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The map label for this gene is mccB [H]

Identifier: 220916976

GI number: 220916976

Start: 2103951

End: 2105027

Strand: Direct

Name: mccB [H]

Synonym: A2cp1_1872

Alternate gene names: 220916976

Gene position: 2103951-2105027 (Clockwise)

Preceding gene: 220916974

Following gene: 220916977

Centisome position: 41.83

GC content: 78.18

Gene sequence:

>1077_bases
ATGGCCGATCCGCTCCGCCCCGAGACCCTCGCCCTCCACGCCGACGCCGGCCTCGAGCCGTCCCCCGACGTCGCCCCGCC
CATCCACCTCTCCACCACCTTCGACGCGGACAACCCGGAGGGCCTCGTCTACTCGCGCGACGAGCAGCCGACGCGCCGCC
GCCTGGAGGCGGTGCTCGGCGCGCTGGAGGGGGGCGGCACCGCGGTGGTGTACGCCTCCGGTCTCGCGGCGGTCACGGCG
GCCCTGCTCCACCTGCAGCCCCGGCGCGTGGCCATCGCCCGCGGCGGGTACCACGGCACGCACGCCGCCATCGACGCGCT
GGCGCGGCTCGGGGTGGAGAAGGTCCCGCTCGACGCGCCGGTGGGCAAGGGCGACCTCGTCTGGCTGGAGACCCCGCGCA
ATCCGACCTGCGAGGTGCAGGACGTCGCGGCGCACGCGGCGCGCGCCCGCGCGGCCGGGGCGCTGCTGGTGGTGGACGGG
ACGTTCGCGACGCCGGCGCTGCAGCAGCCGCTCGCGCTCGGCGCCGACCTGGTGATGCACTCGCTCACCAAGTTCCTCTC
CGGCCACTCCGACGCGCTGGGCGGCGTGCTGGTGGCCCGCGATCCGGCGCTGGGCGCCGCGCTGCGCCGCGGGCGCACGG
TCGGCGGCGCGGTGCTGGGCGCGCTCGAGACCTGGCTCGTCCTGCGCGGCGTGCGCACGCTGGGCGTCCGGGTCCGGGCG
CAGTCCGCGACCGCCACGCGCCTGGCCGAGTTCCTCGCGCCGCGGGTGGCGCGCGTGTGGCACCCCTCGCGCCCGGACTT
CCCGGGCCGGGAGCTGGCCGCCCGCCAGATGCGTGGGCCCGGGCCCATGCTCGCGTTCGAGCTCGGCAGCGAGGCCGAGG
CGCGGGCGCTCCCCGGCAAGCTCCGGCTGTTCCGGGACGCGACCTCGCTCGGCGGCGTCGAGTCGCTCGTCGAGTGGCGA
CGCAAGGTGGACCCCGAGGCGCCGCCGGCGCTGCTGCGCGTCTCGGCCGGCCTCGAGGATCCCGAGGACCTCGTCGCGGA
CCTCGAGCAGGGGCTCCGCGCCGTGGCCGCCGGATAG

Upstream 100 bases:

>100_bases
CGCGCCCGAAACCGGAGCGTGACGCCCGGTGACCGGGCGGGGCCGGGGTCACGCGTGCGGCAGCTTGCCGCCGGGGCCGG
GCGGGACGAGGATGCGCCGC

Downstream 100 bases:

>100_bases
GGCGCCTGGCCGGCGGTCCCCGGCGGTGCCGGGCCGCGCGTCCGGGGCCATGCTTCAGCGAGGCCATGCGGCGCCGCACC
GCCAGACGCCTCGCCGTCGC

Product: Cys/Met metabolism pyridoxal-phosphate-dependent protein

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MADPLRPETLALHADAGLEPSPDVAPPIHLSTTFDADNPEGLVYSRDEQPTRRRLEAVLGALEGGGTAVVYASGLAAVTA
ALLHLQPRRVAIARGGYHGTHAAIDALARLGVEKVPLDAPVGKGDLVWLETPRNPTCEVQDVAAHAARARAAGALLVVDG
TFATPALQQPLALGADLVMHSLTKFLSGHSDALGGVLVARDPALGAALRRGRTVGGAVLGALETWLVLRGVRTLGVRVRA
QSATATRLAEFLAPRVARVWHPSRPDFPGRELAARQMRGPGPMLAFELGSEAEARALPGKLRLFRDATSLGGVESLVEWR
RKVDPEAPPALLRVSAGLEDPEDLVADLEQGLRAVAAG

Sequences:

>Translated_358_residues
MADPLRPETLALHADAGLEPSPDVAPPIHLSTTFDADNPEGLVYSRDEQPTRRRLEAVLGALEGGGTAVVYASGLAAVTA
ALLHLQPRRVAIARGGYHGTHAAIDALARLGVEKVPLDAPVGKGDLVWLETPRNPTCEVQDVAAHAARARAAGALLVVDG
TFATPALQQPLALGADLVMHSLTKFLSGHSDALGGVLVARDPALGAALRRGRTVGGAVLGALETWLVLRGVRTLGVRVRA
QSATATRLAEFLAPRVARVWHPSRPDFPGRELAARQMRGPGPMLAFELGSEAEARALPGKLRLFRDATSLGGVESLVEWR
RKVDPEAPPALLRVSAGLEDPEDLVADLEQGLRAVAAG
>Mature_357_residues
ADPLRPETLALHADAGLEPSPDVAPPIHLSTTFDADNPEGLVYSRDEQPTRRRLEAVLGALEGGGTAVVYASGLAAVTAA
LLHLQPRRVAIARGGYHGTHAAIDALARLGVEKVPLDAPVGKGDLVWLETPRNPTCEVQDVAAHAARARAAGALLVVDGT
FATPALQQPLALGADLVMHSLTKFLSGHSDALGGVLVARDPALGAALRRGRTVGGAVLGALETWLVLRGVRTLGVRVRAQ
SATATRLAEFLAPRVARVWHPSRPDFPGRELAARQMRGPGPMLAFELGSEAEARALPGKLRLFRDATSLGGVESLVEWRR
KVDPEAPPALLRVSAGLEDPEDLVADLEQGLRAVAAG

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=341, Percent_Identity=35.7771260997067, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI299473759, Length=331, Percent_Identity=34.441087613293, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI25453487, Length=328, Percent_Identity=30.4878048780488, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1790375, Length=367, Percent_Identity=41.6893732970027, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1789383, Length=339, Percent_Identity=32.4483775811209, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71980708, Length=391, Percent_Identity=32.7365728900256, Blast_Score=193, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17538055, Length=357, Percent_Identity=35.8543417366947, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560056, Length=337, Percent_Identity=34.1246290801187, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321904, Length=372, Percent_Identity=38.9784946236559, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=381, Percent_Identity=35.6955380577428, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=29.0322580645161, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6321170, Length=290, Percent_Identity=32.0689655172414, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323333, Length=440, Percent_Identity=27.0454545454545, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19922554, Length=371, Percent_Identity=35.3099730458221, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 37538; Mature: 37407

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPLRPETLALHADAGLEPSPDVAPPIHLSTTFDADNPEGLVYSRDEQPTRRRLEAVLG
CCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCHHHHHHHHHHH
ALEGGGTAVVYASGLAAVTAALLHLQPRRVAIARGGYHGTHAAIDALARLGVEKVPLDAP
HHCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
VGKGDLVWLETPRNPTCEVQDVAAHAARARAAGALLVVDGTFATPALQQPLALGADLVMH
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHH
SLTKFLSGHSDALGGVLVARDPALGAALRRGRTVGGAVLGALETWLVLRGVRTLGVRVRA
HHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEE
QSATATRLAEFLAPRVARVWHPSRPDFPGRELAARQMRGPGPMLAFELGSEAEARALPGK
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHCCCCH
LRLFRDATSLGGVESLVEWRRKVDPEAPPALLRVSAGLEDPEDLVADLEQGLRAVAAG
HHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADPLRPETLALHADAGLEPSPDVAPPIHLSTTFDADNPEGLVYSRDEQPTRRRLEAVLG
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCHHHHHHHHHHH
ALEGGGTAVVYASGLAAVTAALLHLQPRRVAIARGGYHGTHAAIDALARLGVEKVPLDAP
HHCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
VGKGDLVWLETPRNPTCEVQDVAAHAARARAAGALLVVDGTFATPALQQPLALGADLVMH
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHH
SLTKFLSGHSDALGGVLVARDPALGAALRRGRTVGGAVLGALETWLVLRGVRTLGVRVRA
HHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEE
QSATATRLAEFLAPRVARVWHPSRPDFPGRELAARQMRGPGPMLAFELGSEAEARALPGK
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHCCCCH
LRLFRDATSLGGVESLVEWRRKVDPEAPPALLRVSAGLEDPEDLVADLEQGLRAVAAG
HHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]