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The map label for this gene is atoC [H]

Identifier: 220917058

GI number: 220917058

Start: 2208363

End: 2209757

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_1954

Alternate gene names: 220917058

Gene position: 2208363-2209757 (Clockwise)

Preceding gene: 220917057

Following gene: 220917059

Centisome position: 43.91

GC content: 70.18

Gene sequence:

>1395_bases
ATGTCCAACGAGAGAACGCGCATCCTGGTGGTGGACGACGAGGAGATCGTCCGCGAGTCGCTGGGCGGCTGGCTCGAGAA
GGACGGCTACTCCGTCCACGTGGCGGCGGACGGGTTCGCCGCGGTCGAGAAGCTCAAGGGGGAGCGCTGGTCGATCCTCA
TCGTCGACCTGAAGATGCCGGGGATGGACGGCCTGCAGGTGCTGGAGGAGGCGAAGAAGCTCCTGCCCGAGCTGGCGGTC
GTGATCATGACCGCCTACGCCACGGTGGACACCGCGGTCGCGGCCATGAAGCTGGGCGCCTACGACTACCTCGTGAAGCC
GTTCGATCCCGAGGAGCTGTCGCTGATGATGCAGAAGATCGTCTCCCAGCAGACGCTGGTGCGGGAGAACGCGGTCCTGC
GCCAGGCGCTGAAGCGCGAGTACAAGTTCCGCGACCTGCTCTCGAAGAGCCCGGCCATGCAGTCGGTGTTCGAGCTGGCG
CGCACCGCGGCCCGCTCCAACTCCACCATCCTGGTGCTGGGCGAGTCCGGCAGCGGCAAGGAGGTCCTGGCGCGCGCCAT
CCACCAGGAGAGCCCGCGGGCGGAGGGGCCGTTCGTGGCGGTCTCCTGCGCCGCGCTCACCGAGAGCCTGCTCGAGTCCG
AGCTGTTCGGGCACGAGAAGGGCGCGTTCACCGGCGCGATCGCCCGCCGCAAGGGCAAGTTCGAGGCCGCCCACGGCGGC
ACGCTGTTCCTCGACGAGGTGGGCGACATCGGGCCCAAGCTGCAGCTCGACCTGCTGCGGGTGCTGGAGGAGCGGCGCTT
CCACCGCATCGGCGGCAACGAGAGCGTCGACGTGGACGTCCGGATCATCGCCGCCACGAACCGCGACCTGAAGCGCGCGG
TGGCGGAGGGGAAGTTCCGCGAGGACCTGTTCTACCGGCTCAACGTCATCCCCATCCTCATCCCCCCGCTGCGGGACCGG
CGCGAGGACGTCCCGCTCCTGGTGGAGAGCTTCGTGGAGCGGCTGTCGGTGGAGATGAAGAAGCGGATCGACGGCGTCTC
CTCCGAGGCGATGAGCGCGCTCATGGCGCACGACTGGCCCGGCAACGTGCGCGAGCTCCGGAACATCCTGGAGCGGGGCG
CGGTGGTCTGCACCGGCCCGGTGATCCAGATCGCCGACCTGGGCCTCCCCGGGAAGCCGGAGACCGCGCCGCGGCCCGGC
ACGCTCGCCTCGCTGGAGGAGGTGGAGCGGCGCCACGTCTCGGCGGTCCTGGCGCACACCGGCGGCAACGTGAGCCAGTC
GGCGCGCATCCTCGGCATCGACCGGGTCACCCTCTACAACAAGATGCGCAAGTGGGGGCTGCGCCGGGACGGCGAGGACG
AGCCGTCCCGCGACGGCGAGACCGGCGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCGCTCGTCGGGCGTTCGCAACGTGGACGAGAAGATGCCGGAGCTCTGCTCCGAGTGCCGACGCAGGCTCGAGGAGCTG
CAGGCCGGAGGTCCCAGGTG

Downstream 100 bases:

>100_bases
CCGGCGCGCCGGCCCGCGCCCCCGCGCGCACGCGCCACCCCCGCCGCTGCCCCGCCGGACCGCCCGCGCCCCCGCGCACG
GCGGCGCGACGCCGCGTCCG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSNERTRILVVDDEEIVRESLGGWLEKDGYSVHVAADGFAAVEKLKGERWSILIVDLKMPGMDGLQVLEEAKKLLPELAV
VIMTAYATVDTAVAAMKLGAYDYLVKPFDPEELSLMMQKIVSQQTLVRENAVLRQALKREYKFRDLLSKSPAMQSVFELA
RTAARSNSTILVLGESGSGKEVLARAIHQESPRAEGPFVAVSCAALTESLLESELFGHEKGAFTGAIARRKGKFEAAHGG
TLFLDEVGDIGPKLQLDLLRVLEERRFHRIGGNESVDVDVRIIAATNRDLKRAVAEGKFREDLFYRLNVIPILIPPLRDR
REDVPLLVESFVERLSVEMKKRIDGVSSEAMSALMAHDWPGNVRELRNILERGAVVCTGPVIQIADLGLPGKPETAPRPG
TLASLEEVERRHVSAVLAHTGGNVSQSARILGIDRVTLYNKMRKWGLRRDGEDEPSRDGETGAR

Sequences:

>Translated_464_residues
MSNERTRILVVDDEEIVRESLGGWLEKDGYSVHVAADGFAAVEKLKGERWSILIVDLKMPGMDGLQVLEEAKKLLPELAV
VIMTAYATVDTAVAAMKLGAYDYLVKPFDPEELSLMMQKIVSQQTLVRENAVLRQALKREYKFRDLLSKSPAMQSVFELA
RTAARSNSTILVLGESGSGKEVLARAIHQESPRAEGPFVAVSCAALTESLLESELFGHEKGAFTGAIARRKGKFEAAHGG
TLFLDEVGDIGPKLQLDLLRVLEERRFHRIGGNESVDVDVRIIAATNRDLKRAVAEGKFREDLFYRLNVIPILIPPLRDR
REDVPLLVESFVERLSVEMKKRIDGVSSEAMSALMAHDWPGNVRELRNILERGAVVCTGPVIQIADLGLPGKPETAPRPG
TLASLEEVERRHVSAVLAHTGGNVSQSARILGIDRVTLYNKMRKWGLRRDGEDEPSRDGETGAR
>Mature_463_residues
SNERTRILVVDDEEIVRESLGGWLEKDGYSVHVAADGFAAVEKLKGERWSILIVDLKMPGMDGLQVLEEAKKLLPELAVV
IMTAYATVDTAVAAMKLGAYDYLVKPFDPEELSLMMQKIVSQQTLVRENAVLRQALKREYKFRDLLSKSPAMQSVFELAR
TAARSNSTILVLGESGSGKEVLARAIHQESPRAEGPFVAVSCAALTESLLESELFGHEKGAFTGAIARRKGKFEAAHGGT
LFLDEVGDIGPKLQLDLLRVLEERRFHRIGGNESVDVDVRIIAATNRDLKRAVAEGKFREDLFYRLNVIPILIPPLRDRR
EDVPLLVESFVERLSVEMKKRIDGVSSEAMSALMAHDWPGNVRELRNILERGAVVCTGPVIQIADLGLPGKPETAPRPGT
LASLEEVERRHVSAVLAHTGGNVSQSARILGIDRVTLYNKMRKWGLRRDGEDEPSRDGETGAR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=46.2389380530973, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1790437, Length=452, Percent_Identity=45.1327433628319, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1788905, Length=448, Percent_Identity=40.625, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=40.5919661733615, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=45.7478005865103, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1789087, Length=335, Percent_Identity=45.6716417910448, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789233, Length=330, Percent_Identity=43.3333333333333, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1786524, Length=333, Percent_Identity=39.6396396396396, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=40.4984423676012, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1787583, Length=318, Percent_Identity=37.4213836477987, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI87081872, Length=235, Percent_Identity=44.6808510638298, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=33.0218068535826, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789828, Length=274, Percent_Identity=37.2262773722628, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790863, Length=116, Percent_Identity=30.1724137931034, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=28.6885245901639, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786599, Length=109, Percent_Identity=34.8623853211009, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=34.1269841269841, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790552, Length=107, Percent_Identity=33.6448598130841, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082012, Length=107, Percent_Identity=32.7102803738318, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789402, Length=102, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790860, Length=163, Percent_Identity=26.3803680981595, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51277; Mature: 51145

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNERTRILVVDDEEIVRESLGGWLEKDGYSVHVAADGFAAVEKLKGERWSILIVDLKMP
CCCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEEEEECC
GMDGLQVLEEAKKLLPELAVVIMTAYATVDTAVAAMKLGAYDYLVKPFDPEELSLMMQKI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHH
VSQQTLVRENAVLRQALKREYKFRDLLSKSPAMQSVFELARTAARSNSTILVLGESGSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
EVLARAIHQESPRAEGPFVAVSCAALTESLLESELFGHEKGAFTGAIARRKGKFEAAHGG
HHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEECCCC
TLFLDEVGDIGPKLQLDLLRVLEERRFHRIGGNESVDVDVRIIAATNRDLKRAVAEGKFR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHHCCCHH
EDLFYRLNVIPILIPPLRDRREDVPLLVESFVERLSVEMKKRIDGVSSEAMSALMAHDWP
HHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GNVRELRNILERGAVVCTGPVIQIADLGLPGKPETAPRPGTLASLEEVERRHVSAVLAHT
CCHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GGNVSQSARILGIDRVTLYNKMRKWGLRRDGEDEPSRDGETGAR
CCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNERTRILVVDDEEIVRESLGGWLEKDGYSVHVAADGFAAVEKLKGERWSILIVDLKMP
CCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEEEEECC
GMDGLQVLEEAKKLLPELAVVIMTAYATVDTAVAAMKLGAYDYLVKPFDPEELSLMMQKI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHH
VSQQTLVRENAVLRQALKREYKFRDLLSKSPAMQSVFELARTAARSNSTILVLGESGSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
EVLARAIHQESPRAEGPFVAVSCAALTESLLESELFGHEKGAFTGAIARRKGKFEAAHGG
HHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEECCCC
TLFLDEVGDIGPKLQLDLLRVLEERRFHRIGGNESVDVDVRIIAATNRDLKRAVAEGKFR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHHCCCHH
EDLFYRLNVIPILIPPLRDRREDVPLLVESFVERLSVEMKKRIDGVSSEAMSALMAHDWP
HHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GNVRELRNILERGAVVCTGPVIQIADLGLPGKPETAPRPGTLASLEEVERRHVSAVLAHT
CCHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GGNVSQSARILGIDRVTLYNKMRKWGLRRDGEDEPSRDGETGAR
CCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]