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The map label for this gene is capL [H]

Identifier: 220916586

GI number: 220916586

Start: 1651694

End: 1653040

Strand: Reverse

Name: capL [H]

Synonym: A2cp1_1480

Alternate gene names: 220916586

Gene position: 1653040-1651694 (Counterclockwise)

Preceding gene: 220916587

Following gene: 220916585

Centisome position: 32.87

GC content: 72.9

Gene sequence:

>1347_bases
ATGATCGAGACCCACGCCGCCGAGCCCGACCACGCCACCGACCTGCTCTCCCGCCTCGCCGCCCGCACCGCCCGGGTGGC
GGTGGTGGGGCTCGGCTACGTCGGCCTGCCGCTCGCCCTCACCTTCGCCCGCCGCGGCCTGTCCGCGCTGGGCGTGGACG
TCGATCCGGACAAGGCGCGCGCGGTGGGCGAGGGGCGCAGCTACCTGCGGACCGTGGACGGCGCCGCGGTGCGCGACGCG
GTGCGGGACGGCCGCCTCGAGGCCACCACCGAGTTCGCCCGCGTGACCGCCTGCGACGCGGTGGTGATCTGCGTGCCCAC
GCCGCTCACCCGGGAGCGCGAGCCGGACCTGTCCTTCGTCGAGCGGACCGGCGAGGCGATCGCGCCGCACCTCCGCGCGG
GCCAGGCGGTGGTGCTCGAGTCCACCTCGTACCCGGGCACCACCGAGGAGGTGCTGCTGCCCATCCTGGAGCGCGGCAGC
GGGCTGCGCGCGGGGCGCGACTTCTTCCTGGCGTTCTCGCCCGAGCGCGAGGACCCCGGCTCGGGCGTGGCCACCCACGC
CATCCCCAAGATCGTCGGCGGCTACACGCCGTCGTGCCTCGAGGCGGCGCTCGCGCTCTACGCGTCGGCGTTCGACCGCG
TGGTGCCGGTCTCGTCCACCCGGGTGGCCGAGATGACGAAGCTGCTCGAGAACGTGTTCCGCAGCGTGAACATCGCGCTG
GTGAACGAGCTGAAGATCCTCTGCCACCGGATGGACCTGGACGTGAACGAGGTCATCGACGCCGCGTCCACCAAGCCGTT
CGGCTTCATGCCGTTCCAGCCCGGCCCGGGCCTGGGCGGCCACTGCATCCCCATCGACCCGTTCTACCTGACGTGGAAGG
CGCGGCAGTTCGAGTTCCAGACGCGCTTCATCGAGCTGGCCGGCGAGGTGAACACCGAGATGCCGCGCTACGTGGTGCAC
CGGACCATGGAGGCGCTCGACGCGCGCGGCCGCACGCTGAAGGGCGCGAAGGTGCTGGTGCTGGGCATCGCCTACAAGAA
GGACGTGGACGACATGCGCGAGAGCCCGGCGGTCCGCATCATCGAGCTCCTGCAGGAGCGCGGCGCGGAGGTGGTCTACC
ACGACCCCTACGTCCCCCGGGTCCCGCGCATGCGCCAGCACCGGCTCGACATGGTCAGCGTGCCGCTCACCGACGAGGCG
CTCGAGACCGCCGACGCGGTGCTGGTCGCCACCGACCACGGCTGCGTGGACTACGCGCGCGTGGTGGAGCGCGCCCGCCT
GGTGGTGGACACGCGCAACGCCTGCCGCGCGGTGCGCGTCGGGCGCGAGAGGATCGTGAAGGCCTGA

Upstream 100 bases:

>100_bases
TCGTCCCCGCGTCCGTCGCGACGCTGGCCGGCCCGCTGGCCTGTCCGGCCGCGCTCGCCACGCTGTTCCTCCACGTCGAA
GCCGAAGGGAGTCACCCCCG

Downstream 100 bases:

>100_bases
GCGGGCCCGGCCCGGCGGACCCGCGGGGCGCTCGCCGCGGGATGCGGTGAAGCGCGGGCGCTGGGCCCGTGCTACATGGG
CGGGATCAGGCTCCCGAGGT

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MIETHAAEPDHATDLLSRLAARTARVAVVGLGYVGLPLALTFARRGLSALGVDVDPDKARAVGEGRSYLRTVDGAAVRDA
VRDGRLEATTEFARVTACDAVVICVPTPLTREREPDLSFVERTGEAIAPHLRAGQAVVLESTSYPGTTEEVLLPILERGS
GLRAGRDFFLAFSPEREDPGSGVATHAIPKIVGGYTPSCLEAALALYASAFDRVVPVSSTRVAEMTKLLENVFRSVNIAL
VNELKILCHRMDLDVNEVIDAASTKPFGFMPFQPGPGLGGHCIPIDPFYLTWKARQFEFQTRFIELAGEVNTEMPRYVVH
RTMEALDARGRTLKGAKVLVLGIAYKKDVDDMRESPAVRIIELLQERGAEVVYHDPYVPRVPRMRQHRLDMVSVPLTDEA
LETADAVLVATDHGCVDYARVVERARLVVDTRNACRAVRVGRERIVKA

Sequences:

>Translated_448_residues
MIETHAAEPDHATDLLSRLAARTARVAVVGLGYVGLPLALTFARRGLSALGVDVDPDKARAVGEGRSYLRTVDGAAVRDA
VRDGRLEATTEFARVTACDAVVICVPTPLTREREPDLSFVERTGEAIAPHLRAGQAVVLESTSYPGTTEEVLLPILERGS
GLRAGRDFFLAFSPEREDPGSGVATHAIPKIVGGYTPSCLEAALALYASAFDRVVPVSSTRVAEMTKLLENVFRSVNIAL
VNELKILCHRMDLDVNEVIDAASTKPFGFMPFQPGPGLGGHCIPIDPFYLTWKARQFEFQTRFIELAGEVNTEMPRYVVH
RTMEALDARGRTLKGAKVLVLGIAYKKDVDDMRESPAVRIIELLQERGAEVVYHDPYVPRVPRMRQHRLDMVSVPLTDEA
LETADAVLVATDHGCVDYARVVERARLVVDTRNACRAVRVGRERIVKA
>Mature_448_residues
MIETHAAEPDHATDLLSRLAARTARVAVVGLGYVGLPLALTFARRGLSALGVDVDPDKARAVGEGRSYLRTVDGAAVRDA
VRDGRLEATTEFARVTACDAVVICVPTPLTREREPDLSFVERTGEAIAPHLRAGQAVVLESTSYPGTTEEVLLPILERGS
GLRAGRDFFLAFSPEREDPGSGVATHAIPKIVGGYTPSCLEAALALYASAFDRVVPVSSTRVAEMTKLLENVFRSVNIAL
VNELKILCHRMDLDVNEVIDAASTKPFGFMPFQPGPGLGGHCIPIDPFYLTWKARQFEFQTRFIELAGEVNTEMPRYVVH
RTMEALDARGRTLKGAKVLVLGIAYKKDVDDMRESPAVRIIELLQERGAEVVYHDPYVPRVPRMRQHRLDMVSVPLTDEA
LETADAVLVATDHGCVDYARVVERARLVVDTRNACRAVRVGRERIVKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=375, Percent_Identity=25.3333333333333, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI296040438, Length=283, Percent_Identity=26.1484098939929, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI296040443, Length=198, Percent_Identity=29.7979797979798, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=36.7901234567901, Blast_Score=230, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17560350, Length=401, Percent_Identity=24.6882793017456, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136908, Length=373, Percent_Identity=24.1286863270777, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49060; Mature: 49060

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00720 RASGEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETHAAEPDHATDLLSRLAARTARVAVVGLGYVGLPLALTFARRGLSALGVDVDPDKAR
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHCCHHHCCCCCCCHHHH
AVGEGRSYLRTVDGAAVRDAVRDGRLEATTEFARVTACDAVVICVPTPLTREREPDLSFV
HHHCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH
ERTGEAIAPHLRAGQAVVLESTSYPGTTEEVLLPILERGSGLRAGRDFFLAFSPEREDPG
HHCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
SGVATHAIPKIVGGYTPSCLEAALALYASAFDRVVPVSSTRVAEMTKLLENVFRSVNIAL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VNELKILCHRMDLDVNEVIDAASTKPFGFMPFQPGPGLGGHCIPIDPFYLTWKARQFEFQ
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECHHHHHH
TRFIELAGEVNTEMPRYVVHRTMEALDARGRTLKGAKVLVLGIAYKKDVDDMRESPAVRI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEEEEHHHCCHHHHHCCCHHHH
IELLQERGAEVVYHDPYVPRVPRMRQHRLDMVSVPLTDEALETADAVLVATDHGCVDYAR
HHHHHHCCCEEEEECCCCCCCCCHHHHCCCEEECCCCHHHHHCCCEEEEEECCCHHHHHH
VVERARLVVDTRNACRAVRVGRERIVKA
HHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIETHAAEPDHATDLLSRLAARTARVAVVGLGYVGLPLALTFARRGLSALGVDVDPDKAR
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHCCHHHCCCCCCCHHHH
AVGEGRSYLRTVDGAAVRDAVRDGRLEATTEFARVTACDAVVICVPTPLTREREPDLSFV
HHHCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH
ERTGEAIAPHLRAGQAVVLESTSYPGTTEEVLLPILERGSGLRAGRDFFLAFSPEREDPG
HHCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
SGVATHAIPKIVGGYTPSCLEAALALYASAFDRVVPVSSTRVAEMTKLLENVFRSVNIAL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VNELKILCHRMDLDVNEVIDAASTKPFGFMPFQPGPGLGGHCIPIDPFYLTWKARQFEFQ
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECHHHHHH
TRFIELAGEVNTEMPRYVVHRTMEALDARGRTLKGAKVLVLGIAYKKDVDDMRESPAVRI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEEEEHHHCCHHHHHCCCHHHH
IELLQERGAEVVYHDPYVPRVPRMRQHRLDMVSVPLTDEALETADAVLVATDHGCVDYAR
HHHHHHCCCEEEEECCCCCCCCCHHHHCCCEEECCCCHHHHHCCCEEEEEECCCHHHHHH
VVERARLVVDTRNACRAVRVGRERIVKA
HHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]