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The map label for this gene is pbpC [H]

Identifier: 220917031

GI number: 220917031

Start: 2174421

End: 2176769

Strand: Direct

Name: pbpC [H]

Synonym: A2cp1_1927

Alternate gene names: 220917031

Gene position: 2174421-2176769 (Clockwise)

Preceding gene: 220917030

Following gene: 220917032

Centisome position: 43.23

GC content: 80.12

Gene sequence:

>2349_bases
GTGCGCGAGGCGTTCCAGCGGGCCGCGAGGGCCCTCCGTCCCGCCCTCGCGCGGCTCGCGGCCGCGCTCGGCGGCCTGGG
CGCGGTCGCCGCGCTCGCGGCGGCGGTGTTCGTCGCCTGGCCGCTGCCGGACGGCCTGCTCGAGCGCCGGCCGGTGGCGG
CGGTGCGCTTCACCGACCGTGACGGCGGGCTCCTGCGCGAGGTGGCCTCGCGGGCGGACGGGCGCAGCGTGCCGCTGCCA
CCGGGCGAGCCGGTGCCGCCGCGGGTCCGCGCCGCGTTCCTCGCCGCGGAGGACGCGCGCTTCGACCGCCACCCCGGCGT
GGACCCGCTGGCGGTGGCCCGCGCCGGCTGGCAGCTCGTCCGGTACCGGCGGGTGGTGTCGGGCGCGTCCACCCTCACCA
TGCAGCTCGCCCGCGCGCTCGTCCCGCACCCGCGCACCGCGGGCGGCAAGGCGCTCGAGGCGCTGTGGGCGCTGCGGCTC
GAGGCGCACCTCGGCAAGGACGAGCTCCTCCGCGCGTACCTCGACCGCGTCCCGCTCGGCGGCGACCTGCACGGCGTGGA
GGCGGCGGCCGGGCTGTACTTCGGCCGTCCGGCGCGGACGCTCTCCGCGGCGCAGGCGGCGCTGCTCGCCGGGCTGGCGC
GCGCACCCACCGCGCTCGATCCGCTCCGGCGGCCCGAGGCCTCGCGCGACCGCGCCCTGGCGGTGCTCGGTCGGATGGAG
GCGCTCGGCCTCGTCCGCGCCGAGGAGGCGCGGCTGGCCCGGGAGGCGCCGCTCGACCTCGCCGCGGCCGAGCGGAGCTT
CGAGGCGCCGCACCTGGTGGACGCGCTCTCGGCCCGGCTGGGCGCGCTGGGGCTCGACGCCGCCGCCGAGGTGGAGACCA
CGCTGGACCGCGGCCTGCAGCGCGACGTGGAGGACCTCGTCCGCGCCGAGCTGGCCGGCGATCCGCGCCTCGGCAACGCC
GCCGTCGTCGTGGTGGACAACGCGAGCGGCGAGGTGCTCGCGTACGTCGGCTCGGCGGACTTCCTCGACGCGGCCGGGCT
CGGCCAGAACGACGGCGTGCGGGCACGCCGCCAGCCGGGCTCGGCGCTGAAGCCGTTCGCCTACGGCCTGGCGCTCGCCC
GCGGCTGGACCGCGGCGTCGGTCCTGTCCGACGTGGAGGTCCGGCTCGCCACCCCGACCGGCGACTGGGTCCCGCGCAAC
TACGACCGGCGGGCGCACGGCCCGGTGCCGCTCCGGGCCGCGCTGCAGAACAGCTACAACGTGCCCGCGGTGCGGCTGGC
CGAGGCGCTCGGGCCGGAGCGGGTGCTGCGCACGCTCGGGGCGGCCGGGTTCGAGTCGCTGTCCGGCGGCGCCGACCGCT
ACGGCGCCGGGGTGGTGCTGGGGAACGGCGACGCGACCCTGCGCGAGCTGGCGCGCGCGTACCGCGGGCTCGCCCGCGGC
GGCGTGCTGGAGCCGCTCCGCGAGGTGCGGGCTGGGCGCGACGCGGCCGGGCGGCCGCTGGCGGTGGCGCGCGAGCTCGC
GCCGCGGCGCTTCCTGCCGGCGGGCGCGGTGGCGCTGCTCACCGACGTCCTCTCCGACGAGGCGGCACGTGCACCCGCCT
TCGGCGTGCACAACGCGCTCCGGCTCCCGTTCCCGGTGGCGGCGAAGACCGGGACCTCGCGCGCGTACGTGGACAACTGG
ACGGCGGGCTACACCGCCGAGCGGACCGTGGCGGTGTGGGTGGGGAGCTTCGACGGGCGCCCGATGCAGGGCGTCTCCGG
GATCACCGGGGCCGGGCCCATCTTCGCCCGGGTGATGGTGCGCGCCATGCGCGGCATCGAGCCCGCGCCGCTGGTGGACC
GCGGCCGCTTCATCCACGCCCGCGTGTGCCCGCTCACCGGCCTGCGCGCAGGCCCTGGCTGCCCGGGCGCGCTCGACGAG
GTCTTCCTGCCCGGCACGGCGCCCTCGGCGACCTGCGGTGCGCACGCGCGCGGCCCGGGCGGGCCGGTGGCGCTCGCGCC
GGAGCTGCTGGGCTGGGCGCGGGCCGAAGGGATCGCGGCCGTGGCCGACGGGCGCGCTCCGGGAGCCACTGGCGCCGGCG
GGGCGCGGGTGCTCCTCCCCGCCGAGGGCGACGAGTACCTGGTCGAGGCGGGCTATCCGGCGGGCGCGCAGGGCATCCCG
CTGCGGCTGGCGCTGCCGCCGGGCACGGTGCGGGCGGAGGTGCGGGTCGGGGACGAGCGGCTCGCGCTCGGGCCGCCGTT
CGCGGGGCGGCTCGAGGCCCGGCCCGGGCGCCACCGGCTGGAGGTGTGGCTCCCCGGCGGTGCCGCGCCGGCCGCGGTCA
GCACCTTCACGGTGCGGGGCGCGCAGTGA

Upstream 100 bases:

>100_bases
CGCCGGCGCGGGCCGAGGAGATGTACGCGCCGGAGGTGTTCGGCCGCTCCGACGCGGGCACGTTCGAGGTGCGGGCCGGC
GGCGGCCGCTAGGGGGCGCG

Downstream 100 bases:

>100_bases
CGGCGCGGAGGGTGGCCGTCGCGGGGATGCTCCTGCTGGTGGGCCCGGGCTCCGCTTCGCACGCCGCGCCGTCGGTCGCG
GCTCCGGCGGCGGCGTCCTC

Product: glycosyl transferase family protein

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 782; Mature: 782

Protein sequence:

>782_residues
MREAFQRAARALRPALARLAAALGGLGAVAALAAAVFVAWPLPDGLLERRPVAAVRFTDRDGGLLREVASRADGRSVPLP
PGEPVPPRVRAAFLAAEDARFDRHPGVDPLAVARAGWQLVRYRRVVSGASTLTMQLARALVPHPRTAGGKALEALWALRL
EAHLGKDELLRAYLDRVPLGGDLHGVEAAAGLYFGRPARTLSAAQAALLAGLARAPTALDPLRRPEASRDRALAVLGRME
ALGLVRAEEARLAREAPLDLAAAERSFEAPHLVDALSARLGALGLDAAAEVETTLDRGLQRDVEDLVRAELAGDPRLGNA
AVVVVDNASGEVLAYVGSADFLDAAGLGQNDGVRARRQPGSALKPFAYGLALARGWTAASVLSDVEVRLATPTGDWVPRN
YDRRAHGPVPLRAALQNSYNVPAVRLAEALGPERVLRTLGAAGFESLSGGADRYGAGVVLGNGDATLRELARAYRGLARG
GVLEPLREVRAGRDAAGRPLAVARELAPRRFLPAGAVALLTDVLSDEAARAPAFGVHNALRLPFPVAAKTGTSRAYVDNW
TAGYTAERTVAVWVGSFDGRPMQGVSGITGAGPIFARVMVRAMRGIEPAPLVDRGRFIHARVCPLTGLRAGPGCPGALDE
VFLPGTAPSATCGAHARGPGGPVALAPELLGWARAEGIAAVADGRAPGATGAGGARVLLPAEGDEYLVEAGYPAGAQGIP
LRLALPPGTVRAEVRVGDERLALGPPFAGRLEARPGRHRLEVWLPGGAAPAAVSTFTVRGAQ

Sequences:

>Translated_782_residues
MREAFQRAARALRPALARLAAALGGLGAVAALAAAVFVAWPLPDGLLERRPVAAVRFTDRDGGLLREVASRADGRSVPLP
PGEPVPPRVRAAFLAAEDARFDRHPGVDPLAVARAGWQLVRYRRVVSGASTLTMQLARALVPHPRTAGGKALEALWALRL
EAHLGKDELLRAYLDRVPLGGDLHGVEAAAGLYFGRPARTLSAAQAALLAGLARAPTALDPLRRPEASRDRALAVLGRME
ALGLVRAEEARLAREAPLDLAAAERSFEAPHLVDALSARLGALGLDAAAEVETTLDRGLQRDVEDLVRAELAGDPRLGNA
AVVVVDNASGEVLAYVGSADFLDAAGLGQNDGVRARRQPGSALKPFAYGLALARGWTAASVLSDVEVRLATPTGDWVPRN
YDRRAHGPVPLRAALQNSYNVPAVRLAEALGPERVLRTLGAAGFESLSGGADRYGAGVVLGNGDATLRELARAYRGLARG
GVLEPLREVRAGRDAAGRPLAVARELAPRRFLPAGAVALLTDVLSDEAARAPAFGVHNALRLPFPVAAKTGTSRAYVDNW
TAGYTAERTVAVWVGSFDGRPMQGVSGITGAGPIFARVMVRAMRGIEPAPLVDRGRFIHARVCPLTGLRAGPGCPGALDE
VFLPGTAPSATCGAHARGPGGPVALAPELLGWARAEGIAAVADGRAPGATGAGGARVLLPAEGDEYLVEAGYPAGAQGIP
LRLALPPGTVRAEVRVGDERLALGPPFAGRLEARPGRHRLEVWLPGGAAPAAVSTFTVRGAQ
>Mature_782_residues
MREAFQRAARALRPALARLAAALGGLGAVAALAAAVFVAWPLPDGLLERRPVAAVRFTDRDGGLLREVASRADGRSVPLP
PGEPVPPRVRAAFLAAEDARFDRHPGVDPLAVARAGWQLVRYRRVVSGASTLTMQLARALVPHPRTAGGKALEALWALRL
EAHLGKDELLRAYLDRVPLGGDLHGVEAAAGLYFGRPARTLSAAQAALLAGLARAPTALDPLRRPEASRDRALAVLGRME
ALGLVRAEEARLAREAPLDLAAAERSFEAPHLVDALSARLGALGLDAAAEVETTLDRGLQRDVEDLVRAELAGDPRLGNA
AVVVVDNASGEVLAYVGSADFLDAAGLGQNDGVRARRQPGSALKPFAYGLALARGWTAASVLSDVEVRLATPTGDWVPRN
YDRRAHGPVPLRAALQNSYNVPAVRLAEALGPERVLRTLGAAGFESLSGGADRYGAGVVLGNGDATLRELARAYRGLARG
GVLEPLREVRAGRDAAGRPLAVARELAPRRFLPAGAVALLTDVLSDEAARAPAFGVHNALRLPFPVAAKTGTSRAYVDNW
TAGYTAERTVAVWVGSFDGRPMQGVSGITGAGPIFARVMVRAMRGIEPAPLVDRGRFIHARVCPLTGLRAGPGCPGALDE
VFLPGTAPSATCGAHARGPGGPVALAPELLGWARAEGIAAVADGRAPGATGAGGARVLLPAEGDEYLVEAGYPAGAQGIP
LRLALPPGTVRAEVRVGDERLALGPPFAGRLEARPGRHRLEVWLPGGAAPAAVSTFTVRGAQ

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=591, Percent_Identity=38.0710659898477, Blast_Score=302, Evalue=6e-83,
Organism=Escherichia coli, GI1786343, Length=591, Percent_Identity=30.6260575296108, Blast_Score=158, Evalue=2e-39,
Organism=Escherichia coli, GI87082258, Length=306, Percent_Identity=32.6797385620915, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI1789601, Length=167, Percent_Identity=35.3293413173653, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 81286; Mature: 81286

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAFQRAARALRPALARLAAALGGLGAVAALAAAVFVAWPLPDGLLERRPVAAVRFTDR
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECC
DGGLLREVASRADGRSVPLPPGEPVPPRVRAAFLAAEDARFDRHPGVDPLAVARAGWQLV
CCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RYRRVVSGASTLTMQLARALVPHPRTAGGKALEALWALRLEAHLGKDELLRAYLDRVPLG
HHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
GDLHGVEAAAGLYFGRPARTLSAAQAALLAGLARAPTALDPLRRPEASRDRALAVLGRME
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
ALGLVRAEEARLAREAPLDLAAAERSFEAPHLVDALSARLGALGLDAAAEVETTLDRGLQ
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RDVEDLVRAELAGDPRLGNAAVVVVDNASGEVLAYVGSADFLDAAGLGQNDGVRARRQPG
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCC
SALKPFAYGLALARGWTAASVLSDVEVRLATPTGDWVPRNYDRRAHGPVPLRAALQNSYN
CCCCHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
VPAVRLAEALGPERVLRTLGAAGFESLSGGADRYGAGVVLGNGDATLRELARAYRGLARG
CCHHHHHHHCCHHHHHHHHHHCCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
GVLEPLREVRAGRDAAGRPLAVARELAPRRFLPAGAVALLTDVLSDEAARAPAFGVHNAL
CHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
RLPFPVAAKTGTSRAYVDNWTAGYTAERTVAVWVGSFDGRPMQGVSGITGAGPIFARVMV
CCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
RAMRGIEPAPLVDRGRFIHARVCPLTGLRAGPGCPGALDEVFLPGTAPSATCGAHARGPG
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHEECCCCCCCCCCCCCCCCCC
GPVALAPELLGWARAEGIAAVADGRAPGATGAGGARVLLPAEGDEYLVEAGYPAGAQGIP
CCEEECHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCC
LRLALPPGTVRAEVRVGDERLALGPPFAGRLEARPGRHRLEVWLPGGAAPAAVSTFTVRG
EEEECCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECC
AQ
CC
>Mature Secondary Structure
MREAFQRAARALRPALARLAAALGGLGAVAALAAAVFVAWPLPDGLLERRPVAAVRFTDR
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECC
DGGLLREVASRADGRSVPLPPGEPVPPRVRAAFLAAEDARFDRHPGVDPLAVARAGWQLV
CCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RYRRVVSGASTLTMQLARALVPHPRTAGGKALEALWALRLEAHLGKDELLRAYLDRVPLG
HHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
GDLHGVEAAAGLYFGRPARTLSAAQAALLAGLARAPTALDPLRRPEASRDRALAVLGRME
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
ALGLVRAEEARLAREAPLDLAAAERSFEAPHLVDALSARLGALGLDAAAEVETTLDRGLQ
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RDVEDLVRAELAGDPRLGNAAVVVVDNASGEVLAYVGSADFLDAAGLGQNDGVRARRQPG
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCC
SALKPFAYGLALARGWTAASVLSDVEVRLATPTGDWVPRNYDRRAHGPVPLRAALQNSYN
CCCCHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
VPAVRLAEALGPERVLRTLGAAGFESLSGGADRYGAGVVLGNGDATLRELARAYRGLARG
CCHHHHHHHCCHHHHHHHHHHCCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
GVLEPLREVRAGRDAAGRPLAVARELAPRRFLPAGAVALLTDVLSDEAARAPAFGVHNAL
CHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
RLPFPVAAKTGTSRAYVDNWTAGYTAERTVAVWVGSFDGRPMQGVSGITGAGPIFARVMV
CCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
RAMRGIEPAPLVDRGRFIHARVCPLTGLRAGPGCPGALDEVFLPGTAPSATCGAHARGPG
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHEECCCCCCCCCCCCCCCCCC
GPVALAPELLGWARAEGIAAVADGRAPGATGAGGARVLLPAEGDEYLVEAGYPAGAQGIP
CCEEECHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCC
LRLALPPGTVRAEVRVGDERLALGPPFAGRLEARPGRHRLEVWLPGGAAPAAVSTFTVRG
EEEECCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECC
AQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]