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The map label for this gene is proC [H]

Identifier: 220916580

GI number: 220916580

Start: 1644587

End: 1645411

Strand: Reverse

Name: proC [H]

Synonym: A2cp1_1474

Alternate gene names: 220916580

Gene position: 1645411-1644587 (Counterclockwise)

Preceding gene: 220916581

Following gene: 220916579

Centisome position: 32.72

GC content: 74.67

Gene sequence:

>825_bases
ATGCCACTCGGGAAGAAGATCGCGTTCCTCGGGACGGGGAACATGGCCGAGGCCCTGGTGAAGGGCCTGCTGCGGGCCGG
GACCGCCAGCCGCGAGGAGATCCTCTGCTCGGAGCCGCGGGCCGAGCGGCGCGCGGAGATCCAGGCGCGCTACGGCGTGG
AGACCTCCGGGGACAACCGTGCCCTCGCCGAGCGGGCCGACATCGTGGTCATCTCGGTGAAGCCGCAGATCATCGAGCAC
CTGCTGGTGGAGATCGCCCCGGCCATCGACCACCGGAAGCTCGTGATCTCCATCGCGGCCGGCATCCCCATCCTCGCCAT
CGCCCGCAAGCTCGGCGCCGGAGTCCGCATCGTCCGCGTCATGCCCAACACGCCGGCGCTGGTGGGCGCGGGCGCGACCG
CGCTGGCCCGCGGCGCGCACGCCACCGACGCCGACCTGGAGCAGGCGCGCGCGCTGTTCCAGTCGGTCGGCACCACCGAG
GTGGTGGAGGAGCCGCTGCTCGACGCGGTGACCGGCCTCTCCGGCTCCGGCCCCGCGTTCGTGTTCCTCGCCATCGAGGC
GCTCGCCGACGGCGGCGTGAAGGTCGGCCTGGCGCGGCCGGTGGCGATGGCGCTCGCGGCGCAGACGGTGCTCGGCTCGG
CGAAGCTCGTGCTCGAGACCGGCGAGCACCCGGGGCGCCTCAAGGACCAGGTCACCAGCCCCGGCGGCACGGCCATCGCG
GGCGTCCACGCGCTGGAGGTGGGCGGGCTGCGCGCCGCGCTCATCGCCGCGGTGGAGGCCGCCACCCGCCGCTCCCGCGA
GCTGGGCGAGAAGGCGGCCAAGTGA

Upstream 100 bases:

>100_bases
GGGCAAGGACGAGATCTTCGAGCGCTTCACCCTGGGCCGATTCGAGTCCGGCGCGGTCGCCCGGGAGGACTTCATCATCG
GGTAGCGGTAATCTGCCCGG

Downstream 100 bases:

>100_bases
TCCGCCCCGGCGCCCGCACCGCCGCGCTCGCCGCCGCGCTCGCGCTGGCGGCCTGCCGCACCACCGCCGGCGCGGTGCTG
CGCGTCGATCCCCCGCCCTC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPLGKKIAFLGTGNMAEALVKGLLRAGTASREEILCSEPRAERRAEIQARYGVETSGDNRALAERADIVVISVKPQIIEH
LLVEIAPAIDHRKLVISIAAGIPILAIARKLGAGVRIVRVMPNTPALVGAGATALARGAHATDADLEQARALFQSVGTTE
VVEEPLLDAVTGLSGSGPAFVFLAIEALADGGVKVGLARPVAMALAAQTVLGSAKLVLETGEHPGRLKDQVTSPGGTAIA
GVHALEVGGLRAALIAAVEAATRRSRELGEKAAK

Sequences:

>Translated_274_residues
MPLGKKIAFLGTGNMAEALVKGLLRAGTASREEILCSEPRAERRAEIQARYGVETSGDNRALAERADIVVISVKPQIIEH
LLVEIAPAIDHRKLVISIAAGIPILAIARKLGAGVRIVRVMPNTPALVGAGATALARGAHATDADLEQARALFQSVGTTE
VVEEPLLDAVTGLSGSGPAFVFLAIEALADGGVKVGLARPVAMALAAQTVLGSAKLVLETGEHPGRLKDQVTSPGGTAIA
GVHALEVGGLRAALIAAVEAATRRSRELGEKAAK
>Mature_273_residues
PLGKKIAFLGTGNMAEALVKGLLRAGTASREEILCSEPRAERRAEIQARYGVETSGDNRALAERADIVVISVKPQIIEHL
LVEIAPAIDHRKLVISIAAGIPILAIARKLGAGVRIVRVMPNTPALVGAGATALARGAHATDADLEQARALFQSVGTTEV
VEEPLLDAVTGLSGSGPAFVFLAIEALADGGVKVGLARPVAMALAAQTVLGSAKLVLETGEHPGRLKDQVTSPGGTAIAG
VHALEVGGLRAALIAAVEAATRRSRELGEKAAK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=46.1254612546125, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=45.7875457875458, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=44.4444444444444, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=41.1111111111111, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=43.609022556391, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=48.8805970149254, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=37.5438596491228, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=33.0985915492958, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=47.940074906367, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=43.1654676258993, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=52.046783625731, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28131; Mature: 28000

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLGKKIAFLGTGNMAEALVKGLLRAGTASREEILCSEPRAERRAEIQARYGVETSGDNR
CCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCH
ALAERADIVVISVKPQIIEHLLVEIAPAIDHRKLVISIAAGIPILAIARKLGAGVRIVRV
HHHHHCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEHHCCCHHHHHHHHHCCCEEEEEE
MPNTPALVGAGATALARGAHATDADLEQARALFQSVGTTEVVEEPLLDAVTGLSGSGPAF
CCCCCCEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEE
VFLAIEALADGGVKVGLARPVAMALAAQTVLGSAKLVLETGEHPGRLKDQVTSPGGTAIA
EEEEHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCCCCEEH
GVHALEVGGLRAALIAAVEAATRRSRELGEKAAK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLGKKIAFLGTGNMAEALVKGLLRAGTASREEILCSEPRAERRAEIQARYGVETSGDNR
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCH
ALAERADIVVISVKPQIIEHLLVEIAPAIDHRKLVISIAAGIPILAIARKLGAGVRIVRV
HHHHHCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEHHCCCHHHHHHHHHCCCEEEEEE
MPNTPALVGAGATALARGAHATDADLEQARALFQSVGTTEVVEEPLLDAVTGLSGSGPAF
CCCCCCEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEE
VFLAIEALADGGVKVGLARPVAMALAAQTVLGSAKLVLETGEHPGRLKDQVTSPGGTAIA
EEEEHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCCCCEEH
GVHALEVGGLRAALIAAVEAATRRSRELGEKAAK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]