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The map label for this gene is folE [H]

Identifier: 220917101

GI number: 220917101

Start: 2252376

End: 2253056

Strand: Direct

Name: folE [H]

Synonym: A2cp1_1998

Alternate gene names: 220917101

Gene position: 2252376-2253056 (Clockwise)

Preceding gene: 220917100

Following gene: 220917102

Centisome position: 44.78

GC content: 81.5

Gene sequence:

>681_bases
GTGGCCGCTAGGCTCCGCGCCCTGCGGCCGGCCCGCCCGCGCGCCTCGGCCCCGGCCGCCGCCGAGGCGACCGCCCGCTT
CCTCGACGCGCTGGGGCTGCCGCCGGAGGTGCGGGCCTCGCCCGAGCTGGCCGGCACCCCGCGCCGCGTGGCGGAGGCCT
GGCTCGAGGACCTGGTGGACGGCTACCGGATCGAGCCGGCCGAGGTGCTGGCCGACGCCATGCCGAGCGCCGGCCGCGCG
CTGGTGACGCTCACCGGCATCGACTTCCACTCCGTCTGCCCGCACCACCTGCTGCCCTCGCGCGGCGTCGCGCACGTCGC
GTACCTGCCCGGCGGCAGGGTGGTGGGCTTCGGGCAGCTGGTGCGCCTGGTGGACTGCCTCGCGCACCGGCTGGTGCTCG
CGGAGGACCTGGCGCAGTCGGTGGCCGACGCGCTGGTGGAGCACCTCGGCGCGCGCGGCGCGGGGTGCGTGCTCGACGCC
GAGCACCTGTGCCTGACCGTGCGCGGCGAGCGGCGCGCCCGCGCCCGCGCGCACGCCGAGGGCTTCGCCGGGGCGCTGGC
GCGGAGCGGCGTGGCCCGGCGCAGCTTCGCCCAGGCCATCGCGCGCGCGGACGGCCCGCGGCCGGCCCGCCGCGGCGCGC
GGCGCGGGCGGGTCCGCGGGGCGGGCCCGAGGGCGCGATGA

Upstream 100 bases:

>100_bases
GCCCGCTGGGTGTGGGAGGTGCTCGAGCCGCACCTGCCCGGCCTGTGCGAGATCCGGCTCTACGAGATCCCGGACTCGTG
CGTGACGTACCGGGGGCCGG

Downstream 100 bases:

>100_bases
CCGCCGGGCGGACCGCCATCGTCACCGGCGGCGGCCGCGGCATCGGCGCGGCGGTGGCGCGGGCGCTCACCGCGCGCGGC
CTGCGCGTCACGGTGTTCGC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MAARLRALRPARPRASAPAAAEATARFLDALGLPPEVRASPELAGTPRRVAEAWLEDLVDGYRIEPAEVLADAMPSAGRA
LVTLTGIDFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQLVRLVDCLAHRLVLAEDLAQSVADALVEHLGARGAGCVLDA
EHLCLTVRGERRARARAHAEGFAGALARSGVARRSFAQAIARADGPRPARRGARRGRVRGAGPRAR

Sequences:

>Translated_226_residues
MAARLRALRPARPRASAPAAAEATARFLDALGLPPEVRASPELAGTPRRVAEAWLEDLVDGYRIEPAEVLADAMPSAGRA
LVTLTGIDFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQLVRLVDCLAHRLVLAEDLAQSVADALVEHLGARGAGCVLDA
EHLCLTVRGERRARARAHAEGFAGALARSGVARRSFAQAIARADGPRPARRGARRGRVRGAGPRAR
>Mature_225_residues
AARLRALRPARPRASAPAAAEATARFLDALGLPPEVRASPELAGTPRRVAEAWLEDLVDGYRIEPAEVLADAMPSAGRAL
VTLTGIDFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQLVRLVDCLAHRLVLAEDLAQSVADALVEHLGARGAGCVLDAE
HLCLTVRGERRARARAHAEGFAGALARSGVARRSFAQAIARADGPRPARRGARRGRVRGAGPRAR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=196, Percent_Identity=31.1224489795918, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI4503949, Length=196, Percent_Identity=31.1224489795918, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI66932970, Length=156, Percent_Identity=33.974358974359, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI66932972, Length=144, Percent_Identity=34.7222222222222, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1788476, Length=164, Percent_Identity=29.8780487804878, Blast_Score=77, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560486, Length=161, Percent_Identity=29.1925465838509, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321706, Length=165, Percent_Identity=29.6969696969697, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656791, Length=193, Percent_Identity=26.4248704663212, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656796, Length=193, Percent_Identity=26.4248704663212, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656782, Length=193, Percent_Identity=26.4248704663212, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23854; Mature: 23723

Theoretical pI: Translated: 11.74; Mature: 11.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARLRALRPARPRASAPAAAEATARFLDALGLPPEVRASPELAGTPRRVAEAWLEDLVD
CCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GYRIEPAEVLADAMPSAGRALVTLTGIDFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQL
CCCCCHHHHHHHHCCCCCCEEEEEECCCHHHCCCHHCCCCCCCEEEEECCCCCEECHHHH
VRLVDCLAHRLVLAEDLAQSVADALVEHLGARGAGCVLDAEHLCLTVRGERRARARAHAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHEEEEECCCHHHHHHHHHH
GFAGALARSGVARRSFAQAIARADGPRPARRGARRGRVRGAGPRAR
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AARLRALRPARPRASAPAAAEATARFLDALGLPPEVRASPELAGTPRRVAEAWLEDLVD
CCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GYRIEPAEVLADAMPSAGRALVTLTGIDFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQL
CCCCCHHHHHHHHCCCCCCEEEEEECCCHHHCCCHHCCCCCCCEEEEECCCCCEECHHHH
VRLVDCLAHRLVLAEDLAQSVADALVEHLGARGAGCVLDAEHLCLTVRGERRARARAHAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHEEEEECCCHHHHHHHHHH
GFAGALARSGVARRSFAQAIARADGPRPARRGARRGRVRGAGPRAR
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]