Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 220915656

GI number: 220915656

Start: 615691

End: 616437

Strand: Direct

Name: ribA [H]

Synonym: A2cp1_0537

Alternate gene names: 220915656

Gene position: 615691-616437 (Clockwise)

Preceding gene: 220915655

Following gene: 220915657

Centisome position: 12.24

GC content: 73.63

Gene sequence:

>747_bases
ATGACCGGCGGCGGCGACGCGCTGGCGCAGCTCGTGCTGCGCGATCGGGATCACGAGTGCGAGGGCTTCGGGCCGGGCCG
CGTCTGCGTCCGCGTCGTCGCGGTGGCGCGCCTCCCGACGCGCGCCGGCCCGTTCCGGATCGTCGCGTTCTGGAACAACC
GCGACGCAAAGGAGCACGTGGCGCTGGTGCACGGCGACGTGGTGGGCGCGGCGGACGTGCCGGTGCGCCTCCACTCGGAG
TGCCTGACCGGCGACGTGATGGGCTCGCTCCGCTGCGACTGCCGCGACCAGCTCACCGAGGGGCTCGCCGCGATCCAGCG
CGAGGGGCGCGGGGTGCTGCTGTACCTGCGGCAGGAGGGGCGCGGGATCGGCCTCATCAACAAGATCCGCGCGTACGCGC
TGCAGGAGCAGGGGCTCGACACGGTCGAGGCGAACCTCGCGCTCGGCTTCCGCGACGACGAGCGCGACTACGCCGTGGCG
GCCCACATGATCCACGGCCTGGAGCTCCGCTCCATCCGCCTCATCACCAACAACCCGGAGAAGATCCGGCAGCTCACCGC
GTACCGGGTCGACGTGAGCGGGCGCATCCCGCACGTGATCCCGCCGGGCGAGCACAACCGCTTCTACCTGGAGACGAAGG
CGCGGCGGTCCGGGCACCTGATCGACCTCGCGGCGCTCGAGCCGCGCTCCGAGCAGGCCGACCCGGTGGTGGTCGCGCCG
GCGCCCGGCACGCCCGGCGGGGAGTGA

Upstream 100 bases:

>100_bases
TGGGCGTGGCGGGCGATCGCTTCGCCCCGGGCGGCGGCATCGAGGCGGCGTGGCGCTCGGGCCGCGCGCTGGCGGGACGG
GTCCTCGCGGGGGAGGGGGC

Downstream 100 bases:

>100_bases
TCGTCCGGTCCCGTGGCGGCCGACCGCTCCGCCCCGGCACGCGGCCCGCGGGAGGCGGGCGCCGCGCGGGGCGCACGCCG
GCGGGTCGCTCGCCGGGGCG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTGGGDALAQLVLRDRDHECEGFGPGRVCVRVVAVARLPTRAGPFRIVAFWNNRDAKEHVALVHGDVVGAADVPVRLHSE
CLTGDVMGSLRCDCRDQLTEGLAAIQREGRGVLLYLRQEGRGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDYAVA
AHMIHGLELRSIRLITNNPEKIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRSGHLIDLAALEPRSEQADPVVVAP
APGTPGGE

Sequences:

>Translated_248_residues
MTGGGDALAQLVLRDRDHECEGFGPGRVCVRVVAVARLPTRAGPFRIVAFWNNRDAKEHVALVHGDVVGAADVPVRLHSE
CLTGDVMGSLRCDCRDQLTEGLAAIQREGRGVLLYLRQEGRGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDYAVA
AHMIHGLELRSIRLITNNPEKIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRSGHLIDLAALEPRSEQADPVVVAP
APGTPGGE
>Mature_247_residues
TGGGDALAQLVLRDRDHECEGFGPGRVCVRVVAVARLPTRAGPFRIVAFWNNRDAKEHVALVHGDVVGAADVPVRLHSEC
LTGDVMGSLRCDCRDQLTEGLAAIQREGRGVLLYLRQEGRGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDYAVAA
HMIHGLELRSIRLITNNPEKIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRSGHLIDLAALEPRSEQADPVVVAPA
PGTPGGE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=51.8134715025907, Blast_Score=198, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319438, Length=186, Percent_Identity=40.3225806451613, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 27096; Mature: 26965

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGGDALAQLVLRDRDHECEGFGPGRVCVRVVAVARLPTRAGPFRIVAFWNNRDAKEHV
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEE
ALVHGDVVGAADVPVRLHSECLTGDVMGSLRCDCRDQLTEGLAAIQREGRGVLLYLRQEG
EEEECCEECCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECC
RGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDYAVAAHMIHGLELRSIRLITNNPE
CCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCEEEEEEEEECCHH
KIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRSGHLIDLAALEPRSEQADPVVVAP
HHHHHHHEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEC
APGTPGGE
CCCCCCCC
>Mature Secondary Structure 
TGGGDALAQLVLRDRDHECEGFGPGRVCVRVVAVARLPTRAGPFRIVAFWNNRDAKEHV
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEE
ALVHGDVVGAADVPVRLHSECLTGDVMGSLRCDCRDQLTEGLAAIQREGRGVLLYLRQEG
EEEECCEECCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECC
RGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDYAVAAHMIHGLELRSIRLITNNPE
CCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCEEEEEEEEECCHH
KIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRSGHLIDLAALEPRSEQADPVVVAP
HHHHHHHEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEC
APGTPGGE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA