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The map label for this gene is ytcI [H]

Identifier: 220917899

GI number: 220917899

Start: 3096455

End: 3098161

Strand: Reverse

Name: ytcI [H]

Synonym: A2cp1_2800

Alternate gene names: 220917899

Gene position: 3098161-3096455 (Counterclockwise)

Preceding gene: 220917902

Following gene: 220917898

Centisome position: 61.6

GC content: 70.88

Gene sequence:

>1707_bases
ATGTCGTCGACCGACGTCTTCCGCCGCGCCCGCGACTTCCTGGTCACCCACCGCGAGGATTACGAGACCGCGTACCGCGA
GTTCCGCTGGCCGGTGCTCGACCGGTTCAACTGGGCGCTGGACTGGTTCGACATGATCGCGGACGGCAACGGCCGCACCG
CGCTGCACATCATCGAGGACTACGGCGCCGAGCTCCGGCTCTCCTACGTCGAGCTGGCCGAGCGCTCCAACCGCGTGGCG
ACCTACCTGCGCCGCCACGGCGTGGAGCGCGGGCACCGCGTGCTGATGATGCTGCCGAACTGCGTGCAGATCTGGGAGGT
GATGCTCGCCTCGATGAAGCTGGGGGCGTGCGTCATCCCCGCCACGTCGCTGCTCACGCCCGAGGACGTCCAGGACCGCA
TCGAGCGGGGGCGGGTGGGGCACGTCATCACCGACGCGGCCGGCACCGAGAAGTTCCGGGTGGTGAACGGGAGCTTCACG
CGGCACGTGGTGGGCGAGGCGGTGCCGGGCTGGATGCAGTACGAGGACGCCTACGACGAGGGCTCGTTCTTCCTGCCCCA
CGGCGAGACGCTGGCCTCCGACCCGGTGCTGCTCTACTTCACGAGCGGCACCACCGCGAAGCCGAAGCTGGTGGTGCACA
CGCACAAGAGCTACCCGGTCGGCCACCTCTCCACGATGTACTGGATCGGCCTCCGCGAGGGCGACAAGCACCTCAACGTC
TCGTCCCCGGGCTGGGCGAAGCACGCCTGGTCGAGCTTCTTCGCGCCGTTCAACGCGGGCGCGACGGTCTGCGTCTACAA
CTACGCCCGGTTCAGCGCCGCCCGCACGCTGGAGGTGCTGGCGCGCCACCAGATCACCACCCTGTGCGCGCCGCCCACCG
TGTGGCGCATGCTGATCCTCGAGGACCTGGCGAAGCACCCGGTGAAGCTCCGCGAGCTGCTCAGCGCCGGCGAGCCGCTC
AACCCCGAGGTGATCGAGAAGGTGCGCCAGGCCTGGGGCATCACCATCCGCGACGGCTACGGACAGACCGAGACCACCTG
CCAGATCGGCAACTCGCCCGGCCAGCCGCTGAAGCCCGGGTCCATGGGCCGGCCGCTCCCCGGCTACAGGATCGCGCTGC
TCGACGAGGAGGGGCGCCCCGCGCCGGAGGAGGGCGAGATCTGCATCGACCTCGAGGCCCGGCCGGCCTCGCTCATGGCG
GGCTACGAGGGCGACGCGAACCTGAACGACTTCGTCACCCGGCACGGGCACTACCACACCGGCGACGTCGCCACGCGCGA
CGAGGAGGGCTACATCACCTACGTCGGGCGCTCCGACGACGTCTTCAAGAGCTCGGACTACCGGATCAGCCCGTTCGAGC
TGGAGAGCGCGCTCATCGAGCACGACGCGGTGGCCGAGGCGGCGGTGGTGCCGAGCCCGGACGCGGTGCGCGGGCTCCTG
CCCAAGGCGTTCATCATCCTGAAGCCGGGGCGCACCCCGGACCGCGAGCTGGCGCTCGAGATCTTCCGGTTCCTGCGGCG
CCGCCTGGCCCCGTACAAGCGCATCCGCCGCGTCGAGTTCTCCGAGCTGCCCAAGACGGTGTCGGGCAAGATCCGGCGCG
TCGAGCTGCGGCGCCGCGAGCAGGCGCGGGCGCCCTCGGCGCCCCGGGGCCCGCTCGAGTTCTGGCAGGAGGACTTCCCG
GAGCTCGCGGCGGGCGAGGGGCGCTGA

Upstream 100 bases:

>100_bases
GCACTGCGCCAGGATCCCGCTCGGGGCGGCGGCGCTGCGCCCTCGCGCGCACCTCGCGGGTCGCTGGCACACTCGATCGA
CCCCACAGCGAGGAGCCCGC

Downstream 100 bases:

>100_bases
TCGCCGCCGCGCTGCGGCGTCCGGCCGCGGGCGGGGCGCGCGGCGACGGCCGCGCGGGGCGGGTCCGGGCGGGCCGGCCG
CGCGCGCCCGCGCGCTGCGA

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSSTDVFRRARDFLVTHREDYETAYREFRWPVLDRFNWALDWFDMIADGNGRTALHIIEDYGAELRLSYVELAERSNRVA
TYLRRHGVERGHRVLMMLPNCVQIWEVMLASMKLGACVIPATSLLTPEDVQDRIERGRVGHVITDAAGTEKFRVVNGSFT
RHVVGEAVPGWMQYEDAYDEGSFFLPHGETLASDPVLLYFTSGTTAKPKLVVHTHKSYPVGHLSTMYWIGLREGDKHLNV
SSPGWAKHAWSSFFAPFNAGATVCVYNYARFSAARTLEVLARHQITTLCAPPTVWRMLILEDLAKHPVKLRELLSAGEPL
NPEVIEKVRQAWGITIRDGYGQTETTCQIGNSPGQPLKPGSMGRPLPGYRIALLDEEGRPAPEEGEICIDLEARPASLMA
GYEGDANLNDFVTRHGHYHTGDVATRDEEGYITYVGRSDDVFKSSDYRISPFELESALIEHDAVAEAAVVPSPDAVRGLL
PKAFIILKPGRTPDRELALEIFRFLRRRLAPYKRIRRVEFSELPKTVSGKIRRVELRRREQARAPSAPRGPLEFWQEDFP
ELAAGEGR

Sequences:

>Translated_568_residues
MSSTDVFRRARDFLVTHREDYETAYREFRWPVLDRFNWALDWFDMIADGNGRTALHIIEDYGAELRLSYVELAERSNRVA
TYLRRHGVERGHRVLMMLPNCVQIWEVMLASMKLGACVIPATSLLTPEDVQDRIERGRVGHVITDAAGTEKFRVVNGSFT
RHVVGEAVPGWMQYEDAYDEGSFFLPHGETLASDPVLLYFTSGTTAKPKLVVHTHKSYPVGHLSTMYWIGLREGDKHLNV
SSPGWAKHAWSSFFAPFNAGATVCVYNYARFSAARTLEVLARHQITTLCAPPTVWRMLILEDLAKHPVKLRELLSAGEPL
NPEVIEKVRQAWGITIRDGYGQTETTCQIGNSPGQPLKPGSMGRPLPGYRIALLDEEGRPAPEEGEICIDLEARPASLMA
GYEGDANLNDFVTRHGHYHTGDVATRDEEGYITYVGRSDDVFKSSDYRISPFELESALIEHDAVAEAAVVPSPDAVRGLL
PKAFIILKPGRTPDRELALEIFRFLRRRLAPYKRIRRVEFSELPKTVSGKIRRVELRRREQARAPSAPRGPLEFWQEDFP
ELAAGEGR
>Mature_567_residues
SSTDVFRRARDFLVTHREDYETAYREFRWPVLDRFNWALDWFDMIADGNGRTALHIIEDYGAELRLSYVELAERSNRVAT
YLRRHGVERGHRVLMMLPNCVQIWEVMLASMKLGACVIPATSLLTPEDVQDRIERGRVGHVITDAAGTEKFRVVNGSFTR
HVVGEAVPGWMQYEDAYDEGSFFLPHGETLASDPVLLYFTSGTTAKPKLVVHTHKSYPVGHLSTMYWIGLREGDKHLNVS
SPGWAKHAWSSFFAPFNAGATVCVYNYARFSAARTLEVLARHQITTLCAPPTVWRMLILEDLAKHPVKLRELLSAGEPLN
PEVIEKVRQAWGITIRDGYGQTETTCQIGNSPGQPLKPGSMGRPLPGYRIALLDEEGRPAPEEGEICIDLEARPASLMAG
YEGDANLNDFVTRHGHYHTGDVATRDEEGYITYVGRSDDVFKSSDYRISPFELESALIEHDAVAEAAVVPSPDAVRGLLP
KAFIILKPGRTPDRELALEIFRFLRRRLAPYKRIRRVEFSELPKTVSGKIRRVELRRREQARAPSAPRGPLEFWQEDFPE
LAAGEGR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=541, Percent_Identity=37.1534195933457, Blast_Score=342, Evalue=7e-94,
Organism=Homo sapiens, GI122937307, Length=541, Percent_Identity=37.8927911275416, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI38505220, Length=532, Percent_Identity=36.6541353383459, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI58082049, Length=531, Percent_Identity=33.1450094161959, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI157311624, Length=531, Percent_Identity=33.3333333333333, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI157311622, Length=531, Percent_Identity=33.3333333333333, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI115511026, Length=509, Percent_Identity=33.3988212180747, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI42544134, Length=375, Percent_Identity=32.5333333333333, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI28416953, Length=520, Percent_Identity=30.1923076923077, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI13375727, Length=560, Percent_Identity=27.6785714285714, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI195947378, Length=441, Percent_Identity=27.437641723356, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI8923896, Length=368, Percent_Identity=33.1521739130435, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI253970489, Length=368, Percent_Identity=33.1521739130435, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI156151445, Length=542, Percent_Identity=25.830258302583, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI187761345, Length=383, Percent_Identity=25.065274151436, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI187761343, Length=383, Percent_Identity=25.065274151436, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1790505, Length=553, Percent_Identity=31.4647377938517, Blast_Score=185, Evalue=8e-48,
Organism=Escherichia coli, GI221142682, Length=513, Percent_Identity=25.7309941520468, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788107, Length=524, Percent_Identity=26.3358778625954, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786529, Length=533, Percent_Identity=27.3921200750469, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786810, Length=504, Percent_Identity=25.9920634920635, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=25.2895752895753, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788595, Length=481, Percent_Identity=23.9085239085239, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786801, Length=435, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=530, Percent_Identity=29.811320754717, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71983001, Length=530, Percent_Identity=29.811320754717, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17559526, Length=552, Percent_Identity=25, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=554, Percent_Identity=25.812274368231, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=501, Percent_Identity=25.9481037924152, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=521, Percent_Identity=25.3358925143954, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=486, Percent_Identity=24.6913580246914, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994694, Length=532, Percent_Identity=24.0601503759398, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994703, Length=532, Percent_Identity=24.0601503759398, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994690, Length=532, Percent_Identity=24.0601503759398, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=30.0546448087432, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71996755, Length=482, Percent_Identity=24.6887966804979, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=483, Percent_Identity=23.3954451345756, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=370, Percent_Identity=26.4864864864865, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=523, Percent_Identity=23.3269598470363, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319264, Length=531, Percent_Identity=28.8135593220339, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323182, Length=534, Percent_Identity=27.5280898876405, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319699, Length=351, Percent_Identity=27.9202279202279, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24667955, Length=523, Percent_Identity=29.0630975143403, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI62472339, Length=523, Percent_Identity=28.8718929254302, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24667959, Length=363, Percent_Identity=32.7823691460055, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355225, Length=574, Percent_Identity=25.9581881533101, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI21355181, Length=500, Percent_Identity=25.2, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24581924, Length=524, Percent_Identity=25.5725190839695, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648260, Length=489, Percent_Identity=23.721881390593, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18859661, Length=518, Percent_Identity=23.1660231660232, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550496, Length=532, Percent_Identity=23.3082706766917, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21356947, Length=474, Percent_Identity=22.9957805907173, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552801, Length=533, Percent_Identity=23.6397748592871, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653035, Length=497, Percent_Identity=24.9496981891348, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648257, Length=499, Percent_Identity=23.4468937875752, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358303, Length=472, Percent_Identity=22.8813559322034, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281365686, Length=211, Percent_Identity=27.0142180094787, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356441, Length=486, Percent_Identity=21.1934156378601, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 64130; Mature: 63998

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTDVFRRARDFLVTHREDYETAYREFRWPVLDRFNWALDWFDMIADGNGRTALHIIED
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
YGAELRLSYVELAERSNRVATYLRRHGVERGHRVLMMLPNCVQIWEVMLASMKLGACVIP
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEC
ATSLLTPEDVQDRIERGRVGHVITDAAGTEKFRVVNGSFTRHVVGEAVPGWMQYEDAYDE
HHHCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHCCCC
GSFFLPHGETLASDPVLLYFTSGTTAKPKLVVHTHKSYPVGHLSTMYWIGLREGDKHLNV
CCEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCEECC
SSPGWAKHAWSSFFAPFNAGATVCVYNYARFSAARTLEVLARHQITTLCAPPTVWRMLIL
CCCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EDLAKHPVKLRELLSAGEPLNPEVIEKVRQAWGITIRDGYGQTETTCQIGNSPGQPLKPG
HHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCCCCC
SMGRPLPGYRIALLDEEGRPAPEEGEICIDLEARPASLMAGYEGDANLNDFVTRHGHYHT
CCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCHHEECCCCCCCHHHHHHHCCCEEC
GDVATRDEEGYITYVGRSDDVFKSSDYRISPFELESALIEHDAVAEAAVVPSPDAVRGLL
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
PKAFIILKPGRTPDRELALEIFRFLRRRLAPYKRIRRVEFSELPKTVSGKIRRVELRRRE
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCHHHCCHHHCCHHHHHHHHHHH
QARAPSAPRGPLEFWQEDFPELAAGEGR
HHCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSTDVFRRARDFLVTHREDYETAYREFRWPVLDRFNWALDWFDMIADGNGRTALHIIED
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
YGAELRLSYVELAERSNRVATYLRRHGVERGHRVLMMLPNCVQIWEVMLASMKLGACVIP
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEC
ATSLLTPEDVQDRIERGRVGHVITDAAGTEKFRVVNGSFTRHVVGEAVPGWMQYEDAYDE
HHHCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHCCCC
GSFFLPHGETLASDPVLLYFTSGTTAKPKLVVHTHKSYPVGHLSTMYWIGLREGDKHLNV
CCEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCEECC
SSPGWAKHAWSSFFAPFNAGATVCVYNYARFSAARTLEVLARHQITTLCAPPTVWRMLIL
CCCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EDLAKHPVKLRELLSAGEPLNPEVIEKVRQAWGITIRDGYGQTETTCQIGNSPGQPLKPG
HHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCCCCC
SMGRPLPGYRIALLDEEGRPAPEEGEICIDLEARPASLMAGYEGDANLNDFVTRHGHYHT
CCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCHHEECCCCCCCHHHHHHHCCCEEC
GDVATRDEEGYITYVGRSDDVFKSSDYRISPFELESALIEHDAVAEAAVVPSPDAVRGLL
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
PKAFIILKPGRTPDRELALEIFRFLRRRLAPYKRIRRVEFSELPKTVSGKIRRVELRRRE
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCHHHCCHHHCCHHHHHHHHHHH
QARAPSAPRGPLEFWQEDFPELAAGEGR
HHCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]