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The map label for this gene is ampC [C]

Identifier: 220916760

GI number: 220916760

Start: 1848095

End: 1849342

Strand: Direct

Name: ampC [C]

Synonym: A2cp1_1655

Alternate gene names: 220916760

Gene position: 1848095-1849342 (Clockwise)

Preceding gene: 220916755

Following gene: 220916761

Centisome position: 36.75

GC content: 75.16

Gene sequence:

>1248_bases
ATGGCGGGTTCGATCGCGGCGTCGCTGAGGGCGCACGGCAGGTTGCGGGCACAGGAGCTCCGCGTCGCTGGCCTGGTCCG
TCCGGGCTTCGAGGCGGTGCGGCAGGCGTTCGAGGAGAACTTCGAGCGGCGCGGCGAGCTGGGCGCTGCCTGCGCGGTCT
ACCTGCGCGGCGAGAAGGTCGTGGACCTCTGGGGCGGCGTCCGCGACGCGGCGACCTGCGAGCCGTGGCGGGAGGACACC
ATGGCCCTGGTGTTCTCCGCGACGAAGGGCCTGGCGAGCCTCGCCATCGCGCTCGCCCATTCCCGCGGGCTGATCGACTT
CGACGAGCGGGTGAGCACGTACTGGCCGGAGTTCGCGCAGGCGGGGAAGGGCGCCATCACGGTCCGGCAGCTGCTCGCGC
ACCAGGCCGGCCTGTTCGCGCTCGACGAGCGGCCGGACGCAAGGCTCGTCGCGGATCCGGAGCGGCTGGCCGCGGTCCTC
GCCCGGCAGAAGCCGGCCTGGCCCGCCGGGACGCGGCAGGCGTACCACGCGATCACCGTGGGCCTCTACCAGGGCGAGCT
GCTGCGCCGGGTCGACCCGGCGCGCCGGACGCTGGGCCGCTTCTTCCAGGAGGAGCTGGCGACGCCGCTCGGGCTCGAGT
TCTACATCCGGCTCCCGCCGTCGATCCCGGACGCGAGGCTCGCGCCGCTGTTCCGATCCGGGCGCATGCCGCTCCGCATG
CTCCTCACCATGCCCCCCGCGCTCGCGATCGCCGGCATGAACCCGCGCTCGCGCCTGCGCCGCGCGCTGCAGGGCTCCGA
GCTGCCGGAGCAGTGCGCACGCGGCGTCTACGCGCGCGACCTGGAGATCCCGGCGGGCGGCGGGGTGGGGACGGCGCGCG
CCATGGCGCGGGCGTACGGGGTGTTCGCGGCCGGCGGGAAGGAACTCGGCCTGCGAGAGGAGACGCTGCGGCAGCTCATG
GCGCCCCCGGTGCGGCCGGTGCGCGGGTTCCGGGACGCGTGCCTGAAGGTGGAGATCGCCTACGCGCTGGGGTTCGCGAA
GCCGAGCGCCGGGTACCCGTGGGGCCACCCGAGCGCGTTCGGCGCGCCGGGCGCGGGCGGGTCCTTCGGCTTCGCGGATC
CGCACGCCGGGATCGGCTTCGGCTACGTCCCCAACCGGATGGGCATGCACCTCGACGATCCGAGGGCGGCCGCGCTGCGG
CGCGCGGTGTACGGATCGATCGGCGTCGAGGACCCGTACCGCGGCTGA

Upstream 100 bases:

>100_bases
CACGCCGCCGCTCCTCGTCGAGGCCGTGACCCTCGGCCCGATTGACGCGCCGGCGCCGTCGCGGGGGAATGGCTCCGCGC
GCATGCGCGAGGAGGGCGCC

Downstream 100 bases:

>100_bases
GGGGGCTCGAGGAAGCGCATGCGCACCGAGCTGGAGAAGATGCTGGCGGGGGAGTCGTACGCCCCGCCCGGCGTGAGGGT
CGGCGCGAGGAGCGTCATCG

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Beta-Lactamase Class C; Esterase/Lipase LipP; Esterase A; Esterase/Lipase/Beta-Lactamase; Lactone Hydrolase; Esterase LipL; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Beta-Lactamase Family Protein; Fusion Of Enoyl-CoA Hydratase; Beta-Lactamase-Like Protein; Lipase LipE; Beta-Lactamase Protein; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; Beta-Lactamase Family

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAGSIAASLRAHGRLRAQELRVAGLVRPGFEAVRQAFEENFERRGELGAACAVYLRGEKVVDLWGGVRDAATCEPWREDT
MALVFSATKGLASLAIALAHSRGLIDFDERVSTYWPEFAQAGKGAITVRQLLAHQAGLFALDERPDARLVADPERLAAVL
ARQKPAWPAGTRQAYHAITVGLYQGELLRRVDPARRTLGRFFQEELATPLGLEFYIRLPPSIPDARLAPLFRSGRMPLRM
LLTMPPALAIAGMNPRSRLRRALQGSELPEQCARGVYARDLEIPAGGGVGTARAMARAYGVFAAGGKELGLREETLRQLM
APPVRPVRGFRDACLKVEIAYALGFAKPSAGYPWGHPSAFGAPGAGGSFGFADPHAGIGFGYVPNRMGMHLDDPRAAALR
RAVYGSIGVEDPYRG

Sequences:

>Translated_415_residues
MAGSIAASLRAHGRLRAQELRVAGLVRPGFEAVRQAFEENFERRGELGAACAVYLRGEKVVDLWGGVRDAATCEPWREDT
MALVFSATKGLASLAIALAHSRGLIDFDERVSTYWPEFAQAGKGAITVRQLLAHQAGLFALDERPDARLVADPERLAAVL
ARQKPAWPAGTRQAYHAITVGLYQGELLRRVDPARRTLGRFFQEELATPLGLEFYIRLPPSIPDARLAPLFRSGRMPLRM
LLTMPPALAIAGMNPRSRLRRALQGSELPEQCARGVYARDLEIPAGGGVGTARAMARAYGVFAAGGKELGLREETLRQLM
APPVRPVRGFRDACLKVEIAYALGFAKPSAGYPWGHPSAFGAPGAGGSFGFADPHAGIGFGYVPNRMGMHLDDPRAAALR
RAVYGSIGVEDPYRG
>Mature_414_residues
AGSIAASLRAHGRLRAQELRVAGLVRPGFEAVRQAFEENFERRGELGAACAVYLRGEKVVDLWGGVRDAATCEPWREDTM
ALVFSATKGLASLAIALAHSRGLIDFDERVSTYWPEFAQAGKGAITVRQLLAHQAGLFALDERPDARLVADPERLAAVLA
RQKPAWPAGTRQAYHAITVGLYQGELLRRVDPARRTLGRFFQEELATPLGLEFYIRLPPSIPDARLAPLFRSGRMPLRML
LTMPPALAIAGMNPRSRLRRALQGSELPEQCARGVYARDLEIPAGGGVGTARAMARAYGVFAAGGKELGLREETLRQLMA
PPVRPVRGFRDACLKVEIAYALGFAKPSAGYPWGHPSAFGAPGAGGSFGFADPHAGIGFGYVPNRMGMHLDDPRAAALRR
AVYGSIGVEDPYRG

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI17538001, Length=416, Percent_Identity=32.4519230769231, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17535191, Length=401, Percent_Identity=32.1695760598504, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71983659, Length=398, Percent_Identity=31.6582914572864, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71983666, Length=301, Percent_Identity=34.5514950166113, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538474, Length=396, Percent_Identity=30.8080808080808, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17535177, Length=303, Percent_Identity=32.6732673267327, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71990590, Length=392, Percent_Identity=26.2755102040816, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 44877; Mature: 44746

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSIAASLRAHGRLRAQELRVAGLVRPGFEAVRQAFEENFERRGELGAACAVYLRGEKV
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
VDLWGGVRDAATCEPWREDTMALVFSATKGLASLAIALAHSRGLIDFDERVSTYWPEFAQ
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHH
AGKGAITVRQLLAHQAGLFALDERPDARLVADPERLAAVLARQKPAWPAGTRQAYHAITV
CCCCHHHHHHHHHHHCCCEEECCCCCCCEEECHHHHHHHHHHCCCCCCCCCHHHHHHHEE
GLYQGELLRRVDPARRTLGRFFQEELATPLGLEFYIRLPPSIPDARLAPLFRSGRMPLRM
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHH
LLTMPPALAIAGMNPRSRLRRALQGSELPEQCARGVYARDLEIPAGGGVGTARAMARAYG
HHHCCCHHEEECCCHHHHHHHHHCCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHH
VFAAGGKELGLREETLRQLMAPPVRPVRGFRDACLKVEIAYALGFAKPSAGYPWGHPSAF
HHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEHHHHCCCCCCCCCCCCCCCCC
GAPGAGGSFGFADPHAGIGFGYVPNRMGMHLDDPRAAALRRAVYGSIGVEDPYRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AGSIAASLRAHGRLRAQELRVAGLVRPGFEAVRQAFEENFERRGELGAACAVYLRGEKV
CCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
VDLWGGVRDAATCEPWREDTMALVFSATKGLASLAIALAHSRGLIDFDERVSTYWPEFAQ
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHH
AGKGAITVRQLLAHQAGLFALDERPDARLVADPERLAAVLARQKPAWPAGTRQAYHAITV
CCCCHHHHHHHHHHHCCCEEECCCCCCCEEECHHHHHHHHHHCCCCCCCCCHHHHHHHEE
GLYQGELLRRVDPARRTLGRFFQEELATPLGLEFYIRLPPSIPDARLAPLFRSGRMPLRM
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHH
LLTMPPALAIAGMNPRSRLRRALQGSELPEQCARGVYARDLEIPAGGGVGTARAMARAYG
HHHCCCHHEEECCCHHHHHHHHHCCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHH
VFAAGGKELGLREETLRQLMAPPVRPVRGFRDACLKVEIAYALGFAKPSAGYPWGHPSAF
HHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEHHHHCCCCCCCCCCCCCCCCC
GAPGAGGSFGFADPHAGIGFGYVPNRMGMHLDDPRAAALRRAVYGSIGVEDPYRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA