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The map label for this gene is zraR [H]

Identifier: 220915565

GI number: 220915565

Start: 506284

End: 507729

Strand: Reverse

Name: zraR [H]

Synonym: A2cp1_0446

Alternate gene names: 220915565

Gene position: 507729-506284 (Counterclockwise)

Preceding gene: 220915566

Following gene: 220915564

Centisome position: 10.1

GC content: 73.51

Gene sequence:

>1446_bases
TTGGCTGACATTCCGGGACGCATGATCGACCCCGCTCCGCCGGAGGACCCGCGGGCGCCGCGGATCGCCGAGCCGCCCAC
CGGCGGCAAGGTGCTGGTCGTCGACGACCAGAAGAACATGCGCGCCACCACCGCCATCCTGCTCCGGCAGGCCGGCCACG
TGGTGGAGGAGGCGGAGGACGGCGCGTCCGCCACGCAGCGGGTGCAGCACGAGAGCTTCGACGTCGTGCTCACCGACCTG
CGCATGCCGACCGTGGACGGCATGGAGGTGCTGCGGGCGGTGCAGCAGGCGTCGCCCGAGACGCAGGTCATCGTGATGAC
CGCGTACGGCACCATCGAGTCGGCGGTGGAGGCGATCCGGCGCGGCGCGTACGACTTCCTGGCGAAGCCGTTCAAGGAGA
GCGAGGTCCTGCTCCGCGTCGCCAAGGCGCTGGAGAAGCGGCGGCTGCTCGGCGAGGTGAACCTGTTCGCCGAGGAGTTC
CGCAAGCGCTACGGCCTCGAGCACATCGTGGGCCGCTCGCCCGCCATGCGCGAGGTGCTCGACCGCGTGCTGCGCGTCGC
GCCCACCGACGCGACCGTGCTCGTCACCGGCGAGTCCGGCACCGGCAAGGAGCTGGTGGCCCGCGCGCTCCACGTGACCA
GCCGCCGCAGCGACAAGCCGTTCGTCCCGGTGAACTGCGCCGCCATCACCGACACGCTGCTCGAGTCGGAGCTGTTCGGC
CACGCGCGCGGCGCCTTCACCGGCGCCACGCGGGCGCGCCGGGGCATGTTCGAGGAGGCGAACGGCGGCACGCTGTTCAT
CGACGAGATCGGCGAGACCTCCCCCGGGTTCCAGGCGAAGCTGCTGCGCGCGCTGCAGGAGGGCGAGATCCGCCGGGTGG
GCGAGTCCAGCCCGGTGCAGGTCAACGTCCGCATCATCGCCGCCACCAACCAGGACCTGCGCCGCGCCATCGCCGAGCGG
CGCTTCCGCGAGGACCTGTTCTACCGCCTGAACGTGGTGCCGCTGCGCATCCCGCCGCTCCGCGAGCGCCGCGAGGACGT
CCCGCTCCTCGCCGCGCACTTCCTCCAGCGCTTCGTGCAGCGCACCGGCAGCGAGCGCGTGCTCACCCCCGAGGCGGTGG
CCTCGCTCGTGGCCCACGACTGGCCGGGGAACGTCCGCGAGCTCGAGAACATCATCGAGCAGGCGGCCGCGCTCTGCACC
GGCCGCGAGATCCGGGCCGCCGACGTCCAGATCGAGGCGCGGGCCGCGCCGGCGGGCGGCGCCGGGGTGACGCTCGCCGA
CGCGGTCGAGGACACCGAGCGCCGGGCCATCACCGCCGCGCTGGCGCGCTGCGGGAACGACCTGGGCCGGGTGGCCCGCG
ACCTCGGCATCTCCGGCACCACGCTGTGGCGCAAGATGAAGCGCCTCGGCATCGAGGCGCGCGAGCACCCTCCCGTCACC
CCCTGA

Upstream 100 bases:

>100_bases
GTGACCAGCCGGCCCGGCGCCGGAACCGCCTTCGCGCTGCGCTTCCCGCTCACCCCGCTCGCGGGGGAGGACGGCGGCCC
GGTTGAAAAGGAGGCGGGGA

Downstream 100 bases:

>100_bases
CGGGGAGCTCCGCCGGACCCGGGAGGCATCCGCGCCCGGGGCCCGTTTCACTTTTGCAACGCCATCTTGCACCTACGAAA
TCACGCCCCGGACCTTCGAG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MADIPGRMIDPAPPEDPRAPRIAEPPTGGKVLVVDDQKNMRATTAILLRQAGHVVEEAEDGASATQRVQHESFDVVLTDL
RMPTVDGMEVLRAVQQASPETQVIVMTAYGTIESAVEAIRRGAYDFLAKPFKESEVLLRVAKALEKRRLLGEVNLFAEEF
RKRYGLEHIVGRSPAMREVLDRVLRVAPTDATVLVTGESGTGKELVARALHVTSRRSDKPFVPVNCAAITDTLLESELFG
HARGAFTGATRARRGMFEEANGGTLFIDEIGETSPGFQAKLLRALQEGEIRRVGESSPVQVNVRIIAATNQDLRRAIAER
RFREDLFYRLNVVPLRIPPLRERREDVPLLAAHFLQRFVQRTGSERVLTPEAVASLVAHDWPGNVRELENIIEQAAALCT
GREIRAADVQIEARAAPAGGAGVTLADAVEDTERRAITAALARCGNDLGRVARDLGISGTTLWRKMKRLGIEAREHPPVT
P

Sequences:

>Translated_481_residues
MADIPGRMIDPAPPEDPRAPRIAEPPTGGKVLVVDDQKNMRATTAILLRQAGHVVEEAEDGASATQRVQHESFDVVLTDL
RMPTVDGMEVLRAVQQASPETQVIVMTAYGTIESAVEAIRRGAYDFLAKPFKESEVLLRVAKALEKRRLLGEVNLFAEEF
RKRYGLEHIVGRSPAMREVLDRVLRVAPTDATVLVTGESGTGKELVARALHVTSRRSDKPFVPVNCAAITDTLLESELFG
HARGAFTGATRARRGMFEEANGGTLFIDEIGETSPGFQAKLLRALQEGEIRRVGESSPVQVNVRIIAATNQDLRRAIAER
RFREDLFYRLNVVPLRIPPLRERREDVPLLAAHFLQRFVQRTGSERVLTPEAVASLVAHDWPGNVRELENIIEQAAALCT
GREIRAADVQIEARAAPAGGAGVTLADAVEDTERRAITAALARCGNDLGRVARDLGISGTTLWRKMKRLGIEAREHPPVT
P
>Mature_480_residues
ADIPGRMIDPAPPEDPRAPRIAEPPTGGKVLVVDDQKNMRATTAILLRQAGHVVEEAEDGASATQRVQHESFDVVLTDLR
MPTVDGMEVLRAVQQASPETQVIVMTAYGTIESAVEAIRRGAYDFLAKPFKESEVLLRVAKALEKRRLLGEVNLFAEEFR
KRYGLEHIVGRSPAMREVLDRVLRVAPTDATVLVTGESGTGKELVARALHVTSRRSDKPFVPVNCAAITDTLLESELFGH
ARGAFTGATRARRGMFEEANGGTLFIDEIGETSPGFQAKLLRALQEGEIRRVGESSPVQVNVRIIAATNQDLRRAIAERR
FREDLFYRLNVVPLRIPPLRERREDVPLLAAHFLQRFVQRTGSERVLTPEAVASLVAHDWPGNVRELENIIEQAAALCTG
REIRAADVQIEARAAPAGGAGVTLADAVEDTERRAITAALARCGNDLGRVARDLGISGTTLWRKMKRLGIEAREHPPVTP

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=45.2488687782805, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=43.5164835164835, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=40.7563025210084, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1788905, Length=448, Percent_Identity=40.4017857142857, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI87082117, Length=340, Percent_Identity=46.7647058823529, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=45.7680250783699, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789087, Length=400, Percent_Identity=40.5, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=45, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1787583, Length=320, Percent_Identity=39.0625, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786524, Length=327, Percent_Identity=40.9785932721713, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=45.4545454545455, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87081858, Length=314, Percent_Identity=31.5286624203822, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789828, Length=246, Percent_Identity=35.7723577235772, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=32.4786324786325, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=35, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082012, Length=123, Percent_Identity=28.4552845528455, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=118, Percent_Identity=32.2033898305085, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=29.6610169491525, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52798; Mature: 52667

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIPGRMIDPAPPEDPRAPRIAEPPTGGKVLVVDDQKNMRATTAILLRQAGHVVEEAED
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GASATQRVQHESFDVVLTDLRMPTVDGMEVLRAVQQASPETQVIVMTAYGTIESAVEAIR
CHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHH
RGAYDFLAKPFKESEVLLRVAKALEKRRLLGEVNLFAEEFRKRYGLEHIVGRSPAMREVL
HCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHH
DRVLRVAPTDATVLVTGESGTGKELVARALHVTSRRSDKPFVPVNCAAITDTLLESELFG
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHH
HARGAFTGATRARRGMFEEANGGTLFIDEIGETSPGFQAKLLRALQEGEIRRVGESSPVQ
HHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHCCCCCCCEE
VNVRIIAATNQDLRRAIAERRFREDLFYRLNVVPLRIPPLRERREDVPLLAAHFLQRFVQ
EEEEEEEECCHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHCCCCHHHHHHHHHHHH
RTGSERVLTPEAVASLVAHDWPGNVRELENIIEQAAALCTGREIRAADVQIEARAAPAGG
HCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECEEEEEECCCCCC
AGVTLADAVEDTERRAITAALARCGNDLGRVARDLGISGTTLWRKMKRLGIEAREHPPVT
CCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
P
C
>Mature Secondary Structure 
ADIPGRMIDPAPPEDPRAPRIAEPPTGGKVLVVDDQKNMRATTAILLRQAGHVVEEAED
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GASATQRVQHESFDVVLTDLRMPTVDGMEVLRAVQQASPETQVIVMTAYGTIESAVEAIR
CHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHH
RGAYDFLAKPFKESEVLLRVAKALEKRRLLGEVNLFAEEFRKRYGLEHIVGRSPAMREVL
HCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHH
DRVLRVAPTDATVLVTGESGTGKELVARALHVTSRRSDKPFVPVNCAAITDTLLESELFG
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHH
HARGAFTGATRARRGMFEEANGGTLFIDEIGETSPGFQAKLLRALQEGEIRRVGESSPVQ
HHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHCCCCCCCEE
VNVRIIAATNQDLRRAIAERRFREDLFYRLNVVPLRIPPLRERREDVPLLAAHFLQRFVQ
EEEEEEEECCHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHCCCCHHHHHHHHHHHH
RTGSERVLTPEAVASLVAHDWPGNVRELENIIEQAAALCTGREIRAADVQIEARAAPAGG
HCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECEEEEEECCCCCC
AGVTLADAVEDTERRAITAALARCGNDLGRVARDLGISGTTLWRKMKRLGIEAREHPPVT
CCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]