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The map label for this gene is mutS2 [H]

Identifier: 220916642

GI number: 220916642

Start: 1716061

End: 1718451

Strand: Reverse

Name: mutS2 [H]

Synonym: A2cp1_1536

Alternate gene names: 220916642

Gene position: 1718451-1716061 (Counterclockwise)

Preceding gene: 220916644

Following gene: 220916641

Centisome position: 34.17

GC content: 77.79

Gene sequence:

>2391_bases
ATGCGCGCCGAAGACACGCTGAACGAGCTGGGCTGGCCGTGGATCCTGGAGGCGCTGGCGGGCCGCTGCCGGCTGCCGGC
GGGGCGCCGCCAGGCCGCCGCCCTCCCCTTCCTGCCGGACGCGCCCGCCGTCCGCGAGGCGCTGGCGCGGGTGGGCGAGG
CGCGCGCGCTCTCGGAGGCGGGCACGTCGCTGCCGCTCGGCGGCGTCGCCGACGTGGAGCCGCACCTCGACCGCGCGGCC
AAGGGCGGCGTGCTCGAGCCGCTCGCGCTCCGCGAGTGCGCCGGGCTCGCCCGCGCCGCCGCCCGCACCCGGGCCACGCT
GGAGCCGCGCGCGGCCGAGCTCCCGCGGCTGTGGGCGCTCGCCGAGGCGCTCTCGCCGAGCGCGGGGGTGGCGGATCGCA
TCGAGCGCGCCATCGAGCCGGACGGGTCGATCTCCGACCGCGCCAGCCCGGCCCTCGCCGCCGCGCGCGACCGCTCCCGC
GGGCTGCACCGCGCCCTGAAGGCCCAGGTCGAGGCGCTGCTCGACGACGGCGACATGCAGCGCAACCTGCGCGACCGCTA
CTTCACCATCCGCAACGACCGCTACGTGCTCCCGGTGCTGGCGAGCGCGCGCGGGCAGGTCCCGGGCATCGTCCACAACG
CCTCGCAGTCCGGCCAGACGCTGTTCGTGGAGCCGGACTCGATGGTGGAGCTCGGCAACGAGCTGTCCATCGCGAACGCC
ATGGCCGCCGAGGAGGAGCAGCGCATCCTCCGCGAGCTGTCGCAGGCGCTCACCGCCGGCGCCGGCGCGCTGGCGCGCGA
CCTCCAGCTGCTGGCCCGCCTCGACCTGCTCGAGGCGGAGGCCCGGCTCGCGTCGGATCTCGACGCGCACGCGCCGGAGG
TGGGCCCGGAGCCGGCCGGCTTCGAGCTGCTCTCGCTCCGCCACCCGCTGCTCGTGCTGCAGGCCAAGAAGGTGGTGGCC
AGCCACGTGCGCCTCTCGCCCCCGCAGCGCGCGCTCATCGTCTCCGGCCCGAACGGCGGCGGCAAGACGGTGGCCATCAC
CGCGGTGGGCCTCTCGGCGCTCATGCTGCGCGCCGGCCTGCCGGTGGCGGCCGCCGAGGGCTCGCGCCTCCCGTTCTACC
TGGAGGTGAAGGCGGCGGTGGACGAGCGCGGCGACCTCACCAAGGACCTGTCCACCTTCACCGCGCACCTCACCGCGGTG
AAGGACATGCTGGCCGGCGCGGTGCCGGGCTCGTTGATCCTGGTGGACGAGATCGCCGCCGACACCGATCCGCGCGAGGG
CGCCGCGCTCGCCGCGGCGATCCTCGAGGCGCTGGTCGAGCGCGGGGCCACCGTGCTCGTCACCACCCACCTCGACGAGC
TGAAGGCGCTCGCGCTCACCGACGCCCGCTACGGCAACGCCCGCGTCGGCTTCGACGCGGAGCGGCTGGTGCCCACCTAC
CAGGTGCACCTGGGCGCGCCGGGCAGCTCGTCGGCCATCGAGGTCGCGGCGCGGGTCGGGCTGCCGCCCGCGGTGGTGGA
GCGGGCGCGCGCGGCGCGGCACGGCCAGGGCGGCGCGCTGGGCGAGGCGCTCCGCGCGCTCGACGACGAGCGCGGCCGGC
TCGCGGCCGAGCGGCGCGGCGCAGAGGAGGCGCGCGCCGCGGCCCGGGCGGCCGAGCAGCGCGCGCGGGCGGCGGAGGAG
GCGGCGCGGCGGGCGGAGCGCGACGCGGGCGCGCGCATGGGCGCGGCGCTGGCGGAGGAGATCGAGGCGGCGCGCGCCGA
GGTGGCCGAGCTCATGGCCGAGCTGCAGGCGCAGCCCAGCGTGAAGAAGGCGGCCGAGTCGAAGGCGCGGCTCGACGCGT
GGCACGCCACGGTCTCGCAGGCCGCGGAGGCCACGCGCGCCCGCGCCGAGGCCGGCCCGGAGGCGCTGCCCGGCGGCGAG
CTGAAGCCGGGCGCGCGGGTGCGGATCCTGTCGCTCGGGCAGGAGGGCGAGGTCGTCGAGGTGGACGGCAAGGACGCGCT
GGTGCGCGCCGGGCCGCTCAAGATTCGCCGCCCGGTGAAGGACCTGCTGGCGCTCGCCGGCAAGGCGCGCGACGCGGGGC
TCGCTCGCACGCGGGGGGAGAAGCTCGCGGCCGCGAGCGCGGCGCGGCCGGACGCGCCGGTGAGCGCCGAGCGCCGCCTC
GACGCGCGCGGCCTGCGCGTGGAGGAGCTGCTGCGCGAGGTCGATCGCTTCCTCGACCGCATGTACTCGGACGGTGAAGC
CGAGTGCGTGGTGCTGCACGGCCACGGCACCGGGGCGCTGAAGCAGGCGCTGCGGGATCACCTTGCCGCATCCCCTTACG
TGGGAGCCTCCCGTTCCGGCGATCGGCACGAGGGCGGCGATGCGGTGACGGTGATCGGCCTCCGCCGCTAG

Upstream 100 bases:

>100_bases
GCGCATCACGCGCATGATAACCCCGGGGACCGCTCGCCCCTTCCCCCGGCGCGCGCCGGCCCTGGCGCGCCGCCGCCAGG
CGCGGTAGGTCACGGCCCGC

Downstream 100 bases:

>100_bases
CAGGTCGCGGGACCTCTGGAAGATCGCGCACTTGACGGAGTGCGGCACGAACGCGCAGTCCCTGCGCGGGTGCAAGATTT
GCCGACCGGAACAACAATTC

Product: Smr protein/MutS2

Products: ADP; phosphate; H+

Alternate protein names: NA

Number of amino acids: Translated: 796; Mature: 796

Protein sequence:

>796_residues
MRAEDTLNELGWPWILEALAGRCRLPAGRRQAAALPFLPDAPAVREALARVGEARALSEAGTSLPLGGVADVEPHLDRAA
KGGVLEPLALRECAGLARAAARTRATLEPRAAELPRLWALAEALSPSAGVADRIERAIEPDGSISDRASPALAAARDRSR
GLHRALKAQVEALLDDGDMQRNLRDRYFTIRNDRYVLPVLASARGQVPGIVHNASQSGQTLFVEPDSMVELGNELSIANA
MAAEEEQRILRELSQALTAGAGALARDLQLLARLDLLEAEARLASDLDAHAPEVGPEPAGFELLSLRHPLLVLQAKKVVA
SHVRLSPPQRALIVSGPNGGGKTVAITAVGLSALMLRAGLPVAAAEGSRLPFYLEVKAAVDERGDLTKDLSTFTAHLTAV
KDMLAGAVPGSLILVDEIAADTDPREGAALAAAILEALVERGATVLVTTHLDELKALALTDARYGNARVGFDAERLVPTY
QVHLGAPGSSSAIEVAARVGLPPAVVERARAARHGQGGALGEALRALDDERGRLAAERRGAEEARAAARAAEQRARAAEE
AARRAERDAGARMGAALAEEIEAARAEVAELMAELQAQPSVKKAAESKARLDAWHATVSQAAEATRARAEAGPEALPGGE
LKPGARVRILSLGQEGEVVEVDGKDALVRAGPLKIRRPVKDLLALAGKARDAGLARTRGEKLAAASAARPDAPVSAERRL
DARGLRVEELLREVDRFLDRMYSDGEAECVVLHGHGTGALKQALRDHLAASPYVGASRSGDRHEGGDAVTVIGLRR

Sequences:

>Translated_796_residues
MRAEDTLNELGWPWILEALAGRCRLPAGRRQAAALPFLPDAPAVREALARVGEARALSEAGTSLPLGGVADVEPHLDRAA
KGGVLEPLALRECAGLARAAARTRATLEPRAAELPRLWALAEALSPSAGVADRIERAIEPDGSISDRASPALAAARDRSR
GLHRALKAQVEALLDDGDMQRNLRDRYFTIRNDRYVLPVLASARGQVPGIVHNASQSGQTLFVEPDSMVELGNELSIANA
MAAEEEQRILRELSQALTAGAGALARDLQLLARLDLLEAEARLASDLDAHAPEVGPEPAGFELLSLRHPLLVLQAKKVVA
SHVRLSPPQRALIVSGPNGGGKTVAITAVGLSALMLRAGLPVAAAEGSRLPFYLEVKAAVDERGDLTKDLSTFTAHLTAV
KDMLAGAVPGSLILVDEIAADTDPREGAALAAAILEALVERGATVLVTTHLDELKALALTDARYGNARVGFDAERLVPTY
QVHLGAPGSSSAIEVAARVGLPPAVVERARAARHGQGGALGEALRALDDERGRLAAERRGAEEARAAARAAEQRARAAEE
AARRAERDAGARMGAALAEEIEAARAEVAELMAELQAQPSVKKAAESKARLDAWHATVSQAAEATRARAEAGPEALPGGE
LKPGARVRILSLGQEGEVVEVDGKDALVRAGPLKIRRPVKDLLALAGKARDAGLARTRGEKLAAASAARPDAPVSAERRL
DARGLRVEELLREVDRFLDRMYSDGEAECVVLHGHGTGALKQALRDHLAASPYVGASRSGDRHEGGDAVTVIGLRR
>Mature_796_residues
MRAEDTLNELGWPWILEALAGRCRLPAGRRQAAALPFLPDAPAVREALARVGEARALSEAGTSLPLGGVADVEPHLDRAA
KGGVLEPLALRECAGLARAAARTRATLEPRAAELPRLWALAEALSPSAGVADRIERAIEPDGSISDRASPALAAARDRSR
GLHRALKAQVEALLDDGDMQRNLRDRYFTIRNDRYVLPVLASARGQVPGIVHNASQSGQTLFVEPDSMVELGNELSIANA
MAAEEEQRILRELSQALTAGAGALARDLQLLARLDLLEAEARLASDLDAHAPEVGPEPAGFELLSLRHPLLVLQAKKVVA
SHVRLSPPQRALIVSGPNGGGKTVAITAVGLSALMLRAGLPVAAAEGSRLPFYLEVKAAVDERGDLTKDLSTFTAHLTAV
KDMLAGAVPGSLILVDEIAADTDPREGAALAAAILEALVERGATVLVTTHLDELKALALTDARYGNARVGFDAERLVPTY
QVHLGAPGSSSAIEVAARVGLPPAVVERARAARHGQGGALGEALRALDDERGRLAAERRGAEEARAAARAAEQRARAAEE
AARRAERDAGARMGAALAEEIEAARAEVAELMAELQAQPSVKKAAESKARLDAWHATVSQAAEATRARAEAGPEALPGGE
LKPGARVRILSLGQEGEVVEVDGKDALVRAGPLKIRRPVKDLLALAGKARDAGLARTRGEKLAAASAARPDAPVSAERRL
DARGLRVEELLREVDRFLDRMYSDGEAECVVLHGHGTGALKQALRDHLAASPYVGASRSGDRHEGGDAVTVIGLRR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI26638666, Length=281, Percent_Identity=30.6049822064057, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4505253, Length=281, Percent_Identity=30.6049822064057, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI26638664, Length=282, Percent_Identity=30.4964539007092, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI262231786, Length=254, Percent_Identity=29.9212598425197, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI4557761, Length=287, Percent_Identity=27.5261324041812, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI36949366, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI284813531, Length=281, Percent_Identity=25.2669039145907, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1789089, Length=275, Percent_Identity=33.4545454545455, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=274, Percent_Identity=24.4525547445255, Blast_Score=76, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17539736, Length=350, Percent_Identity=23.7142857142857, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324482, Length=314, Percent_Identity=28.0254777070064, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321912, Length=317, Percent_Identity=25.5520504731861, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319935, Length=345, Percent_Identity=22.3188405797101, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24584320, Length=279, Percent_Identity=30.8243727598566, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: 3.6.3.14

Molecular weight: Translated: 83746; Mature: 83746

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAEDTLNELGWPWILEALAGRCRLPAGRRQAAALPFLPDAPAVREALARVGEARALSEA
CCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GTSLPLGGVADVEPHLDRAAKGGVLEPLALRECAGLARAAARTRATLEPRAAELPRLWAL
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AEALSPSAGVADRIERAIEPDGSISDRASPALAAARDRSRGLHRALKAQVEALLDDGDMQ
HHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RNLRDRYFTIRNDRYVLPVLASARGQVPGIVHNASQSGQTLFVEPDSMVELGNELSIANA
HHHHHCEEEECCCCEEEEEHHCCCCCCCCEEECCCCCCCEEEECCHHHHHCCCCHHHHHH
MAAEEEQRILRELSQALTAGAGALARDLQLLARLDLLEAEARLASDLDAHAPEVGPEPAG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FELLSLRHPLLVLQAKKVVASHVRLSPPQRALIVSGPNGGGKTVAITAVGLSALMLRAGL
CHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCCC
PVAAAEGSRLPFYLEVKAAVDERGDLTKDLSTFTAHLTAVKDMLAGAVPGSLILVDEIAA
CEEECCCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHC
DTDPREGAALAAAILEALVERGATVLVTTHLDELKALALTDARYGNARVGFDAERLVPTY
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHCCCEE
QVHLGAPGSSSAIEVAARVGLPPAVVERARAARHGQGGALGEALRALDDERGRLAAERRG
EEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCC
AEEARAAARAAEQRARAAEEAARRAERDAGARMGAALAEEIEAARAEVAELMAELQAQPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VKKAAESKARLDAWHATVSQAAEATRARAEAGPEALPGGELKPGARVRILSLGQEGEVVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEE
VDGKDALVRAGPLKIRRPVKDLLALAGKARDAGLARTRGEKLAAASAARPDAPVSAERRL
ECCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHCCCCCCCCCCHHHHH
DARGLRVEELLREVDRFLDRMYSDGEAECVVLHGHGTGALKQALRDHLAASPYVGASRSG
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
DRHEGGDAVTVIGLRR
CCCCCCCEEEEEEECC
>Mature Secondary Structure
MRAEDTLNELGWPWILEALAGRCRLPAGRRQAAALPFLPDAPAVREALARVGEARALSEA
CCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GTSLPLGGVADVEPHLDRAAKGGVLEPLALRECAGLARAAARTRATLEPRAAELPRLWAL
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AEALSPSAGVADRIERAIEPDGSISDRASPALAAARDRSRGLHRALKAQVEALLDDGDMQ
HHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RNLRDRYFTIRNDRYVLPVLASARGQVPGIVHNASQSGQTLFVEPDSMVELGNELSIANA
HHHHHCEEEECCCCEEEEEHHCCCCCCCCEEECCCCCCCEEEECCHHHHHCCCCHHHHHH
MAAEEEQRILRELSQALTAGAGALARDLQLLARLDLLEAEARLASDLDAHAPEVGPEPAG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FELLSLRHPLLVLQAKKVVASHVRLSPPQRALIVSGPNGGGKTVAITAVGLSALMLRAGL
CHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCCC
PVAAAEGSRLPFYLEVKAAVDERGDLTKDLSTFTAHLTAVKDMLAGAVPGSLILVDEIAA
CEEECCCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHC
DTDPREGAALAAAILEALVERGATVLVTTHLDELKALALTDARYGNARVGFDAERLVPTY
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHCCCEE
QVHLGAPGSSSAIEVAARVGLPPAVVERARAARHGQGGALGEALRALDDERGRLAAERRG
EEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCC
AEEARAAARAAEQRARAAEEAARRAERDAGARMGAALAEEIEAARAEVAELMAELQAQPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VKKAAESKARLDAWHATVSQAAEATRARAEAGPEALPGGELKPGARVRILSLGQEGEVVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEE
VDGKDALVRAGPLKIRRPVKDLLALAGKARDAGLARTRGEKLAAASAARPDAPVSAERRL
ECCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHCCCCCCCCCCHHHHH
DARGLRVEELLREVDRFLDRMYSDGEAECVVLHGHGTGALKQALRDHLAASPYVGASRSG
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
DRHEGGDAVTVIGLRR
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA