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The map label for this gene is purM

Identifier: 220917801

GI number: 220917801

Start: 2982570

End: 2983607

Strand: Direct

Name: purM

Synonym: A2cp1_2702

Alternate gene names: 220917801

Gene position: 2982570-2983607 (Clockwise)

Preceding gene: 220917800

Following gene: 220917802

Centisome position: 59.3

GC content: 74.08

Gene sequence:

>1038_bases
ATGTCCCTGACCTACCGCGACGCAGGCGTCGACATCGACGAGGGAGACCGGCTCGTCGACCTCATCAAGCCGCACGCCCG
GCCCACCCTGCGCCCGGAGGTGCTCGGCGGCATCGGCGGGTTCGGCGGGCTCTTCGCGCTCGACGTGAAGAAGTACCGCG
AGCCGGTGCTGGTGTCGGGCACCGACGGCGTCGGGACCAAGCTCAAGGTGGCGTTCGCCGCCGATCGCCACGACACCGTG
GGCATCGACCTCGTGGCGATGTGCGTGAACGACATCGCGGTGGTGGGGGCCGAGCCGCTCTTCTTCCTCGACTACTACGC
CACGGGCAAGCTCAGCGCCGAGCAGGGCGCCCAGGTGGTGAAGGGGATCGCGGAGGGCTGCCGGCAGGCGGGCTGCGCCC
TCATCGGCGGCGAGACCGCCGAGCTGCCCGGGTTCTACGAGCGCGGCGAGTACGACCTGGCCGGCTTCGCGGTCGGCTGC
GTCGACCGCCCGCGCATCGTGGACGGCACCCGGGTGGCCCGGGGCGACGTGGTGATCGGGATCGCGTCCTCCGGCCTGCA
CTCCAACGGCTTCTCGCTCGCGCGCAAGGCGCTCCTCGAGCGCTACCCGCTCGATCACCGGTTCGACGCGCTGGGCGGGC
GCACGCTGGCGGACGCGCTGCTCGAGCCCACCCGCATCTACGCGAAGGACGTGCTGGCGCTGCTGGAGCAGGTGCCGGTC
CGGGCGTTCGCGCACATCACCGGCGGCGGGCTGCCCGGCAACGTGCCGCGCACCCTGCCCGACGGCACGCGGGCGGTGCT
CGAGGAGCAGCGCTGGCCGCGGCCGGCCATCTTCGACCTGGTGGAGCGCGAGGGGCAGGTCCCGCGCGACGAGATGTACC
GCACCTTCAACATGGGCCTCGGCCTGGTGGCGGTGGTCGCGCCCGGCGACGAGGCGGCGGCGCACGCGGCGCTCCGGGCG
CGCGGGCTGGAGGCGTGGACGGTCGGCGCCATCGAGGCGGGCGGGCCCGGGGAGGCCACCTGCGAGGTGGTGCGGTGA

Upstream 100 bases:

>100_bases
CGATCGGCTGGCTCGAGGCTTCGACCCGCCCTCCCCGCCCCCCGCGGCGCCCGGGCGCTCGCGGCTTGCAGCGGCCGCGC
CGTCGCGGTAAGGCGCAGCC

Downstream 100 bases:

>100_bases
CCCGGCTCGGCGTCCTCGCCTCGGGCGGCGGCACGAACCTCCAGGCGCTGCTCGACGCCTGCGCGGCCGGGCGCGTGGAC
GCGCAGGTCGCGGTGGTGCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSLTYRDAGVDIDEGDRLVDLIKPHARPTLRPEVLGGIGGFGGLFALDVKKYREPVLVSGTDGVGTKLKVAFAADRHDTV
GIDLVAMCVNDIAVVGAEPLFFLDYYATGKLSAEQGAQVVKGIAEGCRQAGCALIGGETAELPGFYERGEYDLAGFAVGC
VDRPRIVDGTRVARGDVVIGIASSGLHSNGFSLARKALLERYPLDHRFDALGGRTLADALLEPTRIYAKDVLALLEQVPV
RAFAHITGGGLPGNVPRTLPDGTRAVLEEQRWPRPAIFDLVEREGQVPRDEMYRTFNMGLGLVAVVAPGDEAAAHAALRA
RGLEAWTVGAIEAGGPGEATCEVVR

Sequences:

>Translated_345_residues
MSLTYRDAGVDIDEGDRLVDLIKPHARPTLRPEVLGGIGGFGGLFALDVKKYREPVLVSGTDGVGTKLKVAFAADRHDTV
GIDLVAMCVNDIAVVGAEPLFFLDYYATGKLSAEQGAQVVKGIAEGCRQAGCALIGGETAELPGFYERGEYDLAGFAVGC
VDRPRIVDGTRVARGDVVIGIASSGLHSNGFSLARKALLERYPLDHRFDALGGRTLADALLEPTRIYAKDVLALLEQVPV
RAFAHITGGGLPGNVPRTLPDGTRAVLEEQRWPRPAIFDLVEREGQVPRDEMYRTFNMGLGLVAVVAPGDEAAAHAALRA
RGLEAWTVGAIEAGGPGEATCEVVR
>Mature_344_residues
SLTYRDAGVDIDEGDRLVDLIKPHARPTLRPEVLGGIGGFGGLFALDVKKYREPVLVSGTDGVGTKLKVAFAADRHDTVG
IDLVAMCVNDIAVVGAEPLFFLDYYATGKLSAEQGAQVVKGIAEGCRQAGCALIGGETAELPGFYERGEYDLAGFAVGCV
DRPRIVDGTRVARGDVVIGIASSGLHSNGFSLARKALLERYPLDHRFDALGGRTLADALLEPTRIYAKDVLALLEQVPVR
AFAHITGGGLPGNVPRTLPDGTRAVLEEQRWPRPAIFDLVEREGQVPRDEMYRTFNMGLGLVAVVAPGDEAAAHAALRAR
GLEAWTVGAIEAGGPGEATCEVVR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=49.7109826589595, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=49.7109826589595, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=49.7109826589595, Blast_Score=325, Evalue=5e-89,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=57.2289156626506, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567511, Length=352, Percent_Identity=41.4772727272727, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=46.8842729970326, Blast_Score=292, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24582400, Length=313, Percent_Identity=43.4504792332268, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_ANAD2 (B8JDJ0)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493105.1
- ProteinModelPortal:   B8JDJ0
- SMR:   B8JDJ0
- GeneID:   7299703
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2702
- HOGENOM:   HBG531222
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36600; Mature: 36469

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTYRDAGVDIDEGDRLVDLIKPHARPTLRPEVLGGIGGFGGLFALDVKKYREPVLVSG
CCCEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHEEHHHHCCCEEEEC
TDGVGTKLKVAFAADRHDTVGIDLVAMCVNDIAVVGAEPLFFLDYYATGKLSAEQGAQVV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
KGIAEGCRQAGCALIGGETAELPGFYERGEYDLAGFAVGCVDRPRIVDGTRVARGDVVIG
HHHHHHHHHCCCEEECCCCCCCCCCHHCCCCCCCEEEEECCCCCEECCCCEEECCCEEEE
IASSGLHSNGFSLARKALLERYPLDHRFDALGGRTLADALLEPTRIYAKDVLALLEQVPV
EECCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCH
RAFAHITGGGLPGNVPRTLPDGTRAVLEEQRWPRPAIFDLVEREGQVPRDEMYRTFNMGL
HHHHEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCC
GLVAVVAPGDEAAAHAALRARGLEAWTVGAIEAGGPGEATCEVVR
CEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEECC
>Mature Secondary Structure 
SLTYRDAGVDIDEGDRLVDLIKPHARPTLRPEVLGGIGGFGGLFALDVKKYREPVLVSG
CCEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHEEHHHHCCCEEEEC
TDGVGTKLKVAFAADRHDTVGIDLVAMCVNDIAVVGAEPLFFLDYYATGKLSAEQGAQVV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
KGIAEGCRQAGCALIGGETAELPGFYERGEYDLAGFAVGCVDRPRIVDGTRVARGDVVIG
HHHHHHHHHCCCEEECCCCCCCCCCHHCCCCCCCEEEEECCCCCEECCCCEEECCCEEEE
IASSGLHSNGFSLARKALLERYPLDHRFDALGGRTLADALLEPTRIYAKDVLALLEQVPV
EECCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCH
RAFAHITGGGLPGNVPRTLPDGTRAVLEEQRWPRPAIFDLVEREGQVPRDEMYRTFNMGL
HHHHEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCC
GLVAVVAPGDEAAAHAALRARGLEAWTVGAIEAGGPGEATCEVVR
CEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA