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The map label for this gene is ispH [H]

Identifier: 220917536

GI number: 220917536

Start: 2694978

End: 2695868

Strand: Reverse

Name: ispH [H]

Synonym: A2cp1_2436

Alternate gene names: 220917536

Gene position: 2695868-2694978 (Counterclockwise)

Preceding gene: 220917538

Following gene: 220917535

Centisome position: 53.6

GC content: 71.6

Gene sequence:

>891_bases
ATGGAGGGGTCGGGTGGCTGGCCGTCGCAGGGCGCGCCGTTATATAGAGGCGCCGTGGACGTCAAGATCGCGAAGACCGC
CGGGTTCTGCTGGGGTGTGCGCCGCACCGTCGACAAGGTGATGGAGGTCGCCGACCAGCACCGGGCCCCCGTCGTCACCC
TCGGGCCCATCATCCACAACCCCCAGGCGGTCGCCCGCTTCAGCGAGAAGGGCGTCGGGACCGTGAACGGGATCGGCGAG
GTGACCGACGGGACCACCGTCGTGGTCCGCACCCACGGCGCGGTCCGCGAGGAGCTGGAGCGCGCCGAGGCGCGCGGGCT
CGAGGTGGTGGACGGCACCTGCCCCTACGTGAAGTACCCGCAGGCCATGGCCCAGCGCCTCTCGCGCGAGGGCTACCACA
TCGTCATCGTCGGGGACGCGAACCACGCCGAGATCAAGGGCGTCATCTCGTACTCCGAGCAGCCGTGCACGGTGGTGAAG
CCGGGCGGCCCGGTCCCCGAGATCAAGGCGAAGAAGGTCGCGGTCATCGCCCAGACCACCTGCATCGGCGCGGAGTTCGA
GAGGGTGGTGGGCGTCCTGGCCCTCCGGCACAAGGAGGTCCGGGCCGTGAACACCATCTGCAACGACACCGAGGAGCGCC
AGGCGGACGCCCGGGCGCTCGCCAGCGAGGTCGACGCGGTGGTGGTGGTGGGCGGGAAGAACAGCGCCAACACGCGCCAC
CTCGCCGAGATCTGCCGCGCCATCCAGCCGCGCACCTGGCACGTCGAGACCGAGGCCGAGCTCGAGGCGGCCTGGTTCGA
GGGGTGCCGCGTGGTCGGCCTTTCGGCGGGGGCATCGACGCCGGACTGGGTGGTCGAGGGGGTGGCGGCCTGGCTGCGGG
TCCTCCGCTAG

Upstream 100 bases:

>100_bases
TCGCATCGCCAGTCCTCCAGCGGGGGTCCTGTGCCGAGAGGCCCGCCCCGGGAACTTCGTGACTCCGAGTAGAGGGGACA
ACCCCGGCGGTGCGCCACGG

Downstream 100 bases:

>100_bases
CCGGGGCCCGCCTTGACGCTGCAATTTCAGACGTGTAGCGTGCGCACTCCGTAATCCGGAATGTAGGCCGGGGTACGCCC
GGCGCGCGACGGCTCCTCGA

Product: hydroxymethylbutenyl pyrophosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MEGSGGWPSQGAPLYRGAVDVKIAKTAGFCWGVRRTVDKVMEVADQHRAPVVTLGPIIHNPQAVARFSEKGVGTVNGIGE
VTDGTTVVVRTHGAVREELERAEARGLEVVDGTCPYVKYPQAMAQRLSREGYHIVIVGDANHAEIKGVISYSEQPCTVVK
PGGPVPEIKAKKVAVIAQTTCIGAEFERVVGVLALRHKEVRAVNTICNDTEERQADARALASEVDAVVVVGGKNSANTRH
LAEICRAIQPRTWHVETEAELEAAWFEGCRVVGLSAGASTPDWVVEGVAAWLRVLR

Sequences:

>Translated_296_residues
MEGSGGWPSQGAPLYRGAVDVKIAKTAGFCWGVRRTVDKVMEVADQHRAPVVTLGPIIHNPQAVARFSEKGVGTVNGIGE
VTDGTTVVVRTHGAVREELERAEARGLEVVDGTCPYVKYPQAMAQRLSREGYHIVIVGDANHAEIKGVISYSEQPCTVVK
PGGPVPEIKAKKVAVIAQTTCIGAEFERVVGVLALRHKEVRAVNTICNDTEERQADARALASEVDAVVVVGGKNSANTRH
LAEICRAIQPRTWHVETEAELEAAWFEGCRVVGLSAGASTPDWVVEGVAAWLRVLR
>Mature_296_residues
MEGSGGWPSQGAPLYRGAVDVKIAKTAGFCWGVRRTVDKVMEVADQHRAPVVTLGPIIHNPQAVARFSEKGVGTVNGIGE
VTDGTTVVVRTHGAVREELERAEARGLEVVDGTCPYVKYPQAMAQRLSREGYHIVIVGDANHAEIKGVISYSEQPCTVVK
PGGPVPEIKAKKVAVIAQTTCIGAEFERVVGVLALRHKEVRAVNTICNDTEERQADARALASEVDAVVVVGGKNSANTRH
LAEICRAIQPRTWHVETEAELEAAWFEGCRVVGLSAGASTPDWVVEGVAAWLRVLR

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=285, Percent_Identity=30.1754385964912, Blast_Score=135, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 31771; Mature: 31771

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGSGGWPSQGAPLYRGAVDVKIAKTAGFCWGVRRTVDKVMEVADQHRAPVVTLGPIIHN
CCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
PQAVARFSEKGVGTVNGIGEVTDGTTVVVRTHGAVREELERAEARGLEVVDGTCPYVKYP
CHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEECCCCCCEECH
QAMAQRLSREGYHIVIVGDANHAEIKGVISYSEQPCTVVKPGGPVPEIKAKKVAVIAQTT
HHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCEEECCCCCCCCCCCCEEEEEEEHH
CIGAEFERVVGVLALRHKEVRAVNTICNDTEERQADARALASEVDAVVVVGGKNSANTRH
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
LAEICRAIQPRTWHVETEAELEAAWFEGCRVVGLSAGASTPDWVVEGVAAWLRVLR
HHHHHHHCCCCEEEECCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEGSGGWPSQGAPLYRGAVDVKIAKTAGFCWGVRRTVDKVMEVADQHRAPVVTLGPIIHN
CCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
PQAVARFSEKGVGTVNGIGEVTDGTTVVVRTHGAVREELERAEARGLEVVDGTCPYVKYP
CHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEECCCCCCEECH
QAMAQRLSREGYHIVIVGDANHAEIKGVISYSEQPCTVVKPGGPVPEIKAKKVAVIAQTT
HHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCEEECCCCCCCCCCCCEEEEEEEHH
CIGAEFERVVGVLALRHKEVRAVNTICNDTEERQADARALASEVDAVVVVGGKNSANTRH
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
LAEICRAIQPRTWHVETEAELEAAWFEGCRVVGLSAGASTPDWVVEGVAAWLRVLR
HHHHHHHCCCCEEEECCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA