCGAGATGACGCTGGTGGCCGCGCTCATCGGGCGCGTGCTCGACGCGCCGGCCGACGAGCAGGTGCTGGCGCGCGTGCGC
GGCGAGGTGAAGGACCTCTGCGCGCACTTCCCGATGTACGCGGATCGCGTCTGA

Upstream 100 bases:

>100_bases
GACAAGATCGGCGCCCTGGAGCGCTGAACCGCCCCGTTGCCTGACCCGGCGGGGCGCGATAGAACCGCCCTCCCGCCACG
CTCCCGAGGAGAGAACGAAG

Downstream 100 bases:

>100_bases
CGGCCGTGCCGCGGGCCGGGGCCGGCCGGGGCCCCGCGCCGGGCGGCGGGCCGGGGTGAGTGGACCATGCGCTGTCCGTA
CTGCGGACACCTCGAGGACC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MMPTQRLAEADPQIAKLIREETRRQAEGLELIASENFVSPAVLEALGSTLTNKYAEGYPGKRYYGGCEVVDQVEQLAIDR
AKQLFGADHANVQPHAGSQANMAAYFALAKPGDTVLAMSLNFGGHLTHGSPVNFSGKLFKIVPYGLRQSDETIDMDEVAR
LAREHKPRILMVGASAYSRTLHFDRFAEIANEVGAAMVVDMAHIAGLVAAGLHPSPVPHSEIVTTTTHKTLRGPRGGMIL
CREAHAKTLNSQIFPGIQGGPLEHVIAAKAVAFGEALRPEFKAYQRRIVENAQVLAEGLKSAGLRLVSGGTDNHLMLVDL
RPKKLTGKIAEEALGKAGITVNKNMIPWDPEKPMTTSGIRVGTPALTTRGMGSREMTLVAALIGRVLDAPADEQVLARVR
GEVKDLCAHFPMYADRV

Sequences:

>Translated_417_residues
MMPTQRLAEADPQIAKLIREETRRQAEGLELIASENFVSPAVLEALGSTLTNKYAEGYPGKRYYGGCEVVDQVEQLAIDR
AKQLFGADHANVQPHAGSQANMAAYFALAKPGDTVLAMSLNFGGHLTHGSPVNFSGKLFKIVPYGLRQSDETIDMDEVAR
LAREHKPRILMVGASAYSRTLHFDRFAEIANEVGAAMVVDMAHIAGLVAAGLHPSPVPHSEIVTTTTHKTLRGPRGGMIL
CREAHAKTLNSQIFPGIQGGPLEHVIAAKAVAFGEALRPEFKAYQRRIVENAQVLAEGLKSAGLRLVSGGTDNHLMLVDL
RPKKLTGKIAEEALGKAGITVNKNMIPWDPEKPMTTSGIRVGTPALTTRGMGSREMTLVAALIGRVLDAPADEQVLARVR
GEVKDLCAHFPMYADRV
>Mature_417_residues
MMPTQRLAEADPQIAKLIREETRRQAEGLELIASENFVSPAVLEALGSTLTNKYAEGYPGKRYYGGCEVVDQVEQLAIDR
AKQLFGADHANVQPHAGSQANMAAYFALAKPGDTVLAMSLNFGGHLTHGSPVNFSGKLFKIVPYGLRQSDETIDMDEVAR
LAREHKPRILMVGASAYSRTLHFDRFAEIANEVGAAMVVDMAHIAGLVAAGLHPSPVPHSEIVTTTTHKTLRGPRGGMIL
CREAHAKTLNSQIFPGIQGGPLEHVIAAKAVAFGEALRPEFKAYQRRIVENAQVLAEGLKSAGLRLVSGGTDNHLMLVDL
RPKKLTGKIAEEALGKAGITVNKNMIPWDPEKPMTTSGIRVGTPALTTRGMGSREMTLVAALIGRVLDAPADEQVLARVR
GEVKDLCAHFPMYADRV

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=43.2671081677704, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=43.2671081677704, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=43.2671081677704, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=43.2671081677704, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=42.8256070640177, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI22547186, Length=429, Percent_Identity=44.7552447552448, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI22547189, Length=414, Percent_Identity=43.2367149758454, Blast_Score=302, Evalue=5e-82,
Organism=Escherichia coli, GI1788902, Length=412, Percent_Identity=59.4660194174757, Blast_Score=484, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI25144732, Length=398, Percent_Identity=45.2261306532663, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=398, Percent_Identity=45.2261306532663, Blast_Score=338, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=436, Percent_Identity=43.348623853211, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=430, Percent_Identity=41.6279069767442, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24640005, Length=404, Percent_Identity=47.7722772277228, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221329721, Length=404, Percent_Identity=47.7722772277228, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_ANAD2 (B8JEW9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493331.1
- ProteinModelPortal:   B8JEW9
- SMR:   B8JEW9
- GeneID:   7299859
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2928
- HOGENOM:   HBG301263
- ProtClustDB:   PRK00011
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 44989; Mature: 44989

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPTQRLAEADPQIAKLIREETRRQAEGLELIASENFVSPAVLEALGSTLTNKYAEGYPG
CCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
KRYYGGCEVVDQVEQLAIDRAKQLFGADHANVQPHAGSQANMAAYFALAKPGDTVLAMSL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
NFGGHLTHGSPVNFSGKLFKIVPYGLRQSDETIDMDEVARLAREHKPRILMVGASAYSRT
CCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHH
LHFDRFAEIANEVGAAMVVDMAHIAGLVAAGLHPSPVPHSEIVTTTTHKTLRGPRGGMIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHCCCCCCEEE
CREAHAKTLNSQIFPGIQGGPLEHVIAAKAVAFGEALRPEFKAYQRRIVENAQVLAEGLK
EEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
SAGLRLVSGGTDNHLMLVDLRPKKLTGKIAEEALGKAGITVNKNMIPWDPEKPMTTSGIR
HCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCEE
VGTPALTTRGMGSREMTLVAALIGRVLDAPADEQVLARVRGEVKDLCAHFPMYADRV
ECCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MMPTQRLAEADPQIAKLIREETRRQAEGLELIASENFVSPAVLEALGSTLTNKYAEGYPG
CCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
KRYYGGCEVVDQVEQLAIDRAKQLFGADHANVQPHAGSQANMAAYFALAKPGDTVLAMSL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
NFGGHLTHGSPVNFSGKLFKIVPYGLRQSDETIDMDEVARLAREHKPRILMVGASAYSRT
CCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHH
LHFDRFAEIANEVGAAMVVDMAHIAGLVAAGLHPSPVPHSEIVTTTTHKTLRGPRGGMIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHCCCCCCEEE
CREAHAKTLNSQIFPGIQGGPLEHVIAAKAVAFGEALRPEFKAYQRRIVENAQVLAEGLK
EEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
SAGLRLVSGGTDNHLMLVDLRPKKLTGKIAEEALGKAGITVNKNMIPWDPEKPMTTSGIR
HCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCEE
VGTPALTTRGMGSREMTLVAALIGRVLDAPADEQVLARVRGEVKDLCAHFPMYADRV
ECCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA