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The map label for this gene is htrA [H]

Identifier: 220916349

GI number: 220916349

Start: 1394288

End: 1395481

Strand: Reverse

Name: htrA [H]

Synonym: A2cp1_1243

Alternate gene names: 220916349

Gene position: 1395481-1394288 (Counterclockwise)

Preceding gene: 220916350

Following gene: 220916348

Centisome position: 27.75

GC content: 76.55

Gene sequence:

>1194_bases
ATGTCGGGCTGGACGGTGCTGCTGGCGGCGGTGCAGCTGGTCGCGGGCCCCGCGCCCGGCGCGGGCGGGGCGGCCCCCGC
GGCCCCCGCGGCGGCGGCTTCACCCGTGGCGGCGTCCGCCGGGGCGAGCGCGCGCGGCGCGCTCTACACCGAGGCCGCGC
GGGCCCCCGCGCCGCCGCCGCAGGCGATGGCGGGGCTCCCCGATCTCTCCCGGCTCGCCGAGGCGGCCATCCCGGCGGTG
GTCGGGGTGGTGACGCTCCAGCCCGAGCCACCGCAGGGGCAGGGCAGCGACGACGGCCTGCGGGAGCTGTTCGACAAGCT
GCACGACGGGCCGCGGCGCGGGATCGGCTCGGGCTTCGTGATCCAGCGCGACGGCTGGGTGCTCACCAACGCCCACGTGG
TGGAGGGCGCCGACCGCGTCGAGGTGGACCTGGGGGGCGGCGTCCCCCGGCTGGCCGCGCGCGTGGTGGGGCTCGACGGG
GAGTCGGACGTGGCGCTCCTCAAGGTGGACGCGCCGCGGCCGCTGCCGGTGGTGCCGCTGGGCGACTCCGACCGGATCAC
CGTGGCGGAGTGGGTGATGGTCATCGGGAGCCCGTTCGGCCTCGACCACTCCGTCACGCTCGGCATCATCAGCCACACCG
GCCGCAACGACATCTCGCCGGTGGGACGGCCTGGCACCTACGACTTCATCCAGACCGACGCGTCCATCAACCCGGGGAAC
TCCGGCGGCCCGCTCCTCAACCTGCGCGGCGAGGTGGTCGGGATCGCCACCGCCGTCAACGCCACCGGTCAGGGGATCGG
CTTCGCCATCCCCATCAACATGGCGAAGGAGATCGTCGGCCAGCTCCGCGAACGCGGGCGGGTGGTGCGGAGCTGGATGG
GCGTGTCGGTCCGCGAGCTCACCCCGCAGCAGGGCGTCCCGCCCGGCGGCGTGGAGATCACCGAGGTGGCGGCCGGCGGC
CCGGCCGCCGTCGCGGGGCTGCGCCCGGGCGACGTGATCATCTCGATCCAGGGGCACGCGGTGCACACCCCCTCGCGCCT
GCGCTGGTACGTCTCGACCGCCGGCGTGGGGCGCGAGGTGGAGCTGCGCCTCCGGCGCGCCGGCAACCCGGAGCGGACGC
AGAAGGTGCTGCTCGCGGAGGTGCCGGTCCACGAGCAGGCCCGGGCCGAGGCGCGGCAGGTGCTGGGCGAGTGA

Upstream 100 bases:

>100_bases
CGGGTCCGCGCCCTGACACGCGGGTGCGCCTTCTTGCGCACCTCGTCGCCGCCGCCCCACCTTGGATCGGGAGCTCGCGC
CTGCGCGGGCGGAGGTGGCC

Downstream 100 bases:

>100_bases
TCCGGGCCGGCCGCGGCCCCCGCGCTGTTGCGCTCCGGCCGCGGGTCTGGTAACCACCGCCCCTCTATGGCCGAGACGAC
CACGAAGACCAAGAAGAAGG

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSGWTVLLAAVQLVAGPAPGAGGAAPAAPAAAASPVAASAGASARGALYTEAARAPAPPPQAMAGLPDLSRLAEAAIPAV
VGVVTLQPEPPQGQGSDDGLRELFDKLHDGPRRGIGSGFVIQRDGWVLTNAHVVEGADRVEVDLGGGVPRLAARVVGLDG
ESDVALLKVDAPRPLPVVPLGDSDRITVAEWVMVIGSPFGLDHSVTLGIISHTGRNDISPVGRPGTYDFIQTDASINPGN
SGGPLLNLRGEVVGIATAVNATGQGIGFAIPINMAKEIVGQLRERGRVVRSWMGVSVRELTPQQGVPPGGVEITEVAAGG
PAAVAGLRPGDVIISIQGHAVHTPSRLRWYVSTAGVGREVELRLRRAGNPERTQKVLLAEVPVHEQARAEARQVLGE

Sequences:

>Translated_397_residues
MSGWTVLLAAVQLVAGPAPGAGGAAPAAPAAAASPVAASAGASARGALYTEAARAPAPPPQAMAGLPDLSRLAEAAIPAV
VGVVTLQPEPPQGQGSDDGLRELFDKLHDGPRRGIGSGFVIQRDGWVLTNAHVVEGADRVEVDLGGGVPRLAARVVGLDG
ESDVALLKVDAPRPLPVVPLGDSDRITVAEWVMVIGSPFGLDHSVTLGIISHTGRNDISPVGRPGTYDFIQTDASINPGN
SGGPLLNLRGEVVGIATAVNATGQGIGFAIPINMAKEIVGQLRERGRVVRSWMGVSVRELTPQQGVPPGGVEITEVAAGG
PAAVAGLRPGDVIISIQGHAVHTPSRLRWYVSTAGVGREVELRLRRAGNPERTQKVLLAEVPVHEQARAEARQVLGE
>Mature_396_residues
SGWTVLLAAVQLVAGPAPGAGGAAPAAPAAAASPVAASAGASARGALYTEAARAPAPPPQAMAGLPDLSRLAEAAIPAVV
GVVTLQPEPPQGQGSDDGLRELFDKLHDGPRRGIGSGFVIQRDGWVLTNAHVVEGADRVEVDLGGGVPRLAARVVGLDGE
SDVALLKVDAPRPLPVVPLGDSDRITVAEWVMVIGSPFGLDHSVTLGIISHTGRNDISPVGRPGTYDFIQTDASINPGNS
GGPLLNLRGEVVGIATAVNATGQGIGFAIPINMAKEIVGQLRERGRVVRSWMGVSVRELTPQQGVPPGGVEITEVAAGGP
AAVAGLRPGDVIISIQGHAVHTPSRLRWYVSTAGVGREVELRLRRAGNPERTQKVLLAEVPVHEQARAEARQVLGE

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=259, Percent_Identity=40.1544401544402, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI22129776, Length=259, Percent_Identity=35.1351351351351, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI24308541, Length=246, Percent_Identity=34.5528455284553, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI7019477, Length=246, Percent_Identity=39.8373983739837, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1789629, Length=325, Percent_Identity=38.1538461538462, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1786356, Length=263, Percent_Identity=40.3041825095057, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789630, Length=235, Percent_Identity=40.4255319148936, Blast_Score=157, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24646839, Length=253, Percent_Identity=36.3636363636364, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 40674; Mature: 40543

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGWTVLLAAVQLVAGPAPGAGGAAPAAPAAAASPVAASAGASARGALYTEAARAPAPPP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEHHHCCCCCCH
QAMAGLPDLSRLAEAAIPAVVGVVTLQPEPPQGQGSDDGLRELFDKLHDGPRRGIGSGFV
HHHCCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEE
IQRDGWVLTNAHVVEGADRVEVDLGGGVPRLAARVVGLDGESDVALLKVDAPRPLPVVPL
EECCCEEEECCEEECCCCEEEEECCCCHHHHHHEEECCCCCCCEEEEEECCCCCCEEEEC
GDSDRITVAEWVMVIGSPFGLDHSVTLGIISHTGRNDISPVGRPGTYDFIQTDASINPGN
CCCCCEEHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCC
SGGPLLNLRGEVVGIATAVNATGQGIGFAIPINMAKEIVGQLRERGRVVRSWMGVSVREL
CCCCEEEECCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
TPQQGVPPGGVEITEVAAGGPAAVAGLRPGDVIISIQGHAVHTPSRLRWYVSTAGVGREV
CCCCCCCCCCCEEEEECCCCCCEEECCCCCCEEEEECCCEECCCCCEEEEEEECCCCCEE
ELRLRRAGNPERTQKVLLAEVPVHEQARAEARQVLGE
EEEEECCCCHHHHHEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SGWTVLLAAVQLVAGPAPGAGGAAPAAPAAAASPVAASAGASARGALYTEAARAPAPPP
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEHHHCCCCCCH
QAMAGLPDLSRLAEAAIPAVVGVVTLQPEPPQGQGSDDGLRELFDKLHDGPRRGIGSGFV
HHHCCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEE
IQRDGWVLTNAHVVEGADRVEVDLGGGVPRLAARVVGLDGESDVALLKVDAPRPLPVVPL
EECCCEEEECCEEECCCCEEEEECCCCHHHHHHEEECCCCCCCEEEEEECCCCCCEEEEC
GDSDRITVAEWVMVIGSPFGLDHSVTLGIISHTGRNDISPVGRPGTYDFIQTDASINPGN
CCCCCEEHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCC
SGGPLLNLRGEVVGIATAVNATGQGIGFAIPINMAKEIVGQLRERGRVVRSWMGVSVREL
CCCCEEEECCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
TPQQGVPPGGVEITEVAAGGPAAVAGLRPGDVIISIQGHAVHTPSRLRWYVSTAGVGREV
CCCCCCCCCCCEEEEECCCCCCEEECCCCCCEEEEECCCEECCCCCEEEEEEECCCCCEE
ELRLRRAGNPERTQKVLLAEVPVHEQARAEARQVLGE
EEEEECCCCHHHHHEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]