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The map label for this gene is crp [H]

Identifier: 220917799

GI number: 220917799

Start: 2981397

End: 2982044

Strand: Reverse

Name: crp [H]

Synonym: A2cp1_2700

Alternate gene names: 220917799

Gene position: 2982044-2981397 (Counterclockwise)

Preceding gene: 220917807

Following gene: 220917798

Centisome position: 59.29

GC content: 70.83

Gene sequence:

>648_bases
ATGCCAGACGATCAGCTCCTCCAGCGCTTCGGCAGGGAGTTCCCGCGCGGGAGCGTGCTGTTCCGCGAGGGCGAGCCGGG
CCGCGAGATGTTCGTGGTGCAGCAGGGGCGGGTGACGCTCTCGACGACCGCCGGGGGCGTCGAGAAGATCCTGGCGTCGA
TGGGGCCGGGTGAGTTCCTCGGCGAGATGTCGATCCTGAACAACCGGCCCCGATCGGCCACCGCCACCTGCGCGGAGGAC
GCCCGGCTGCTGGTCATCGACGCCCTGACGTTCGAGGCGATGATCCGGGGCAACGCGGAGATCGCCGTCCGGATGGTCAA
GAAGCTGGCGGACCGCCTGCAGGAGGCGGAGGAGCAGATCGCGAACCTGCTCTTCCAGGACGCCTCGTCGCGGGTGGTGC
ACTTCCTCGTCACCGCGGCGGACAAGGCCTCCCGCGGCCCGGCCGGCCACGAGATCGAGGTGGCGCCGCGCGAGCTCGCC
GGCCGGGTGGGCGTCCGTCCGGAGGAGGCGGACGAGGCGCTGGCGAAGCTGGTGAAGGCGAAGATCGTCGCCGTCCGCCC
GGACGGCTTCCTGGTGCCGGACGTCTCGAAGCTCCGCCACTTCCTCGAGTTCCTGCAGGTGAAGGCGCAGTTCGGGGGCA
TCGCGTGA

Upstream 100 bases:

>100_bases
CGATTCGTTGACAGCCCTCCGCGAGGTCGGCTAGGACCGCCGTTCGGCTCCCGGCATGCCGGCCTCGAGGCGAGGCGGCG
CCGGCCGGCCGCCCGACCCC

Downstream 100 bases:

>100_bases
CGGGGTGCGCCCCCCGCGCCCGGGGCGCGCTCGCGCCCTAGACTGGAAAGCACATGGCCTGGTTCTCCAAGCAGAAGAAG
CTGAAGTCGAAGGAGTCCAC

Product: cyclic nucleotide-binding protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MPDDQLLQRFGREFPRGSVLFREGEPGREMFVVQQGRVTLSTTAGGVEKILASMGPGEFLGEMSILNNRPRSATATCAED
ARLLVIDALTFEAMIRGNAEIAVRMVKKLADRLQEAEEQIANLLFQDASSRVVHFLVTAADKASRGPAGHEIEVAPRELA
GRVGVRPEEADEALAKLVKAKIVAVRPDGFLVPDVSKLRHFLEFLQVKAQFGGIA

Sequences:

>Translated_215_residues
MPDDQLLQRFGREFPRGSVLFREGEPGREMFVVQQGRVTLSTTAGGVEKILASMGPGEFLGEMSILNNRPRSATATCAED
ARLLVIDALTFEAMIRGNAEIAVRMVKKLADRLQEAEEQIANLLFQDASSRVVHFLVTAADKASRGPAGHEIEVAPRELA
GRVGVRPEEADEALAKLVKAKIVAVRPDGFLVPDVSKLRHFLEFLQVKAQFGGIA
>Mature_214_residues
PDDQLLQRFGREFPRGSVLFREGEPGREMFVVQQGRVTLSTTAGGVEKILASMGPGEFLGEMSILNNRPRSATATCAEDA
RLLVIDALTFEAMIRGNAEIAVRMVKKLADRLQEAEEQIANLLFQDASSRVVHFLVTAADKASRGPAGHEIEVAPRELAG
RVGVRPEEADEALAKLVKAKIVAVRPDGFLVPDVSKLRHFLEFLQVKAQFGGIA

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=185, Percent_Identity=25.9459459459459, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 23449; Mature: 23318

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDDQLLQRFGREFPRGSVLFREGEPGREMFVVQQGRVTLSTTAGGVEKILASMGPGEFL
CCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHCCCHHHH
GEMSILNNRPRSATATCAEDARLLVIDALTFEAMIRGNAEIAVRMVKKLADRLQEAEEQI
HHHHHHCCCCCCCHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ANLLFQDASSRVVHFLVTAADKASRGPAGHEIEVAPRELAGRVGVRPEEADEALAKLVKA
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHCCCCCCHHHHHHHHHHHH
KIVAVRPDGFLVPDVSKLRHFLEFLQVKAQFGGIA
HEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PDDQLLQRFGREFPRGSVLFREGEPGREMFVVQQGRVTLSTTAGGVEKILASMGPGEFL
CCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHCCCHHHH
GEMSILNNRPRSATATCAEDARLLVIDALTFEAMIRGNAEIAVRMVKKLADRLQEAEEQI
HHHHHHCCCCCCCHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ANLLFQDASSRVVHFLVTAADKASRGPAGHEIEVAPRELAGRVGVRPEEADEALAKLVKA
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHCCCCCCHHHHHHHHHHHH
KIVAVRPDGFLVPDVSKLRHFLEFLQVKAQFGGIA
HEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]