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The map label for this gene is aceK [H]

Identifier: 220917028

GI number: 220917028

Start: 2165860

End: 2167614

Strand: Direct

Name: aceK [H]

Synonym: A2cp1_1924

Alternate gene names: 220917028

Gene position: 2165860-2167614 (Clockwise)

Preceding gene: 220917027

Following gene: 220917029

Centisome position: 43.06

GC content: 74.76

Gene sequence:

>1755_bases
ATGCTCGACGAGCGGGGCGCGCTCGCGCGGGGCGCGGCGGAGGCCATCCGGGCGGGGTACGAGGCGTACCAGGCCGAGCG
CGCGCGCATCACCGCGCGCGCCCGCGGTCGCTTCGAGGCGCGCGACTGGGCGGGCGCGCAGCGCGACGCGCGGGAGCGGC
TCGACCTGCGCGACGGCGTGGTGCACCGGACCGTCGGCGAGGTCCGGGCGGAGCTGGGCGGGGCGGTCCAGGACCGCGAG
GTGTGGCGCCGCGCCAAGGAGGCGTTCGAGGCGGCGGCCGGGTCCAGGCCGGACTTCGAGGTCGCCGGGTCGTTCTTCAA
CTCGGTCACGCGGCGCGTGTTCACCACGGTCGGCGTCGACCCGGCCATCGAGTTCCTGGCGGCGGACGCGCCGCCGCCGC
GCGAGGATCCCCCGCAGCACCGCACCTTCCCGCGCGAGGCGACCACCGAGGCGCTACTCGCGCGCGTCCTGCGCGCGACC
CCGATCTCGGCGTCGTTCGAGGATCTCGCCCGCGACGCGCGCCTCGCCGCCCTGGAGCTGGACGCTCACGTGCGCGGCCT
CCCGGATCGCCAGCCGATCGAGGCGGTGGAGCTGGCGCGGCCGGTCTTCTACCGCGGGAAGGGCGCGTACCTGGTCGGAC
GGATCCGGCGCGGCCGGCACCTGACGCCGCTCGTGCTGGCGCTCGCGCACGGCGAGCGCGGCGTGGCGCTCGACGCGATC
CTGTTCACCGAGGAGGACGTGTCGATCGTGTTCGGCTTCACCCGCTCCTACTTCCACGTGGAGCTGGAGCGCCCCCGCGC
CATGGTGGCGTTCCTGTCCACGCTGCTGCCGCTGAAGCGGCGCTCGGAGCTCTACACCGGCCTCGGCTACCACAAGCACG
GCAAGGCCGAGCTGTACCGCGAGGTGACGCTCCACCTCGCCGACGGCGAGGACCGCTTCGTGCCGGCGCGCGGCGACCGC
GGGCTGGTGATGTGCGTGTTCACGCTCCCCGGCCTGGACGTCATCTTCAAGGTCATCCGCGATCGGTTCGCCCCGCCCAA
GCAGACCACCCGGCGCGAGGTGATGGACCGGTACCGCCACGTGTTCCGCCACGACCGCGCCGGGCGGCTGGTGGACGCGC
AGGAGTACGAGCACCTCGCGTTCCCGGCCGGCCGCTTCGCGCCGGCGCTGCTCGACGAGCTGCGCACCGAGTGCGGCGAC
GGCGTGCGGGTGGCGGATGGGGAGGTGGCCATCCGGCACCTCTACGCCGAGCGCCGCGTCACGCCGCTCAACCTGTTCGT
CCGCGAGGCGGACGAGTGGACGGCGCGCCAGGCGGTGCTCGACTTCGGCTGCGCGCTGCGCGACCTCGCCGCCACCGACA
CCTTCCCCGGCGACCTGCTCCTCAAGAACTTCGGCGTCACGCGCCACGGCCGCGTCATCTTCTACGACTACGACGAGCTC
ACCCGGGTGACCGACTGCAACTTCCGCGACCTGCCCGCCGCGGGCGGGGGCGACGACGGATGGGGCGGCGGCCCCGACGC
CGGCTACGACGGCGGCGATCCGCCGTTCTACGTCGGGCCCGCGGACGTGTTCCCGGAGGAGCTGCTGCCGTTCCTCGGGC
TGACGGGGCGGCTCCGCGAGGTGTTCCTGCGGGCCCACGGGGAGCTGCTCACCGGGCGCTGGTGGCGCGGGATCCAGGCG
CGGCTGCGGGCGGGGGAGATCGTGGACATCTTCCCGTACCGCGAGGAGCAGCGGCTCCGCCACGCCCGTCCATGA

Upstream 100 bases:

>100_bases
GCGGCCGCCGCGGCCGCCTGAGCGCGGCCGCCCCGCCGGCGACGCCCGCCCCGCGGGGCGCTCCCGGCGGTGGCGGCGCC
CGGGCCTTACAACCCCTGGC

Downstream 100 bases:

>100_bases
GCCGATCCGAGACGATTCGACCTTCCCGGGACCTGGCCTCCGCGGCGCGGCGTGCCAGGATGCGCCGCCCTCGCGTGCCC
TCCCTGGTGTCCACCGCGGC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MLDERGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARERLDLRDGVVHRTVGEVRAELGGAVQDRE
VWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTVGVDPAIEFLAADAPPPREDPPQHRTFPREATTEALLARVLRAT
PISASFEDLARDARLAALELDAHVRGLPDRQPIEAVELARPVFYRGKGAYLVGRIRRGRHLTPLVLALAHGERGVALDAI
LFTEEDVSIVFGFTRSYFHVELERPRAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVTLHLADGEDRFVPARGDR
GLVMCVFTLPGLDVIFKVIRDRFAPPKQTTRREVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGD
GVRVADGEVAIRHLYAERRVTPLNLFVREADEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDYDEL
TRVTDCNFRDLPAAGGGDDGWGGGPDAGYDGGDPPFYVGPADVFPEELLPFLGLTGRLREVFLRAHGELLTGRWWRGIQA
RLRAGEIVDIFPYREEQRLRHARP

Sequences:

>Translated_584_residues
MLDERGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARERLDLRDGVVHRTVGEVRAELGGAVQDRE
VWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTVGVDPAIEFLAADAPPPREDPPQHRTFPREATTEALLARVLRAT
PISASFEDLARDARLAALELDAHVRGLPDRQPIEAVELARPVFYRGKGAYLVGRIRRGRHLTPLVLALAHGERGVALDAI
LFTEEDVSIVFGFTRSYFHVELERPRAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVTLHLADGEDRFVPARGDR
GLVMCVFTLPGLDVIFKVIRDRFAPPKQTTRREVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGD
GVRVADGEVAIRHLYAERRVTPLNLFVREADEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDYDEL
TRVTDCNFRDLPAAGGGDDGWGGGPDAGYDGGDPPFYVGPADVFPEELLPFLGLTGRLREVFLRAHGELLTGRWWRGIQA
RLRAGEIVDIFPYREEQRLRHARP
>Mature_584_residues
MLDERGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARERLDLRDGVVHRTVGEVRAELGGAVQDRE
VWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTVGVDPAIEFLAADAPPPREDPPQHRTFPREATTEALLARVLRAT
PISASFEDLARDARLAALELDAHVRGLPDRQPIEAVELARPVFYRGKGAYLVGRIRRGRHLTPLVLALAHGERGVALDAI
LFTEEDVSIVFGFTRSYFHVELERPRAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVTLHLADGEDRFVPARGDR
GLVMCVFTLPGLDVIFKVIRDRFAPPKQTTRREVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGD
GVRVADGEVAIRHLYAERRVTPLNLFVREADEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDYDEL
TRVTDCNFRDLPAAGGGDDGWGGGPDAGYDGGDPPFYVGPADVFPEELLPFLGLTGRLREVFLRAHGELLTGRWWRGIQA
RLRAGEIVDIFPYREEQRLRHARP

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=576, Percent_Identity=36.8055555555556, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 65622; Mature: 65622

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDERGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARERLDLRDGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHH
VHRTVGEVRAELGGAVQDREVWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTVGVD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PAIEFLAADAPPPREDPPQHRTFPREATTEALLARVLRATPISASFEDLARDARLAALEL
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEE
DAHVRGLPDRQPIEAVELARPVFYRGKGAYLVGRIRRGRHLTPLVLALAHGERGVALDAI
CHHHCCCCCCCCHHHHHHHCCHHCCCCCCEEEEEHHCCCCCCHHHHHHHCCCCCCEEEEE
LFTEEDVSIVFGFTRSYFHVELERPRAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYR
EEECCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEE
EVTLHLADGEDRFVPARGDRGLVMCVFTLPGLDVIFKVIRDRFAPPKQTTRREVMDRYRH
EHEEEEECCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGDGVRVADGEVAIRHLYAERRV
HHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
TPLNLFVREADEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDYDEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEHHHH
TRVTDCNFRDLPAAGGGDDGWGGGPDAGYDGGDPPFYVGPADVFPEELLPFLGLTGRLRE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHCCHHHHHHHHCCHHHHHH
VFLRAHGELLTGRWWRGIQARLRAGEIVDIFPYREEQRLRHARP
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCC
>Mature Secondary Structure
MLDERGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARERLDLRDGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHH
VHRTVGEVRAELGGAVQDREVWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTVGVD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PAIEFLAADAPPPREDPPQHRTFPREATTEALLARVLRATPISASFEDLARDARLAALEL
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEE
DAHVRGLPDRQPIEAVELARPVFYRGKGAYLVGRIRRGRHLTPLVLALAHGERGVALDAI
CHHHCCCCCCCCHHHHHHHCCHHCCCCCCEEEEEHHCCCCCCHHHHHHHCCCCCCEEEEE
LFTEEDVSIVFGFTRSYFHVELERPRAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYR
EEECCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEE
EVTLHLADGEDRFVPARGDRGLVMCVFTLPGLDVIFKVIRDRFAPPKQTTRREVMDRYRH
EHEEEEECCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGDGVRVADGEVAIRHLYAERRV
HHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
TPLNLFVREADEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDYDEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEHHHH
TRVTDCNFRDLPAAGGGDDGWGGGPDAGYDGGDPPFYVGPADVFPEELLPFLGLTGRLRE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHCCHHHHHHHHCCHHHHHH
VFLRAHGELLTGRWWRGIQARLRAGEIVDIFPYREEQRLRHARP
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA