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The map label for this gene is atoC [H]

Identifier: 220917498

GI number: 220917498

Start: 2656220

End: 2657629

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_2398

Alternate gene names: 220917498

Gene position: 2657629-2656220 (Counterclockwise)

Preceding gene: 220917499

Following gene: 220917496

Centisome position: 52.84

GC content: 70.35

Gene sequence:

>1410_bases
ATGAGATACCGCGTCCTCATCGTGGACGACGAGACCGACAGCCGCGAGGCGCTGGCGGAGCTCACCCAGCGCTGGGGCTA
CGACGTCCAGACCGCCAGCGACGGCACCGAGGCGCTCCGCCGCGCCATCGAGGGCCACCCCGACGTCATCCTCACCGATC
TGGTGATGCCGAACATGGACGGCCTGTGGCTCCTGCGCGCGCTGCGCGCCGAGCTGCCCGACTGCCCGGTGGTGCTGCTC
ACCGGTCGCGGCACCATCCAGACCGCGGTGCAGGCCATCCGCGAGGGCGCGTTCGACTTCATCGAGAAGCCGCTGGAGGT
GCCGCGCCTGCGCCTCGTGCTGGAGCGGGCGCTCGAGAAGAAGGAGACGATGCGAGAGGTGCAGCTGCTCCGCAGGCGCA
TCGCCGCGCTCGCCCCCGGCACCGACATGATCGGCTCCGGGCCCGCCATGCAGCGGGTGTTCGAGCTGGTGAAGAAGGTG
TCCCCCTCGAACGCCAGCGTGGTGATCGCGGGGGAGAGCGGCACCGGCAAGGAGGTGGTGGCGCGCGCCATCCACAACCT
GTCGCCGCGCAAGGACAAGCCGTTCGTGGCGCTGAACTGCTCGGCCATCCCGGCCACGCTGATCGAGTCCGAGCTGTTCG
GCTACGAGCGCGGCGCGTTCACCGGCGCCGACCAGCGGCGGCTCGGGAACTTCGAGCTGGCCCACAACGGGACGCTGTTC
CTGGACGAGATCGGCGAGCTGCCGCTCGAGCTGCAGGCCAAGTTCCTGCGCGTGCTGGAGGAGCGGAAGATCCGGCGGCT
GGGCGGGCGCTCCGAGGTCGAGGTGGACGTGCGGGTGATCTGCGCCACCAACCGCGACCTGAAGGAGGAGATCCGCCGCG
GCCGCTTCCGCGAGGATCTCTACTTCCGGCTGCACGTCTTCAGCATCCTGCTCCCCACGCTGAAGGAGCGGCGCGAGGAC
GTCCCGCTGCTCGTCCACCACTTCATCGAGAAGTTCAACGCCGAGACCGGCAAGCGCGTGCAGGGCGTCTCGCCCGCTGC
CATGGCGGTCCTGCAGGGCTACGCCTGGCCCGGCAACATCCGCGAGCTCCGGAACACGGTCGAGCGGGCGATGATCCTGG
TGGACGGCGAGGTGATCGGCGAGGAGCAGCTCCCGCCCGACATGCCGGCCAGCCGTCCCGAGGCCGCCACGCTGCGCGTG
CCGCTCGGCCTGCACATCGACAAGGTCGAGAAGGAGTACATCCTCGCCTCGTTGCAGCGGAACGGCGGCAACAAGGCGCG
CACCGCCGAGATCCTCGGGATCAGCGAGAAGACGCTCTACAACAAGCTGAACCGCTACGCGGCCGAGGCCCGGTCGCGCG
GCGAGGCGTCGGAGGGCGATCCCGCCGCGGCGGGAGGCGCGAAGGCCTAG

Upstream 100 bases:

>100_bases
TGGCCGCCGCCGCGGCGGAGGCGCTGGGCGGCCGCCAGGAAGTCATCCGCGAAGGCGGCGAGCAGCGGACGGTGCTGCGC
CTGCCGAGGAACGAACGCTC

Downstream 100 bases:

>100_bases
CCGGCGCTGGCCGAGGCGTGGGGCTCGGTGGCCGCGAGCGCCACCCGCCCGCGCCCGGCCCGCTTCGCCACGTACAGCGC
CGCGTCGGCCGCGCGCACCA

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRYRVLIVDDETDSREALAELTQRWGYDVQTASDGTEALRRAIEGHPDVILTDLVMPNMDGLWLLRALRAELPDCPVVLL
TGRGTIQTAVQAIREGAFDFIEKPLEVPRLRLVLERALEKKETMREVQLLRRRIAALAPGTDMIGSGPAMQRVFELVKKV
SPSNASVVIAGESGTGKEVVARAIHNLSPRKDKPFVALNCSAIPATLIESELFGYERGAFTGADQRRLGNFELAHNGTLF
LDEIGELPLELQAKFLRVLEERKIRRLGGRSEVEVDVRVICATNRDLKEEIRRGRFREDLYFRLHVFSILLPTLKERRED
VPLLVHHFIEKFNAETGKRVQGVSPAAMAVLQGYAWPGNIRELRNTVERAMILVDGEVIGEEQLPPDMPASRPEAATLRV
PLGLHIDKVEKEYILASLQRNGGNKARTAEILGISEKTLYNKLNRYAAEARSRGEASEGDPAAAGGAKA

Sequences:

>Translated_469_residues
MRYRVLIVDDETDSREALAELTQRWGYDVQTASDGTEALRRAIEGHPDVILTDLVMPNMDGLWLLRALRAELPDCPVVLL
TGRGTIQTAVQAIREGAFDFIEKPLEVPRLRLVLERALEKKETMREVQLLRRRIAALAPGTDMIGSGPAMQRVFELVKKV
SPSNASVVIAGESGTGKEVVARAIHNLSPRKDKPFVALNCSAIPATLIESELFGYERGAFTGADQRRLGNFELAHNGTLF
LDEIGELPLELQAKFLRVLEERKIRRLGGRSEVEVDVRVICATNRDLKEEIRRGRFREDLYFRLHVFSILLPTLKERRED
VPLLVHHFIEKFNAETGKRVQGVSPAAMAVLQGYAWPGNIRELRNTVERAMILVDGEVIGEEQLPPDMPASRPEAATLRV
PLGLHIDKVEKEYILASLQRNGGNKARTAEILGISEKTLYNKLNRYAAEARSRGEASEGDPAAAGGAKA
>Mature_469_residues
MRYRVLIVDDETDSREALAELTQRWGYDVQTASDGTEALRRAIEGHPDVILTDLVMPNMDGLWLLRALRAELPDCPVVLL
TGRGTIQTAVQAIREGAFDFIEKPLEVPRLRLVLERALEKKETMREVQLLRRRIAALAPGTDMIGSGPAMQRVFELVKKV
SPSNASVVIAGESGTGKEVVARAIHNLSPRKDKPFVALNCSAIPATLIESELFGYERGAFTGADQRRLGNFELAHNGTLF
LDEIGELPLELQAKFLRVLEERKIRRLGGRSEVEVDVRVICATNRDLKEEIRRGRFREDLYFRLHVFSILLPTLKERRED
VPLLVHHFIEKFNAETGKRVQGVSPAAMAVLQGYAWPGNIRELRNTVERAMILVDGEVIGEEQLPPDMPASRPEAATLRV
PLGLHIDKVEKEYILASLQRNGGNKARTAEILGISEKTLYNKLNRYAAEARSRGEASEGDPAAAGGAKA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=43.8053097345133, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=46.1883408071749, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=39.5299145299145, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1788905, Length=461, Percent_Identity=39.2624728850325, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI87082117, Length=336, Percent_Identity=44.6428571428571, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=44.794952681388, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789087, Length=308, Percent_Identity=45.1298701298701, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI87082152, Length=310, Percent_Identity=45.4838709677419, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1786524, Length=324, Percent_Identity=42.2839506172839, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=37.888198757764, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI87081872, Length=306, Percent_Identity=39.8692810457516, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=32.7868852459016, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789828, Length=323, Percent_Identity=32.1981424148607, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787375, Length=135, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=31.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=32.2033898305085, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=33.6065573770492, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=33.0434782608696, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=122, Percent_Identity=29.5081967213115, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=174, Percent_Identity=26.4367816091954, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52215; Mature: 52215

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYRVLIVDDETDSREALAELTQRWGYDVQTASDGTEALRRAIEGHPDVILTDLVMPNMD
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHCCCCC
GLWLLRALRAELPDCPVVLLTGRGTIQTAVQAIREGAFDFIEKPLEVPRLRLVLERALEK
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KETMREVQLLRRRIAALAPGTDMIGSGPAMQRVFELVKKVSPSNASVVIAGESGTGKEVV
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
ARAIHNLSPRKDKPFVALNCSAIPATLIESELFGYERGAFTGADQRRLGNFELAHNGTLF
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEECCCCEE
LDEIGELPLELQAKFLRVLEERKIRRLGGRSEVEVDVRVICATNRDLKEEIRRGRFREDL
EHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHCCCCHHHH
YFRLHVFSILLPTLKERREDVPLLVHHFIEKFNAETGKRVQGVSPAAMAVLQGYAWPGNI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCH
RELRNTVERAMILVDGEVIGEEQLPPDMPASRPEAATLRVPLGLHIDKVEKEYILASLQR
HHHHHHHHHHEEEECCCEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
NGGNKARTAEILGISEKTLYNKLNRYAAEARSRGEASEGDPAAAGGAKA
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRYRVLIVDDETDSREALAELTQRWGYDVQTASDGTEALRRAIEGHPDVILTDLVMPNMD
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHCCCCC
GLWLLRALRAELPDCPVVLLTGRGTIQTAVQAIREGAFDFIEKPLEVPRLRLVLERALEK
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KETMREVQLLRRRIAALAPGTDMIGSGPAMQRVFELVKKVSPSNASVVIAGESGTGKEVV
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
ARAIHNLSPRKDKPFVALNCSAIPATLIESELFGYERGAFTGADQRRLGNFELAHNGTLF
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEECCCCEE
LDEIGELPLELQAKFLRVLEERKIRRLGGRSEVEVDVRVICATNRDLKEEIRRGRFREDL
EHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHCCCCHHHH
YFRLHVFSILLPTLKERREDVPLLVHHFIEKFNAETGKRVQGVSPAAMAVLQGYAWPGNI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCH
RELRNTVERAMILVDGEVIGEEQLPPDMPASRPEAATLRVPLGLHIDKVEKEYILASLQR
HHHHHHHHHHEEEECCCEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
NGGNKARTAEILGISEKTLYNKLNRYAAEARSRGEASEGDPAAAGGAKA
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]