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The map label for this gene is dfrA [H]

Identifier: 220916435

GI number: 220916435

Start: 1480023

End: 1481006

Strand: Reverse

Name: dfrA [H]

Synonym: A2cp1_1329

Alternate gene names: 220916435

Gene position: 1481006-1480023 (Counterclockwise)

Preceding gene: 220916448

Following gene: 220916434

Centisome position: 29.45

GC content: 78.46

Gene sequence:

>984_bases
ATGGTTCACATCCGGGCGTCCATGCGAGCCCTCGTCACCGGCGCCGGCGGCTTCCTCGGCATGGCGCTGGTGCGCGCGCT
GGCCGCCCGCGGCGACCGCGTGCGCGCGCTGGTCCGTCGCCCGTCGGAGGCGCTCGCCCAGGCCGGCGCCGAGGTGATGG
TCGGGGACGCCACCGATCCGCGCGCGCTCCGCGCCGCCGTGGCCGGGCAGGAGCTGGTGTTCCACCTCGCCGGCGTGCGG
CGCGCCGCCGATCCGGAGGAGTTCCTGCGGGTGAACGCCGGCTCGACCCGGCTCGCGCTGGAGGCCTGCGTGGAGCGCGC
GCCCGGGCTCCGGCGCTTCGTGCTCGCCGGCTCGCGCGCCGCCTGCGCGCCGTCGCGCGAGCCCATCCGCGAGGACGCGC
CGCTCGCGCCGGTGGAGCCGTACGGCGCGTCCAAGGCCGAGGCGGAGCGCGTGGCGCTGTCGTTCGCGGCGCAGGTCCCG
GTGGCGATCGCGCGCCCGCCCCGGATCATGGGCCCCGGCGACCGCGAGAACCTGCTGTTCTTCAGGATCGCGCGGGCCAG
GCTCGCGCTCGACCTGGGCGACCGCCCGCTGTCCTGGATCGACGTGGACGACTGCGCCCGCGCGCTGCTGCTGCTCGGCG
ATCGGGACGCGGCGCGCGGGGAGGCGTTCTTCCTGGCGGCGCCGGAGCCGGTCACCGCGCGAGGGCTGATGGAGGAGGCG
GCGCGGGCGCTCGGGGTGCGGGCGCGCCGGCTGCCGGTCCCGGAGGCGCTGCTGCGCGGGATCGGGCGCGCCGGTGACGC
GGCGGGCCGCGCGCTGGGGAGACGGCTGCCGGTCGGATCGAAGCTGGTGGCGCAGGTGCTCGCGCCGGGCTGGGTGTGCG
ATGCCTCGAAGGCGCGCGAGCGGCTCGGCTTCGAGGCGACGACTTCACTCGCCGCGTCGATGGCCCGCGCTGCCGCCTGG
TACCGCGCCGCCGGCTGGCTGTAG

Upstream 100 bases:

>100_bases
CGGACCTCCCGTCCGGGTTCGGATCAAGCTGTGGCCCGGGACCAGCGGGGGACAAGGGGGCGGCGCCGGCCCTCGGCCGG
GTTGACGGGCGCCGGATCGC

Downstream 100 bases:

>100_bases
GCCGCCGAAGCCCCCGCTACGCCCTTGCCAACCGGGTCGTCCATTGCGTATGCCTCGCGGGTCATGGCGGATCCCGGCAA
GGCCGCGTTCTTCGACATCG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MVHIRASMRALVTGAGGFLGMALVRALAARGDRVRALVRRPSEALAQAGAEVMVGDATDPRALRAAVAGQELVFHLAGVR
RAADPEEFLRVNAGSTRLALEACVERAPGLRRFVLAGSRAACAPSREPIREDAPLAPVEPYGASKAEAERVALSFAAQVP
VAIARPPRIMGPGDRENLLFFRIARARLALDLGDRPLSWIDVDDCARALLLLGDRDAARGEAFFLAAPEPVTARGLMEEA
ARALGVRARRLPVPEALLRGIGRAGDAAGRALGRRLPVGSKLVAQVLAPGWVCDASKARERLGFEATTSLAASMARAAAW
YRAAGWL

Sequences:

>Translated_327_residues
MVHIRASMRALVTGAGGFLGMALVRALAARGDRVRALVRRPSEALAQAGAEVMVGDATDPRALRAAVAGQELVFHLAGVR
RAADPEEFLRVNAGSTRLALEACVERAPGLRRFVLAGSRAACAPSREPIREDAPLAPVEPYGASKAEAERVALSFAAQVP
VAIARPPRIMGPGDRENLLFFRIARARLALDLGDRPLSWIDVDDCARALLLLGDRDAARGEAFFLAAPEPVTARGLMEEA
ARALGVRARRLPVPEALLRGIGRAGDAAGRALGRRLPVGSKLVAQVLAPGWVCDASKARERLGFEATTSLAASMARAAAW
YRAAGWL
>Mature_327_residues
MVHIRASMRALVTGAGGFLGMALVRALAARGDRVRALVRRPSEALAQAGAEVMVGDATDPRALRAAVAGQELVFHLAGVR
RAADPEEFLRVNAGSTRLALEACVERAPGLRRFVLAGSRAACAPSREPIREDAPLAPVEPYGASKAEAERVALSFAAQVP
VAIARPPRIMGPGDRENLLFFRIARARLALDLGDRPLSWIDVDDCARALLLLGDRDAARGEAFFLAAPEPVTARGLMEEA
ARALGVRARRLPVPEALLRGIGRAGDAAGRALGRRLPVGSKLVAQVLAPGWVCDASKARERLGFEATTSLAASMARAAAW
YRAAGWL

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI310132178, Length=278, Percent_Identity=25.8992805755396, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310113012, Length=278, Percent_Identity=25.8992805755396, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI239745448, Length=278, Percent_Identity=25.8992805755396, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 34608; Mature: 34608

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHIRASMRALVTGAGGFLGMALVRALAARGDRVRALVRRPSEALAQAGAEVMVGDATDP
CEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCEEEEECCCCH
RALRAAVAGQELVFHLAGVRRAADPEEFLRVNAGSTRLALEACVERAPGLRRFVLAGSRA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHCCCCEEHHHCCCCC
ACAPSREPIREDAPLAPVEPYGASKAEAERVALSFAAQVPVAIARPPRIMGPGDRENLLF
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHH
FRIARARLALDLGDRPLSWIDVDDCARALLLLGDRDAARGEAFFLAAPEPVTARGLMEEA
HHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHH
ARALGVRARRLPVPEALLRGIGRAGDAAGRALGRRLPVGSKLVAQVLAPGWVCDASKARE
HHHHCCHHHCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCEECHHHHHH
RLGFEATTSLAASMARAAAWYRAAGWL
HCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVHIRASMRALVTGAGGFLGMALVRALAARGDRVRALVRRPSEALAQAGAEVMVGDATDP
CEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCEEEEECCCCH
RALRAAVAGQELVFHLAGVRRAADPEEFLRVNAGSTRLALEACVERAPGLRRFVLAGSRA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHCCCCEEHHHCCCCC
ACAPSREPIREDAPLAPVEPYGASKAEAERVALSFAAQVPVAIARPPRIMGPGDRENLLF
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHH
FRIARARLALDLGDRPLSWIDVDDCARALLLLGDRDAARGEAFFLAAPEPVTARGLMEEA
HHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHH
ARALGVRARRLPVPEALLRGIGRAGDAAGRALGRRLPVGSKLVAQVLAPGWVCDASKARE
HHHHCCHHHCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCEECHHHHHH
RLGFEATTSLAASMARAAAWYRAAGWL
HCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]