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The map label for this gene is ispB [H]

Identifier: 220915526

GI number: 220915526

Start: 458950

End: 459999

Strand: Reverse

Name: ispB [H]

Synonym: A2cp1_0407

Alternate gene names: 220915526

Gene position: 459999-458950 (Counterclockwise)

Preceding gene: 220915527

Following gene: 220915525

Centisome position: 9.15

GC content: 77.24

Gene sequence:

>1050_bases
ATGGCGGCGCAAGAGCAGGCCATCCTCTCCCAGCTCGACGCGAGCGCGCAGCGCGGCGTCCGCCCGGAGCGCGCGCAGGC
GGCGCTCGCCGGCGTGCCGAGCCTCCCGGAGAGCCTGCTCGAGCTGGAGGCGCAGCTCACCCGCGCCACCGAGGACGCCG
AGGCGAAGCTCCAGGCGGCCGCGCGCCACCTCGTCTCCGCCGGCGGCAAGCGCATCCGGCCCATGGTGACGCTGCTCGCC
TGCGGCGCCTGCGGCGGCGAGATGCGCGGCGCGGTGCCGTACGCGGTGGCCGCCGAGCTGACCCACTCGGCCACGCTGCT
GCACGACGACGTCATCGACGACGGCCCGGTGCGCCGCGGCCAGCCGGCCTCGCGCGTCATCTGGGGCAACGCCGTGTCGG
TGCTCTCCGGCGACTGGCTGCTCACCCGCGCGCTCGAGATCGTCTCGGCCGAGCCGGCCCGCTCCGCGGCGCTGCCGCCG
CTGCTCGCCACCATGCGGCGGCTGGTGGAGGGCGAGGTGCTCCAGCTCTCGCTCCGCGGCGGCTTCTCCGCCACCGAGCA
GGCGTACATGGACGTGGTGATGGGCAAGACCGCGTCGCTGTTCGGCTGGGCGGCCGCGGCCGGCGCCTGGGCCGCCGGCG
AGGTGGGCGAGATCCCCGCCGCGCTGGTGCGCTTCGGCGAGGGCATCGGGGTCGCGTTCCAGCTCGTGGACGACGCGCTC
GACTACGCCGCCGATCCGCGGCTCCTCGGCAAGCGGCTCGGCACCGACCTCATCGAGGGGAAGGCCACGCTGCCGCTCAT
CCGCGCCTGCGAGGCGGAGCCGGCGCTGCGGGGGCGGCTCGGGGGCGTGGTGGACGGCACCGCCGACGTCGAGGCGGTGG
CCGGCGAGGTGATCGCGGTCGTGAAGCGCGTCGGCGGGGTGGACGCCGCGCGCGCGCTCGCCCGGGAGCACACCCGCACC
GCGCTCGAGGCGCTGGAGCAGGTGCCGGACGGCGTGCACCGCCGGGCGCTGCACGCCGCGGCGCTGCAGCTGACCGAGCG
GGCGTTCTGA

Upstream 100 bases:

>100_bases
GAGCGGCGCGCCCCGGAGGGCCGCATTCGTTGACCCCGCGGCGCCAGCCGCGCTATATGCGGCTTCAACTTTCGTTGAAG
GTTCCCCCGGAGGCGCGGAA

Downstream 100 bases:

>100_bases
TCTAACGGGGGCTGCGCCCCGCCGCCCTGAGCTTGCCGAAGGGCGTCGGGGCCCCACTCCCGCTGCGCGGGGCCCGTGAC
CGCTCGCGCCCGCGTGCGCG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAAQEQAILSQLDASAQRGVRPERAQAALAGVPSLPESLLELEAQLTRATEDAEAKLQAAARHLVSAGGKRIRPMVTLLA
CGACGGEMRGAVPYAVAAELTHSATLLHDDVIDDGPVRRGQPASRVIWGNAVSVLSGDWLLTRALEIVSAEPARSAALPP
LLATMRRLVEGEVLQLSLRGGFSATEQAYMDVVMGKTASLFGWAAAAGAWAAGEVGEIPAALVRFGEGIGVAFQLVDDAL
DYAADPRLLGKRLGTDLIEGKATLPLIRACEAEPALRGRLGGVVDGTADVEAVAGEVIAVVKRVGGVDAARALAREHTRT
ALEALEQVPDGVHRRALHAAALQLTERAF

Sequences:

>Translated_349_residues
MAAQEQAILSQLDASAQRGVRPERAQAALAGVPSLPESLLELEAQLTRATEDAEAKLQAAARHLVSAGGKRIRPMVTLLA
CGACGGEMRGAVPYAVAAELTHSATLLHDDVIDDGPVRRGQPASRVIWGNAVSVLSGDWLLTRALEIVSAEPARSAALPP
LLATMRRLVEGEVLQLSLRGGFSATEQAYMDVVMGKTASLFGWAAAAGAWAAGEVGEIPAALVRFGEGIGVAFQLVDDAL
DYAADPRLLGKRLGTDLIEGKATLPLIRACEAEPALRGRLGGVVDGTADVEAVAGEVIAVVKRVGGVDAARALAREHTRT
ALEALEQVPDGVHRRALHAAALQLTERAF
>Mature_348_residues
AAQEQAILSQLDASAQRGVRPERAQAALAGVPSLPESLLELEAQLTRATEDAEAKLQAAARHLVSAGGKRIRPMVTLLAC
GACGGEMRGAVPYAVAAELTHSATLLHDDVIDDGPVRRGQPASRVIWGNAVSVLSGDWLLTRALEIVSAEPARSAALPPL
LATMRRLVEGEVLQLSLRGGFSATEQAYMDVVMGKTASLFGWAAAAGAWAAGEVGEIPAALVRFGEGIGVAFQLVDDALD
YAADPRLLGKRLGTDLIEGKATLPLIRACEAEPALRGRLGGVVDGTADVEAVAGEVIAVVKRVGGVDAARALAREHTRTA
LEALEQVPDGVHRRALHAAALQLTERAF

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=306, Percent_Identity=29.0849673202614, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1789578, Length=275, Percent_Identity=38.5454545454545, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1786623, Length=211, Percent_Identity=32.7014218009479, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17505681, Length=304, Percent_Identity=30.9210526315789, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319475, Length=301, Percent_Identity=28.9036544850498, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325188, Length=186, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24651612, Length=298, Percent_Identity=29.8657718120805, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 36378; Mature: 36247

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQEQAILSQLDASAQRGVRPERAQAALAGVPSLPESLLELEAQLTRATEDAEAKLQAA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHH
ARHLVSAGGKRIRPMVTLLACGACGGEMRGAVPYAVAAELTHSATLLHDDVIDDGPVRRG
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QPASRVIWGNAVSVLSGDWLLTRALEIVSAEPARSAALPPLLATMRRLVEGEVLQLSLRG
CCCCEEEECCHHHHHCCCHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCCCEEEEEECC
GFSATEQAYMDVVMGKTASLFGWAAAAGAWAAGEVGEIPAALVRFGEGIGVAFQLVDDAL
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
DYAADPRLLGKRLGTDLIEGKATLPLIRACEAEPALRGRLGGVVDGTADVEAVAGEVIAV
HHCCCHHHHHHHHCHHHHCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
VKRVGGVDAARALAREHTRTALEALEQVPDGVHRRALHAAALQLTERAF
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAQEQAILSQLDASAQRGVRPERAQAALAGVPSLPESLLELEAQLTRATEDAEAKLQAA
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHH
ARHLVSAGGKRIRPMVTLLACGACGGEMRGAVPYAVAAELTHSATLLHDDVIDDGPVRRG
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QPASRVIWGNAVSVLSGDWLLTRALEIVSAEPARSAALPPLLATMRRLVEGEVLQLSLRG
CCCCEEEECCHHHHHCCCHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCCCEEEEEECC
GFSATEQAYMDVVMGKTASLFGWAAAAGAWAAGEVGEIPAALVRFGEGIGVAFQLVDDAL
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
DYAADPRLLGKRLGTDLIEGKATLPLIRACEAEPALRGRLGGVVDGTADVEAVAGEVIAV
HHCCCHHHHHHHHCHHHHCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
VKRVGGVDAARALAREHTRTALEALEQVPDGVHRRALHAAALQLTERAF
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]