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The map label for this gene is comEC [H]

Identifier: 220917785

GI number: 220917785

Start: 2964228

End: 2966531

Strand: Direct

Name: comEC [H]

Synonym: A2cp1_2686

Alternate gene names: 220917785

Gene position: 2964228-2966531 (Clockwise)

Preceding gene: 220917781

Following gene: 220917786

Centisome position: 58.94

GC content: 81.73

Gene sequence:

>2304_bases
GTGACGCGCCGGCCGCTGCTCCTGCCGGCCCTCGGCCTGGCGCTCGGCGTCGGCCTCGGGCTCGAGACCTCGGCGATGCC
AGCGGCCGCGCTGGGCGCGCTCCCGCTGGCGCTCGTCCCGCGCCTCGCCCCGCTCGCGTTCGGTGCGGCCGGCTGGCTGG
CCGCCGCCTCCGCGCGCGTCCCGCCGGTCGCTCCGCCGGAAGGGATCGTGGAGCTGCGCGGCCGGGTGGTGGGCGCGCCC
GATCGCCTGGAGGACCGGGTCCGGTTCCCGCTCCGAACCCCGGGCGGCGCCCTCGTCGAGGCCTGGGCGGAGCCCACCCC
GTGGCCGCTCGCGCTCGGCGACGAGGTGCGGTTCCGCGCCGCGCTCCGGGCGCCGGGCGGACGCCGGAACCCCGGCGGCC
GCGACCCGGGGGAGCGGCTGCGCGCGGGGGGCGCGGCGCTCGTGGCGCTCGCCGAGGGACCGGTGGTCCGCACCGCGGCG
CCCGCGGCCGCCTCGCGGCTCGAGCGTGCCCGCGACCAGCTCGCCGAGGCGGCCGGGCGCTGGCTCCCGCCGGAGCAGGC
GGCGCTGGTGCGCGCCATCGGCACCGGCGACCGCGCCGCGCTCGACCCCGCCGCCTCGGCGTCCTTCGCGCGGAGCGGCC
TCGCGCACGTGCTGGCCGTGTCCGGCTTCCACCTCGTGGTGGTGGCGTTCGGGCTGGAGCGGCTGCTGCGGGCGCTGCTG
CTGCGCAGCGACGCGCTGGCGAGCCGCGCGGATCCCCGGCGCCTCGCCGCCGCGCTCACCCTCCCCTGCGCCCTCCTGTA
CGCGCTCGCCACCGGCGCCGGGGCGCCGGTGGCCCGGGCCGCCCTCGCCGCCGCCGTCATCCTGGCCGGCGCGCTGCTCG
ACCGGGCGCCCGACCCGCTCAACTCCCTCGCGCTCGCCGCGGTCGCCGTCCTCGCGGCGGAGCCGGCCGCGCTGCTCGAC
GCCTCGTTCCAGCTCTCCTTCGCGGCCGTGGCCGGGCTCGCCCTCTGGGCCACCCCGCTGCGACGCGCGCTCCCCGTCAC
GCGCCCTGCCCCGGGCAGCTGGCGCGCGCGGCTCGTCGAGCCGTTCCTGTCCGGCGCGGCCGCGACGGTGGCCGCCACGC
TCGCCACCGCCCCGGTGCTCGCGTTCCACTTCCGCCAGCTCCCGCTGCTCGGGGTGGCGGCGAACGTGGCCGCCATCCCG
CTCGGCGCCGCGCTCACCGCCCTCGCGGCCCTCTCCGCGGTGGCGGCCGCCGCGTCGCCGCTGGCGGCGGCGCCGTTCCT
GCTCGCGGCCGGCCCGCTCGCCGCGGCGCTGCGGGCGGTCTCGGACGCGGCCGCCGCGCCGCGGTGGGGGGCGGTCGGGC
TCGCCGCGCCGGGCGGATGGGCGGCCGCCGCGGCCACCGCGCTCGTCCTCGCGATCCCTGCGCTGCCCCGGCGCCTCCGC
CTCGCCGCGGGCGCGCTCGCCGCGGCGCTGCTGCTCCTCCCGGGCCCGCTCCGCGCGGCGGCCGCGCGCGCGCGCGGCGG
GCTGGAGGTGATCTTCGTGTCGGTCGGCCAGGGCGACGCGGCGCTGCTCCGGCTGCCGGACGGGAGCGCGGTGCTGGTGG
ACGGCGGCGGCGCCGCGGGCGGCGGGCCGGATCCGGGCGCGCGCGATCTCGTGCCGCTGCTGCGCGACCTCGGGGTCCGC
CGGCTCGAGGCGGTGTTCGTCTCGCACCCGCACCCGGACCACGTGCTCGGGCTGGAGGCGGTGGCGCGGGCCTTCCCGGT
GGCCCGCGCGTTCTCGAACGGCGACCGCGGCGACGGCCCGGCGCGCGAGGTGCTCGCCGCGCTCTCGCCGATCCCGCTCG
CGCCCGGCGAGGCCTGGGAGCGCGCCGGCGTCCGCTTCGAGGCGCTCGGCGGGGATCGGACGCCGTTCGCCGCGAACGAC
GCCTCGCTGGTGCTGCGCGCCACCTACGGCGCGACGTCGTTCCTGTTCCCGGGCGACGTCGAGGCGGCCGGCGAGGCGGC
GGCCGTCGCGCGCGGCGGGCTCCGCGCCGACGTCGTGAAGATCCCGCACCACGGCTCGCGCACCTCCTCCACCGAGCCGT
TCGTCCGCGCGGTCGGGGCCCGGTGGGCGGTGGCGTGCCTGGGAGCGCACAACCGCTTCGGCTTCCCGCACCCGGAGCCG
CTGGCGCGCTGGGCCGCGGCGGGCGCCGAGGTGCTCCGCACCGACGAGGGCGCCGTCCGCTTCCTGTCCGACGGGCGGGC
GGTCCGGCGCGTGGAGGCCGGCTCCGTGCTGGACGCCCTGGCCACCTGGCGGGAGCAGCCCTAG

Upstream 100 bases:

>100_bases
ACACGGTCAATAACACTCGAATTTTCGAGCATATTCGTGACGACCCCGCTGGGACGGCGGCCTGCGTCACGATCCGTCCG
CCGGCCGCCGGGGCAGCCCG

Downstream 100 bases:

>100_bases
CTTGCGCGCATGAGCATCGAGGACATCGACCTGGCGGCGCTCGCCGAGCGCATCCAGCGCCACATCCCGAGCACCGAGCC
GCCGGTCGGCTACCTGCGCG

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 767; Mature: 766

Protein sequence:

>767_residues
MTRRPLLLPALGLALGVGLGLETSAMPAAALGALPLALVPRLAPLAFGAAGWLAAASARVPPVAPPEGIVELRGRVVGAP
DRLEDRVRFPLRTPGGALVEAWAEPTPWPLALGDEVRFRAALRAPGGRRNPGGRDPGERLRAGGAALVALAEGPVVRTAA
PAAASRLERARDQLAEAAGRWLPPEQAALVRAIGTGDRAALDPAASASFARSGLAHVLAVSGFHLVVVAFGLERLLRALL
LRSDALASRADPRRLAAALTLPCALLYALATGAGAPVARAALAAAVILAGALLDRAPDPLNSLALAAVAVLAAEPAALLD
ASFQLSFAAVAGLALWATPLRRALPVTRPAPGSWRARLVEPFLSGAAATVAATLATAPVLAFHFRQLPLLGVAANVAAIP
LGAALTALAALSAVAAAASPLAAAPFLLAAGPLAAALRAVSDAAAAPRWGAVGLAAPGGWAAAAATALVLAIPALPRRLR
LAAGALAAALLLLPGPLRAAAARARGGLEVIFVSVGQGDAALLRLPDGSAVLVDGGGAAGGGPDPGARDLVPLLRDLGVR
RLEAVFVSHPHPDHVLGLEAVARAFPVARAFSNGDRGDGPAREVLAALSPIPLAPGEAWERAGVRFEALGGDRTPFAAND
ASLVLRATYGATSFLFPGDVEAAGEAAAVARGGLRADVVKIPHHGSRTSSTEPFVRAVGARWAVACLGAHNRFGFPHPEP
LARWAAAGAEVLRTDEGAVRFLSDGRAVRRVEAGSVLDALATWREQP

Sequences:

>Translated_767_residues
MTRRPLLLPALGLALGVGLGLETSAMPAAALGALPLALVPRLAPLAFGAAGWLAAASARVPPVAPPEGIVELRGRVVGAP
DRLEDRVRFPLRTPGGALVEAWAEPTPWPLALGDEVRFRAALRAPGGRRNPGGRDPGERLRAGGAALVALAEGPVVRTAA
PAAASRLERARDQLAEAAGRWLPPEQAALVRAIGTGDRAALDPAASASFARSGLAHVLAVSGFHLVVVAFGLERLLRALL
LRSDALASRADPRRLAAALTLPCALLYALATGAGAPVARAALAAAVILAGALLDRAPDPLNSLALAAVAVLAAEPAALLD
ASFQLSFAAVAGLALWATPLRRALPVTRPAPGSWRARLVEPFLSGAAATVAATLATAPVLAFHFRQLPLLGVAANVAAIP
LGAALTALAALSAVAAAASPLAAAPFLLAAGPLAAALRAVSDAAAAPRWGAVGLAAPGGWAAAAATALVLAIPALPRRLR
LAAGALAAALLLLPGPLRAAAARARGGLEVIFVSVGQGDAALLRLPDGSAVLVDGGGAAGGGPDPGARDLVPLLRDLGVR
RLEAVFVSHPHPDHVLGLEAVARAFPVARAFSNGDRGDGPAREVLAALSPIPLAPGEAWERAGVRFEALGGDRTPFAAND
ASLVLRATYGATSFLFPGDVEAAGEAAAVARGGLRADVVKIPHHGSRTSSTEPFVRAVGARWAVACLGAHNRFGFPHPEP
LARWAAAGAEVLRTDEGAVRFLSDGRAVRRVEAGSVLDALATWREQP
>Mature_766_residues
TRRPLLLPALGLALGVGLGLETSAMPAAALGALPLALVPRLAPLAFGAAGWLAAASARVPPVAPPEGIVELRGRVVGAPD
RLEDRVRFPLRTPGGALVEAWAEPTPWPLALGDEVRFRAALRAPGGRRNPGGRDPGERLRAGGAALVALAEGPVVRTAAP
AAASRLERARDQLAEAAGRWLPPEQAALVRAIGTGDRAALDPAASASFARSGLAHVLAVSGFHLVVVAFGLERLLRALLL
RSDALASRADPRRLAAALTLPCALLYALATGAGAPVARAALAAAVILAGALLDRAPDPLNSLALAAVAVLAAEPAALLDA
SFQLSFAAVAGLALWATPLRRALPVTRPAPGSWRARLVEPFLSGAAATVAATLATAPVLAFHFRQLPLLGVAANVAAIPL
GAALTALAALSAVAAAASPLAAAPFLLAAGPLAAALRAVSDAAAAPRWGAVGLAAPGGWAAAAATALVLAIPALPRRLRL
AAGALAAALLLLPGPLRAAAARARGGLEVIFVSVGQGDAALLRLPDGSAVLVDGGGAAGGGPDPGARDLVPLLRDLGVRR
LEAVFVSHPHPDHVLGLEAVARAFPVARAFSNGDRGDGPAREVLAALSPIPLAPGEAWERAGVRFEALGGDRTPFAANDA
SLVLRATYGATSFLFPGDVEAAGEAAAVARGGLRADVVKIPHHGSRTSSTEPFVRAVGARWAVACLGAHNRFGFPHPEPL
ARWAAAGAEVLRTDEGAVRFLSDGRAVRRVEAGSVLDALATWREQP

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=652, Percent_Identity=25.920245398773, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 77410; Mature: 77279

Theoretical pI: Translated: 11.70; Mature: 11.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.1 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRPLLLPALGLALGVGLGLETSAMPAAALGALPLALVPRLAPLAFGAAGWLAAASARV
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PPVAPPEGIVELRGRVVGAPDRLEDRVRFPLRTPGGALVEAWAEPTPWPLALGDEVRFRA
CCCCCCHHHHHHCCCEECCCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEECCCCHHHHH
ALRAPGGRRNPGGRDPGERLRAGGAALVALAEGPVVRTAAPAAASRLERARDQLAEAAGR
HHCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCC
WLPPEQAALVRAIGTGDRAALDPAASASFARSGLAHVLAVSGFHLVVVAFGLERLLRALL
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LRSDALASRADPRRLAAALTLPCALLYALATGAGAPVARAALAAAVILAGALLDRAPDPL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
NSLALAAVAVLAAEPAALLDASFQLSFAAVAGLALWATPLRRALPVTRPAPGSWRARLVE
HHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
PFLSGAAATVAATLATAPVLAFHFRQLPLLGVAANVAAIPLGAALTALAALSAVAAAASP
HHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LAAAPFLLAAGPLAAALRAVSDAAAAPRWGAVGLAAPGGWAAAAATALVLAIPALPRRLR
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHH
LAAGALAAALLLLPGPLRAAAARARGGLEVIFVSVGQGDAALLRLPDGSAVLVDGGGAAG
HHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCEEEEECCCCCC
GGPDPGARDLVPLLRDLGVRRLEAVFVSHPHPDHVLGLEAVARAFPVARAFSNGDRGDGP
CCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
AREVLAALSPIPLAPGEAWERAGVRFEALGGDRTPFAANDASLVLRATYGATSFLFPGDV
HHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEECCCCEECCCCCC
EAAGEAAAVARGGLRADVVKIPHHGSRTSSTEPFVRAVGARWAVACLGAHNRFGFPHPEP
CCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHH
LARWAAAGAEVLRTDEGAVRFLSDGRAVRRVEAGSVLDALATWREQP
HHHHHHHCHHHHCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRRPLLLPALGLALGVGLGLETSAMPAAALGALPLALVPRLAPLAFGAAGWLAAASARV
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PPVAPPEGIVELRGRVVGAPDRLEDRVRFPLRTPGGALVEAWAEPTPWPLALGDEVRFRA
CCCCCCHHHHHHCCCEECCCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEECCCCHHHHH
ALRAPGGRRNPGGRDPGERLRAGGAALVALAEGPVVRTAAPAAASRLERARDQLAEAAGR
HHCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCC
WLPPEQAALVRAIGTGDRAALDPAASASFARSGLAHVLAVSGFHLVVVAFGLERLLRALL
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LRSDALASRADPRRLAAALTLPCALLYALATGAGAPVARAALAAAVILAGALLDRAPDPL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
NSLALAAVAVLAAEPAALLDASFQLSFAAVAGLALWATPLRRALPVTRPAPGSWRARLVE
HHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
PFLSGAAATVAATLATAPVLAFHFRQLPLLGVAANVAAIPLGAALTALAALSAVAAAASP
HHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LAAAPFLLAAGPLAAALRAVSDAAAAPRWGAVGLAAPGGWAAAAATALVLAIPALPRRLR
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHH
LAAGALAAALLLLPGPLRAAAARARGGLEVIFVSVGQGDAALLRLPDGSAVLVDGGGAAG
HHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCEEEEECCCCCC
GGPDPGARDLVPLLRDLGVRRLEAVFVSHPHPDHVLGLEAVARAFPVARAFSNGDRGDGP
CCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
AREVLAALSPIPLAPGEAWERAGVRFEALGGDRTPFAANDASLVLRATYGATSFLFPGDV
HHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEECCCCEECCCCCC
EAAGEAAAVARGGLRADVVKIPHHGSRTSSTEPFVRAVGARWAVACLGAHNRFGFPHPEP
CCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHH
LARWAAAGAEVLRTDEGAVRFLSDGRAVRRVEAGSVLDALATWREQP
HHHHHHHCHHHHCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]