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The map label for this gene is uraA [H]

Identifier: 220915191

GI number: 220915191

Start: 78773

End: 80071

Strand: Reverse

Name: uraA [H]

Synonym: A2cp1_0070

Alternate gene names: 220915191

Gene position: 80071-78773 (Counterclockwise)

Preceding gene: 220915197

Following gene: 220915184

Centisome position: 1.59

GC content: 70.28

Gene sequence:

>1299_bases
ATGAAGAGGACCGTGGACGTCGGGGAGCGGCTGCCGCTGCTCCAGAGCATTCCCCTGTCGCTGCAGCACCTGTTCGCCAT
GTTCGGCGCCACCGTGCTGGTGCCGTTCCTGGTCGGGCTCGACACCTCGGTGACCTTGTTCACCAGCGGTGTCGGCACGC
TCGTCTACATCTTCATCACGAAGGGGAAGATCCCGGCCTACCTCGGCTCCTCGTTCGCGTTCATCGCCGCGCTCTCCGCC
ATCATCGGGGTCGCGCCCGGCCAGGCCGCGCCGGCCGACCGGGTGGCCGTGGCCATGGGCGGCTGCGTGGCGGTGGGCGT
CTGCTACCTCGTGGTGGCGGCGCTCATCGCGAAGTTCGGCACCGGCTGGATCGACCGCCTGCTCCCGCCGGTGGTGATCG
GCTCGGTGGTGATGGTCATCGGCCTCGGCCTCGCCCGCGTGGCGGTGGTCAACATGGCCATGAACGGCGGCGGCCCCACC
TACCGGCCGGAGTTCTTCGCGGTGGCGCTCGCGTCGCTCGCCATCGCCATCCTGGCGGCGGTGTTCCTGAAGGGCTTCCT
GGGCGTCATCCCGGTGCTCATCGGCATCGTGGGCGGCTACGTGGTGGCGCTCCTCGCCGGCCAGGTGGACCTCTCCGGCG
TGGCGGCGGCGCGGCCGCTGGCGGTGCCGCCCTTCGTGCTCCCGCGGTTCACCTGGGCGGCCATCATCACGCTCGCCCCC
ATCTCGCTCGTGGTCATCACCGAGCACATCGGCCACCTCATCGTCACGAACAACGTGGTGGGCCGGGACTTCGTGAAGGA
CCCGGGCCTGCACCGCTCGCTCGCCGGCGACGGCGTCGCGACCATGATCTCCGGCGCGCTGGGCGGCCCGCCCAACACCA
CCTACGGCGAGAACATCGGCGTCATGGCCATCACCCGCGTCTTCTCGGTGTGGGTGATCGGCGGCGCGGCGGTGCTCGCC
GTCCTGATGTCCTTCCTGCCGCCGGTGGGCGCGCTCATCCGCTCCATCCCGACCCAGGTGATGGGCGGCATCTGCATCCT
GCTGTTCGGGATCATCGCCTCCGCCGGCATCCGCATGCTGGTCGAGGCGGGCATCGACTTCTCGCAGAAGCGGAACCTGA
TCATCGCCTCGGTGGTGCTGGTCATCGGCGTGGGCGGCGCCGAGATGCACTTCGGCTCGGTGAAGATCGACGCCATGCCG
CTCGCCACCTACGTCGGCATCCTGCTCAACCTGGTGCTGCCGCGCGGGATGGAGGGCACCGCCGCGAACGGCGCCGTCGC
CGAGGCGCCGGACGTGTAG

Upstream 100 bases:

>100_bases
AGGGCATGATGCGCCGCCCCAGCCCTCCGGCACCCCGGCCGCCTCGCGGCCAGCGCCCGGGCGAGCGGGCGCGTCGCGTG
GCGCATCTCGAGGAGGGACC

Downstream 100 bases:

>100_bases
CCGGCGGGACCCGCTCGCCCCTCGGTGCGCCCGGGGCGAGCGGGCCGCTCGGCACCGGTGAGGCGATCCCGCCCGCGGTG
AGCCGTCGGCCGCGGGCGGG

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPFLVGLDTSVTLFTSGVGTLVYIFITKGKIPAYLGSSFAFIAALSA
IIGVAPGQAAPADRVAVAMGGCVAVGVCYLVVAALIAKFGTGWIDRLLPPVVIGSVVMVIGLGLARVAVVNMAMNGGGPT
YRPEFFAVALASLAIAILAAVFLKGFLGVIPVLIGIVGGYVVALLAGQVDLSGVAAARPLAVPPFVLPRFTWAAIITLAP
ISLVVITEHIGHLIVTNNVVGRDFVKDPGLHRSLAGDGVATMISGALGGPPNTTYGENIGVMAITRVFSVWVIGGAAVLA
VLMSFLPPVGALIRSIPTQVMGGICILLFGIIASAGIRMLVEAGIDFSQKRNLIIASVVLVIGVGGAEMHFGSVKIDAMP
LATYVGILLNLVLPRGMEGTAANGAVAEAPDV

Sequences:

>Translated_432_residues
MKRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPFLVGLDTSVTLFTSGVGTLVYIFITKGKIPAYLGSSFAFIAALSA
IIGVAPGQAAPADRVAVAMGGCVAVGVCYLVVAALIAKFGTGWIDRLLPPVVIGSVVMVIGLGLARVAVVNMAMNGGGPT
YRPEFFAVALASLAIAILAAVFLKGFLGVIPVLIGIVGGYVVALLAGQVDLSGVAAARPLAVPPFVLPRFTWAAIITLAP
ISLVVITEHIGHLIVTNNVVGRDFVKDPGLHRSLAGDGVATMISGALGGPPNTTYGENIGVMAITRVFSVWVIGGAAVLA
VLMSFLPPVGALIRSIPTQVMGGICILLFGIIASAGIRMLVEAGIDFSQKRNLIIASVVLVIGVGGAEMHFGSVKIDAMP
LATYVGILLNLVLPRGMEGTAANGAVAEAPDV
>Mature_432_residues
MKRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPFLVGLDTSVTLFTSGVGTLVYIFITKGKIPAYLGSSFAFIAALSA
IIGVAPGQAAPADRVAVAMGGCVAVGVCYLVVAALIAKFGTGWIDRLLPPVVIGSVVMVIGLGLARVAVVNMAMNGGGPT
YRPEFFAVALASLAIAILAAVFLKGFLGVIPVLIGIVGGYVVALLAGQVDLSGVAAARPLAVPPFVLPRFTWAAIITLAP
ISLVVITEHIGHLIVTNNVVGRDFVKDPGLHRSLAGDGVATMISGALGGPPNTTYGENIGVMAITRVFSVWVIGGAAVLA
VLMSFLPPVGALIRSIPTQVMGGICILLFGIIASAGIRMLVEAGIDFSQKRNLIIASVVLVIGVGGAEMHFGSVKIDAMP
LATYVGILLNLVLPRGMEGTAANGAVAEAPDV

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=49.0338164251208, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI87081818, Length=417, Percent_Identity=41.0071942446043, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI87082181, Length=393, Percent_Identity=28.7531806615776, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1790087, Length=413, Percent_Identity=27.1186440677966, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87082178, Length=449, Percent_Identity=25.8351893095768, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21356175, Length=431, Percent_Identity=25.754060324826, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44173; Mature: 44173

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]