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The map label for this gene is ptpA [H]

Identifier: 220917718

GI number: 220917718

Start: 2894092

End: 2896299

Strand: Reverse

Name: ptpA [H]

Synonym: A2cp1_2619

Alternate gene names: 220917718

Gene position: 2896299-2894092 (Counterclockwise)

Preceding gene: 220917719

Following gene: 220917717

Centisome position: 57.59

GC content: 79.03

Gene sequence:

>2208_bases
ATGCCCGCGCTCCTGTGCCCGTTCCTCCTGGCCGCGGCCGTGGCCGCCGACGCCGCGCCCACGCCGCCGCCCTCGGATCC
GTTCCTGCGCCAGTACGCCGAGACGCGCGGCTTCCGCGCCGGGCGGCCCACCGGCGTCCAGCTCTCGCCGGACGGGCGCA
CGGCCCTGTTCCTGCGCTCCGGGCCGCGGTCGCGCGCGCAGGCGCTCCTCGAGACCGACCTCGCCACCGGGGTGACGCGC
ACCGTCGTCGAGGCGGACGGGGCCGGGGCGCTCTCGCCCGAGGAGGCGGCGCGCCTGGAGCGGCAGCGCATCACCGCGCG
CGGCATCACGCACTTCGTGCTCTCGCCGGACGGGGCGCGGGTGGTGTACGGGCTGGGCGGGCGCCTGTGGCTGCTCGACC
GCTCCGCCGGCCGCGCGGCCCCGCTGCCGGGCTCCGAGGGCGCGCTCGACCCGCGCTTCTCGCCGGACGGCCGCGCGCTC
GCGTACGTGAAGCGCGGGGACCTGTACGTGCGCGCGGTGCCGCGCGGACCCGAGCGGCGGCTCACGCGCGCCCGCGGGCC
GCAGGTGACGAACGGCCTCGCCGAGTTCGTGGCGCAGGAGGAGATGGACCGCGACGAGGGCTTCTGGTGGTCGCCCGACG
CGCGGCGGATCGCCTACGCGGAGGTGGACGAGTCGGCGGTGGAGCGGCGCATGCTCTGCGACCCGGCGCGCCCGGCGCGG
CCGTGCGAGGCGCGTGCCTACCCGCGGGCCGGCACGCCCAACGCCGCCGTGCGCCTGAAGGTGGTGCCCGCCGCGGGCGG
TCCGGCCGTGGAGATGCGCTGGGACGCGGGGCGCTACCCGTACCTGGCCGCGGTGCGCTGGTCGAAGGGCGGGCCGCTCG
CGCTGCTGGTGCAGGACCGGCTCCAGCGCGAGGAGCGGCTGCTCGCGGCCGATCCCGCCACCGGCGCGACCCGCGCGCTG
CTCGCCGAGCGCGACGACGCCTGGCTGAACCTGTGGCCGGGCATGCCGGCGTTCCTCCCCGACGGCCGCTTCTGGTGGGT
GACCGAGCGCGGCGGCGCGCCGGAGGTGGAGCTGCGCGCCCCCGACGGCGCGCGGCTCGGGCTGGCGGTCCCGCGCGAGC
TCGGGTACGCGGCGTTCGCGGGGGTGGACGGCGACGCGCTGGTGTTCGCGGGCGCGCCGGATCCCACGCGCGAGGAGCTG
TACCGGGTGCGGCCCGGCTCGGCGCCCGAACGGCTCGCGCTCGGCGAGCCGGGGCCGGCGACGCGCAAGGCGGTGCTGGC
GCCGTGCGGCGGCAACGTGGCGGTCACCTGGAGCACGCTGCGCCGGTTGCCGGTCACCGCCGTGTTCGCCGCGGACGGCG
CGCGGCTGGCGGTGCTGCCGAGCGTCGCGGAGGAGCCGGCGTTCGTGCCCACCACCGAGCTGCGGCAGCTCGGCGGGGCG
GACGGGATCCGGGCGGCGGTGCTGCGGCCGCGCGCGCTCGGCGCCGGGGCGCGGCTGCCGGTGGTGGTGGACGTGTACGG
CGGCCCGGTGCCTGCGTACTACGTGCCGCAGGTCGCGCACCGGCCCATGCTGATCGAGCAGTGGCTGGCCGACCAGGGCT
TCCTGGTGGCCGTCTTCGAGGGGCGGGGCACGCCGCGCCGCGGCCGCGCCTGGGAGCGCGCCATCGCGGGCGACCTCGGC
ACGGTGCCGCTCGAGGACCAGGTGGCGGCCCTCGAGGCGCTCGGGCGCGAGGTCCCGGAGGCCGACGTGGCGCGCGCCGG
GATCACCGGCTGGTCGTTCGGCGGCTACCTCGCGGCGCTCGCGGTGATGCGCCGGCCGGATCGCTTCCAGGCGGCGGTCG
CGGGCGCGCCGGTCGCGGACTGGGAGCAGTACGACACGTACTACACCGAGCGCTACCTGGGCCTGCCCGGCGATCGCGCC
GAGGCGTACGCCCGGAGCGGGCTGCTGGCCTGGGCGCCGCGCCTGCAGCGGCCGCTGCTCCTGCTGCACGGGACGGCCGA
CGACAACGTGTTCCTGTCGCACTCGCTCGCGCTGGCCGACGCGCTGTTCCGCGCCGGGCGCCCGTTCGAGCTCGTCCCGA
TCGCCGGCGCGACGCACGCGGTGCCGGAGCCGCTCGCGGCGGAGCGGCGCTGGGAGTGGACCGCAGGATTCTTCCGCCGG
ACGCTGGGCGCGGTGCGACCCGGCCCCGCCCTCGCGCCCGCGCCCTGA

Upstream 100 bases:

>100_bases
ACCTCCTCTGCACCCGCCATCGGCTCGGGCCCGCCCCGCGGCGCAGGGCGGGCGGACGGTCCGCGGCGCCGCGCCGGCGC
GGGTGATACAAACGGGGCCG

Downstream 100 bases:

>100_bases
TCCGGGGATTCCGCCGGCGCGCGAGACCCCGGCCCCGGCGGGGGAGGGTCGCCGGCCGCCCTGGCTCGGGCGCGGACGGT
CGGTGAATGCGCCCGCCGCT

Product: peptidase S9 prolyl oligopeptidase active site domain-containing protein

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MPALLCPFLLAAAVAADAAPTPPPSDPFLRQYAETRGFRAGRPTGVQLSPDGRTALFLRSGPRSRAQALLETDLATGVTR
TVVEADGAGALSPEEAARLERQRITARGITHFVLSPDGARVVYGLGGRLWLLDRSAGRAAPLPGSEGALDPRFSPDGRAL
AYVKRGDLYVRAVPRGPERRLTRARGPQVTNGLAEFVAQEEMDRDEGFWWSPDARRIAYAEVDESAVERRMLCDPARPAR
PCEARAYPRAGTPNAAVRLKVVPAAGGPAVEMRWDAGRYPYLAAVRWSKGGPLALLVQDRLQREERLLAADPATGATRAL
LAERDDAWLNLWPGMPAFLPDGRFWWVTERGGAPEVELRAPDGARLGLAVPRELGYAAFAGVDGDALVFAGAPDPTREEL
YRVRPGSAPERLALGEPGPATRKAVLAPCGGNVAVTWSTLRRLPVTAVFAADGARLAVLPSVAEEPAFVPTTELRQLGGA
DGIRAAVLRPRALGAGARLPVVVDVYGGPVPAYYVPQVAHRPMLIEQWLADQGFLVAVFEGRGTPRRGRAWERAIAGDLG
TVPLEDQVAALEALGREVPEADVARAGITGWSFGGYLAALAVMRRPDRFQAAVAGAPVADWEQYDTYYTERYLGLPGDRA
EAYARSGLLAWAPRLQRPLLLLHGTADDNVFLSHSLALADALFRAGRPFELVPIAGATHAVPEPLAAERRWEWTAGFFRR
TLGAVRPGPALAPAP

Sequences:

>Translated_735_residues
MPALLCPFLLAAAVAADAAPTPPPSDPFLRQYAETRGFRAGRPTGVQLSPDGRTALFLRSGPRSRAQALLETDLATGVTR
TVVEADGAGALSPEEAARLERQRITARGITHFVLSPDGARVVYGLGGRLWLLDRSAGRAAPLPGSEGALDPRFSPDGRAL
AYVKRGDLYVRAVPRGPERRLTRARGPQVTNGLAEFVAQEEMDRDEGFWWSPDARRIAYAEVDESAVERRMLCDPARPAR
PCEARAYPRAGTPNAAVRLKVVPAAGGPAVEMRWDAGRYPYLAAVRWSKGGPLALLVQDRLQREERLLAADPATGATRAL
LAERDDAWLNLWPGMPAFLPDGRFWWVTERGGAPEVELRAPDGARLGLAVPRELGYAAFAGVDGDALVFAGAPDPTREEL
YRVRPGSAPERLALGEPGPATRKAVLAPCGGNVAVTWSTLRRLPVTAVFAADGARLAVLPSVAEEPAFVPTTELRQLGGA
DGIRAAVLRPRALGAGARLPVVVDVYGGPVPAYYVPQVAHRPMLIEQWLADQGFLVAVFEGRGTPRRGRAWERAIAGDLG
TVPLEDQVAALEALGREVPEADVARAGITGWSFGGYLAALAVMRRPDRFQAAVAGAPVADWEQYDTYYTERYLGLPGDRA
EAYARSGLLAWAPRLQRPLLLLHGTADDNVFLSHSLALADALFRAGRPFELVPIAGATHAVPEPLAAERRWEWTAGFFRR
TLGAVRPGPALAPAP
>Mature_734_residues
PALLCPFLLAAAVAADAAPTPPPSDPFLRQYAETRGFRAGRPTGVQLSPDGRTALFLRSGPRSRAQALLETDLATGVTRT
VVEADGAGALSPEEAARLERQRITARGITHFVLSPDGARVVYGLGGRLWLLDRSAGRAAPLPGSEGALDPRFSPDGRALA
YVKRGDLYVRAVPRGPERRLTRARGPQVTNGLAEFVAQEEMDRDEGFWWSPDARRIAYAEVDESAVERRMLCDPARPARP
CEARAYPRAGTPNAAVRLKVVPAAGGPAVEMRWDAGRYPYLAAVRWSKGGPLALLVQDRLQREERLLAADPATGATRALL
AERDDAWLNLWPGMPAFLPDGRFWWVTERGGAPEVELRAPDGARLGLAVPRELGYAAFAGVDGDALVFAGAPDPTREELY
RVRPGSAPERLALGEPGPATRKAVLAPCGGNVAVTWSTLRRLPVTAVFAADGARLAVLPSVAEEPAFVPTTELRQLGGAD
GIRAAVLRPRALGAGARLPVVVDVYGGPVPAYYVPQVAHRPMLIEQWLADQGFLVAVFEGRGTPRRGRAWERAIAGDLGT
VPLEDQVAALEALGREVPEADVARAGITGWSFGGYLAALAVMRRPDRFQAAVAGAPVADWEQYDTYYTERYLGLPGDRAE
AYARSGLLAWAPRLQRPLLLLHGTADDNVFLSHSLALADALFRAGRPFELVPIAGATHAVPEPLAAERRWEWTAGFFRRT
LGAVRPGPALAPAP

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=682, Percent_Identity=26.2463343108504, Blast_Score=200, Evalue=4e-51,
Organism=Homo sapiens, GI37577089, Length=682, Percent_Identity=26.2463343108504, Blast_Score=200, Evalue=5e-51,
Organism=Homo sapiens, GI194394146, Length=737, Percent_Identity=26.0515603799186, Blast_Score=200, Evalue=5e-51,
Organism=Homo sapiens, GI18765694, Length=621, Percent_Identity=23.9935587761675, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI16933540, Length=691, Percent_Identity=24.4573082489146, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI85787627, Length=611, Percent_Identity=23.4042553191489, Blast_Score=141, Evalue=3e-33,
Organism=Homo sapiens, GI295842359, Length=611, Percent_Identity=23.4042553191489, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI295842403, Length=611, Percent_Identity=23.4042553191489, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI295849272, Length=611, Percent_Identity=23.4042553191489, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI52426756, Length=616, Percent_Identity=23.3766233766234, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI37577091, Length=752, Percent_Identity=22.6063829787234, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI86792774, Length=607, Percent_Identity=21.7462932454695, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI86792778, Length=607, Percent_Identity=21.7462932454695, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI86792863, Length=607, Percent_Identity=21.7462932454695, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI18450278, Length=312, Percent_Identity=24.6794871794872, Blast_Score=76, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508017, Length=222, Percent_Identity=36.036036036036, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508019, Length=222, Percent_Identity=36.036036036036, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17550672, Length=616, Percent_Identity=24.8376623376623, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17564634, Length=649, Percent_Identity=23.5747303543914, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17564632, Length=598, Percent_Identity=24.247491638796, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324793, Length=243, Percent_Identity=27.1604938271605, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321817, Length=242, Percent_Identity=31.404958677686, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551969, Length=753, Percent_Identity=27.0916334661355, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI45550825, Length=753, Percent_Identity=26.8260292164675, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI45553511, Length=753, Percent_Identity=26.8260292164675, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI17933704, Length=615, Percent_Identity=26.0162601626016, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI161083744, Length=612, Percent_Identity=25.9803921568627, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI221331178, Length=612, Percent_Identity=25.9803921568627, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24582032, Length=656, Percent_Identity=24.5426829268293, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24582257, Length=201, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45551475, Length=202, Percent_Identity=32.1782178217822, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221372266, Length=202, Percent_Identity=32.1782178217822, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221372263, Length=202, Percent_Identity=32.1782178217822, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 78913; Mature: 78781

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALLCPFLLAAAVAADAAPTPPPSDPFLRQYAETRGFRAGRPTGVQLSPDGRTALFLRS
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEC
GPRSRAQALLETDLATGVTRTVVEADGAGALSPEEAARLERQRITARGITHFVLSPDGAR
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCE
VVYGLGGRLWLLDRSAGRAAPLPGSEGALDPRFSPDGRALAYVKRGDLYVRAVPRGPERR
EEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEECCCCHHHH
LTRARGPQVTNGLAEFVAQEEMDRDEGFWWSPDARRIAYAEVDESAVERRMLCDPARPAR
HHHHCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEECCCHHHHHHHHHCCCCCCCC
PCEARAYPRAGTPNAAVRLKVVPAAGGPAVEMRWDAGRYPYLAAVRWSKGGPLALLVQDR
CCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEHHH
LQREERLLAADPATGATRALLAERDDAWLNLWPGMPAFLPDGRFWWVTERGGAPEVELRA
HHHHHHEEECCCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEC
PDGARLGLAVPRELGYAAFAGVDGDALVFAGAPDPTREELYRVRPGSAPERLALGEPGPA
CCCCEEEEECHHHCCCEEEECCCCCEEEEECCCCCCHHHHHCCCCCCCCCCEECCCCCCC
TRKAVLAPCGGNVAVTWSTLRRLPVTAVFAADGARLAVLPSVAEEPAFVPTTELRQLGGA
CCEEEEEECCCCEEEEHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHCCCC
DGIRAAVLRPRALGAGARLPVVVDVYGGPVPAYYVPQVAHRPMLIEQWLADQGFLVAVFE
CCCHHHHCCCHHCCCCCCCCEEEEECCCCCCCCCCCHHHCCCHHHHHHHCCCCEEEEEEE
GRGTPRRGRAWERAIAGDLGTVPLEDQVAALEALGREVPEADVARAGITGWSFGGYLAAL
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHH
AVMRRPDRFQAAVAGAPVADWEQYDTYYTERYLGLPGDRAEAYARSGLLAWAPRLQRPLL
HHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHCCHHHCCCEE
LLHGTADDNVFLSHSLALADALFRAGRPFELVPIAGATHAVPEPLAAERRWEWTAGFFRR
EEECCCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHH
TLGAVRPGPALAPAP
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
PALLCPFLLAAAVAADAAPTPPPSDPFLRQYAETRGFRAGRPTGVQLSPDGRTALFLRS
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEC
GPRSRAQALLETDLATGVTRTVVEADGAGALSPEEAARLERQRITARGITHFVLSPDGAR
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCE
VVYGLGGRLWLLDRSAGRAAPLPGSEGALDPRFSPDGRALAYVKRGDLYVRAVPRGPERR
EEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEECCCCHHHH
LTRARGPQVTNGLAEFVAQEEMDRDEGFWWSPDARRIAYAEVDESAVERRMLCDPARPAR
HHHHCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEECCCHHHHHHHHHCCCCCCCC
PCEARAYPRAGTPNAAVRLKVVPAAGGPAVEMRWDAGRYPYLAAVRWSKGGPLALLVQDR
CCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEHHH
LQREERLLAADPATGATRALLAERDDAWLNLWPGMPAFLPDGRFWWVTERGGAPEVELRA
HHHHHHEEECCCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEC
PDGARLGLAVPRELGYAAFAGVDGDALVFAGAPDPTREELYRVRPGSAPERLALGEPGPA
CCCCEEEEECHHHCCCEEEECCCCCEEEEECCCCCCHHHHHCCCCCCCCCCEECCCCCCC
TRKAVLAPCGGNVAVTWSTLRRLPVTAVFAADGARLAVLPSVAEEPAFVPTTELRQLGGA
CCEEEEEECCCCEEEEHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHCCCC
DGIRAAVLRPRALGAGARLPVVVDVYGGPVPAYYVPQVAHRPMLIEQWLADQGFLVAVFE
CCCHHHHCCCHHCCCCCCCCEEEEECCCCCCCCCCCHHHCCCHHHHHHHCCCCEEEEEEE
GRGTPRRGRAWERAIAGDLGTVPLEDQVAALEALGREVPEADVARAGITGWSFGGYLAAL
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHH
AVMRRPDRFQAAVAGAPVADWEQYDTYYTERYLGLPGDRAEAYARSGLLAWAPRLQRPLL
HHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHCCHHHCCCEE
LLHGTADDNVFLSHSLALADALFRAGRPFELVPIAGATHAVPEPLAAERRWEWTAGFFRR
EEECCCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHH
TLGAVRPGPALAPAP
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA