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The map label for this gene is myrA [H]

Identifier: 220916891

GI number: 220916891

Start: 1997115

End: 1997960

Strand: Direct

Name: myrA [H]

Synonym: A2cp1_1787

Alternate gene names: 220916891

Gene position: 1997115-1997960 (Clockwise)

Preceding gene: 220916889

Following gene: 220916895

Centisome position: 39.71

GC content: 76.24

Gene sequence:

>846_bases
GTGCTCCCCGAGATCCTTCGACATCTGCGCTGCCCCGTCTGCCGGGCACCGCTCACCGCGGTTCCCGGAGCCGTGCGCTG
TCCGGCGGGGCACGCGTTCGATCTCGCGCGCCAGGGCTACGTGAACTTGCTTCGCGGCCGCTCGCCGGGCACCGGCGACG
ACGCTGACATGGTCGCCGCCCGCGAGGCGTTCCTCGGCGCGGGACACTTCGCGCCCCTGGGGGCGGCGCTCGCGCGCGCG
GCCCAGGCGCACGCCGGCCCCGACGGCATCGTGCTGGAGGTCGGCGCGGGGACAGGACACCATCTCCGCTCCGTGCTCGA
GGCGCTTCCGGATCGCTTCGGACTCGCCCTGGACCTCTCCCGCCACGCCGCGAGGCGGGCCGCGCGGGCACACCCGCGCC
TGGGCGCCGTGGTCGCCGACGCCTGGGAGCCGCTGCCGATCGCGGATGCGTGCGCGGCGCTGGTCCTCGACGTCTTCGCG
CCCAGGAACGTCGCGGAGTTCCGGCGCGTTCTCGCGCCGGGCGGAGCGCTGCTCCTCGTCACCCCCGCGCCCGCGCACCT
CGCCGAACTGCGTAAGCCGCTCGGGCTGCTCGAGGTCGACCCCGACAAGGCGCGCCGGGTGTCGGAGGCGCTGGAGGGCC
GCTTCGCACTCGCGGCCTCGGAGTCGCTCGAGTGGACCCTCTCCCTCCCGCGGACCGACGTCCTCGCCGCGGCTCGGATG
GGCCCGTCCGCCCACCACACCGCCCTCGACGTCCTCGCTGCGCGCGTTGCCGGGCTCGACGAACCGGTGCGTGTGTCCGC
CGCGGTCCAGGTGCAGGTGTACCGGCCGGCGGCGAGCGCGGCGTGA

Upstream 100 bases:

>100_bases
GGAGCACGACGAGGCCGATGGCCGGGCGGGAGGCGAGAAGCATGCGAGAAGCGTAGCGCGTCCCGGCGCGGGGGTGGGAT
TCGCGTATCATCCGCCACCG

Downstream 100 bases:

>100_bases
CGGCTGCGATGACGGCCACCGCGCCTCGACGCCCTACGAAGGGGCCTCGCAGCGCACGCCGTGCAGGACGCGGAGCAGGT
ACGTGCCCGCCGGGAAGAGC

Product: type 11 methyltransferase

Products: S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLPEILRHLRCPVCRAPLTAVPGAVRCPAGHAFDLARQGYVNLLRGRSPGTGDDADMVAAREAFLGAGHFAPLGAALARA
AQAHAGPDGIVLEVGAGTGHHLRSVLEALPDRFGLALDLSRHAARRAARAHPRLGAVVADAWEPLPIADACAALVLDVFA
PRNVAEFRRVLAPGGALLLVTPAPAHLAELRKPLGLLEVDPDKARRVSEALEGRFALAASESLEWTLSLPRTDVLAAARM
GPSAHHTALDVLAARVAGLDEPVRVSAAVQVQVYRPAASAA

Sequences:

>Translated_281_residues
MLPEILRHLRCPVCRAPLTAVPGAVRCPAGHAFDLARQGYVNLLRGRSPGTGDDADMVAAREAFLGAGHFAPLGAALARA
AQAHAGPDGIVLEVGAGTGHHLRSVLEALPDRFGLALDLSRHAARRAARAHPRLGAVVADAWEPLPIADACAALVLDVFA
PRNVAEFRRVLAPGGALLLVTPAPAHLAELRKPLGLLEVDPDKARRVSEALEGRFALAASESLEWTLSLPRTDVLAAARM
GPSAHHTALDVLAARVAGLDEPVRVSAAVQVQVYRPAASAA
>Mature_281_residues
MLPEILRHLRCPVCRAPLTAVPGAVRCPAGHAFDLARQGYVNLLRGRSPGTGDDADMVAAREAFLGAGHFAPLGAALARA
AQAHAGPDGIVLEVGAGTGHHLRSVLEALPDRFGLALDLSRHAARRAARAHPRLGAVVADAWEPLPIADACAALVLDVFA
PRNVAEFRRVLAPGGALLLVTPAPAHLAELRKPLGLLEVDPDKARRVSEALEGRFALAASESLEWTLSLPRTDVLAAARM
GPSAHHTALDVLAARVAGLDEPVRVSAAVQVQVYRPAASAA

Specific function: Confers strong resistance to mycinamicin (MM) and tylosin (TY). May function as methyltransferase [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=240, Percent_Identity=35.4166666666667, Blast_Score=135, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.51 [C]

Molecular weight: Translated: 29303; Mature: 29303

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPEILRHLRCPVCRAPLTAVPGAVRCPAGHAFDLARQGYVNLLRGRSPGTGDDADMVAA
CCHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
REAFLGAGHFAPLGAALARAAQAHAGPDGIVLEVGAGTGHHLRSVLEALPDRFGLALDLS
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHH
RHAARRAARAHPRLGAVVADAWEPLPIADACAALVLDVFAPRNVAEFRRVLAPGGALLLV
HHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEE
TPAPAHLAELRKPLGLLEVDPDKARRVSEALEGRFALAASESLEWTLSLPRTDVLAAARM
CCCCHHHHHHHCCCCCEEECHHHHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHC
GPSAHHTALDVLAARVAGLDEPVRVSAAVQVQVYRPAASAA
CCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MLPEILRHLRCPVCRAPLTAVPGAVRCPAGHAFDLARQGYVNLLRGRSPGTGDDADMVAA
CCHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
REAFLGAGHFAPLGAALARAAQAHAGPDGIVLEVGAGTGHHLRSVLEALPDRFGLALDLS
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHH
RHAARRAARAHPRLGAVVADAWEPLPIADACAALVLDVFAPRNVAEFRRVLAPGGALLLV
HHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEE
TPAPAHLAELRKPLGLLEVDPDKARRVSEALEGRFALAASESLEWTLSLPRTDVLAAARM
CCCCHHHHHHHCCCCCEEECHHHHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHC
GPSAHHTALDVLAARVAGLDEPVRVSAAVQVQVYRPAASAA
CCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Unidentified protein factor B [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; rRNA [C]

Specific reaction: S-Adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

General reaction: Methyl group transfer [C]

Inhibitor: Mg2+; Unidentified protein factor A1 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8163173 [H]