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The map label for this gene is caiT [H]

Identifier: 220905602

GI number: 220905602

Start: 2821399

End: 2822976

Strand: Reverse

Name: caiT [H]

Synonym: Ddes_2342

Alternate gene names: 220905602

Gene position: 2822976-2821399 (Counterclockwise)

Preceding gene: 220905605

Following gene: 220905600

Centisome position: 98.24

GC content: 58.56

Gene sequence:

>1578_bases
ATGGCTGAAATCAAGCCCACTGGCGCATCTGGCGAAAACAGCGCCGAGGACCTGCGACCGGACTGGAAGATATTTGTTCC
GGGCCTGCTTATCGTGCTGCTCATCAGTTTGCCCGCAGTAATTGTGCCCAAGGCTGCGGAATCGGTGCTTACGGCAATTT
ACCAGCCTTTTGCGGCCAACTTCGGCACGCTGTACCTCTGGATAACCGTTGGCCTGATCTTTCTCTGCTTCTACTTTGCC
TTCAGCCGCTGGGGCGACATCAAGTTTGGCGAACCTGACGAAAAGCCCCAGTTTGCCCTGCCGTCCTGGATAGCCATGAT
TTTCTGTTCCGGCGTGGGCGGCGCCATCATGTTCTGGGCCATTACCGAGCCACTCTGGAACATACTTATTCCGCCGCAGT
ACGCCGACCCCATGAGCACGCAGGCTTATGACTGGGCGCTGGCCTACCTGCTGATGCACTGGGGACCCAACGCCTGGTGC
ACCTATCTGATTACGGCGCTACCCATTGCCTACATGTTCTACATCCGCAAGGAGCCTTTCCTGCGGGTCAGCACGGCCAC
AGAAATGATTATCGGCCAGCGCATGGCGCGCGGCTGGCTGGGCCTGTGCATTGACGTGTTCTTTATCCTGGGGCTCATGT
TCTGTACGGCCGTGACCATGTGCCTTTCTTTGCCCACAGTGGCCTATGCACTGCAAAGCGTGTTCGGCATCAGTCCCAAC
CTGACCACGCAGGTCGTCATTCTGGCCTTCAGCGGTCTGGTAGCGGGCTATACCGTGTACCGGGGGCTGGACAAGGGCAT
CAAGTGGCTGAGCGACGTCAACGTCATTTTGGCCCTGCTGCTGGCGGCTTACTGTTTCTTCGCCGGCCCGACCGTGCAGC
TTTTCAACATTTTCACCAATGCCTTCGGTAAATGGCTGGGCAACTACCCCAACATGGTCTTCTGGACAGACCCCTGGGGC
GGTGGCAGCTTTCCGCAGGACTGGACCATTTTTTACGCCCTGTTCTGGGCGGGTTTTGGTCCTTTTATGGGCCTGTTCAT
TGCGCGTATTTCACGCGGCCGCACCGTGCGTGAAATCATTTTGTGGGGCATGACGGGAACGGTCTCCGGCGGCTGTCTGA
TGCACGGCATCTTTGGCTCCTATTCCCTCTATGTACAGCATGCCGGCATGCTGGATGCCGTAAGCATTCTCAAGGCCGAG
GGCGGGCCAGCCGCCATGATTGCCGTGCTCGGCACATTGCCGTTCAAGGAAGTGGTGCTGGTGGCGTACTGCCTGCTGTC
CACCATTTTTCTGGCAACCACGGTCAACTCCGGCTCCTATGTGGTCGCCAGTACGGCCACGCGCCGCCTCAGCCCCGATT
CCGAGCCTCATCGCCTGCACCGTACCTTCTGGTGCCTTGTGCAGTGCATTCTGGCCCTGGGCATGATCTGCATGGGCGGC
CTTGGCGTTGCCAAGATGTTCGGCAATTTTTCCGGCGCGCTCATGGCCCTGCCGTCGCTGCTGCTGACCTTCTGCTGGCT
CAAGATTATCCGCACTGACGGGCCTTCGGTGCTGCGCAAGTACCAGACAAAGCTCTGA

Upstream 100 bases:

>100_bases
CATTATAAAATAATACAAGTATTTCAGCTTGGTGAATTTTGGCACGACTACTGCAGAATGGGTGAAAATCTTTTTCACTA
TCTGCTCATCGGGAGGCAAC

Downstream 100 bases:

>100_bases
GAACACGGCCGCACCCCGAGCGGCCCAAGGGCGTAGCCCGTGTAAACAGTCCGGAAACCGGCGGTTCTCCTTCCTGCCGG
TTTCCGGACTGTCTTTATGG

Product: BCCT transporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAEIKPTGASGENSAEDLRPDWKIFVPGLLIVLLISLPAVIVPKAAESVLTAIYQPFAANFGTLYLWITVGLIFLCFYFA
FSRWGDIKFGEPDEKPQFALPSWIAMIFCSGVGGAIMFWAITEPLWNILIPPQYADPMSTQAYDWALAYLLMHWGPNAWC
TYLITALPIAYMFYIRKEPFLRVSTATEMIIGQRMARGWLGLCIDVFFILGLMFCTAVTMCLSLPTVAYALQSVFGISPN
LTTQVVILAFSGLVAGYTVYRGLDKGIKWLSDVNVILALLLAAYCFFAGPTVQLFNIFTNAFGKWLGNYPNMVFWTDPWG
GGSFPQDWTIFYALFWAGFGPFMGLFIARISRGRTVREIILWGMTGTVSGGCLMHGIFGSYSLYVQHAGMLDAVSILKAE
GGPAAMIAVLGTLPFKEVVLVAYCLLSTIFLATTVNSGSYVVASTATRRLSPDSEPHRLHRTFWCLVQCILALGMICMGG
LGVAKMFGNFSGALMALPSLLLTFCWLKIIRTDGPSVLRKYQTKL

Sequences:

>Translated_525_residues
MAEIKPTGASGENSAEDLRPDWKIFVPGLLIVLLISLPAVIVPKAAESVLTAIYQPFAANFGTLYLWITVGLIFLCFYFA
FSRWGDIKFGEPDEKPQFALPSWIAMIFCSGVGGAIMFWAITEPLWNILIPPQYADPMSTQAYDWALAYLLMHWGPNAWC
TYLITALPIAYMFYIRKEPFLRVSTATEMIIGQRMARGWLGLCIDVFFILGLMFCTAVTMCLSLPTVAYALQSVFGISPN
LTTQVVILAFSGLVAGYTVYRGLDKGIKWLSDVNVILALLLAAYCFFAGPTVQLFNIFTNAFGKWLGNYPNMVFWTDPWG
GGSFPQDWTIFYALFWAGFGPFMGLFIARISRGRTVREIILWGMTGTVSGGCLMHGIFGSYSLYVQHAGMLDAVSILKAE
GGPAAMIAVLGTLPFKEVVLVAYCLLSTIFLATTVNSGSYVVASTATRRLSPDSEPHRLHRTFWCLVQCILALGMICMGG
LGVAKMFGNFSGALMALPSLLLTFCWLKIIRTDGPSVLRKYQTKL
>Mature_524_residues
AEIKPTGASGENSAEDLRPDWKIFVPGLLIVLLISLPAVIVPKAAESVLTAIYQPFAANFGTLYLWITVGLIFLCFYFAF
SRWGDIKFGEPDEKPQFALPSWIAMIFCSGVGGAIMFWAITEPLWNILIPPQYADPMSTQAYDWALAYLLMHWGPNAWCT
YLITALPIAYMFYIRKEPFLRVSTATEMIIGQRMARGWLGLCIDVFFILGLMFCTAVTMCLSLPTVAYALQSVFGISPNL
TTQVVILAFSGLVAGYTVYRGLDKGIKWLSDVNVILALLLAAYCFFAGPTVQLFNIFTNAFGKWLGNYPNMVFWTDPWGG
GSFPQDWTIFYALFWAGFGPFMGLFIARISRGRTVREIILWGMTGTVSGGCLMHGIFGSYSLYVQHAGMLDAVSILKAEG
GPAAMIAVLGTLPFKEVVLVAYCLLSTIFLATTVNSGSYVVASTATRRLSPDSEPHRLHRTFWCLVQCILALGMICMGGL
GVAKMFGNFSGALMALPSLLLTFCWLKIIRTDGPSVLRKYQTKL

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=472, Percent_Identity=30.9322033898305, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788102, Length=406, Percent_Identity=32.0197044334975, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786506, Length=473, Percent_Identity=28.3298097251586, Blast_Score=185, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 57913; Mature: 57782

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKPTGASGENSAEDLRPDWKIFVPGLLIVLLISLPAVIVPKAAESVLTAIYQPFAAN
CCCCCCCCCCCCCCHHHCCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
FGTLYLWITVGLIFLCFYFAFSRWGDIKFGEPDEKPQFALPSWIAMIFCSGVGGAIMFWA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
ITEPLWNILIPPQYADPMSTQAYDWALAYLLMHWGPNAWCTYLITALPIAYMFYIRKEPF
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
LRVSTATEMIIGQRMARGWLGLCIDVFFILGLMFCTAVTMCLSLPTVAYALQSVFGISPN
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTTQVVILAFSGLVAGYTVYRGLDKGIKWLSDVNVILALLLAAYCFFAGPTVQLFNIFTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AFGKWLGNYPNMVFWTDPWGGGSFPQDWTIFYALFWAGFGPFMGLFIARISRGRTVREII
HHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LWGMTGTVSGGCLMHGIFGSYSLYVQHAGMLDAVSILKAEGGPAAMIAVLGTLPFKEVVL
HHCCCCCCCCCHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
VAYCLLSTIFLATTVNSGSYVVASTATRRLSPDSEPHRLHRTFWCLVQCILALGMICMGG
HHHHHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LGVAKMFGNFSGALMALPSLLLTFCWLKIIRTDGPSVLRKYQTKL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
AEIKPTGASGENSAEDLRPDWKIFVPGLLIVLLISLPAVIVPKAAESVLTAIYQPFAAN
CCCCCCCCCCCCCHHHCCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC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HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA