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The map label for this gene is sdaA [H]

Identifier: 220905570

GI number: 220905570

Start: 2775620

End: 2777041

Strand: Reverse

Name: sdaA [H]

Synonym: Ddes_2309

Alternate gene names: 220905570

Gene position: 2777041-2775620 (Counterclockwise)

Preceding gene: 220905571

Following gene: 220905569

Centisome position: 96.65

GC content: 61.11

Gene sequence:

>1422_bases
ATGTTGAGCGTTTTTGATCTGTTCAAAATCGGCATCGGGCCGTCCAGTTCGCACACTGTGGGTCCCATGGTGGCGGGCAA
GGCCTTTGCGGGCGAACTGGCGGTATTGGGGCTGCTGCCCCTGACCGGACGTGTAACCGTGGATCTCTTTGGTTCTCTGG
CCCTTACGGGCGAAGGGCACGGCACTACCGGAGCCATCCTGGGTGGCCTTGAGGGCGAGGAACCGGCTACGGTGGATACC
GCCCATCTGGTGCGGCGCACAGCAGAACTGAAAAATAATGCGGACCTGAATCTTATTTGCGCGCATCGCATTCCGTTTAT
CTACGAACGCGACATGCTTTTGCACAAGGGCCTGTTTCTGCCCCGGCACTCCAACGGCATGAAGCTTGTGGCTTACGCCG
CTGACGGCACGGAACTGCATTCCCGCGTGTACTATTCCATCGGCGGCGGTTTTATACGCACTGATGCGGACTTTGAAACC
GGGCCGGAAGAATACCCCGCGCCGCCGTACGTCTATGAAACAGCCGAAGAACTGTTCGCCCATTGCGAACGGGAAGGCAA
GACCGTGGCCCAGATTGTCATGGTCAATGAAAGTTTTTGGCACTCAGAGGCTGAGGTGCGCCGCCGTGCCCAGGCCGTCA
TGGATGTCATGCGTGATTCGGTGGAGCGCGGCTGTTATACCGACGGCGTATTGCCCGGCGGCTACAACGTGCGCCGTCGC
GCGCCCAATCTGCTGCGCAAGGTCAGTGCCCTTCAGGCCCAGGGCCGCCGTGATCTGAGTCTGTGGCCCACGCTGTATGC
TTTTGCCGTTGCCGAAGAAAACGCCTCCGGCGGGCGGGTGGTGACGGCTCCGACCAACGGAGCGGCCGGTATTGTACCCG
CGGTACTGACCTACTACCAGAATTTCTACCCCCATGCCACGGAAGACGGCGCACTGGATTTTCTGCTTACGGCCGGGGCC
ATCGGGCTTTTTTACAAGATCAATGCCTCCATCTCCGGGGCTGAGGTGGGCTGCCAGGGTGAAGTGGGCGTGGCCTGTTC
TATGGCTGCCGGAGCCTACTGCGCGGTAACGGGCGGCAGCGTAAAGCAGGTGGAAGTGGCGGCGGAGATCGGTATGGAGC
ATAACCTGGGCCTTACCTGCGACCCTGTGGGCGGCCTTGTGCAGATACCCTGCATCGAGCGCAACGGGGTAGCTGCGGAA
CGCGCGGTCAACTGCGCCCAGCTTTCACGGCTGGAAGACGGGCGGCAGCGCGTTATTTCTCTGGATGCCATCATTGAGGT
CATGTACCGCACGGGCCTTGATTTGCAGTCCCGCTACAAGGAAACCTCGCTGGGCGGCCTGGCTCAGGCCGTGGCCGAGG
GGCTTGAACGCAAAAAGCAGGGCGGCGCGGGGCCGTCCGGCAGGAAGGAAGCAGTATCATGA

Upstream 100 bases:

>100_bases
CGTGCCACACGTTGCGTGGCGGGGCCTCCTGTGTCACAAGAGAATAGGCGGAGTTGCGCGCCATTGTGCAGCGCTGCACA
TTTTTTTCGCGGGGGACGTC

Downstream 100 bases:

>100_bases
GTGAAATACATATAGTGGCCGAACTGGAAGTGCTGCCGCAGTATCGCGAAGCCTTCATGCCCGAGCTGCGCGCTCTGGTG
GACGGCAGCCGCGGAGAACC

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MLSVFDLFKIGIGPSSSHTVGPMVAGKAFAGELAVLGLLPLTGRVTVDLFGSLALTGEGHGTTGAILGGLEGEEPATVDT
AHLVRRTAELKNNADLNLICAHRIPFIYERDMLLHKGLFLPRHSNGMKLVAYAADGTELHSRVYYSIGGGFIRTDADFET
GPEEYPAPPYVYETAEELFAHCEREGKTVAQIVMVNESFWHSEAEVRRRAQAVMDVMRDSVERGCYTDGVLPGGYNVRRR
APNLLRKVSALQAQGRRDLSLWPTLYAFAVAEENASGGRVVTAPTNGAAGIVPAVLTYYQNFYPHATEDGALDFLLTAGA
IGLFYKINASISGAEVGCQGEVGVACSMAAGAYCAVTGGSVKQVEVAAEIGMEHNLGLTCDPVGGLVQIPCIERNGVAAE
RAVNCAQLSRLEDGRQRVISLDAIIEVMYRTGLDLQSRYKETSLGGLAQAVAEGLERKKQGGAGPSGRKEAVS

Sequences:

>Translated_473_residues
MLSVFDLFKIGIGPSSSHTVGPMVAGKAFAGELAVLGLLPLTGRVTVDLFGSLALTGEGHGTTGAILGGLEGEEPATVDT
AHLVRRTAELKNNADLNLICAHRIPFIYERDMLLHKGLFLPRHSNGMKLVAYAADGTELHSRVYYSIGGGFIRTDADFET
GPEEYPAPPYVYETAEELFAHCEREGKTVAQIVMVNESFWHSEAEVRRRAQAVMDVMRDSVERGCYTDGVLPGGYNVRRR
APNLLRKVSALQAQGRRDLSLWPTLYAFAVAEENASGGRVVTAPTNGAAGIVPAVLTYYQNFYPHATEDGALDFLLTAGA
IGLFYKINASISGAEVGCQGEVGVACSMAAGAYCAVTGGSVKQVEVAAEIGMEHNLGLTCDPVGGLVQIPCIERNGVAAE
RAVNCAQLSRLEDGRQRVISLDAIIEVMYRTGLDLQSRYKETSLGGLAQAVAEGLERKKQGGAGPSGRKEAVS
>Mature_473_residues
MLSVFDLFKIGIGPSSSHTVGPMVAGKAFAGELAVLGLLPLTGRVTVDLFGSLALTGEGHGTTGAILGGLEGEEPATVDT
AHLVRRTAELKNNADLNLICAHRIPFIYERDMLLHKGLFLPRHSNGMKLVAYAADGTELHSRVYYSIGGGFIRTDADFET
GPEEYPAPPYVYETAEELFAHCEREGKTVAQIVMVNESFWHSEAEVRRRAQAVMDVMRDSVERGCYTDGVLPGGYNVRRR
APNLLRKVSALQAQGRRDLSLWPTLYAFAVAEENASGGRVVTAPTNGAAGIVPAVLTYYQNFYPHATEDGALDFLLTAGA
IGLFYKINASISGAEVGCQGEVGVACSMAAGAYCAVTGGSVKQVEVAAEIGMEHNLGLTCDPVGGLVQIPCIERNGVAAE
RAVNCAQLSRLEDGRQRVISLDAIIEVMYRTGLDLQSRYKETSLGGLAQAVAEGLERKKQGGAGPSGRKEAVS

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=49.7797356828194, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI48994925, Length=462, Percent_Identity=49.1341991341991, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1789161, Length=457, Percent_Identity=49.0153172866521, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 50367; Mature: 50367

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVFDLFKIGIGPSSSHTVGPMVAGKAFAGELAVLGLLPLTGRVTVDLFGSLALTGEGH
CCCHHHHHHHCCCCCCCCCCCCHHCCCHHHCCCCEEEEECCCCEEEEEEEEEEEEECCCC
GTTGAILGGLEGEEPATVDTAHLVRRTAELKNNADLNLICAHRIPFIYERDMLLHKGLFL
CCCHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCHHHHCCCCC
PRHSNGMKLVAYAADGTELHSRVYYSIGGGFIRTDADFETGPEEYPAPPYVYETAEELFA
EECCCCCEEEEEECCCHHHHHEEEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
HCEREGKTVAQIVMVNESFWHSEAEVRRRAQAVMDVMRDSVERGCYTDGVLPGGYNVRRR
HHHHCCCEEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
APNLLRKVSALQAQGRRDLSLWPTLYAFAVAEENASGGRVVTAPTNGAAGIVPAVLTYYQ
HHHHHHHHHHHHHCCCCCCCHHHHHHEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
NFYPHATEDGALDFLLTAGAIGLFYKINASISGAEVGCQGEVGVACSMAAGAYCAVTGGS
HHCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEEECCC
VKQVEVAAEIGMEHNLGLTCDPVGGLVQIPCIERNGVAAERAVNCAQLSRLEDGRQRVIS
CEEEEHHHHHCCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LDAIIEVMYRTGLDLQSRYKETSLGGLAQAVAEGLERKKQGGAGPSGRKEAVS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCC
>Mature Secondary Structure
MLSVFDLFKIGIGPSSSHTVGPMVAGKAFAGELAVLGLLPLTGRVTVDLFGSLALTGEGH
CCCHHHHHHHCCCCCCCCCCCCHHCCCHHHCCCCEEEEECCCCEEEEEEEEEEEEECCCC
GTTGAILGGLEGEEPATVDTAHLVRRTAELKNNADLNLICAHRIPFIYERDMLLHKGLFL
CCCHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCHHHHCCCCC
PRHSNGMKLVAYAADGTELHSRVYYSIGGGFIRTDADFETGPEEYPAPPYVYETAEELFA
EECCCCCEEEEEECCCHHHHHEEEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
HCEREGKTVAQIVMVNESFWHSEAEVRRRAQAVMDVMRDSVERGCYTDGVLPGGYNVRRR
HHHHCCCEEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
APNLLRKVSALQAQGRRDLSLWPTLYAFAVAEENASGGRVVTAPTNGAAGIVPAVLTYYQ
HHHHHHHHHHHHHCCCCCCCHHHHHHEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
NFYPHATEDGALDFLLTAGAIGLFYKINASISGAEVGCQGEVGVACSMAAGAYCAVTGGS
HHCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEEECCC
VKQVEVAAEIGMEHNLGLTCDPVGGLVQIPCIERNGVAAERAVNCAQLSRLEDGRQRVIS
CEEEEHHHHHCCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LDAIIEVMYRTGLDLQSRYKETSLGGLAQAVAEGLERKKQGGAGPSGRKEAVS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]