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The map label for this gene is sbcD [H]

Identifier: 220915582

GI number: 220915582

Start: 534304

End: 535563

Strand: Reverse

Name: sbcD [H]

Synonym: A2cp1_0463

Alternate gene names: 220915582

Gene position: 535563-534304 (Counterclockwise)

Preceding gene: 220915584

Following gene: 220915581

Centisome position: 10.65

GC content: 78.49

Gene sequence:

>1260_bases
GTGGCCATCCGCATCCTCCACACCGCCGACTGGCACCTCGGCCACGCGCTGCACGGCGTGGACCGCGGCCCCGAGCACGA
GCGCTTCGTGGCGTGGCTGCTCGACACCGTCGAAGCCGAGGCGGTGGACGCGGTCATCGTGGCGGGTGACGTGTTCGACG
CCTCCAACCCGCCCGCGGGCGCGCAGGCGCTCTGGTATCGCTTCCTGGCCGAGGCCTGGCGGCGCCTGCCGCGGCTGCAG
CTCGTGGTGGTGGGCGGGAACCACGACTCCGCCTCGCGGCTCGACGCGGTGGACCCGCTGCTGCGCGAGATGGGCCGGCT
GCACGTGGTGGGCGGCGTGCCGCGCGCCGCCGCCGGCGCGCCGGATCTGGAGCGGCTGCTCGTGCCGCTGGAGGACGCGG
CGGGCCGGCGGGCGGCCTGGGTGGCGGCGGTGCCGTACCTGCGCGCCGCCGATCTGGGCGCGGGCGCGGGCGCGGCCGAC
GACGACGCCGCCGAGGCCACGCGCCGCTTCTACGCCGCCGCGCTGGAGCGGGCGCGAGCGAGGCGCGCGCCGGGCGAGGC
GCTCCTCGCCACCGGCCACCTCTATGCGGTGGGCGGGAAGATCTCGGAGCTCTCCGAGCGGCGGCTCGCGGTGGGCAACC
AGGCCGCGGTGCCCGCCGACGCGTTCCCGGCCGACCTCGCCTACGTCGCGCTCGGCCACCTGCACCTCGCGCAGGCGGTG
GGCGGCCGCGAGACGGTGCGCTACTCGGGCTCGGTGCTGCCGCTCTCGTTCGCCGAGCGCGGCTACCGCCACGGCGTGGT
GGTGGCCGACCTGGACGGTGAGGCGGTGCGCGCGCAGCGGGTGCTGCGCGTCCCGCGGTTCGTGGAGCTCGTCTCGGTGC
CGGACGCCGAGGCGCCGGCGCCGCTCCCCGAGGTGCTCGCCGCGCTCGAGGCGCTGCCGGCGCGCGGCGACGGGCCGGAC
GCGCTGCGGCCGCTCCTCGAGGTGAAGGTGCGGCTGGAGCGGCCCGAGCCGGCGCTGCGCGCGCTGCTCGACCAGGCGCT
CGCGGGCAAGGAGGCGCGCCTCGTGCGCATCGCCACCACGCTCGCCGGCACCGGCCGCGCGCTGGGCGACGGCGAGCGGC
GCGCGCTCGGCGACCTCGTGCCGGAGGAGGTCTTCCGGCGGAAGTACGACGCCGACTACGGCGGGCCGCCGCCCGACGCG
CTCCTGGAGGCGTTCCGCGCGCTGCTCCAGGAGGTCGAGTCGGAGGAGGGGGCGCGGTGA

Upstream 100 bases:

>100_bases
CCACCTCGTCCGACACGGTCTTTGGCGTGAGCGGCCCCGGACCCGCCGCCGCCGGACGCGGACGGCGCATGTCCGACCGG
CGCGTATCCTCCTGGCGTTC

Downstream 100 bases:

>100_bases
GGATCCTGGCCATCCGCGGCGAGAACCTCGCCAGCCTCTACGGCAAGTTCGAGCTGCGGCTCGACCGCGCGCCCATCGCC
GGCGCGGGCATCTTCTCCAT

Product: nuclease SbcCD, D subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MAIRILHTADWHLGHALHGVDRGPEHERFVAWLLDTVEAEAVDAVIVAGDVFDASNPPAGAQALWYRFLAEAWRRLPRLQ
LVVVGGNHDSASRLDAVDPLLREMGRLHVVGGVPRAAAGAPDLERLLVPLEDAAGRRAAWVAAVPYLRAADLGAGAGAAD
DDAAEATRRFYAAALERARARRAPGEALLATGHLYAVGGKISELSERRLAVGNQAAVPADAFPADLAYVALGHLHLAQAV
GGRETVRYSGSVLPLSFAERGYRHGVVVADLDGEAVRAQRVLRVPRFVELVSVPDAEAPAPLPEVLAALEALPARGDGPD
ALRPLLEVKVRLERPEPALRALLDQALAGKEARLVRIATTLAGTGRALGDGERRALGDLVPEEVFRRKYDADYGGPPPDA
LLEAFRALLQEVESEEGAR

Sequences:

>Translated_419_residues
MAIRILHTADWHLGHALHGVDRGPEHERFVAWLLDTVEAEAVDAVIVAGDVFDASNPPAGAQALWYRFLAEAWRRLPRLQ
LVVVGGNHDSASRLDAVDPLLREMGRLHVVGGVPRAAAGAPDLERLLVPLEDAAGRRAAWVAAVPYLRAADLGAGAGAAD
DDAAEATRRFYAAALERARARRAPGEALLATGHLYAVGGKISELSERRLAVGNQAAVPADAFPADLAYVALGHLHLAQAV
GGRETVRYSGSVLPLSFAERGYRHGVVVADLDGEAVRAQRVLRVPRFVELVSVPDAEAPAPLPEVLAALEALPARGDGPD
ALRPLLEVKVRLERPEPALRALLDQALAGKEARLVRIATTLAGTGRALGDGERRALGDLVPEEVFRRKYDADYGGPPPDA
LLEAFRALLQEVESEEGAR
>Mature_418_residues
AIRILHTADWHLGHALHGVDRGPEHERFVAWLLDTVEAEAVDAVIVAGDVFDASNPPAGAQALWYRFLAEAWRRLPRLQL
VVVGGNHDSASRLDAVDPLLREMGRLHVVGGVPRAAAGAPDLERLLVPLEDAAGRRAAWVAAVPYLRAADLGAGAGAADD
DAAEATRRFYAAALERARARRAPGEALLATGHLYAVGGKISELSERRLAVGNQAAVPADAFPADLAYVALGHLHLAQAVG
GRETVRYSGSVLPLSFAERGYRHGVVVADLDGEAVRAQRVLRVPRFVELVSVPDAEAPAPLPEVLAALEALPARGDGPDA
LRPLLEVKVRLERPEPALRALLDQALAGKEARLVRIATTLAGTGRALGDGERRALGDLVPEEVFRRKYDADYGGPPPDAL
LEAFRALLQEVESEEGAR

Specific function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sbcD family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=398, Percent_Identity=31.9095477386935, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 44672; Mature: 44541

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRILHTADWHLGHALHGVDRGPEHERFVAWLLDTVEAEAVDAVIVAGDVFDASNPPAG
CEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCH
AQALWYRFLAEAWRRLPRLQLVVVGGNHDSASRLDAVDPLLREMGRLHVVGGVPRAAAGA
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
PDLERLLVPLEDAAGRRAAWVAAVPYLRAADLGAGAGAADDDAAEATRRFYAAALERARA
CCHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RRAPGEALLATGHLYAVGGKISELSERRLAVGNQAAVPADAFPADLAYVALGHLHLAQAV
HCCCCCCEEECCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GGRETVRYSGSVLPLSFAERGYRHGVVVADLDGEAVRAQRVLRVPRFVELVSVPDAEAPA
CCCCEEEECCCEEEEHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLPEVLAALEALPARGDGPDALRPLLEVKVRLERPEPALRALLDQALAGKEARLVRIATT
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHEEEEEHH
LAGTGRALGDGERRALGDLVPEEVFRRKYDADYGGPPPDALLEAFRALLQEVESEEGAR
HCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AIRILHTADWHLGHALHGVDRGPEHERFVAWLLDTVEAEAVDAVIVAGDVFDASNPPAG
EEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCH
AQALWYRFLAEAWRRLPRLQLVVVGGNHDSASRLDAVDPLLREMGRLHVVGGVPRAAAGA
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
PDLERLLVPLEDAAGRRAAWVAAVPYLRAADLGAGAGAADDDAAEATRRFYAAALERARA
CCHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RRAPGEALLATGHLYAVGGKISELSERRLAVGNQAAVPADAFPADLAYVALGHLHLAQAV
HCCCCCCEEECCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GGRETVRYSGSVLPLSFAERGYRHGVVVADLDGEAVRAQRVLRVPRFVELVSVPDAEAPA
CCCCEEEECCCEEEEHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLPEVLAALEALPARGDGPDALRPLLEVKVRLERPEPALRALLDQALAGKEARLVRIATT
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHEEEEEHH
LAGTGRALGDGERRALGDLVPEEVFRRKYDADYGGPPPDALLEAFRALLQEVESEEGAR
HCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]