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The map label for this gene is cheA [H]

Identifier: 220918019

GI number: 220918019

Start: 3233909

End: 3235966

Strand: Reverse

Name: cheA [H]

Synonym: A2cp1_2920

Alternate gene names: 220918019

Gene position: 3235966-3233909 (Counterclockwise)

Preceding gene: 220918020

Following gene: 220918018

Centisome position: 64.34

GC content: 75.22

Gene sequence:

>2058_bases
ATGCCGGCCGACCGATCCCAGAAGGCGCTCGCCGAGTTCGTCTCCGAAGCGCAGGAGACGATCGACGCGCTCGGCCACGG
GCTCATGCAGCTCGAGGCGGGCGGGCACGAGGATCCGGACCCGGACGTCCTGAACGGCGTCTTCCGCGCCGCCCACACGC
TGAAGGGCCTGTCCTCGATGTCCGGGGTGGAGCGCCTCACGCGCCTCGCCCACGCGCTCGAGGACCTGCTCGACGAGGTG
CGGCTGGGCCGGCGCCGGCTGGACCGCCCCGCGCTCGACCTGCTGCTCGAGGCGCCGGAGGTGCTGTCGCGCATCGTGGC
GGAGGAGGCCTCCGGCGCGGCGCCGGCGAGCACCGACGCCGCCGCCCGGCTCACCGACCGGCTCCGCGCCGGCGAGGCGC
CGCCGCCGGCCCGCGCGGCCGACTCGCTCGCGACCGTGGCGCTGGGGCCCGAGGTCCTCGGCATCCTCACCGAGTACGAG
GAGCACCGGCTCCGCGCCAACCTCGACAAGGGGCTGGGGCTGCACCGGGTGAAGGTGAGCTTCGACCTGGACGGGTTCGA
CCGCGAGCTGGCCGCGCTGAACGGGCGGCTGAAGCGGCTCGGCGAGGTGGTCTCGACGCTGCCGTCCTCGGACCTGCGCG
ATCCCCAGGCGATCGCGTTCGAGCTGCTGTTCGCCTCGAAGGAGCCGGTGGACGCGATCCGCCGCGAGGCGGGCCCGGCC
GCGGCGGTCGAGGCGGTGCCGCGGGTCGAGGCGCCGCCGCCCGCGCCGCGCGCCGACGCGCCCCGGCGCGCCGGCGGCGC
GCTCTCCCCCGCGCCCGAGGCCCCATCGGACGACGCCGCGTCGCTGCGCTCCGCCTCGCAGGCGGTGCGGGTGGACATCC
ACGAGCTCGACCGGCTCATGAACGCCGTCGGCGAGCTGGTGCTGGTCAAGACGAGCCTCGTCGCGCTCGCGGAGCGGCTC
CGCGCCGAGGGGCGCGACCCGGCCGCGGCGGCCGAGCTGCAGCGCATCAACCGCACGCTGGAGCGCCGCCTGGAGGAGCT
GCAGGCCGGCATCCTCGAGGTGCGCATGGTCCCGCTGGAGCAGGTGTTCGACAAGCTCTCGCGGATGGTGCGCAAGCTGG
CGCGCGAGGTCGGCAAGGAGATCGACCTCCGGGTCTCGGGCGGCGAGGTGGAGCTCGACAAGCTCATCGTCGAGGACCTC
TCCGATCCGCTCATGCACCTCATCCGCAACGCCATCGACCACGGGATCGAGGCGCCCGAGCGGCGCGCCCGGGCCGGCAA
GCCGCCGCTCGGCACCGTGCGGCTGGAGGCGGCTCCGCAGGGCAACAAGGTCCGGATCGTGGTCGAGGACGACGGCGGCG
GCATCGACGAGGATCGCATCCGGGAGGTGGCGGTCCAGCGCGGGCTGGCGACCGCGGGCGACGTCGGCGCGCTGTCCCGC
CGCGAGCTCATGAACCTCATCTTCGTGCCCGGGTTCTCCACCGCGCGCCAGGTCACCAGCCTCTCCGGCCGCGGCGTGGG
CATGGACGTGGTGAAGAGCAACGTCGCCGCGCTGTCCGGGATCATCGACCTGCACACCGAGCGCGGGCGCGGCACCCGCT
TCGAGATCACCCTGCCGGTGACGCTCGCGATCGTGCGCGCGCTGGTGGTGTGGGTGGCGGGCCGGACCTACGCGGTGCCG
CTCAACAGCGTGCTGGAGATCCTGGAGGTCCGCGCCGCCGAGGTGCGCACGCTCTCCACGCGCGAGGTGGTCACCGTGCG
CGGCGCGACGCTGCCGCTGGTGCGCCTGTCCACCTTCTTCGGGCTGCCCGGCGCCGGCGCGCCGGAGCGGCTGTTCGTGG
TGGTGGTCGGGCTGGCGCAGGAGCGGCTGGGCGTGGCGGTGGACGCGGTGGTCGGGCAGCAGGACGTGGTGGTGAAGCCG
CTCGGCTCGGTGCTGCAGGGCGTGCGCGGCATCGCCGGCGCCACCGACCTGGGCAGCCGCCGCACGGTGCTGGTGCTGGA
CGTGGGCGCCATCATCGAGGACGTGGTGTCGGGGGAGCCCCGCGAGGCGGCGGGGTAG

Upstream 100 bases:

>100_bases
CCGTCGCGCGTGGAGATGCCGTCCCGGGGCCGCGCCTTGCCGCACGTCGGCGGCGTGGTACGCTGACCCGGCCGCGGGGC
CCGCGCCTCCGCGCCGCCCC

Downstream 100 bases:

>100_bases
CCGGGATGTACCTCGAGCACTTCGGCCTCGCCCGCAAGCCGTTCTCCAAGACGCCGGACCCGGCGTTCCTGTTCCCCTCG
CGCCAGCACGCCGAGGCGCT

Product: chemotaxis protein CheA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MPADRSQKALAEFVSEAQETIDALGHGLMQLEAGGHEDPDPDVLNGVFRAAHTLKGLSSMSGVERLTRLAHALEDLLDEV
RLGRRRLDRPALDLLLEAPEVLSRIVAEEASGAAPASTDAAARLTDRLRAGEAPPPARAADSLATVALGPEVLGILTEYE
EHRLRANLDKGLGLHRVKVSFDLDGFDRELAALNGRLKRLGEVVSTLPSSDLRDPQAIAFELLFASKEPVDAIRREAGPA
AAVEAVPRVEAPPPAPRADAPRRAGGALSPAPEAPSDDAASLRSASQAVRVDIHELDRLMNAVGELVLVKTSLVALAERL
RAEGRDPAAAAELQRINRTLERRLEELQAGILEVRMVPLEQVFDKLSRMVRKLAREVGKEIDLRVSGGEVELDKLIVEDL
SDPLMHLIRNAIDHGIEAPERRARAGKPPLGTVRLEAAPQGNKVRIVVEDDGGGIDEDRIREVAVQRGLATAGDVGALSR
RELMNLIFVPGFSTARQVTSLSGRGVGMDVVKSNVAALSGIIDLHTERGRGTRFEITLPVTLAIVRALVVWVAGRTYAVP
LNSVLEILEVRAAEVRTLSTREVVTVRGATLPLVRLSTFFGLPGAGAPERLFVVVVGLAQERLGVAVDAVVGQQDVVVKP
LGSVLQGVRGIAGATDLGSRRTVLVLDVGAIIEDVVSGEPREAAG

Sequences:

>Translated_685_residues
MPADRSQKALAEFVSEAQETIDALGHGLMQLEAGGHEDPDPDVLNGVFRAAHTLKGLSSMSGVERLTRLAHALEDLLDEV
RLGRRRLDRPALDLLLEAPEVLSRIVAEEASGAAPASTDAAARLTDRLRAGEAPPPARAADSLATVALGPEVLGILTEYE
EHRLRANLDKGLGLHRVKVSFDLDGFDRELAALNGRLKRLGEVVSTLPSSDLRDPQAIAFELLFASKEPVDAIRREAGPA
AAVEAVPRVEAPPPAPRADAPRRAGGALSPAPEAPSDDAASLRSASQAVRVDIHELDRLMNAVGELVLVKTSLVALAERL
RAEGRDPAAAAELQRINRTLERRLEELQAGILEVRMVPLEQVFDKLSRMVRKLAREVGKEIDLRVSGGEVELDKLIVEDL
SDPLMHLIRNAIDHGIEAPERRARAGKPPLGTVRLEAAPQGNKVRIVVEDDGGGIDEDRIREVAVQRGLATAGDVGALSR
RELMNLIFVPGFSTARQVTSLSGRGVGMDVVKSNVAALSGIIDLHTERGRGTRFEITLPVTLAIVRALVVWVAGRTYAVP
LNSVLEILEVRAAEVRTLSTREVVTVRGATLPLVRLSTFFGLPGAGAPERLFVVVVGLAQERLGVAVDAVVGQQDVVVKP
LGSVLQGVRGIAGATDLGSRRTVLVLDVGAIIEDVVSGEPREAAG
>Mature_684_residues
PADRSQKALAEFVSEAQETIDALGHGLMQLEAGGHEDPDPDVLNGVFRAAHTLKGLSSMSGVERLTRLAHALEDLLDEVR
LGRRRLDRPALDLLLEAPEVLSRIVAEEASGAAPASTDAAARLTDRLRAGEAPPPARAADSLATVALGPEVLGILTEYEE
HRLRANLDKGLGLHRVKVSFDLDGFDRELAALNGRLKRLGEVVSTLPSSDLRDPQAIAFELLFASKEPVDAIRREAGPAA
AVEAVPRVEAPPPAPRADAPRRAGGALSPAPEAPSDDAASLRSASQAVRVDIHELDRLMNAVGELVLVKTSLVALAERLR
AEGRDPAAAAELQRINRTLERRLEELQAGILEVRMVPLEQVFDKLSRMVRKLAREVGKEIDLRVSGGEVELDKLIVEDLS
DPLMHLIRNAIDHGIEAPERRARAGKPPLGTVRLEAAPQGNKVRIVVEDDGGGIDEDRIREVAVQRGLATAGDVGALSRR
ELMNLIFVPGFSTARQVTSLSGRGVGMDVVKSNVAALSGIIDLHTERGRGTRFEITLPVTLAIVRALVVWVAGRTYAVPL
NSVLEILEVRAAEVRTLSTREVVTVRGATLPLVRLSTFFGLPGAGAPERLFVVVVGLAQERLGVAVDAVVGQQDVVVKPL
GSVLQGVRGIAGATDLGSRRTVLVLDVGAIIEDVVSGEPREAAG

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=670, Percent_Identity=34.6268656716418, Blast_Score=322, Evalue=4e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73046; Mature: 72915

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADRSQKALAEFVSEAQETIDALGHGLMQLEAGGHEDPDPDVLNGVFRAAHTLKGLSSM
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SGVERLTRLAHALEDLLDEVRLGRRRLDRPALDLLLEAPEVLSRIVAEEASGAAPASTDA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AARLTDRLRAGEAPPPARAADSLATVALGPEVLGILTEYEEHRLRANLDKGLGLHRVKVS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FDLDGFDRELAALNGRLKRLGEVVSTLPSSDLRDPQAIAFELLFASKEPVDAIRREAGPA
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCH
AAVEAVPRVEAPPPAPRADAPRRAGGALSPAPEAPSDDAASLRSASQAVRVDIHELDRLM
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NAVGELVLVKTSLVALAERLRAEGRDPAAAAELQRINRTLERRLEELQAGILEVRMVPLE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHH
QVFDKLSRMVRKLAREVGKEIDLRVSGGEVELDKLIVEDLSDPLMHLIRNAIDHGIEAPE
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RRARAGKPPLGTVRLEAAPQGNKVRIVVEDDGGGIDEDRIREVAVQRGLATAGDVGALSR
HHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
RELMNLIFVPGFSTARQVTSLSGRGVGMDVVKSNVAALSGIIDLHTERGRGTRFEITLPV
HHHHHEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
TLAIVRALVVWVAGRTYAVPLNSVLEILEVRAAEVRTLSTREVVTVRGATLPLVRLSTFF
HHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
GLPGAGAPERLFVVVVGLAQERLGVAVDAVVGQQDVVVKPLGSVLQGVRGIAGATDLGSR
CCCCCCCCCEEEHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
RTVLVLDVGAIIEDVVSGEPREAAG
CEEEEEEHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PADRSQKALAEFVSEAQETIDALGHGLMQLEAGGHEDPDPDVLNGVFRAAHTLKGLSSM
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SGVERLTRLAHALEDLLDEVRLGRRRLDRPALDLLLEAPEVLSRIVAEEASGAAPASTDA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AARLTDRLRAGEAPPPARAADSLATVALGPEVLGILTEYEEHRLRANLDKGLGLHRVKVS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FDLDGFDRELAALNGRLKRLGEVVSTLPSSDLRDPQAIAFELLFASKEPVDAIRREAGPA
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCH
AAVEAVPRVEAPPPAPRADAPRRAGGALSPAPEAPSDDAASLRSASQAVRVDIHELDRLM
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NAVGELVLVKTSLVALAERLRAEGRDPAAAAELQRINRTLERRLEELQAGILEVRMVPLE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHH
QVFDKLSRMVRKLAREVGKEIDLRVSGGEVELDKLIVEDLSDPLMHLIRNAIDHGIEAPE
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RRARAGKPPLGTVRLEAAPQGNKVRIVVEDDGGGIDEDRIREVAVQRGLATAGDVGALSR
HHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
RELMNLIFVPGFSTARQVTSLSGRGVGMDVVKSNVAALSGIIDLHTERGRGTRFEITLPV
HHHHHEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
TLAIVRALVVWVAGRTYAVPLNSVLEILEVRAAEVRTLSTREVVTVRGATLPLVRLSTFF
HHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
GLPGAGAPERLFVVVVGLAQERLGVAVDAVVGQQDVVVKPLGSVLQGVRGIAGATDLGSR
CCCCCCCCCEEEHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
RTVLVLDVGAIIEDVVSGEPREAAG
CEEEEEEHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377 [H]