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The map label for this gene is comEB [H]

Identifier: 220917501

GI number: 220917501

Start: 2660106

End: 2660600

Strand: Reverse

Name: comEB [H]

Synonym: A2cp1_2401

Alternate gene names: 220917501

Gene position: 2660600-2660106 (Counterclockwise)

Preceding gene: 220917503

Following gene: 220917499

Centisome position: 52.9

GC content: 69.9

Gene sequence:

>495_bases
ATGGACAACCGCGTGAGCTGGGACGAGTACTTCATGAACGTGGCGCGCGTCGTCGCCACCCGCGCCACCTGCGATCGCAA
GCACGTCGGTGCGGTGCTGGTGCGCGACAAGACCATCCTCTCCACCGGCTACAACGGCTCGATCCGCGGGCTGCCCCACT
GCAGCGAGGCCGGCCACATGATGGAGGACGGCCACTGCGTGGCGACTGTCCACGCCGAGGCGAACGCCATCATCCAGGCG
GCCAAGAACGGCGTCGCCATCGAGGGCGCCAGCATCTACACCACCGCCTCGCCCTGCTGGCCCTGCTTCAAGCTCATCGC
GAACGCCGGCTGCCGCCGCATCGTGTTCGGCGAGTTCTACCGGGACGCGCGCATCTTCGAGTTCGCGCAGCGGCTCGGGA
TCGAGCTCGTCGAGCTGAAGGTGCCGGCGCGGCCCGACGTGCAGCCGCCGGACACCGGCGTCCCGCACCCGGTCACGGCG
CGGCGGACGGAGTAG

Upstream 100 bases:

>100_bases
CAGCGCCAGGGAAGGGCGGATCATGCGACATGGTATGCCGCGGCGGGCGCCCGGCGTCGGCCCCGTGGGGTAGGATGACC
GACCGCACCAGGGAGGACGG

Downstream 100 bases:

>100_bases
CCGGCGCGGGGCCCGGCGCGCGGGCCGACGGCGCTGGCGCGGGCGCGGACGGCGCTGGCGCGTCCGTGCCGGCCAGCTCG
GCCGGGCCGAGCGTGCGGAG

Product: zinc-binding CMP/dCMP deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MDNRVSWDEYFMNVARVVATRATCDRKHVGAVLVRDKTILSTGYNGSIRGLPHCSEAGHMMEDGHCVATVHAEANAIIQA
AKNGVAIEGASIYTTASPCWPCFKLIANAGCRRIVFGEFYRDARIFEFAQRLGIELVELKVPARPDVQPPDTGVPHPVTA
RRTE

Sequences:

>Translated_164_residues
MDNRVSWDEYFMNVARVVATRATCDRKHVGAVLVRDKTILSTGYNGSIRGLPHCSEAGHMMEDGHCVATVHAEANAIIQA
AKNGVAIEGASIYTTASPCWPCFKLIANAGCRRIVFGEFYRDARIFEFAQRLGIELVELKVPARPDVQPPDTGVPHPVTA
RRTE
>Mature_164_residues
MDNRVSWDEYFMNVARVVATRATCDRKHVGAVLVRDKTILSTGYNGSIRGLPHCSEAGHMMEDGHCVATVHAEANAIIQA
AKNGVAIEGASIYTTASPCWPCFKLIANAGCRRIVFGEFYRDARIFEFAQRLGIELVELKVPARPDVQPPDTGVPHPVTA
RRTE

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=129, Percent_Identity=34.8837209302326, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI61742821, Length=129, Percent_Identity=34.8837209302326, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321938, Length=151, Percent_Identity=33.112582781457, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24667298, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24667302, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 18025; Mature: 18025

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRVSWDEYFMNVARVVATRATCDRKHVGAVLVRDKTILSTGYNGSIRGLPHCSEAGHM
CCCCCCHHHHHHHHHHHHHHHHHCCCHHCCEEEEECCEEEECCCCCCCCCCCCCCCCCCC
MEDGHCVATVHAEANAIIQAAKNGVAIEGASIYTTASPCWPCFKLIANAGCRRIVFGEFY
CCCCCEEEEEECCHHHHHHHHCCCEEEECCEEEECCCCHHHHHHHHHCCCCCEEEHHHHH
RDARIFEFAQRLGIELVELKVPARPDVQPPDTGVPHPVTARRTE
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDNRVSWDEYFMNVARVVATRATCDRKHVGAVLVRDKTILSTGYNGSIRGLPHCSEAGHM
CCCCCCHHHHHHHHHHHHHHHHHCCCHHCCEEEEECCEEEECCCCCCCCCCCCCCCCCCC
MEDGHCVATVHAEANAIIQAAKNGVAIEGASIYTTASPCWPCFKLIANAGCRRIVFGEFY
CCCCCEEEEEECCHHHHHHHHCCCEEEECCEEEECCCCHHHHHHHHHCCCCCEEEHHHHH
RDARIFEFAQRLGIELVELKVPARPDVQPPDTGVPHPVTARRTE
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]