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The map label for this gene is atoC [H]

Identifier: 220917578

GI number: 220917578

Start: 2735297

End: 2736316

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_2478

Alternate gene names: 220917578

Gene position: 2736316-2735297 (Counterclockwise)

Preceding gene: 220917579

Following gene: 220917577

Centisome position: 54.41

GC content: 77.75

Gene sequence:

>1020_bases
ATGCGTCGCACGAACCTGGGCGAGGCGGAGCGAGGCGACGCCGGGGGCGTCGCGGCGGACGGGCTCGTGGCCGAGTCGCC
GCGGATGCGCCGGCTGCTGGCGGACGTCGCGCGGATCGCGCCGAGGGACGTGACGGTCCTGCTGCGGGGCGAGACCGGCA
CCGGGAAGGAGCGGGTGGCGTCGCTCCTCCACGCGCGGAGCCGCCGCGCGGCGGGACCGCTCGTCCGGTGCAACTGCGCG
GCGATCGCGGCCGAGCTGGCGGACGCGGAGCTGTTCGGCGCGGTGCGCGGCGCGTTCACCGGCGCGGTCGAGTCGCGCCG
CGGGTTCTTCTCGGCGGCCGACGGCGGCACGCTGGTGCTCGACGAGATCGGCGAGCTGCCCCGCGCGCTGCAGCCCAAGC
TCCTGCGCGCGCTGCAGGAGGGCGAGCTGCAGCCGGTGGGCGCCGGCCGGGTCGAGCGCGTGGACGTGCGCGTGGTCGCG
TGCACCAACCGCGACCTGGAGGCGGAGGTGCGCGCCGGCCGCTTCCGCGAGGACCTCTACTACCGCCTCGCGGTGGTGGA
GCTCGTCGTGCCCCCGCTGCGCGACCGCCGCGAGGACCTGCCGCGCCTCGCGGTCGACCTCGCGCGCGAGCTCGGTCAGC
GGTTCGGGGTCGAGCGCGTGCGGCTCTCGCCCGCGCTGCTCGGGCGCCTGCAGCAGGCGGACTGGCCCGGCAACGTCCGC
CAGCTCGAGAACGCGATCGCGCGCATGATCGCGCTCTGCCCGGGCCCGGTGCTCGGGCCCGAGGCGATCGCGGTCGTGTT
CCCGACCGCCTCCGGCGCCGCGCGCGACACGGCGCCCGTCGCCCGGAGCGCGCCCCCGCTGGAGGAGCTGCCGCTGCGGG
CGCAGCTCGACGGGCTGGAGCGGCGGGTGATCGCGGCGATGCTGGCCGCGACCGGCGGGAACCAGTCGGCCGCGGCCCGC
CGGCTCGGCCTCGCCCGGACCGTGCTGATCGATCGCCTGAAGAAGTACGGCCTCCTGTGA

Upstream 100 bases:

>100_bases
CCGCGGATCTCGCGGCGCTGCGGCTCCTGCGTGCGGCGGGGAGGTACGGCGGGTGACGGGGCGAGCCGCCCTCGGGCGCG
GCGAGTGGGGGAGGTCGCCG

Downstream 100 bases:

>100_bases
CCGGGTGAGCCACGTCGAGCCGCGCGTGGAGGGCTCGACGTGGGCCGGCCATGTCCCCCGCCGACGTGGCGGGCGGGGAC
ACCCATCCCGCATGCCCGCT

Product: Fis family sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRRTNLGEAERGDAGGVAADGLVAESPRMRRLLADVARIAPRDVTVLLRGETGTGKERVASLLHARSRRAAGPLVRCNCA
AIAAELADAELFGAVRGAFTGAVESRRGFFSAADGGTLVLDEIGELPRALQPKLLRALQEGELQPVGAGRVERVDVRVVA
CTNRDLEAEVRAGRFREDLYYRLAVVELVVPPLRDRREDLPRLAVDLARELGQRFGVERVRLSPALLGRLQQADWPGNVR
QLENAIARMIALCPGPVLGPEAIAVVFPTASGAARDTAPVARSAPPLEELPLRAQLDGLERRVIAAMLAATGGNQSAAAR
RLGLARTVLIDRLKKYGLL

Sequences:

>Translated_339_residues
MRRTNLGEAERGDAGGVAADGLVAESPRMRRLLADVARIAPRDVTVLLRGETGTGKERVASLLHARSRRAAGPLVRCNCA
AIAAELADAELFGAVRGAFTGAVESRRGFFSAADGGTLVLDEIGELPRALQPKLLRALQEGELQPVGAGRVERVDVRVVA
CTNRDLEAEVRAGRFREDLYYRLAVVELVVPPLRDRREDLPRLAVDLARELGQRFGVERVRLSPALLGRLQQADWPGNVR
QLENAIARMIALCPGPVLGPEAIAVVFPTASGAARDTAPVARSAPPLEELPLRAQLDGLERRVIAAMLAATGGNQSAAAR
RLGLARTVLIDRLKKYGLL
>Mature_339_residues
MRRTNLGEAERGDAGGVAADGLVAESPRMRRLLADVARIAPRDVTVLLRGETGTGKERVASLLHARSRRAAGPLVRCNCA
AIAAELADAELFGAVRGAFTGAVESRRGFFSAADGGTLVLDEIGELPRALQPKLLRALQEGELQPVGAGRVERVDVRVVA
CTNRDLEAEVRAGRFREDLYYRLAVVELVVPPLRDRREDLPRLAVDLARELGQRFGVERVRLSPALLGRLQQADWPGNVR
QLENAIARMIALCPGPVLGPEAIAVVFPTASGAARDTAPVARSAPPLEELPLRAQLDGLERRVIAAMLAATGGNQSAAAR
RLGLARTVLIDRLKKYGLL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=319, Percent_Identity=45.4545454545455, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1788550, Length=319, Percent_Identity=41.3793103448276, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI87082152, Length=318, Percent_Identity=45.9119496855346, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI87082117, Length=323, Percent_Identity=44.2724458204334, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1788905, Length=319, Percent_Identity=42.3197492163009, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1790299, Length=329, Percent_Identity=39.5136778115502, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=41.4330218068536, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=36.8421052631579, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1787583, Length=324, Percent_Identity=36.7283950617284, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786524, Length=333, Percent_Identity=37.5375375375375, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI87081872, Length=328, Percent_Identity=37.5, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789828, Length=343, Percent_Identity=32.9446064139942, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI87081858, Length=315, Percent_Identity=31.4285714285714, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 36377; Mature: 36377

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTNLGEAERGDAGGVAADGLVAESPRMRRLLADVARIAPRDVTVLLRGETGTGKERVA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
SLLHARSRRAAGPLVRCNCAAIAAELADAELFGAVRGAFTGAVESRRGFFSAADGGTLVL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEH
DEIGELPRALQPKLLRALQEGELQPVGAGRVERVDVRVVACTNRDLEAEVRAGRFREDLY
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHH
YRLAVVELVVPPLRDRREDLPRLAVDLARELGQRFGVERVRLSPALLGRLQQADWPGNVR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHCCCCCHHH
QLENAIARMIALCPGPVLGPEAIAVVFPTASGAARDTAPVARSAPPLEELPLRAQLDGLE
HHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHH
RRVIAAMLAATGGNQSAAARRLGLARTVLIDRLKKYGLL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRTNLGEAERGDAGGVAADGLVAESPRMRRLLADVARIAPRDVTVLLRGETGTGKERVA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
SLLHARSRRAAGPLVRCNCAAIAAELADAELFGAVRGAFTGAVESRRGFFSAADGGTLVL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEH
DEIGELPRALQPKLLRALQEGELQPVGAGRVERVDVRVVACTNRDLEAEVRAGRFREDLY
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHH
YRLAVVELVVPPLRDRREDLPRLAVDLARELGQRFGVERVRLSPALLGRLQQADWPGNVR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHCCCCCHHH
QLENAIARMIALCPGPVLGPEAIAVVFPTASGAARDTAPVARSAPPLEELPLRAQLDGLE
HHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHH
RRVIAAMLAATGGNQSAAARRLGLARTVLIDRLKKYGLL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]