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The map label for this gene is srrB [H]

Identifier: 220917858

GI number: 220917858

Start: 3044175

End: 3045950

Strand: Reverse

Name: srrB [H]

Synonym: A2cp1_2759

Alternate gene names: 220917858

Gene position: 3045950-3044175 (Counterclockwise)

Preceding gene: 220917860

Following gene: 220917855

Centisome position: 60.56

GC content: 79.84

Gene sequence:

>1776_bases
ATGGCGTCCCGCGCCCGGGCCTCGGTCTGGCCCGCGGCGCTGGCGGTCGGCGTCGTGTCGGTGCTCGGCGTCGCCGCGCT
GGGCGTGCGGACGCAGCGCATGGCGAGCGAGGCGTGGGACCGTCTGCTCGACGAGAACGTGGCGGCGCTGGTGGACACGG
AGCGGCTGGCGACCGCGAGCGAGCTCGGCCTGCGCCTCGCGCGCGACGCCGCGGTGGATGGCGAGCCCGCCACCGTCCGC
GCGCTCGGCCGCAACCAGGCGGAGGTGGCCGACCTGCTCGGGCGCGCCGCGGCGCGCGCGAGCACCCCCGAGGAGCGGGA
GCGCGTGGCCGCGCTCGCGGGGGATCACGCGCTCCTGTGGCGCCTGGGCGAGCAGGCGGCGATGGAGCGGCTGGGCGGGC
AGCCGGCGGGGGTGGTGGCGAGGCGGTTGCAAACCGCGGCGGGCCCGGTGCGGCGCCGCATCGACGACGGGGTCTCGGCG
CTGGTGCGGGCCCACGAGCAGGACCTGGCCCGGGCGCGCCAGGCCGTGGCCGCGGGCGAGCGCCGCGGCCTGCTCGCGCT
GGCCGGCGCGGCGGCGGTGGCGGTGGCGCTCGCGGTGCTGCTCGGCGCGTGGCTGCGCCGCAGCCTCGGCGCGCTCCGGC
GCAGCGAGGCCCGGTTCCGCGCCACCTTCGAGCACGCCGGCGTGGGCATGGCGCACGTGTCGCCGGACGGCCACTGGCTG
CGGCTCAACCGCCGCTACCGGGAGCTGCTGGGCTGCGAGCGCGAGAACCTGCGCGGCGCCACCGTGCTCGACCTGACCCA
CCCCGACGACCGCGCCGCCGAGGCGCAGCGCAGCGCGCGGCTGCTGGCGGGCGACCTCGACGGCTACGCCGCGGAGGAGC
GCCTGCTCCGCCGCGACGGCGGGACGCAGTGGGTCAACGTGACCTGCGCCGCGGTCCGGGACGGCGCGGGGCGCGCGCGC
TACCTGGTGCGGTCCGCGGAGGACGTCTCCGCCCGCCGCCGGGTGGAGGAGGAGCTCCGGGCCGCGGTGCGCGCCCGCGA
CGAGTTCCTGCAGGTCGCGTCGCACGAGCTGCGGACGCCGCTCGCCACGCTGCGCCTCCAGGCGGAGGCGCTCCGGGCGG
CGCTGGCGCGCGGAGGGGCCGACCCGGCGCGCGCGGTGGCCCGGGCCGACGCGGCGCTGCGGCAGACCGCGCGCCTCGAC
GCGCTGGTGGACGCGCTCATCGAGGTCTCGCGGGCGGGCCAGGGCGCGGTGGCCCTGCAGCGCGAGCGGCTCGACCTCGC
CGAGGTTGCGCGGCGCGCGCTGCGCCGGAGCGTCGACCAGGCGTCGCACCACGGCATCGAGCTGCACCTGCGGAGCCGGA
GCGTGCCAGCGTGGGGGGACCGCGCGCGGCTCGAGCAGGCGCTCGGGCACCTGCTCTCGAACGCGGTCCGCCACGGCGCG
GGGCGACCGGTGGAGATCCGCGTCGAGGCCGCGGGCGCGCTCGGCCGCATGGTCGTGGTGGATCACGGGTCCGGCGTGGC
CCCGGCCGACGCCGAGCGGATCTTCGGCCGGTTCGAGCGGGCGACGTCGTGGCGCCACCATGGCGGCCTGGGGCTGGGCC
TGTTCCTGGCGCGGCGCATCGCCGAGGCGCACGGCGGCACGGTGCGCCTGGAGCCGGCGGACGGGGAGGGGACGGCCTTC
GTGCTGGAGGTGCCGCGCGAGCTGCCGCGCGAGGACCTCGCCGTTCACGGCGCCGGCGAGCCGTCCGGCGAGGATCAGCC
GGGGCAGGCGCACTGA

Upstream 100 bases:

>100_bases
TCATCCCGGCCTCCCCGCCGCGGGGCCGCCATATTGCCGGGTGGCGATGGGGCTCGGAACGGGGAGGACGGGGCGGGAGC
GCCCGCGCGGCGCGCCGGGG

Downstream 100 bases:

>100_bases
TCACCAGGGGATGAGCCGCCCGTCGCGGAAGAACCCGCCGCTCGGGCCGTCGTCCGGGAGCGTGGCCAGCCAGACGATCC
CCTCCGCGCCGCGCTCCACC

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MASRARASVWPAALAVGVVSVLGVAALGVRTQRMASEAWDRLLDENVAALVDTERLATASELGLRLARDAAVDGEPATVR
ALGRNQAEVADLLGRAAARASTPEERERVAALAGDHALLWRLGEQAAMERLGGQPAGVVARRLQTAAGPVRRRIDDGVSA
LVRAHEQDLARARQAVAAGERRGLLALAGAAAVAVALAVLLGAWLRRSLGALRRSEARFRATFEHAGVGMAHVSPDGHWL
RLNRRYRELLGCERENLRGATVLDLTHPDDRAAEAQRSARLLAGDLDGYAAEERLLRRDGGTQWVNVTCAAVRDGAGRAR
YLVRSAEDVSARRRVEEELRAAVRARDEFLQVASHELRTPLATLRLQAEALRAALARGGADPARAVARADAALRQTARLD
ALVDALIEVSRAGQGAVALQRERLDLAEVARRALRRSVDQASHHGIELHLRSRSVPAWGDRARLEQALGHLLSNAVRHGA
GRPVEIRVEAAGALGRMVVVDHGSGVAPADAERIFGRFERATSWRHHGGLGLGLFLARRIAEAHGGTVRLEPADGEGTAF
VLEVPRELPREDLAVHGAGEPSGEDQPGQAH

Sequences:

>Translated_591_residues
MASRARASVWPAALAVGVVSVLGVAALGVRTQRMASEAWDRLLDENVAALVDTERLATASELGLRLARDAAVDGEPATVR
ALGRNQAEVADLLGRAAARASTPEERERVAALAGDHALLWRLGEQAAMERLGGQPAGVVARRLQTAAGPVRRRIDDGVSA
LVRAHEQDLARARQAVAAGERRGLLALAGAAAVAVALAVLLGAWLRRSLGALRRSEARFRATFEHAGVGMAHVSPDGHWL
RLNRRYRELLGCERENLRGATVLDLTHPDDRAAEAQRSARLLAGDLDGYAAEERLLRRDGGTQWVNVTCAAVRDGAGRAR
YLVRSAEDVSARRRVEEELRAAVRARDEFLQVASHELRTPLATLRLQAEALRAALARGGADPARAVARADAALRQTARLD
ALVDALIEVSRAGQGAVALQRERLDLAEVARRALRRSVDQASHHGIELHLRSRSVPAWGDRARLEQALGHLLSNAVRHGA
GRPVEIRVEAAGALGRMVVVDHGSGVAPADAERIFGRFERATSWRHHGGLGLGLFLARRIAEAHGGTVRLEPADGEGTAF
VLEVPRELPREDLAVHGAGEPSGEDQPGQAH
>Mature_590_residues
ASRARASVWPAALAVGVVSVLGVAALGVRTQRMASEAWDRLLDENVAALVDTERLATASELGLRLARDAAVDGEPATVRA
LGRNQAEVADLLGRAAARASTPEERERVAALAGDHALLWRLGEQAAMERLGGQPAGVVARRLQTAAGPVRRRIDDGVSAL
VRAHEQDLARARQAVAAGERRGLLALAGAAAVAVALAVLLGAWLRRSLGALRRSEARFRATFEHAGVGMAHVSPDGHWLR
LNRRYRELLGCERENLRGATVLDLTHPDDRAAEAQRSARLLAGDLDGYAAEERLLRRDGGTQWVNVTCAAVRDGAGRARY
LVRSAEDVSARRRVEEELRAAVRARDEFLQVASHELRTPLATLRLQAEALRAALARGGADPARAVARADAALRQTARLDA
LVDALIEVSRAGQGAVALQRERLDLAEVARRALRRSVDQASHHGIELHLRSRSVPAWGDRARLEQALGHLLSNAVRHGAG
RPVEIRVEAAGALGRMVVVDHGSGVAPADAERIFGRFERATSWRHHGGLGLGLFLARRIAEAHGGTVRLEPADGEGTAFV
LEVPRELPREDLAVHGAGEPSGEDQPGQAH

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=126, Percent_Identity=32.5396825396825, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=32.258064516129, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=32.2314049586777, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=362, Percent_Identity=25.414364640884, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788713, Length=269, Percent_Identity=23.7918215613383, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=286, Percent_Identity=25.5244755244755, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=26.0700389105058, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=27.1653543307087, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=30.9090909090909, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=28.936170212766, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=24.4, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=27.1111111111111, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=237, Percent_Identity=27.8481012658228, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788549, Length=272, Percent_Identity=26.1029411764706, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789808, Length=261, Percent_Identity=27.9693486590038, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63267; Mature: 63136

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRARASVWPAALAVGVVSVLGVAALGVRTQRMASEAWDRLLDENVAALVDTERLATAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ELGLRLARDAAVDGEPATVRALGRNQAEVADLLGRAAARASTPEERERVAALAGDHALLW
HHHHHHHHHCCCCCCCCEEHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHH
RLGEQAAMERLGGQPAGVVARRLQTAAGPVRRRIDDGVSALVRAHEQDLARARQAVAAGE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RRGLLALAGAAAVAVALAVLLGAWLRRSLGALRRSEARFRATFEHAGVGMAHVSPDGHWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEE
RLNRRYRELLGCERENLRGATVLDLTHPDDRAAEAQRSARLLAGDLDGYAAEERLLRRDG
EHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GTQWVNVTCAAVRDGAGRARYLVRSAEDVSARRRVEEELRAAVRARDEFLQVASHELRTP
CCEEEEEEEEEHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
LATLRLQAEALRAALARGGADPARAVARADAALRQTARLDALVDALIEVSRAGQGAVALQ
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RERLDLAEVARRALRRSVDQASHHGIELHLRSRSVPAWGDRARLEQALGHLLSNAVRHGA
HHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
GRPVEIRVEAAGALGRMVVVDHGSGVAPADAERIFGRFERATSWRHHGGLGLGLFLARRI
CCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHH
AEAHGGTVRLEPADGEGTAFVLEVPRELPREDLAVHGAGEPSGEDQPGQAH
HHHCCCEEEEECCCCCCCEEEEECCHHCCHHHCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASRARASVWPAALAVGVVSVLGVAALGVRTQRMASEAWDRLLDENVAALVDTERLATAS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ELGLRLARDAAVDGEPATVRALGRNQAEVADLLGRAAARASTPEERERVAALAGDHALLW
HHHHHHHHHCCCCCCCCEEHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHH
RLGEQAAMERLGGQPAGVVARRLQTAAGPVRRRIDDGVSALVRAHEQDLARARQAVAAGE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RRGLLALAGAAAVAVALAVLLGAWLRRSLGALRRSEARFRATFEHAGVGMAHVSPDGHWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEE
RLNRRYRELLGCERENLRGATVLDLTHPDDRAAEAQRSARLLAGDLDGYAAEERLLRRDG
EHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GTQWVNVTCAAVRDGAGRARYLVRSAEDVSARRRVEEELRAAVRARDEFLQVASHELRTP
CCEEEEEEEEEHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
LATLRLQAEALRAALARGGADPARAVARADAALRQTARLDALVDALIEVSRAGQGAVALQ
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RERLDLAEVARRALRRSVDQASHHGIELHLRSRSVPAWGDRARLEQALGHLLSNAVRHGA
HHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
GRPVEIRVEAAGALGRMVVVDHGSGVAPADAERIFGRFERATSWRHHGGLGLGLFLARRI
CCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHH
AEAHGGTVRLEPADGEGTAFVLEVPRELPREDLAVHGAGEPSGEDQPGQAH
HHHCCCEEEEECCCCCCCEEEEECCHHCCHHHCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA