Click here to switch to the map view.

The map label for this gene is etrA [H]

Identifier: 220914954

GI number: 220914954

Start: 333054

End: 333743

Strand: Reverse

Name: etrA [H]

Synonym: Mnod_8112

Alternate gene names: 220914954

Gene position: 333743-333054 (Counterclockwise)

Preceding gene: 220914961

Following gene: 220914953

Centisome position: 72.86

GC content: 65.22

Gene sequence:

>690_bases
ATGGACCAGGCGCCGCGATGGACGAGACCGACGATGGGCACCCTGTTCGCGGGCCTAGAACGCGAACCAGCCGACGCCCT
GCTGGATGCGGCCACGCATCGTCAGTTTGCAGAAGGGACGACCCTCTTCCACCAGGGGGATGCGCCGAGCCAGCTCTTTC
AGGTCAGCGCGGGCTTGGTGAAGCTGTCGCGGGTCAATCCGGAAGGTGAGCAGACGACGCTCCGGTTCATGGGAGCCGGC
GACCTCGTTGGTTGCGTCGCCGTATTCCAGCAATCTCCCTTCCCGGCAACTGCTATCGCCAGCAAGCCCACCAGCGTCTT
GTGTTGGGGAGCAGCGCAGATCCTTGACCTAACGCGTCGCTACCCCGCAATCTCGGCCAACGCTCTGAAAACCGTGGGGG
ACCGTGCCCGGGAGATGATCGACCGGGTGGCCGAGCTGACGGACAAGGGTGTCGAGGCGCGGATCGCCAGCGTCCTCCTA
CGCCTGGCTGGCCAGGTTGGGCGTACCTGTTTGGCGGGCGTCGAGATCGCGTACCCGGTCACGAGGAGGGATGTGGCCGA
GATGACGGGTGTCACCTACTTCACCGTCAGCCGGATCCTCGGCGGTTGGCAGAGGCAGGGCCTCGTGCAGCTCGGTCGGG
TCCGAATCATCGTCATGGAGCCGCAACGCCTGGCCCAAATTGCTGGCTGA

Upstream 100 bases:

>100_bases
CCTCGTGCGGCGCGGCATCGCTTGCGGTGGTTCCTGCGCGTTCGTTGCGCGAAGGGAGGCAGGCCCGGTAAGTTGTAAGG
TGAGAGGACGGAAAGCGGCA

Downstream 100 bases:

>100_bases
GGCGTCGCGAAGCTGAATGCGTCTGACGCCGTCGTCGCTGGGCGGGAGCGGACGTCGGGCGTCTCTCTGACAGCGCTCGC
AAGTCGGTCGAGATTGAACG

Product: transcriptional regulator, Crp/Fnr family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MDQAPRWTRPTMGTLFAGLEREPADALLDAATHRQFAEGTTLFHQGDAPSQLFQVSAGLVKLSRVNPEGEQTTLRFMGAG
DLVGCVAVFQQSPFPATAIASKPTSVLCWGAAQILDLTRRYPAISANALKTVGDRAREMIDRVAELTDKGVEARIASVLL
RLAGQVGRTCLAGVEIAYPVTRRDVAEMTGVTYFTVSRILGGWQRQGLVQLGRVRIIVMEPQRLAQIAG

Sequences:

>Translated_229_residues
MDQAPRWTRPTMGTLFAGLEREPADALLDAATHRQFAEGTTLFHQGDAPSQLFQVSAGLVKLSRVNPEGEQTTLRFMGAG
DLVGCVAVFQQSPFPATAIASKPTSVLCWGAAQILDLTRRYPAISANALKTVGDRAREMIDRVAELTDKGVEARIASVLL
RLAGQVGRTCLAGVEIAYPVTRRDVAEMTGVTYFTVSRILGGWQRQGLVQLGRVRIIVMEPQRLAQIAG
>Mature_229_residues
MDQAPRWTRPTMGTLFAGLEREPADALLDAATHRQFAEGTTLFHQGDAPSQLFQVSAGLVKLSRVNPEGEQTTLRFMGAG
DLVGCVAVFQQSPFPATAIASKPTSVLCWGAAQILDLTRRYPAISANALKTVGDRAREMIDRVAELTDKGVEARIASVLL
RLAGQVGRTCLAGVEIAYPVTRRDVAEMTGVTYFTVSRILGGWQRQGLVQLGRVRIIVMEPQRLAQIAG

Specific function: Regulates anaerobic growth on fumarate, nitrite, Fe(3+), TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+) [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=206, Percent_Identity=27.6699029126214, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24777; Mature: 24777

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQAPRWTRPTMGTLFAGLEREPADALLDAATHRQFAEGTTLFHQGDAPSQLFQVSAGLV
CCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHH
KLSRVNPEGEQTTLRFMGAGDLVGCVAVFQQSPFPATAIASKPTSVLCWGAAQILDLTRR
EEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCEEEEHHHHHHHHHHHH
YPAISANALKTVGDRAREMIDRVAELTDKGVEARIASVLLRLAGQVGRTCLAGVEIAYPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
TRRDVAEMTGVTYFTVSRILGGWQRQGLVQLGRVRIIVMEPQRLAQIAG
HHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCEEEEEECCHHHHHHCC
>Mature Secondary Structure
MDQAPRWTRPTMGTLFAGLEREPADALLDAATHRQFAEGTTLFHQGDAPSQLFQVSAGLV
CCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHH
KLSRVNPEGEQTTLRFMGAGDLVGCVAVFQQSPFPATAIASKPTSVLCWGAAQILDLTRR
EEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCEEEEHHHHHHHHHHHH
YPAISANALKTVGDRAREMIDRVAELTDKGVEARIASVLLRLAGQVGRTCLAGVEIAYPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
TRRDVAEMTGVTYFTVSRILGGWQRQGLVQLGRVRIIVMEPQRLAQIAG
HHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCEEEEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253682; 12368813 [H]