Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 220915260

GI number: 220915260

Start: 156780

End: 157745

Strand: Reverse

Name: prs [H]

Synonym: A2cp1_0139

Alternate gene names: 220915260

Gene position: 157745-156780 (Counterclockwise)

Preceding gene: 220915261

Following gene: 220915259

Centisome position: 3.14

GC content: 69.88

Gene sequence:

>966_bases
ATGGCGAGCAACGGTCACTATCCGGACTACCGGGTCTTCTGCGGCAACGCGAACCGGCCGCTGGCCGAGGCGATCGCGAA
GGAGCTCGGGCGCCCGCTGGCCCGCGCCACCGTGGGCCGCTTCTCCGACGGCGAGATCCAGGTCGAGATCGGCGAGAACG
TCCGCGGCCTCGACACGTTCATCATCCAGTCCACCTCGCCGGACGCGAACACCAACCTGATGGAGCTGCTCATCATGATC
GACGCGCTGAAGCGCGCGTCGGCCGGCTCGATCAACGCGGTGCTGCCCTACTACGGCTACGCGCGCCAGGACCGGAAGGT
CGCGCCGCGCGTGCCCATCACCGCGAAGCTGATCGCCGACCTCATCGAGGCCGCCGGGGCGACGCGCGTGGTCTCGATGG
ACATGCACGCCGGGCAGATCCAGGGCTTCTTCAACGTGCCCTTCGACCACCTCTACGCCGCGCCGGTGCTGCTCGAGCAC
ATGCGCAAGCGCTTCGACGGCAGCGCGCACGACCTCGTCATCGTCTCGCCGGACGCGGGCGGCGTCGAGCGGGCGCGCGC
CTACTCGAAGCGGCTCGGCGCGGGCCTCGGCATCGTGGACAAGCGGCGCACCAAGCCGAACGTCGCCGAGATCATGAACG
TGATCGGCGACGTGAACGGCAAGGTGGCGGTGCTGCTCGACGACATGATCGACACCGCCGGCACGCTCACCCAGGCGGCG
AACGCGCTCGTGGACAAGGGCGCGACGCGGGTGTTCGCGTACGCGACGCACGCGGTGCTGTCCGGCCCGGCGGTGGACCG
GATCATGAAGAGCCCGATCGAGGAGGTGGTGGTGACCGACTCGATCCAGCTCGCCCCGCCCGCCGCGGCCTGCCCGAAGA
TCCGGACGCTCTCGGTCGCCGGCCTGCTCGCCGAGGCCATTCGCCGCATCCACTCGGCCGATTCGCTCAGCTCGCTGTTC
GTCTAG

Upstream 100 bases:

>100_bases
CCGGTATAAGGGCGCCCTTTCGACGACCCGACGTCCGGCGAGAGCCTCCGGGCGTGCGCGTCGCCTTCCATCTTCGCGGG
ATTGAAGGGAGCACGGCGCC

Downstream 100 bases:

>100_bases
GACGAGGGCTGCGCCCTCGCCCCGCCGACGGAGCCGTCGGGGCCCCACTCCTGCTGCGCGGAGCCCGTGATCGCTCGCGC
CCGCGTGCGCGGGCACGCGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MASNGHYPDYRVFCGNANRPLAEAIAKELGRPLARATVGRFSDGEIQVEIGENVRGLDTFIIQSTSPDANTNLMELLIMI
DALKRASAGSINAVLPYYGYARQDRKVAPRVPITAKLIADLIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEH
MRKRFDGSAHDLVIVSPDAGGVERARAYSKRLGAGLGIVDKRRTKPNVAEIMNVIGDVNGKVAVLLDDMIDTAGTLTQAA
NALVDKGATRVFAYATHAVLSGPAVDRIMKSPIEEVVVTDSIQLAPPAAACPKIRTLSVAGLLAEAIRRIHSADSLSSLF
V

Sequences:

>Translated_321_residues
MASNGHYPDYRVFCGNANRPLAEAIAKELGRPLARATVGRFSDGEIQVEIGENVRGLDTFIIQSTSPDANTNLMELLIMI
DALKRASAGSINAVLPYYGYARQDRKVAPRVPITAKLIADLIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEH
MRKRFDGSAHDLVIVSPDAGGVERARAYSKRLGAGLGIVDKRRTKPNVAEIMNVIGDVNGKVAVLLDDMIDTAGTLTQAA
NALVDKGATRVFAYATHAVLSGPAVDRIMKSPIEEVVVTDSIQLAPPAAACPKIRTLSVAGLLAEAIRRIHSADSLSSLF
V
>Mature_320_residues
ASNGHYPDYRVFCGNANRPLAEAIAKELGRPLARATVGRFSDGEIQVEIGENVRGLDTFIIQSTSPDANTNLMELLIMID
ALKRASAGSINAVLPYYGYARQDRKVAPRVPITAKLIADLIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEHM
RKRFDGSAHDLVIVSPDAGGVERARAYSKRLGAGLGIVDKRRTKPNVAEIMNVIGDVNGKVAVLLDDMIDTAGTLTQAAN
ALVDKGATRVFAYATHAVLSGPAVDRIMKSPIEEVVVTDSIQLAPPAAACPKIRTLSVAGLLAEAIRRIHSADSLSSLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=45.6869009584665, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=45.0479233226837, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=44.7284345047923, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=44.620253164557, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=37.6811594202899, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=37.3177842565598, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=29.9319727891156, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=29.9319727891156, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=29.9319727891156, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=29.9319727891156, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=54.2857142857143, Blast_Score=341, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=44.7284345047923, Blast_Score=290, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=44.7284345047923, Blast_Score=290, Evalue=8e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=44.7284345047923, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.9838187702265, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=34.8214285714286, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=43.0868167202572, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=41.9871794871795, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=42.2222222222222, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=39.5939086294416, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=118, Percent_Identity=38.135593220339, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=46.0063897763578, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=42.8571428571429, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24651458, Length=360, Percent_Identity=34.7222222222222, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24651456, Length=360, Percent_Identity=34.7222222222222, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI281362873, Length=360, Percent_Identity=34.7222222222222, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24651454, Length=360, Percent_Identity=34.7222222222222, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24651462, Length=379, Percent_Identity=32.9815303430079, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24651464, Length=379, Percent_Identity=32.9815303430079, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI45552010, Length=379, Percent_Identity=32.9815303430079, Blast_Score=202, Evalue=2e-52,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34309; Mature: 34178

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNGHYPDYRVFCGNANRPLAEAIAKELGRPLARATVGRFSDGEIQVEIGENVRGLDTF
CCCCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCEEE
IIQSTSPDANTNLMELLIMIDALKRASAGSINAVLPYYGYARQDRKVAPRVPITAKLIAD
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHH
LIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEHMRKRFDGSAHDLVIVSPDAG
HHHHCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GVERARAYSKRLGAGLGIVDKRRTKPNVAEIMNVIGDVNGKVAVLLDDMIDTAGTLTQAA
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
NALVDKGATRVFAYATHAVLSGPAVDRIMKSPIEEVVVTDSIQLAPPAAACPKIRTLSVA
HHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHCCCEEECCCCCCCCCHHHHHHH
GLLAEAIRRIHSADSLSSLFV
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASNGHYPDYRVFCGNANRPLAEAIAKELGRPLARATVGRFSDGEIQVEIGENVRGLDTF
CCCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCEEE
IIQSTSPDANTNLMELLIMIDALKRASAGSINAVLPYYGYARQDRKVAPRVPITAKLIAD
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHH
LIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEHMRKRFDGSAHDLVIVSPDAG
HHHHCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GVERARAYSKRLGAGLGIVDKRRTKPNVAEIMNVIGDVNGKVAVLLDDMIDTAGTLTQAA
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
NALVDKGATRVFAYATHAVLSGPAVDRIMKSPIEEVVVTDSIQLAPPAAACPKIRTLSVA
HHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHCCCEEECCCCCCCCCHHHHHHH
GLLAEAIRRIHSADSLSSLFV
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA