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The map label for this gene is zraS [C]

Identifier: 220916958

GI number: 220916958

Start: 2075086

End: 2076822

Strand: Direct

Name: zraS [C]

Synonym: A2cp1_1854

Alternate gene names: 220916958

Gene position: 2075086-2076822 (Clockwise)

Preceding gene: 220916957

Following gene: 220916959

Centisome position: 41.26

GC content: 75.07

Gene sequence:

>1737_bases
ATGGGCCGAATCCAGGCTTGCCTGCTCGTCGCGGCGCTGCTCGCGGCGGCCCCGGTTGCACGGGCGGTCCCGCCCGCGCC
GCAGCCGCAGGGGGGACGCGCGGTGGTGGTCGGGGCCGACCGCTCCTACCCGCCCTACGAGTTCCTCGACGAGAAGGGTC
AGCCGGCGGGGTTCAACGTGGACCTCACCCGCGCCATCGGCGAGGTGATGGGGTTCACGGTCGAATTCCGGTTCGGCGAC
TGGGCGGGGATCCGGGCGGGGCTGGCGGACGGCAGCATCGACGTGCTGCAGGGCATCTCGTGGTCGGAGGAGCGCGCGCG
CAGGCTGGACTTCGCGGCGCCGCACGCGATCGTCCACCACGCGATATTCGTCCGGAAGGACGGCCCGCACCCGCGCTCGA
TCGAGGCGCTGGCCGGGCGCGAGGTGGTGGTGTTCGGCGGCGGGATCATGGACGAGGAGATCACGCGGGCCGGCACGGCG
GCGCGGGTGATCCGGACGCAGACGCCCGCCGACGCGCTGCGCCTGCTCGCCTCGGGCCAGCACGACTGCGTGGTGCTGGC
GCTCCTGCCGGGCATCTACCTGCAGCGCCAGCTCGGGCTCAGCAACGTCGAGCCGGTCGGGGAGCCGGTCCGCGCCGAGC
GCTACGGGTACGCGGTCCGCAAGGGCGATCGCGAGCTGCTGGCCCGCTTCGACGAGGGGCTCGCCATCCTGAAGCAGACC
GGGCGCTACGACGCCATCCACGCGCGCTGGCTGGGGCCGCTCGAGCCGCGGCCCATCGGCTGGCAGGCGGTGGCGCGCTA
CGCGGCGCTCGGCGCGCTGCCCATCCTCGTGCTGCTCGGCGCCAGCGTCGCCTGGAGCCGGTCGCTGCGGCGGCTCGTCG
CGCAGCGCACCGCGTCGCTGCAGCGCGAGGTGGCGGAGCGCGAGCGGGCGGTGGCCGCGCTCCGCGAGCACCAGCACCAG
CTCGTGCAGGCGCAGAAGGCGGCGGCCATGGGCGTGCTGGTGTCCGGGGTGGCCCACGAGATCAACAACCCGGCCGGCTA
CATCCTGCTCAACGTGCCCACGCTGAAGGCCGCGTTCGCCGACGCGCAGGAGGCGCTCGATGCGCGCGCCCGCGAGCGCG
ACCTGAAGCTGGCGGGCGTCCCGTACGCGCGGATGCGCGACGAGATCCCGCAGATGCTCGACGAGATCGCCGAGGGGGGC
CGGCGCATCAAGCGGATCGTGGACGACCTGAAGGACTTCGCCCGCCGCGACGACGCGCCGCGGCTCGAGCCCATGGACCT
CGGCACCTCGGCGCGGGCCGCGGTCCGCCTGCTCGAGGCGCCCATCCGCGCTGCGACCTCGCGGTTCGAGCTGGCGCTCG
CCCCCGGCCTGCCGCGCGTGCGCGGCAACCCGCACCGGCTCGAGCAGGTGATCGTGAACCTGCTCCTGAACGCCTGCCAG
GCGCTCCCCGACCGCGATCGCGCGCTGCGCCTCTCGATCCGCCACGATCCCGTCGCCGGCGAGGTGGTGCTCGAGGTGCG
CGACGAGGGCGTGGGCATCCCGCCCGAGCACCTGGCGCGCCTCACCGACCCGTTCTTCACCACCAAGCGCGAGAGCGGCG
GCACCGGCCTCGGCCTGTCGGTGTCCGCCGGGATCGTGAAGGAGCACGGCGGCCGGCTCGAGTTCGGGTCGCAGCCCGGC
GTCGGCACCACCGCGGCGCTGGTGCTGCCGGCGCTGCGCGAGGAGGGCGCGGCGTGA

Upstream 100 bases:

>100_bases
GAGTCACGCGACGTCCGGCGAGCATCTCCGCCCGGATCCAAGCGATCCCGGCCTGGCCCCCGCTTGTCGCGGCGCCGCGC
GCGTCGTAGCGTGGCGACCG

Downstream 100 bases:

>100_bases
GCGAGTCGTTCTATCCCGCGTTCGCGATCCTGGCGGTGGACGACGAGGCCGCCTGGCTGCGCTCGGTCTCGCTCACGCTC
GAGCGCGCGGCCGGCATCAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MGRIQACLLVAALLAAAPVARAVPPAPQPQGGRAVVVGADRSYPPYEFLDEKGQPAGFNVDLTRAIGEVMGFTVEFRFGD
WAGIRAGLADGSIDVLQGISWSEERARRLDFAAPHAIVHHAIFVRKDGPHPRSIEALAGREVVVFGGGIMDEEITRAGTA
ARVIRTQTPADALRLLASGQHDCVVLALLPGIYLQRQLGLSNVEPVGEPVRAERYGYAVRKGDRELLARFDEGLAILKQT
GRYDAIHARWLGPLEPRPIGWQAVARYAALGALPILVLLGASVAWSRSLRRLVAQRTASLQREVAERERAVAALREHQHQ
LVQAQKAAAMGVLVSGVAHEINNPAGYILLNVPTLKAAFADAQEALDARARERDLKLAGVPYARMRDEIPQMLDEIAEGG
RRIKRIVDDLKDFARRDDAPRLEPMDLGTSARAAVRLLEAPIRAATSRFELALAPGLPRVRGNPHRLEQVIVNLLLNACQ
ALPDRDRALRLSIRHDPVAGEVVLEVRDEGVGIPPEHLARLTDPFFTTKRESGGTGLGLSVSAGIVKEHGGRLEFGSQPG
VGTTAALVLPALREEGAA

Sequences:

>Translated_578_residues
MGRIQACLLVAALLAAAPVARAVPPAPQPQGGRAVVVGADRSYPPYEFLDEKGQPAGFNVDLTRAIGEVMGFTVEFRFGD
WAGIRAGLADGSIDVLQGISWSEERARRLDFAAPHAIVHHAIFVRKDGPHPRSIEALAGREVVVFGGGIMDEEITRAGTA
ARVIRTQTPADALRLLASGQHDCVVLALLPGIYLQRQLGLSNVEPVGEPVRAERYGYAVRKGDRELLARFDEGLAILKQT
GRYDAIHARWLGPLEPRPIGWQAVARYAALGALPILVLLGASVAWSRSLRRLVAQRTASLQREVAERERAVAALREHQHQ
LVQAQKAAAMGVLVSGVAHEINNPAGYILLNVPTLKAAFADAQEALDARARERDLKLAGVPYARMRDEIPQMLDEIAEGG
RRIKRIVDDLKDFARRDDAPRLEPMDLGTSARAAVRLLEAPIRAATSRFELALAPGLPRVRGNPHRLEQVIVNLLLNACQ
ALPDRDRALRLSIRHDPVAGEVVLEVRDEGVGIPPEHLARLTDPFFTTKRESGGTGLGLSVSAGIVKEHGGRLEFGSQPG
VGTTAALVLPALREEGAA
>Mature_577_residues
GRIQACLLVAALLAAAPVARAVPPAPQPQGGRAVVVGADRSYPPYEFLDEKGQPAGFNVDLTRAIGEVMGFTVEFRFGDW
AGIRAGLADGSIDVLQGISWSEERARRLDFAAPHAIVHHAIFVRKDGPHPRSIEALAGREVVVFGGGIMDEEITRAGTAA
RVIRTQTPADALRLLASGQHDCVVLALLPGIYLQRQLGLSNVEPVGEPVRAERYGYAVRKGDRELLARFDEGLAILKQTG
RYDAIHARWLGPLEPRPIGWQAVARYAALGALPILVLLGASVAWSRSLRRLVAQRTASLQREVAERERAVAALREHQHQL
VQAQKAAAMGVLVSGVAHEINNPAGYILLNVPTLKAAFADAQEALDARARERDLKLAGVPYARMRDEIPQMLDEIAEGGR
RIKRIVDDLKDFARRDDAPRLEPMDLGTSARAAVRLLEAPIRAATSRFELALAPGLPRVRGNPHRLEQVIVNLLLNACQA
LPDRDRALRLSIRHDPVAGEVVLEVRDEGVGIPPEHLARLTDPFFTTKRESGGTGLGLSVSAGIVKEHGGRLEFGSQPGV
GTTAALVLPALREEGAA

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=253, Percent_Identity=30.8300395256917, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788549, Length=265, Percent_Identity=28.6792452830189, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787031, Length=247, Percent_Identity=27.5303643724696, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788228, Length=255, Percent_Identity=25.0980392156863, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=297, Percent_Identity=29.96632996633, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=289, Percent_Identity=26.643598615917, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=203, Percent_Identity=29.064039408867, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=264, Percent_Identity=30.6818181818182, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=181, Percent_Identity=28.7292817679558, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787088, Length=252, Percent_Identity=25, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=26.2295081967213, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62409; Mature: 62277

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRIQACLLVAALLAAAPVARAVPPAPQPQGGRAVVVGADRSYPPYEFLDEKGQPAGFNV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCE
DLTRAIGEVMGFTVEFRFGDWAGIRAGLADGSIDVLQGISWSEERARRLDFAAPHAIVHH
EHHHHHHHHHCEEEEEECCCCHHHHHCCCCCCHHHHHCCCCCHHHHHHCCCCCHHHHHHH
AIFVRKDGPHPRSIEALAGREVVVFGGGIMDEEITRAGTAARVIRTQTPADALRLLASGQ
EEEEECCCCCCCCHHHHCCCEEEEECCCCCHHHHHHHCHHHHHHCCCCHHHHHHHHHCCC
HDCVVLALLPGIYLQRQLGLSNVEPVGEPVRAERYGYAVRKGDRELLARFDEGLAILKQT
CCEEEEHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GRYDAIHARWLGPLEPRPIGWQAVARYAALGALPILVLLGASVAWSRSLRRLVAQRTASL
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QREVAERERAVAALREHQHQLVQAQKAAAMGVLVSGVAHEINNPAGYILLNVPTLKAAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHH
DAQEALDARARERDLKLAGVPYARMRDEIPQMLDEIAEGGRRIKRIVDDLKDFARRDDAP
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RLEPMDLGTSARAAVRLLEAPIRAATSRFELALAPGLPRVRGNPHRLEQVIVNLLLNACQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
ALPDRDRALRLSIRHDPVAGEVVLEVRDEGVGIPPEHLARLTDPFFTTKRESGGTGLGLS
CCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCE
VSAGIVKEHGGRLEFGSQPGVGTTAALVLPALREEGAA
ECCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GRIQACLLVAALLAAAPVARAVPPAPQPQGGRAVVVGADRSYPPYEFLDEKGQPAGFNV
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCE
DLTRAIGEVMGFTVEFRFGDWAGIRAGLADGSIDVLQGISWSEERARRLDFAAPHAIVHH
EHHHHHHHHHCEEEEEECCCCHHHHHCCCCCCHHHHHCCCCCHHHHHHCCCCCHHHHHHH
AIFVRKDGPHPRSIEALAGREVVVFGGGIMDEEITRAGTAARVIRTQTPADALRLLASGQ
EEEEECCCCCCCCHHHHCCCEEEEECCCCCHHHHHHHCHHHHHHCCCCHHHHHHHHHCCC
HDCVVLALLPGIYLQRQLGLSNVEPVGEPVRAERYGYAVRKGDRELLARFDEGLAILKQT
CCEEEEHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GRYDAIHARWLGPLEPRPIGWQAVARYAALGALPILVLLGASVAWSRSLRRLVAQRTASL
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QREVAERERAVAALREHQHQLVQAQKAAAMGVLVSGVAHEINNPAGYILLNVPTLKAAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHH
DAQEALDARARERDLKLAGVPYARMRDEIPQMLDEIAEGGRRIKRIVDDLKDFARRDDAP
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RLEPMDLGTSARAAVRLLEAPIRAATSRFELALAPGLPRVRGNPHRLEQVIVNLLLNACQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
ALPDRDRALRLSIRHDPVAGEVVLEVRDEGVGIPPEHLARLTDPFFTTKRESGGTGLGLS
CCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCE
VSAGIVKEHGGRLEFGSQPGVGTTAALVLPALREEGAA
ECCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]