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The map label for this gene is pyrD

Identifier: 220917761

GI number: 220917761

Start: 2937460

End: 2938554

Strand: Reverse

Name: pyrD

Synonym: A2cp1_2662

Alternate gene names: 220917761

Gene position: 2938554-2937460 (Counterclockwise)

Preceding gene: 220917762

Following gene: 220917760

Centisome position: 58.43

GC content: 75.8

Gene sequence:

>1095_bases
ATGCTCTGGCCAGCCCTGCGGTCCGTCCTGTTCCAGCTCGACCCGGAGCGCGTGCACCACCTCGCGCACTGGGCGCTGCA
CCGCGTCCCGCTCGCCGTGGCGCGCGCGCGCCGGCCGGCGTCCATCCCCGCCCTCGCGGTCCGCTGCATGGGGCTCGACT
TCGACGGGCCGGTGGGCCTGGCGGCCGGCTTCGACAAGGGGGACGTGGCGCTGCCGGGGCTCTTCGGGCTGGGCTTCTCG
CACGTCGAGATCGGGACGATCACGCCGCGCCCCCAGCCGGGCAACGATCGCCCGCGCCTGTTCCGCCTTCCCGAGCACCG
CGCGCTGCTCAACCGGATGGGCTTCAACAACGAGGGGATGGAGGCCTGCGCGCGTCGGCTCGCGGCGCTCCCTCCGGCCG
CGCGCCTCGGGCCCGTCGGGATCAACGTCGGGAAGAACAAGGTGACGCCGAACGAGGACGCCGCCGCCGACTACCTCGCG
TGCATCGAGCGGCTCCACCCGTACGCCGACTATCTGGTGGTCAACATCTCGTCGCCGAACACCCCGGGGCTGCGCCAGCT
CCAGGAGCGCGACGCGCTGGATCGCCTGCTGCGCGCCTGCGTGCGCCACCTGGCGGAGCGGGCGCCGGGCAAGCCGCTCC
TGGTGAAGCTCGCGCCGGACCTCTCGCCCGAGGCGCTCGACGAGGCGGTGGACGTGGCCATCGCGGCGGGCGCCGCCGGG
ATCGTGGCGACCAACACCACGCTCTCCCGGGCCGGCGTCGAGCGTCACCCGCGCGCCGCGGAGGCGGGCGGGCTCTCCGG
CGCGCCGCTGGAGCGGCTGGCCACCGACGTGGTCCGGCGCTGCTACGCGCGCGCCGCCGGCCGGGTCCCGATCGTCGGGG
TGGGCGGGGTGATGGACGCGGAGGGCGCGTACGCGAAGATCCGGGCCGGCGCGACGCTGGTCCAGGCGTACACGGGGCTC
ATCTACGGCGGCCCCGCGTTCGTGGGCCGGGTGAACGCCGGCCTGGCCCGGCTGCTCGAGCGGGACGGGTTCAGCACCCT
TTCGGACGCGGTCGGCGCAGACCACCGACAGGGCGGCGGGAAGGCGGCGGGGTAG

Upstream 100 bases:

>100_bases
GACGCCGTCGTCATGACCGCGGATCTGCCCTAGGCGGCCGGCCGCGCCGGGCGGAGGCGGGCTGACAGGCGGCCCCCCGC
TGGTGTAAGCAGGCCGCCCC

Downstream 100 bases:

>100_bases
GCGTGCGTTCTGACCTACGGCCGTCCCTCGCAGGTCGTTTACGTTCCCTCATCGGGGAACAACCATGTAGGGGCCTGAAA
GTTGACGCAGCGCGGTAGGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGLAAGFDKGDVALPGLFGLGFS
HVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGMEACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLA
CIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAG
IVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGL
IYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGGKAAG

Sequences:

>Translated_364_residues
MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGLAAGFDKGDVALPGLFGLGFS
HVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGMEACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLA
CIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAG
IVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGL
IYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGGKAAG
>Mature_364_residues
MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGLAAGFDKGDVALPGLFGLGFS
HVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGMEACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLA
CIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAG
IVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGL
IYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGGKAAG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=366, Percent_Identity=47.5409836065574, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=45.9701492537313, Blast_Score=294, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17509475, Length=327, Percent_Identity=42.8134556574924, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI281361352, Length=317, Percent_Identity=41.6403785488959, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17137316, Length=317, Percent_Identity=41.6403785488959, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_ANAD2 (B8JDF0)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493065.1
- ProteinModelPortal:   B8JDF0
- SMR:   B8JDF0
- GeneID:   7299663
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2662
- HOGENOM:   HBG351027
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38377; Mature: 38377

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCC
AAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGM
CCCCCCCCEECCHHHHCCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCH
EACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPN
HHHHHHHHHCCCCHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCC
TPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
IVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDA
EEEECCHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
EGAYAKIRAGATLVQAYTGLIYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGG
CCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
KAAG
CCCC
>Mature Secondary Structure
MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCC
AAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGM
CCCCCCCCEECCHHHHCCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCH
EACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPN
HHHHHHHHHCCCCHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCC
TPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
IVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDA
EEEECCHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
EGAYAKIRAGATLVQAYTGLIYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGG
CCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
KAAG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA